Detailed information for compound 866798

Basic information

Technical information
  • TDR Targets ID: 866798
  • Name: 2-(3-methoxyphenyl)-1-oxo-N-(4-propan-2-ylphe nyl)isoquinoline-4-carboxamide
  • MW: 412.48 | Formula: C26H24N2O3
  • H donors: 1 H acceptors: 2 LogP: 4.73 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)n1cc(C(=O)Nc2ccc(cc2)C(C)C)c2c(c1=O)cccc2
  • InChi: 1S/C26H24N2O3/c1-17(2)18-11-13-19(14-12-18)27-25(29)24-16-28(20-7-6-8-21(15-20)31-3)26(30)23-10-5-4-9-22(23)24/h4-17H,1-3H3,(H,27,29)
  • InChiKey: VUYXZQLHSXHQLR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-isopropylphenyl)-2-(3-methoxyphenyl)-1-oxo-isoquinoline-4-carboxamide
  • N-(4-isopropylphenyl)-2-(3-methoxyphenyl)-1-oxo-4-isoquinolinecarboxamide
  • N-(4-isopropylphenyl)-1-keto-2-(3-methoxyphenyl)isoquinoline-4-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus poly (ADP ribose) polymerase 0.0128 0.0968 0.1401
Onchocerca volvulus 0.0091 0.066 0.8188
Echinococcus granulosus g protein coupled receptor 0.0091 0.066 0.0956
Schistosoma mansoni tyrosyl-tRNA synthetase 0.0015 0.0031 0.0046
Brugia malayi MH2 domain containing protein 0.0019 0.0061 0.0089
Schistosoma mansoni biogenic amine receptor 0.0091 0.066 0.0977
Brugia malayi putative neuropeptide receptor NPR1 0.0091 0.066 0.0976
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0061 0.0231
Toxoplasma gondii ABC1 family protein 0.0024 0.0101 0.007
Schistosoma mansoni hypothetical protein 0.0091 0.066 0.0977
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0091 0.066 0.0977
Onchocerca volvulus 0.0091 0.066 0.8188
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.066 0.0977
Echinococcus granulosus 7TM GPCR rhodopsin 0.0091 0.066 0.0956
Schistosoma mansoni methionine-tRNA synthetase 0.0047 0.0292 0.0432
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Echinococcus granulosus cpg binding protein 0.0022 0.0091 0.0132
Mycobacterium tuberculosis Probable lipase LipE 0.0024 0.0101 0.007
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0024 0.0101 0.007
Brugia malayi hypothetical protein 0.0091 0.066 0.0976
Onchocerca volvulus 0.0024 0.0101 0.0861
Echinococcus granulosus neuropeptide FF receptor 2 0.0091 0.066 0.0956
Echinococcus multilocularis octanoyltransferase, mitochondrial 0.0016 0.0035 0.0051
Echinococcus multilocularis zinc finger protein 0.0014 0.002 0.0028
Plasmodium vivax replication factor C subunit 1, putative 0.0032 0.0172 0.1084
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.066 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0412 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.0707 0.138
Schistosoma mansoni hypothetical protein 0.0204 0.1604 0.2372
Echinococcus multilocularis neuropeptide FF receptor 2 0.0091 0.066 0.0956
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0101 0.0539
Echinococcus multilocularis neuropeptide receptor 0.0091 0.066 0.0956
Schistosoma mansoni hypothetical protein 0.0094 0.069 0.1021
Loa Loa (eye worm) hypothetical protein 0.0107 0.0799 0.1559
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.066 0.0977
Brugia malayi hypothetical protein 0.0027 0.0132 0.0195
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.066 0.0956
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0324 0.2606 0.5086
Echinococcus granulosus sodium and chloride dependent glycine 0.0053 0.0344 0.0498
Brugia malayi Serotonin receptor 0.0091 0.066 0.0976
Plasmodium falciparum replication factor C subunit 1, putative 0.0032 0.0172 0.1084
Onchocerca volvulus 0.0091 0.066 0.8188
Brugia malayi Bromodomain containing protein 0.0025 0.0112 0.0165
Echinococcus granulosus Immunoglobulin 0.0016 0.0038 0.0055
Loa Loa (eye worm) zinc finger protein 0.0195 0.153 0.2986
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Brugia malayi MH1 domain containing protein 0.0019 0.0061 0.0089
Echinococcus multilocularis leucyl tRNA synthetase 0.0047 0.0292 0.0423
Echinococcus multilocularis neuropeptide receptor A26 0.0091 0.066 0.0956
Loa Loa (eye worm) neuropeptide F receptor 0.0091 0.066 0.1289
Brugia malayi neuropeptide F receptor 0.0091 0.066 0.0976
Mycobacterium ulcerans lipase LipD 0.0024 0.0101 0.007
Loa Loa (eye worm) hypothetical protein 0.0298 0.2391 0.4666
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0061 0.0088
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.066 0.0956
Echinococcus multilocularis serotonin receptor 0.0091 0.066 0.0956
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0091 0.066 0.0976
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0132 0.0278
Echinococcus granulosus g-protein coupled receptor 0.0091 0.066 0.0956
Onchocerca volvulus 0.0091 0.066 0.8188
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0839 0.6911 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0276 0.2213 0.4318
Echinococcus multilocularis neuropeptide Y receptor 0.0091 0.066 0.0956
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0061 0.0082
Echinococcus granulosus rhodopsin orphan GPCR 0.0091 0.066 0.0956
Loa Loa (eye worm) hypothetical protein 0.0032 0.0172 0.0335
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0101 0.0192
Toxoplasma gondii histone lysine methyltransferase SET1 0.004 0.0234 0.0203
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0094 0.069 0.0999
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0091 0.066 0.1289
Plasmodium vivax biotin--[acetyl-CoA-carboxylase] synthetase, putative 0.0171 0.1328 1
Schistosoma mansoni zinc finger protein 0.0014 0.002 0.0029
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0101 0.0066
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0032 0.0172 0.0253
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0132 0.0278
Trichomonas vaginalis esterase, putative 0.0024 0.0101 0.1837
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Brugia malayi beta-lactamase 0.0024 0.0101 0.0148
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0016 0.0036 0.0052
Schistosoma mansoni alpha-1 adrenergic receptor 0.0091 0.066 0.0977
Loa Loa (eye worm) MH1 domain-containing protein 0.0019 0.0061 0.0118
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0038 0.0055
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0006 0.0009
Leishmania major biotin/lipoate protein ligase-like protein 0.0171 0.1328 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0091 0.066 0.0976
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.066 0.0956
Mycobacterium ulcerans epoxide hydrolase EphA 0.0134 0.1022 0.0994
Loa Loa (eye worm) hypothetical protein 0.0155 0.1196 0.2335
Loa Loa (eye worm) transcription factor SMAD2 0.0276 0.2213 0.4318
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0091 0.066 0.0956
Brugia malayi G-protein coupled receptor 0.0091 0.066 0.0976
Echinococcus multilocularis mothers against decapentaplegic 5 0.0019 0.0061 0.0088
Loa Loa (eye worm) multisynthetase complex auxiliary component p43 0.0261 0.2083 0.4066
Echinococcus multilocularis fmrfamide receptor 0.0091 0.066 0.0956
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0091 0.066 0.0956
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0032 0.0172 0.0141
Schistosoma mansoni neuropeptide receptor 0.0091 0.066 0.0977
Loa Loa (eye worm) hypothetical protein 0.0046 0.0289 0.0564
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0061 0.0088
Echinococcus granulosus glycyl tRNA synthetase 0.0155 0.1199 0.1734
Schistosoma mansoni amine GPCR 0.0091 0.066 0.0977
Loa Loa (eye worm) hypothetical protein 0.0032 0.0172 0.0335
Echinococcus granulosus poly ADP ribose polymerase 1 0.0821 0.6762 0.9785
Echinococcus granulosus neuropeptide s receptor 0.0091 0.066 0.0956
Echinococcus granulosus rhodopsin orphan GPCR 0.0091 0.066 0.0956
Brugia malayi hypothetical protein 0.0091 0.066 0.0976
Echinococcus granulosus rhodopsin orphan GPCR 0.0091 0.066 0.0956
Schistosoma mansoni biogenic amine (5HT) receptor 0.0091 0.066 0.0977
Echinococcus granulosus rhodopsin orphan GPCR 0.0091 0.066 0.0956
Entamoeba histolytica hypothetical protein 0.0061 0.0412 0.0566
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0019 0.0061 0.0088
Brugia malayi hypothetical protein 0.0091 0.066 0.0976
Entamoeba histolytica hypothetical protein 0.0128 0.0968 0.1393
Mycobacterium leprae Probable lipase LipE 0.0024 0.0101 0.0066
Brugia malayi ORL1-like opioid receptor 0.0091 0.066 0.0976
Schistosoma mansoni hypothetical protein 0.0091 0.066 0.0977
Loa Loa (eye worm) hypothetical protein 0.0024 0.0101 0.0197
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0053 0.0344 0.0508
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0016 0.0036 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0412 1
Plasmodium falciparum biotin protein ligase, putative 0.0171 0.1328 1
Echinococcus multilocularis sodium and chloride dependent glycine 0.0053 0.0344 0.0498
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0032 0.0172 0.0137
Entamoeba histolytica hypothetical protein 0.0046 0.0289 0.0383
Brugia malayi Pax transcription activation domain interacting protein 0.0032 0.0172 0.0253
Schistosoma mansoni leucyl-tRNA synthetase 0.0047 0.0292 0.0432
Brugia malayi hypothetical protein 0.0091 0.066 0.0976
Loa Loa (eye worm) hypothetical protein 0.0024 0.0101 0.0197
Onchocerca volvulus 0.0091 0.066 0.8188
Loa Loa (eye worm) biotin protein ligase 1 0.0171 0.1328 0.2593
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0412 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0091 0.066 0.0956
Mycobacterium ulcerans lipoate-protein ligase B 0.0016 0.0035 0.0004
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0132 0.0102
Schistosoma mansoni bromodomain containing protein 0.0042 0.0258 0.0382
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0091 0.066 0.0956
Brugia malayi sulfakinin receptor protein 0.0091 0.066 0.0976
Loa Loa (eye worm) G-protein coupled receptor 0.0091 0.066 0.1289
Onchocerca volvulus 0.0091 0.066 0.8188
Mycobacterium ulcerans bifunctional protein BirA 0.0348 0.2813 0.279
Trichomonas vaginalis replication factor C large subunit, putative 0.0032 0.0172 0.3693
Schistosoma mansoni neuropeptide F-like receptor 0.0091 0.066 0.0977
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.066 0.0977
Onchocerca volvulus 0.0091 0.066 0.8188
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0091 0.066 0.0956
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0091 0.066 0.0956
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Brugia malayi AKH receptor 0.0091 0.066 0.0976
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0565 0.4624 0.6692
Entamoeba histolytica zinc finger protein, putative 0.0061 0.0412 0.0566
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Brugia malayi Smad1 0.0019 0.0061 0.0089
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0046 0.0289 0.0418
Leishmania major methionyl-tRNA synthetase, putative 0.0047 0.0292 0.2011
Echinococcus granulosus beta LACTamase domain containing family member 0.0024 0.0101 0.0146
Schistosoma mansoni biogenic amine receptor 0.0091 0.066 0.0977
Brugia malayi beta-lactamase family protein 0.0024 0.0101 0.0148
Onchocerca volvulus DNA ligase 3 homolog 0.0107 0.0799 1
Trichomonas vaginalis D-aminoacylase, putative 0.0024 0.0101 0.1837
Brugia malayi RE15519p 0.0091 0.066 0.0976
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0292 0.2344 0.3392
Chlamydia trachomatis leucine--tRNA ligase 0.0047 0.0292 0.1128
Toxoplasma gondii lipoyl(octanoyl) transferase 0.0016 0.0035 0.0004
Loa Loa (eye worm) Smad1 0.0019 0.0061 0.0118
Schistosoma mansoni opsin-like receptor 0.0091 0.066 0.0977
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0047 0.0292 0.057
Onchocerca volvulus 0.0091 0.066 0.8188
Brugia malayi hypothetical protein 0.0032 0.0172 0.0253
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0091 0.066 0.0976
Loa Loa (eye worm) hypothetical protein 0.0047 0.0292 0.057
Schistosoma mansoni topbp1 0.0032 0.0172 0.0254
Echinococcus granulosus serotonin receptor 0.0091 0.066 0.0956
Brugia malayi follicle stimulating hormone receptor 0.0091 0.066 0.0976
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0047 0.0292 0.0717
Schistosoma mansoni myosin xvIII 0.0091 0.066 0.0977
Wolbachia endosymbiont of Brugia malayi biotin-(acetyl-CoA carboxylase) ligase 0.0171 0.1328 1
Plasmodium vivax lipoate-protein ligase 1, putative 0.0016 0.0035 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0172 0.3693
Schistosoma mansoni hypothetical protein 0.0016 0.0038 0.0056
Brugia malayi hypothetical protein 0.0032 0.0172 0.0253
Entamoeba histolytica hypothetical protein 0.0061 0.0412 0.0566
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0047 0.0292 0.0262
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0046 0.0289 0.0418
Loa Loa (eye worm) hypothetical protein 0.0024 0.0101 0.0197
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.045 0.042
Echinococcus granulosus mothers against decapentaplegic 5 0.0019 0.0061 0.0088
Mycobacterium tuberculosis Probable lipoate biosynthesis protein B LipB 0.0016 0.0035 0.0004
Trypanosoma brucei poly(adp-ribose) polymerase 0.0451 0.3671 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0091 0.066 0.0956
Toxoplasma gondii ATPase, AAA family protein 0.0032 0.0172 0.0141
Echinococcus granulosus tyrosyl tRNA synthetase 0.0015 0.0031 0.0045
Echinococcus granulosus Glycosyltransferase protein LARGE1 0.0034 0.0184 0.0266
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0024 0.0101 0.0197
Schistosoma mansoni hypothetical protein 0.0094 0.069 0.1021
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0091 0.066 0.8188
Echinococcus multilocularis glycosyltransferase protein LARGE2 0.0044 0.0269 0.039
Plasmodium vivax methionine--tRNA ligase, putative 0.0047 0.0292 0.2011
Trypanosoma brucei DNA repair protein, putative 0.0107 0.0799 0.2109
Echinococcus granulosus g protein coupled receptor 0.0091 0.066 0.0956
Echinococcus multilocularis methionine tRNA synthetase 0.0047 0.0292 0.0423
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0451 0.3671 1
Echinococcus multilocularis conserved hypothetical protein 0.0016 0.0038 0.0055
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0061 0.0082
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0101 0.0192
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0091 0.066 0.0977
Echinococcus multilocularis g-protein coupled receptor 0.0091 0.066 0.0956
Brugia malayi methionyl-tRNA synthetase 0.0308 0.2472 0.3655
Loa Loa (eye worm) beta-lactamase 0.0024 0.0101 0.0197
Schistosoma mansoni cpg binding protein 0.002 0.0071 0.0105
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0091 0.066 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0412 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.045 0.3227
Echinococcus multilocularis sex peptide receptor 0.0091 0.066 0.0956
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0091 0.066 0.0956
Echinococcus multilocularis neuropeptides capa receptor 0.0091 0.066 0.0956
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0091 0.066 0.0977
Mycobacterium tuberculosis Conserved protein 0.0024 0.0101 0.007
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.045 0.0665
Brugia malayi G protein-coupled receptor F59B2.13 0.0091 0.066 0.0976
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0047 0.0292 0.0262
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0024 0.0101 0.0148
Echinococcus multilocularis sodium and chloride dependent glycine 0.0053 0.0344 0.0498
Loa Loa (eye worm) G-protein coupled receptor 0.0091 0.066 0.1289
Echinococcus granulosus N terminal of biotin protein ligase 0.0155 0.1196 0.1731
Leishmania major hypothetical protein, conserved 0.0107 0.0799 0.5917
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0091 0.066 0.0977
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Schistosoma mansoni amine GPCR 0.0091 0.066 0.0977
Entamoeba histolytica hypothetical protein, conserved 0.0155 0.1196 0.1731
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Brugia malayi hypothetical protein 0.0091 0.066 0.0976
Schistosoma mansoni hypothetical protein 0.0294 0.2359 0.3489
Echinococcus multilocularis geminin 0.0294 0.2359 0.3414
Brugia malayi Latrophilin receptor protein 2 0.0094 0.069 0.102
Trypanosoma brucei Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0107 0.0799 0.2109
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Brugia malayi Dopamine receptor protein 2 0.0091 0.066 0.0976
Brugia malayi hypothetical protein 0.0091 0.066 0.0976
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0298 0.2391 0.4666
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0094 0.069 0.102
Mycobacterium tuberculosis Probable esterase LipL 0.0024 0.0101 0.007
Schistosoma mansoni hypothetical protein 0.0094 0.069 0.1021
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0061 0.003
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0091 0.066 0.0956
Echinococcus granulosus biogenic amine 5HT receptor 0.0091 0.066 0.0956
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0091 0.066 0.0956
Echinococcus granulosus orexin receptor type 2 0.0091 0.066 0.0956
Entamoeba histolytica biotin--acetyl-CoA-carboxylase ligase, putative 0.0171 0.1328 0.1928
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Loa Loa (eye worm) hypothetical protein 0.0094 0.069 0.1347
Plasmodium falciparum methionine--tRNA ligase, putative 0.0047 0.0292 0.2011
Wolbachia endosymbiont of Brugia malayi lipoate-protein ligase B 0.0016 0.0035 0.0033
Plasmodium vivax methionine--tRNA ligase, putative 0.0047 0.0292 0.2011
Brugia malayi DKFZp564C0469 protein 0.0032 0.0172 0.0253
Trichomonas vaginalis D-aminoacylase, putative 0.0024 0.0101 0.1837
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0853 0.703 0.7021
Echinococcus multilocularis replication factor c subunit 1 0.0032 0.0172 0.0249
Schistosoma mansoni amine GPCR 0.0091 0.066 0.0977
Echinococcus multilocularis cpg binding protein 0.0022 0.0091 0.0132
Schistosoma mansoni methionyl-tRNA synthetase 0.0015 0.0031 0.0046
Loa Loa (eye worm) PHD-finger family protein 0.0013 0.0016 0.0031
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Leishmania major leucyl-tRNA synthetase, putative 0.0047 0.0292 0.2011
Trypanosoma cruzi lipoate-protein ligase, putative 0.0016 0.0035 0.0012
Brugia malayi latrophilin 2 splice variant baaae 0.0204 0.1604 0.2371
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.045 0.042
Brugia malayi Calcitonin receptor-like protein seb-1 0.0298 0.2391 0.3535
Brugia malayi topoisomerase 0.0032 0.0172 0.0253
Brugia malayi lipoate-protein ligase B containing protein 0.0016 0.0035 0.0051
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0061 0.0082
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Loa Loa (eye worm) hypothetical protein 0.0032 0.0172 0.0335
Brugia malayi MH1 domain containing protein 0.0019 0.0061 0.0089
Echinococcus granulosus tm gpcr rhodopsin 0.0091 0.066 0.0956
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0047 0.0292 0.0717
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0006 0.0009
Schistosoma mansoni transcription factor LCR-F1 0.0046 0.0289 0.0427
Echinococcus granulosus rhodopsin orphan GPCR 0.0091 0.066 0.0956
Echinococcus multilocularis nephrin 0.0016 0.0038 0.0055
Brugia malayi PHD-finger family protein 0.0017 0.0049 0.0071
Brugia malayi hypothetical protein 0.0091 0.066 0.0976
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0091 0.066 0.0956
Entamoeba histolytica hypothetical protein 0.0046 0.0289 0.0383
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Echinococcus granulosus geminin 0.0294 0.2359 0.3414
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0292 0.2344 0.3392
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0091 0.066 0.1289
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Schistosoma mansoni biogenic amine (5HT) receptor 0.0091 0.066 0.0977
Schistosoma mansoni sodium/chloride dependent transporter 0.0053 0.0344 0.0509
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Echinococcus multilocularis glycosyltransferase protein LARGE2 0.0044 0.0269 0.039
Onchocerca volvulus Tankyrase homolog 0.0061 0.0412 0.4932
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.066 0.0977
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0032 0.0172 0.3693
Echinococcus granulosus poly (ADP ribose) polymerase 0.0128 0.0968 0.1401
Brugia malayi hypothetical protein 0.0016 0.0038 0.0055
Loa Loa (eye worm) hypothetical protein 0.0451 0.3671 0.7165
Echinococcus granulosus Glycosyl transferase family 8 0.0045 0.0281 0.0407
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.045 0.042
Schistosoma mansoni topbp1 0.0032 0.0172 0.0254
Echinococcus multilocularis glycosyltransferase protein LARGE2 0.0044 0.0269 0.039
Echinococcus multilocularis poly (ADP ribose) polymerase 0.0188 0.1477 0.2137
Loa Loa (eye worm) hypothetical protein 0.0025 0.0113 0.022
Entamoeba histolytica hypothetical protein 0.0046 0.0289 0.0383
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0032 0.0172 0.0386
Brugia malayi Melatonin receptor type 1A 0.0091 0.066 0.0976
Mycobacterium ulcerans esterase/lipase LipP 0.0024 0.0101 0.007
Echinococcus granulosus allatostatin A receptor 0.0091 0.066 0.0956
Echinococcus granulosus smad 0.0019 0.0061 0.0088
Brugia malayi lipoate-protein ligase, mitochondrial precursor, putative 0.0016 0.0035 0.0051
Schistosoma mansoni cpg binding protein 0.0022 0.0091 0.0134
Echinococcus granulosus rhodopsin orphan GPCR 0.0091 0.066 0.0956
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Schistosoma mansoni hypothetical protein 0.0091 0.066 0.0977
Loa Loa (eye worm) hypothetical protein 0.0032 0.0172 0.0335
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0032 0.0172 0.3693
Loa Loa (eye worm) hypothetical protein 0.0024 0.0101 0.0197
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.045 0.0651
Echinococcus granulosus g protein coupled receptor 0.0091 0.066 0.0956
Echinococcus multilocularis serotonin receptor 0.0091 0.066 0.0956
Brugia malayi Tachykinin-like peptides receptor 99D 0.0091 0.066 0.0976
Plasmodium falciparum lipoate-protein ligase 1 0.0016 0.0035 0.0033
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0032 0.0172 0.0209
Entamoeba histolytica hypothetical protein 0.0032 0.0172 0.0209
Echinococcus granulosus hypothetical protein 0.0091 0.066 0.0956
Trichomonas vaginalis penicillin-binding protein, putative 0.0024 0.0101 0.1837
Schistosoma mansoni hypothetical protein 0.0091 0.066 0.0977
Trichomonas vaginalis lipoate-protein ligase, putative 0.0016 0.0035 0.0111
Echinococcus multilocularis zinc finger transcription factor gli2 0.0195 0.153 0.2214
Echinococcus granulosus sex peptide receptor 0.0091 0.066 0.0956
Mycobacterium tuberculosis Conserved protein 0.0024 0.0101 0.007
Onchocerca volvulus Heat shock factor protein 2 homolog 0.0062 0.0425 0.5101
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0239 0.0345
Echinococcus granulosus irregular chiasm roughest protein 0.0016 0.0038 0.0055
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Echinococcus granulosus nephrin 0.0016 0.0038 0.0055
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.0821 0.6762 1
Schistosoma mansoni biotin-protein ligase 0.0171 0.1328 0.1965
Schistosoma mansoni tankyrase 0.0061 0.0412 0.0609
Loa Loa (eye worm) hypothetical protein 0.0032 0.0172 0.0335
Brugia malayi Serotonin receptor 0.0091 0.066 0.0976
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0172 0.0386
Trypanosoma cruzi Biotin--acetyl-CoA-carboxylase ligase, putative 0.0171 0.1328 0.3564
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0155 0.1199 0.2339
Brugia malayi putative neuropeptide receptor 0.0091 0.066 0.0976
Toxoplasma gondii tRNA ligases class I (M) protein 0.0047 0.0292 0.0262
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0091 0.066 0.0977
Leishmania major lipoate-protein ligase-like,lipoyl ligase, putative,lipoyltransferase, putative,lipoate biosynthesis protein, putative 0.0016 0.0035 0.0033
Echinococcus multilocularis neuropeptide s receptor 0.0091 0.066 0.0956
Echinococcus multilocularis muscleblind protein 0.0096 0.0707 0.1023
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0032 0.0172 0.1084
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.066 0.0956
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0101 0.0192
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0061 0.003
Giardia lamblia Hypothetical protein 0.0171 0.1328 1
Onchocerca volvulus 0.0032 0.0172 0.1787
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.066 0.0977
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0047 0.0292 0.6851
Echinococcus multilocularis orexin receptor type 2 0.0091 0.066 0.0956
Mycobacterium tuberculosis Conserved protein 0.0024 0.0101 0.007
Echinococcus granulosus biogenic amine 5HT receptor 0.0091 0.066 0.0956
Schistosoma mansoni methionine-tRNA synthetase 0.0292 0.2344 0.3467
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0023 0.0099 0.0144
Schistosoma mansoni DNA ligase IV 0.0032 0.0172 0.0254
Schistosoma mansoni hypothetical protein 0.0046 0.0289 0.0427
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0091 0.066 0.0977
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.066 0.0977
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0091 0.066 0.0977
Echinococcus multilocularis aminoacyl tRNA synthase complex interacting 0.0015 0.0031 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.2325
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0094 0.069 0.0999
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0091 0.066 0.0977
Schistosoma mansoni histamine h1 receptor 0.0091 0.066 0.0977
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0172 0.3693
Loa Loa (eye worm) hypothetical protein 0.0292 0.2344 0.4575
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0091 0.066 0.0976
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0091 0.066 0.0956
Brugia malayi Dopamine receptor 0.0091 0.066 0.0976
Echinococcus granulosus fetal alzheimer antigen falz 0.0016 0.0036 0.0052
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0091 0.066 0.1289
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0155 0.1199 0.2339
Entamoeba histolytica heat shock transcription factor, putative 0.0062 0.0425 0.0585
Brugia malayi MH2 domain containing protein 0.0019 0.0061 0.0089
Echinococcus multilocularis Smad4 0.0019 0.0061 0.0088
Trypanosoma cruzi lipoyltransferase, putative 0.0016 0.0035 0.0012
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0091 0.066 0.0977
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0091 0.066 0.0976
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0132 0.0781
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Chlamydia trachomatis lipoate protein ligase 0.0016 0.0035 0.0018
Leishmania major hypothetical protein, conserved 0.0024 0.0101 0.0539
Schistosoma mansoni amine GPCR 0.0091 0.066 0.0977
Giardia lamblia Replication factor C, subunit 1 0.0032 0.0172 0.1084
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0091 0.066 0.0977
Brugia malayi Bromodomain containing protein 0.005 0.0322 0.0475
Echinococcus granulosus replication factor c subunit 1 0.0032 0.0172 0.0249
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.0451 0.3671 0.5313
Loa Loa (eye worm) hypothetical protein 0.0625 0.5124 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.066 0.0956
Brugia malayi protein ZK524.3 0.0047 0.0292 0.0431
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0061 0.0089
Loa Loa (eye worm) melatonin receptor type 1A 0.0091 0.066 0.1289
Schistosoma mansoni smad 0.0019 0.0061 0.009
Brugia malayi WGR domain containing protein 0.0451 0.3671 0.5429
Echinococcus granulosus rhodopsin orphan GPCR 0.0091 0.066 0.0956
Entamoeba histolytica heat shock transcription factor, putative 0.0062 0.0425 0.0585
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0024 0.0101 0.015
Chlamydia trachomatis methionine--tRNA ligase 0.0292 0.2344 1
Echinococcus granulosus G protein coupled receptor 139 0.0091 0.066 0.0956
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Onchocerca volvulus 0.002 0.0071 0.0466
Trypanosoma cruzi Biotin--acetyl-CoA-carboxylase ligase, putative 0.0171 0.1328 0.3564
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0172 0.3693
Echinococcus multilocularis smad 0.0019 0.0061 0.0088
Trypanosoma cruzi Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0107 0.0799 0.2109
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0412 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0024 0.0101 0.007
Echinococcus granulosus neuropeptides capa receptor 0.0091 0.066 0.0956
Loa Loa (eye worm) hypothetical protein 0.0024 0.0101 0.0197
Plasmodium falciparum biotin--acetyl-CoA-carboxylase, putative 0.0171 0.1328 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.066 0.0977
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0821 0.6762 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0132 0.0259
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0412 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0091 0.066 0.0956
Mycobacterium leprae Probable methionyl-tRNA synthase MetS 0.0047 0.0292 0.0258
Schistosoma mansoni smad1 5 8 and 0.0019 0.0061 0.009
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0091 0.066 0.0956
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Brugia malayi hypothetical protein 0.0018 0.0051 0.0075
Schistosoma mansoni hypothetical protein 0.0013 0.0016 0.0023
Giardia lamblia Leucyl-tRNA synthetase 0.0047 0.0292 0.2011
Brugia malayi G-protein coupled receptor 0.0091 0.066 0.0976
Mycobacterium tuberculosis Probable hydrolase 0.0024 0.0101 0.007
Onchocerca volvulus 0.0091 0.066 0.8188
Echinococcus multilocularis GPCR, family 2 0.0094 0.069 0.0999
Schistosoma mansoni cpg binding protein 0.0022 0.0091 0.0134
Onchocerca volvulus 0.0091 0.066 0.8188
Trichomonas vaginalis D-aminoacylase, putative 0.0024 0.0101 0.1837
Echinococcus granulosus poly (ADP ribose) polymerase 0.0128 0.0968 0.1401
Loa Loa (eye worm) TYRA-2 protein 0.0091 0.066 0.1289
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0038 0.0055
Schistosoma mansoni sodium/chloride dependent transporter 0.0053 0.0344 0.0509
Entamoeba histolytica hypothetical protein, conserved 0.0155 0.1196 0.1731
Schistosoma mansoni lipoate-protein ligase B 0.0016 0.0035 0.0052
Echinococcus multilocularis muscleblind protein 1 0.0096 0.0707 0.1023
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0032 0.0172 0.0386
Loa Loa (eye worm) latrophilin receptor protein 2 0.0094 0.069 0.1347
Chlamydia trachomatis DNA ligase 0.0032 0.0172 0.0608
Entamoeba histolytica hypothetical protein, conserved 0.0155 0.1196 0.1731
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0091 0.066 0.1289
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0047 0.0292 0.2011
Schistosoma mansoni Smad4 0.0019 0.0061 0.009
Echinococcus granulosus zinc finger transcription factor gli2 0.0195 0.153 0.2214
Echinococcus granulosus neuropeptide Y receptor 0.0091 0.066 0.0956
Echinococcus multilocularis tankyrase 0.0061 0.0412 0.0596
Schistosoma mansoni hypothetical protein 0.0012 0.0006 0.0009
Echinococcus granulosus sodium and chloride dependent glycine 0.0053 0.0344 0.0498
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0091 0.066 0.0977
Mycobacterium ulcerans leucyl-tRNA synthetase 0.0047 0.0292 0.0262
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0172 0.3693
Loa Loa (eye worm) hypothetical protein 0.0062 0.0425 0.0829
Schistosoma mansoni chromosome transmission fidelity factor 0.0032 0.0172 0.0254
Brugia malayi beta-lactamase family protein 0.0024 0.0101 0.0148
Echinococcus multilocularis g protein coupled receptor 0.0091 0.066 0.0956
Mycobacterium tuberculosis Possible bifunctional protein BirA: biotin operon repressor + biotin--[acetyl-CoA-carboxylase] synthetase (biotin--protein ligas 0.0155 0.1196 0.1169
Loa Loa (eye worm) glycosyl transferase family 8 protein 0.0045 0.0281 0.0549
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.1209 1 1
Onchocerca volvulus 0.0024 0.0101 0.0861
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0061 0.0088
Echinococcus granulosus poly (ADP ribose) polymerase 0.0255 0.2034 0.2943
Echinococcus multilocularis biotin protein ligase 0.0171 0.1328 0.1922
Schistosoma mansoni opsin-like receptor 0.0091 0.066 0.0977
Schistosoma mansoni smad1 5 8 and 0.0019 0.0061 0.009
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.066 0.0977
Entamoeba histolytica hypothetical protein, conserved 0.0155 0.1196 0.1731
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0091 0.066 0.0977
Echinococcus granulosus poly adp ribose polymerase 2 0.0451 0.3671 0.5313
Schistosoma mansoni neuropeptide receptor 0.0091 0.066 0.0977
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.045 0.0665
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0024 0.0101 0.015
Echinococcus granulosus nibrin 0.0032 0.0172 0.0249
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0132 0.0781
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0024 0.0101 0.007
Onchocerca volvulus Neuropeptide F receptor homolog 0.0091 0.066 0.8188
Entamoeba histolytica hypothetical protein 0.0061 0.0412 0.0566
Echinococcus multilocularis neuropeptide Y receptor 0.0091 0.066 0.0956
Echinococcus granulosus aminoacyl tRNA synthase complex interacting 0.0015 0.0031 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0172 0.3693
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0038 0.0074
Entamoeba histolytica heat shock transcription factor, putative 0.0062 0.0425 0.0585
Echinococcus multilocularis neuropeptide receptor 0.0091 0.066 0.0956
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0038 0.0074
Schistosoma mansoni poly [ADP-ribose] polymerase 0.039 0.3163 0.4677
Echinococcus granulosus nephrin 0.0016 0.0038 0.0055
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0094 0.069 0.0999
Trypanosoma cruzi FHA domain containing protein, putative 0.0032 0.0172 0.0386
Brugia malayi neuropeptide F receptor 0.0091 0.066 0.0976
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0412 1
Echinococcus multilocularis biotin protein ligase 0.0171 0.1328 0.1922
Echinococcus granulosus neuropeptide Y receptor 0.0091 0.066 0.0956
Schistosoma mansoni glycosyltransferase-related 0.0045 0.0281 0.0416
Entamoeba histolytica hypothetical protein 0.0046 0.0289 0.0383
Schistosoma mansoni opsin-like receptor 0.0091 0.066 0.0977
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0308 0.2472 0.3627
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Onchocerca volvulus 0.0091 0.066 0.8188
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Wolbachia endosymbiont of Brugia malayi leucyl-tRNA synthetase 0.0047 0.0292 0.2011
Schistosoma mansoni hypothetical protein 0.0294 0.2359 0.3489
Echinococcus granulosus peptide allatostatin:somatostatin 0.0091 0.066 0.0956
Loa Loa (eye worm) hypothetical protein 0.0029 0.0146 0.0284
Loa Loa (eye worm) hypothetical protein 0.0096 0.0707 0.138
Loa Loa (eye worm) MH2 domain-containing protein 0.0019 0.0061 0.0118
Brugia malayi methionyl-tRNA synthetase 0.0047 0.0292 0.0431
Trypanosoma cruzi DNA repair protein, putative 0.0107 0.0799 0.2109
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0024 0.0101 0.007
Schistosoma mansoni adenoreceptor 0.0091 0.066 0.0977
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.045 0.042
Brugia malayi glycyl-tRNA synthetase 0.0155 0.1199 0.1772
Echinococcus granulosus neuropeptide receptor 0.0091 0.066 0.0956
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0061 0.0088
Brugia malayi hypothetical protein 0.0091 0.066 0.0976
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0061 0.0088
Echinococcus granulosus GPCR family 2 0.0094 0.069 0.0999
Leishmania major DNA repair protein, putative 0.0107 0.0799 0.5917
Echinococcus granulosus Smad4 0.0019 0.0061 0.0088
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0298 0.2391 0.3535
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0053 0.0344 0.0671
Brugia malayi hypothetical protein 0.0046 0.0289 0.0426
Schistosoma mansoni growth hormone secretagogue receptor 0.0091 0.066 0.0977
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0061 0.0088
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0091 0.066 0.0977
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Echinococcus granulosus zinc finger protein 0.0014 0.002 0.0028
Schistosoma mansoni neuropeptide receptor 0.0091 0.066 0.0977
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0091 0.066 0.0956
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0002
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0091 0.066 0.0956
Echinococcus multilocularis beta LACTamase domain containing family member 0.0024 0.0101 0.0146
Loa Loa (eye worm) neuropeptide F receptor 0.0091 0.066 0.1289
Schistosoma mansoni biogenic amine receptor 0.0091 0.066 0.0977
Brugia malayi Dopamine receptor protein 1 0.0091 0.066 0.0976
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Loa Loa (eye worm) hypothetical protein 0.0027 0.0126 0.0245
Echinococcus multilocularis g protein coupled receptor 0.0091 0.066 0.0956
Brugia malayi Muscleblind-like protein 0.0096 0.0707 0.1045
Toxoplasma gondii pantoate-beta-alanine ligase 0.1209 1 1
Brugia malayi HSF-type DNA-binding domain containing protein 0.0062 0.0425 0.0627
Echinococcus granulosus neuropeptide receptor A26 0.0091 0.066 0.0956
Echinococcus multilocularis N terminal of biotin protein ligase 0.0155 0.1196 0.1731
Treponema pallidum leucyl-tRNA synthetase 0.0047 0.0292 0.0433
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0069
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.0821 0.6762 0.9785
Treponema pallidum biotin--acetyl-CoA-carboxylase ligase 0.0364 0.2945 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0091 0.066 0.0956
Echinococcus multilocularis conserved hypothetical protein 0.0034 0.0184 0.0266
Brugia malayi Glycosyl transferase family 8 protein 0.0045 0.0281 0.0415
Echinococcus granulosus tm gpcr rhodopsin 0.0839 0.6911 1
Loa Loa (eye worm) hypothetical protein 0.0155 0.1196 0.2335
Echinococcus multilocularis neuropeptides capa receptor 0.0091 0.066 0.0956
Brugia malayi Zinc finger, C2H2 type family protein 0.0195 0.153 0.2262
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0451 0.3671 0.543
Echinococcus multilocularis g protein coupled receptor 0.0091 0.066 0.0956
Loa Loa (eye worm) hypothetical protein 0.0053 0.0344 0.0671
Echinococcus multilocularis tyrosyl tRNA synthetase 0.0015 0.0031 0.0045
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0151 0.1167 0.1139
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0061 0.0082
Echinococcus granulosus neuropeptide receptor 0.0091 0.066 0.0956
Echinococcus granulosus methionine tRNA synthetase 0.0047 0.0292 0.0423
Brugia malayi isocitrate dehydrogenase 0.0019 0.0061 0.0089
Mycobacterium ulcerans beta-lactamase 0.0024 0.0101 0.007
Leishmania major hypothetical protein, conserved 0.0027 0.0132 0.0781
Onchocerca volvulus 0.0091 0.066 0.8188
Entamoeba histolytica hypothetical protein 0.0061 0.0412 0.0566
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0094 0.069 0.0999
Echinococcus granulosus octanoyltransferase mitochondrial 0.0016 0.0035 0.0051
Echinococcus multilocularis allatostatin A receptor 0.0091 0.066 0.0956
Entamoeba histolytica hypothetical protein, conserved 0.0155 0.1196 0.1731
Chlamydia trachomatis biotin synthetase 0.0171 0.1328 0.5609
Entamoeba histolytica hypothetical protein, conserved 0.0155 0.1196 0.1731
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Echinococcus granulosus dro:myosuppressin receptor 0.0091 0.066 0.0956
Echinococcus multilocularis nibrin 0.0032 0.0172 0.0249
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.045 0.0651
Echinococcus granulosus glycosyltransferase protein LARGE2 0.0044 0.0269 0.039
Echinococcus granulosus tm gpcr rhodopsin 0.0091 0.066 0.0956
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0043 0.0259 0.0383
Brugia malayi G protein-coupled receptor 0.0091 0.066 0.0976
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0239 0.0345
Mycobacterium ulcerans pantoate--beta-alanine ligase 0.1209 1 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0091 0.066 0.0956
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0023 0.0099 0.0144
Toxoplasma gondii methionyl-tRNA synthetase 0.0062 0.042 0.039
Schistosoma mansoni biotin-protein ligase 0.0155 0.1196 0.1769
Mycobacterium leprae POSSIBLE BIFUNCTIONAL PROTEIN BirA: BIOTIN OPERON REPRESSOR + BIOTIN--[ACETYL-COA-CARBOXYLASE] SYNTHETASE (BIOTIN--PROTEIN LIGAS 0.0155 0.1196 0.1165
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Brugia malayi MH2 domain containing protein 0.0276 0.2213 0.3272
Echinococcus granulosus 7tm_1 domain containing protein 0.0091 0.066 0.0956
Brugia malayi biotin--acetyl-CoA-carboxylase ligase family protein 0.0171 0.1328 0.1964
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0155 0.1199 0.1772
Echinococcus multilocularis Immunoglobulin 0.0016 0.0038 0.0055
Onchocerca volvulus 0.0091 0.066 0.8188
Brugia malayi CXXC zinc finger family protein 0.002 0.0071 0.0104
Onchocerca volvulus 0.0091 0.066 0.8188
Entamoeba histolytica hypothetical protein, conserved 0.0155 0.1196 0.1731
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0091 0.066 0.0977
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0412 1
Loa Loa (eye worm) tnks protein 0.0061 0.0412 0.0804
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0412 1
Schistosoma mansoni neuropeptide F-like receptor 0.0091 0.066 0.0977
Schistosoma mansoni amine GPCR 0.0091 0.066 0.0977
Brugia malayi GnHR receptor homolog 0.0091 0.066 0.0976
Schistosoma mansoni hypothetical protein 0.0094 0.069 0.1021
Loa Loa (eye worm) hypothetical protein 0.0024 0.0101 0.0197
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0061 0.003
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0172 0.0386
Plasmodium falciparum methionine--tRNA ligase 0.0047 0.0292 0.2011
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Mycobacterium tuberculosis Probable lipase LipD 0.0024 0.0101 0.007
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0132 0.0278
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0091 0.066 0.0956
Trypanosoma brucei lipoyltransferase, putative 0.0016 0.0035 0.0012
Chlamydia trachomatis hypothetical protein 0.0155 0.1196 0.5038
Brugia malayi hypothetical protein 0.0091 0.066 0.0976
Trypanosoma brucei Biotin--acetyl-CoA-carboxylase ligase, putative 0.0171 0.1328 0.3564
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0032 0.0172 0.3693
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Echinococcus granulosus 5'partial|biotin protein ligase 0.0155 0.1196 0.1731
Schistosoma mansoni neuropeptide f receptor 76f 0.0091 0.066 0.0977
Echinococcus multilocularis Glycosyltransferase protein LARGE1 0.0034 0.0184 0.0266
Loa Loa (eye worm) hypothetical protein 0.0032 0.0172 0.0335
Onchocerca volvulus 0.0091 0.066 0.8188
Echinococcus granulosus tankyrase 0.0061 0.0412 0.0596
Loa Loa (eye worm) CXXC zinc finger family protein 0.002 0.0071 0.0138
Echinococcus multilocularis dro:myosuppressin receptor 0.0091 0.066 0.0956
Echinococcus granulosus tachykinin peptides receptor 99D 0.0091 0.066 0.0956
Entamoeba histolytica hypothetical protein, conserved 0.0155 0.1196 0.1731
Loa Loa (eye worm) hypothetical protein 0.0053 0.0344 0.0671
Brugia malayi WGR domain containing protein 0.0821 0.6762 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0091 0.066 0.0956
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0019 0.0061 0.009
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0061 0.0231
Loa Loa (eye worm) hypothetical protein 0.0204 0.1604 0.313
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0091 0.066 0.1289
Echinococcus granulosus neuropeptides capa receptor 0.0091 0.066 0.0956
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.066 0.0956
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0061 0.0119
Loa Loa (eye worm) hypothetical protein 0.0047 0.0292 0.057
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0134 0.1022 0.0994
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0451 0.3671 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0061 0.0231
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0061 0.009
Echinococcus granulosus fmrfamide receptor 0.0091 0.066 0.0956
Echinococcus multilocularis Glycosyl transferase, family 8 0.0045 0.0281 0.0407
Schistosoma mansoni neuropeptide receptor 0.0091 0.066 0.0977
Echinococcus multilocularis glycyl tRNA synthetase 0.0155 0.1199 0.1734
Brugia malayi Tnks protein 0.0061 0.0412 0.0608
Echinococcus multilocularis fmrfamide receptor 0.0091 0.066 0.0956
Giardia lamblia Methionyl-tRNA synthetase 0.0047 0.0292 0.2011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0091 0.066 0.0956
Treponema pallidum methionyl-tRNA synthetase 0.0308 0.2472 0.8295
Schistosoma mansoni hypothetical protein 0.0016 0.0038 0.0056
Schistosoma mansoni smad1 5 8 and 0.0019 0.0061 0.009
Brugia malayi larval opioid receptor 0.0091 0.066 0.0976
Echinococcus multilocularis irregular chiasm roughest protein immunoglobulin set domain containing protein 0.0016 0.0038 0.0055
Loa Loa (eye worm) hypothetical protein 0.0091 0.066 0.1289
Echinococcus granulosus WGR domain containing protein 0.0255 0.2034 0.2943
Echinococcus granulosus muscleblind protein 0.0096 0.0707 0.1023
Echinococcus multilocularis G protein coupled receptor 139 0.0091 0.066 0.0956
Plasmodium vivax hypothetical protein, conserved 0.0047 0.0292 0.2011
Onchocerca volvulus 0.0091 0.066 0.8188
Trichomonas vaginalis penicillin-binding protein, putative 0.0024 0.0101 0.1837
Mycobacterium ulcerans hypothetical protein 0.0024 0.0101 0.007
Echinococcus granulosus somatostatin receptor 0.0091 0.066 0.0956
Entamoeba histolytica hypothetical protein, conserved 0.0155 0.1196 0.1731
Echinococcus granulosus TGF beta signal transducer SmadC 0.0019 0.0061 0.0088
Brugia malayi hypothetical protein 0.0091 0.066 0.0976
Echinococcus multilocularis somatostatin receptor 0.0091 0.066 0.0956
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0132 0.0781
Schistosoma mansoni glycyl-tRNA synthetase 0.0155 0.1199 0.1773
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0032 0.0172 0.3693
Onchocerca volvulus 0.0024 0.0101 0.0861
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.045 0.042
Onchocerca volvulus 0.0091 0.066 0.8188

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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