TDR Targets

Basic information

Technical information

TDR Targets ID: 866759
Name: 2-cyclopentyl-N-(2-diethylaminoethyl)-1-oxo-3 -thiophen-2-yl-3,4-dihydroisoquinoline-4-carb oxamide
MW: 439.613 | Formula: C25H33N3O2S
H donors: 1 H acceptors: 2 LogP: 3.69 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCN(CCNC(=O)C1c2ccccc2C(=O)N(C1c1cccs1)C1CCCC1)CC
InChi: 1S/C25H33N3O2S/c1-3-27(4-2)16-15-26-24(29)22-19-12-7-8-13-20(19)25(30)28(18-10-5-6-11-18)23(22)21-14-9-17-31-21/h7-9,12-14,17-18,22-23H,3-6,10-11,15-16H2,1-2H3,(H,26,29)
InChiKey: WPGHDVMCQYUGKH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-cyclopentyl-N-(2-diethylaminoethyl)-1-oxo-3-(2-thienyl)-3,4-dihydroisoquinoline-4-carboxamide
2-cyclopentyl-N-(2-diethylaminoethyl)-1-keto-3-(2-thienyl)-3,4-dihydroisoquinoline-4-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Matrix metalloprotease, N-terminal domain containing protein	0.0075	0.0155	0.0196
Onchocerca volvulus		0.0065	0.01	0.054
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0065	0.01	0.0126
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1428	0.7916	1
Brugia malayi	hypothetical protein	0.0065	0.01	0.0126
Onchocerca volvulus		0.008	0.0184	0.0998
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0065	0.01	0.0126
Brugia malayi	Hemopexin family protein	0.0087	0.0225	0.0285
Mycobacterium ulcerans	NADH dehydrogenase I subunit F	0.0689	0.368	0.368
Trichomonas vaginalis	NADH-ubiquinone oxidoreductase flavoprotein, putative	0.0689	0.368	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.01	0.0126
Brugia malayi	hypothetical protein	0.0065	0.01	0.0126
Giardia lamblia	Glycogen phosphorylase	0.0123	0.043	1
Onchocerca volvulus	Glycogen phosphorylase homolog	0.0123	0.043	0.233
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0068	0.0115	0.0313
Brugia malayi	hypothetical protein	0.0065	0.01	0.0126
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0065	0.01	0.0126
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0065	0.01	0.0126
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0065	0.01	0.2315
Loa Loa (eye worm)	NADH-ubiquinone oxidoreductase 51 kDa subunit	0.0689	0.368	0.4649
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0065	0.01	0.0126
Brugia malayi	hypothetical protein	0.0361	0.1797	0.2271
Mycobacterium ulcerans	proteasome PrcA	0.1791	1	1
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0068	0.0115	0.0145
Echinococcus multilocularis	a disintegrin and metalloproteinase with	0.0087	0.0229	0.0289
Loa Loa (eye worm)	hypothetical protein	0.0065	0.01	0.0126
Trypanosoma brucei	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial, putative	0.0689	0.368	1
Onchocerca volvulus		0.0065	0.01	0.054
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0065	0.01	0.2315
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0065	0.01	0.0126
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0065	0.01	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0065	0.01	0.0126
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0065	0.01	0.0126
Mycobacterium tuberculosis	Probable peptidoglycan hydrolase	0.0075	0.0155	0.0155
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0065	0.01	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0079	0.0099
Brugia malayi	carbohydrate phosphorylase	0.0123	0.043	0.0544
Onchocerca volvulus		0.0065	0.01	0.054
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0065	0.01	0.0126
Toxoplasma gondii	aldehyde dehydrogenase	0.0068	0.0115	1
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0065	0.01	0.0126
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0065	0.01	0.0126
Onchocerca volvulus		0.0065	0.01	0.054
Brugia malayi	Protein-tyrosine phosphatase 1	0.0065	0.01	0.0126
Onchocerca volvulus	4.1 G protein, putative homolog	0.0065	0.01	0.054
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0065	0.01	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0065	0.01	0.0126
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0065	0.01	0.0126
Trypanosoma cruzi	NADH-ubiquinone oxidoreductase, mitochondrial, putative	0.0689	0.368	1
Trypanosoma brucei	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	0.0689	0.368	1
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0065	0.01	0.2315
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0065	0.01	0.0126
Loa Loa (eye worm)	glycogen phosphorylase	0.0123	0.043	0.0544
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.1428	0.7916	1
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0065	0.01	0.0271
Schistosoma mansoni	protein tyrosine phosphatase	0.0065	0.01	0.0126
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0065	0.01	0.0126
Onchocerca volvulus		0.0065	0.01	0.054
Onchocerca volvulus		0.0089	0.0239	0.1292
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0065	0.01	0.0126
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0065	0.01	0.0126
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0065	0.01	0.0126
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0154	0.0609	0.0609
Loa Loa (eye worm)	hypothetical protein	0.0065	0.01	0.0126
Echinococcus multilocularis		0.0065	0.01	0.0126
Onchocerca volvulus		0.0065	0.01	0.054
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0065	0.01	0.0126
Echinococcus multilocularis	transfer RNA-Lys	0.008	0.0184	0.0233
Onchocerca volvulus		0.0065	0.01	0.054
Mycobacterium tuberculosis	Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H)	0.0331	0.1626	0.1626
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0065	0.01	0.0126
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0065	0.01	0.0126
Mycobacterium ulcerans	glycogen phosphorylase GlgP	0.0053	0.0031	0.0031
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0065	0.01	0.0126
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0065	0.01	0.0126
Schistosoma mansoni	ADAMTS5 peptidase (M12 family)	0.0087	0.0229	0.0289
Schistosoma mansoni	aldehyde dehydrogenase	0.0068	0.0115	0.0145
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0068	0.0115	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0065	0.01	0.0126
Onchocerca volvulus		0.0065	0.01	0.054
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0065	0.01	0.0126
Schistosoma mansoni	ADAM17 peptidase (M12 family)	0.0185	0.079	0.0998
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0065	0.01	0.0126
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0065	0.01	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0065	0.01	0.0126
Echinococcus granulosus	single minded 2	0.008	0.0184	0.0233
Schistosoma mansoni	NADH-ubiquinone oxidoreductase	0.0689	0.368	0.4649
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0068	0.0115	0.0145
Brugia malayi	NADH dehydrogenase subunit 1, identical	0.0089	0.0239	0.0301
Brugia malayi	Protein-tyrosine phosphatase	0.0065	0.01	0.0126
Onchocerca volvulus		0.0065	0.01	0.054
Schistosoma mansoni	protein tyrosine phosphatase	0.0065	0.01	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0065	0.01	0.0126
Echinococcus multilocularis	hypothetical protein	0.0065	0.01	0.0126
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0065	0.01	0.0126
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0065	0.01	0.0126
Echinococcus multilocularis	Blood coagulation inhibitor, Disintegrin	0.0116	0.0394	0.0498
Onchocerca volvulus		0.0065	0.01	0.054
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0333	0.1637	0.2068
Onchocerca volvulus	Matrix metalloproteinase homolog	0.0136	0.0506	0.2742
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0289	0.1384	0.1748
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0065	0.01	0.0126
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0065	0.01	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0361	0.1797	0.2271
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0065	0.01	0.0126
Schistosoma mansoni	aryl hydrocarbon receptor	0.0108	0.0345	0.0435
Onchocerca volvulus		0.0065	0.01	0.054
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1428	0.7916	1
Leishmania major	tyrosine specific protein phosphatase, putative	0.0065	0.01	0.0271
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0065	0.01	0.0126
Onchocerca volvulus		0.0065	0.01	0.054
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0065	0.01	0.0126
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0289	0.1384	0.1748
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0065	0.01	0.0126
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0289	0.1384	0.1748
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0065	0.01	0.0126
Trichomonas vaginalis	NADH-ubiquinone oxidoreductase flavoprotein, putative	0.0689	0.368	1
Onchocerca volvulus		0.0065	0.01	0.054
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0065	0.01	0.0126
Schistosoma mansoni	glycogen phosphorylase	0.0123	0.043	0.0544
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0065	0.01	0.0126
Brugia malayi	Matrixin family protein	0.0148	0.0576	0.0728
Loa Loa (eye worm)	hypothetical protein	0.0065	0.01	0.0126
Echinococcus multilocularis	glycogen phosphorylase	0.0123	0.043	0.0544
Brugia malayi	Matrixin family protein	0.0061	0.0079	0.0099
Onchocerca volvulus		0.0065	0.01	0.054
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0065	0.01	0.0126
Mycobacterium ulcerans	membrane protein ComEA	0.0154	0.0609	0.0609
Echinococcus granulosus	matrix metallopeptidase 7 M10 family	0.0223	0.1004	0.1268
Mycobacterium tuberculosis	Possible formate hydrogenlyase HycD (FHL)	0.0089	0.0239	0.0239
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0065	0.01	0.0126
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0068	0.0115	0.0115
Onchocerca volvulus	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial homolog	0.0369	0.1846	1
Loa Loa (eye worm)	matrixin family protein	0.0136	0.0506	0.0639
Entamoeba histolytica	glycogen phosphorylase, putative	0.0053	0.0031	0.073
Loa Loa (eye worm)	hypothetical protein	0.0065	0.01	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0065	0.01	0.0126
Onchocerca volvulus	Matrilysin homolog	0.0061	0.0079	0.0426
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0065	0.01	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0065	0.01	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0065	0.01	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0065	0.01	0.0126
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0065	0.01	0.0126
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0065	0.01	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0065	0.01	0.0126
Mycobacterium tuberculosis	Proteasome alpha subunit PrcA; assembles with beta subunit PrcB.	0.1791	1	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0065	0.01	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0065	0.01	0.0126
Entamoeba histolytica	glycogen phosphorylase, putative	0.0123	0.043	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0289	0.1384	0.1748
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0079	0.0099
Brugia malayi	Matrixin family protein	0.0061	0.0079	0.0099
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0065	0.01	0.0271
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0065	0.01	0.0126
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0065	0.01	0.0271
Echinococcus granulosus	a disintegrin and metalloproteinase with	0.0087	0.0229	0.0289
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0065	0.01	0.0126
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0065	0.01	0.0126
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0065	0.01	0.0126
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0065	0.01	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0065	0.01	0.0126
Echinococcus granulosus	NADH dehydrogenase ubiquinone flavoprotein 1	0.0689	0.368	0.4649
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0065	0.01	0.0126
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0065	0.01	0.0126
Onchocerca volvulus		0.0065	0.01	0.054
Chlamydia trachomatis	glycogen phosphorylase	0.0123	0.043	1
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.0223	0.1004	0.1268
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0065	0.01	0.0126
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0065	0.01	0.0126
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0065	0.01	0.0126
Schistosoma mansoni	aldehyde dehydrogenase	0.0068	0.0115	0.0145
Schistosoma mansoni	hypothetical protein	0.0331	0.1626	0.2054
Mycobacterium tuberculosis	Probable glycogen phosphorylase GlgP	0.0053	0.0031	0.0031
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0123	0.043	0.0923
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0065	0.01	0.0271
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0065	0.01	0.0126
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0065	0.01	0.0126
Onchocerca volvulus		0.0087	0.0225	0.1221
Schistosoma mansoni	matrix metallopeptidase-7 (M10 family)	0.0061	0.0079	0.0099
Mycobacterium tuberculosis	Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F)	0.0689	0.368	0.368
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0068	0.0115	0.0115
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0065	0.01	0.0126
Onchocerca volvulus		0.0065	0.01	0.054
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0065	0.01	0.0126
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0065	0.01	0.0126
Onchocerca volvulus		0.0089	0.0239	0.1292
Leishmania major	NADH-ubiquinone oxidoreductase, mitochondrial, putative	0.0689	0.368	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0065	0.01	0.0126
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0065	0.01	0.0271
Schistosoma mansoni	glycogen phosphorylase	0.0053	0.0031	0.004
Brugia malayi	Protein-tyrosine phosphatase	0.0065	0.01	0.0126
Schistosoma mansoni	NADH dehydrogenase subunit 1	0.0089	0.0239	0.0301
Brugia malayi	hypothetical protein	0.0089	0.0239	0.0301
Brugia malayi	bHLH-PAS transcription factor	0.008	0.0184	0.0233
Echinococcus multilocularis	glycogen phosphorylase	0.0123	0.043	0.0544
Mycobacterium ulcerans	NADH dehydrogenase subunit H	0.0331	0.1626	0.1626
Echinococcus multilocularis	Glycosyl transferase, family 35	0.0123	0.043	0.0544
Treponema pallidum	nitrogen fixation protein (rnfC)	0.0154	0.0609	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.01	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0065	0.01	0.0126
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0065	0.01	0.0126
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0065	0.01	0.0126
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0065	0.01	0.0126
Brugia malayi	NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial precursor	0.0689	0.368	0.4649
Onchocerca volvulus	Matrilysin homolog	0.0136	0.0506	0.2742
Schistosoma mansoni	protein tyrosine phosphatase	0.0065	0.01	0.0126
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0065	0.01	0.0126
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0065	0.01	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0065	0.01	0.0126
Onchocerca volvulus		0.0065	0.01	0.054
Brugia malayi	NADH dehydrogenase subunit 1	0.0089	0.0239	0.0301
Plasmodium vivax	acyl carrier protein, putative	0.0047	0	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0289	0.1384	0.1748
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0123	0.043	0.0923
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0065	0.01	0.0126
Plasmodium falciparum	acyl carrier protein	0.0047	0	0.5
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0065	0.01	0.0126
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.1428	0.7916	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.01	0.0126
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0065	0.01	0.0126
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0065	0.01	0.0126
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0065	0.01	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0065	0.01	0.0126
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0065	0.01	0.0126
Entamoeba histolytica	glycogen phosphorylase, putative	0.0053	0.0031	0.073
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0065	0.01	0.0126
Onchocerca volvulus		0.0065	0.01	0.054
Entamoeba histolytica	glycogenphosphorylase, putative	0.0053	0.0031	0.073
Echinococcus granulosus	adam 17 protease	0.0204	0.0895	0.1131
Mycobacterium ulcerans	putative regulatory protein	0.008	0.0184	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0065	0.01	0.0126
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0065	0.01	0.0126
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0289	0.1384	0.1748
Schistosoma mansoni	pcd6 interacting protein-related	0.0065	0.01	0.0126
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0065	0.01	0.0126
Onchocerca volvulus		0.0065	0.01	0.054
Echinococcus granulosus	glycogen phosphorylase	0.0123	0.043	0.0544
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0065	0.01	0.0126
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0065	0.01	0.0126
Loa Loa (eye worm)	matrix metalloproteinase	0.0061	0.0079	0.0099
Onchocerca volvulus		0.0065	0.01	0.054
Mycobacterium ulcerans	formate hydrogenlyase HycD	0.0089	0.0239	0.0239
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0289	0.1384	0.1748
Trypanosoma cruzi	NADH-ubiquinone oxidoreductase, mitochondrial, putative	0.0689	0.368	1
Brugia malayi	hypothetical protein	0.0065	0.01	0.0126
Echinococcus granulosus	NADH dehydrogenase subunit 1	0.0331	0.1626	0.2054
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0065	0.01	0.0126
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.1428	0.7916	1
Schistosoma mansoni	hypothetical protein	0.0087	0.0225	0.0285
Schistosoma mansoni	glycogen phosphorylase	0.0123	0.043	0.0544
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0068	0.0115	0.0115
Brugia malayi	PAS domain containing protein	0.0108	0.0345	0.0435
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0065	0.01	0.0126
Onchocerca volvulus		0.0065	0.01	0.054
Wolbachia endosymbiont of Brugia malayi	NADH dehydrogenase I subunit F	0.0689	0.368	1
Echinococcus granulosus	Blood coagulation inhibitor Disintegrin	0.0116	0.0394	0.0498
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0065	0.01	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0389	0.1959	0.2475
Schistosoma mansoni	single-minded	0.0108	0.0345	0.0435
Onchocerca volvulus		0.0065	0.01	0.054
Wolbachia endosymbiont of Brugia malayi	NADH dehydrogenase subunit H	0.0331	0.1626	0.4418
Brugia malayi	Matrixin family protein	0.0061	0.0079	0.0099
Mycobacterium leprae	PROBABLE HYDROLASE	0.0075	0.0155	0.0155
Onchocerca volvulus		0.0065	0.01	0.054
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0065	0.01	0.0126
Echinococcus granulosus	glycogen phosphorylase	0.0123	0.043	0.0544
Echinococcus multilocularis	adam 17 protease	0.0185	0.079	0.0998
Onchocerca volvulus		0.0061	0.0079	0.0426
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0065	0.01	0.0126
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0065	0.01	0.0126
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0065	0.01	0.0126
Brugia malayi	hypoxia-induced factor 1	0.0333	0.1637	0.2068
Echinococcus granulosus	Glycosyl transferase family 35	0.0123	0.043	0.0544
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0065	0.01	0.0126
Loa Loa (eye worm)	NADH dehydrogenase subunit 1	0.0089	0.0239	0.0301
Loa Loa (eye worm)	hypothetical protein	0.0065	0.01	0.0126
Brugia malayi	metalloprotease disintegrin 16 with thrombospondin type I motif	0.0087	0.0229	0.0289
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0079	0.0099
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0065	0.01	0.0126
Brugia malayi	Matrixin family protein	0.0061	0.0079	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0065	0.01	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0155	0.0196
Entamoeba histolytica	glycogen phosphorylase, putative	0.0123	0.043	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0065	0.01	0.0126
Mycobacterium ulcerans	hydrolase	0.0075	0.0155	0.0155
Brugia malayi	hypothetical protein	0.0065	0.01	0.0126
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0065	0.01	0.0126
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0065	0.01	0.0126
Loa Loa (eye worm)	matrixin family protein	0.0148	0.0576	0.0728
Loa Loa (eye worm)	hypothetical protein	0.0065	0.01	0.0126
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0065	0.01	0.0126
Echinococcus multilocularis	NADH dehydrogenase (ubiquinone) flavoprotein 1	0.0689	0.368	0.4649

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 866759