TDR Targets

Basic information

Technical information

TDR Targets ID: 866934
Name: methyl 4-[(3-fluoro-4-methylphenyl)sulfamoyl] -1H-pyrrole-2-carboxylate
MW: 312.317 | Formula: C13H13FN2O4S
H donors: 2 H acceptors: 3 LogP: 1.89 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)c1[nH]cc(c1)S(=O)(=O)Nc1ccc(c(c1)F)C
InChi: 1S/C13H13FN2O4S/c1-8-3-4-9(5-11(8)14)16-21(18,19)10-6-12(15-7-10)13(17)20-2/h3-7,15-16H,1-2H3
InChiKey: SVKBSKIBNRTVJM-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

methyl 4-[(3-fluoro-4-methyl-phenyl)sulfamoyl]-1H-pyrrole-2-carboxylate
4-[(3-fluoro-4-methylphenyl)sulfamoyl]-1H-pyrrole-2-carboxylic acid methyl ester
4-[(3-fluoro-4-methyl-phenyl)sulfamoyl]-1H-pyrrole-2-carboxylic acid methyl ester

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glycoprotein hormones, alpha polypeptide	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Toxoplasma gondii	intraflagellar transport protein 172, putative	glycoprotein hormones, alpha polypeptide	116 aa	94 aa	26.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	von Willebrand factor type A domain containing protein	0.0037	0.0032	0.0032
Onchocerca volvulus		0.0037	0.0032	0.0098
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0501	0.5907	1
Toxoplasma gondii	subtilisin SUB12	0.0049	0.0184	0.3812
Loa Loa (eye worm)	hypothetical protein	0.004	0.0076	0.0076
Loa Loa (eye worm)	hypothetical protein	0.004	0.0076	0.0076
Brugia malayi	von Willebrand factor type A domain containing protein	0.0037	0.0032	0.0032
Schistosoma mansoni	hypothetical protein	0.0209	0.2209	0.2209
Echinococcus granulosus	cyclin B	0.0051	0.0204	0.0204
Schistosoma mansoni	tripeptidyl-peptidase II (S08 family)	0.0035	0.001	0.001
Loa Loa (eye worm)	subtilase	0.0035	0.001	0.001
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.004	0.0076	0.0076
Echinococcus multilocularis	C type lectin domian containing protein	0.0064	0.0372	0.0466
Echinococcus multilocularis		0.0664	0.7981	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.004	0.0076	0.0076
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.004	0.0076	0.0076
Trypanosoma brucei	mitotic cyclin 6	0.0051	0.0204	1
Loa Loa (eye worm)	CUTiclin family member	0.0037	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0372	0.0372
Echinococcus multilocularis	protein will die slowly	0.0209	0.2209	0.2767
Onchocerca volvulus		0.004	0.0076	0.0229
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.004	0.0076	0.0076
Mycobacterium ulcerans	hypothetical protein	0.004	0.0076	1
Brugia malayi	Trypsin family protein	0.004	0.0076	0.0076
Schistosoma mansoni	serine/threonine protein kinase	0.0102	0.0862	0.0862
Onchocerca volvulus		0.0064	0.0372	0.1123
Trichomonas vaginalis	conserved hypothetical protein	0.0159	0.1583	0.2667
Brugia malayi	Trypsin family protein	0.004	0.0076	0.0076
Brugia malayi	Zona pellucida-like domain containing protein	0.0037	0.0032	0.0032
Onchocerca volvulus		0.0064	0.0372	0.1123
Onchocerca volvulus		0.0064	0.0372	0.1123
Trichomonas vaginalis	conserved hypothetical protein	0.0159	0.1583	0.2667
Treponema pallidum	76K protein	0.0037	0.0032	0.5
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0204	0.0204
Trichomonas vaginalis	conserved hypothetical protein	0.0159	0.1583	0.2667
Trichomonas vaginalis	cyclins, putative	0.0051	0.0204	0.0329
Loa Loa (eye worm)	hypothetical protein	0.0035	0.001	0.001
Echinococcus granulosus	transmembrane protease serine 3	0.004	0.0076	0.0076
Brugia malayi	von Willebrand Factor	0.0037	0.0032	0.0032
Echinococcus multilocularis	enteropeptidase	0.004	0.0076	0.0095
Onchocerca volvulus		0.0064	0.0372	0.1123
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.0501	0.5907	0.7401
Trichomonas vaginalis	conserved hypothetical protein	0.0159	0.1583	0.2667
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0195	0.2029	0.3423
Trichomonas vaginalis	cyclins, putative	0.0051	0.0204	0.0329
Mycobacterium tuberculosis	Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5)	0.0035	0.001	0.5
Onchocerca volvulus		0.0035	0.001	0.0031
Echinococcus granulosus	C type lectin domian containing protein	0.0064	0.0372	0.0372
Toxoplasma gondii	rhoptry neck protein RON9	0.0064	0.0372	0.7911
Trichomonas vaginalis	cyclin B, putative	0.0051	0.0204	0.0329
Plasmodium vivax	dynein-related AAA-type ATPase, putative	0.0037	0.0032	0.0488
Echinococcus multilocularis	Furin 1	0.0195	0.2029	0.2542
Brugia malayi	hypothetical protein	0.0064	0.0372	0.0372
Loa Loa (eye worm)	hypothetical protein	0.0068	0.043	0.043
Onchocerca volvulus		0.0064	0.0372	0.1123
Brugia malayi	Trypsin family protein	0.0296	0.3311	0.3311
Leishmania major	cyclin	0.0051	0.0204	1
Trypanosoma cruzi	cyclin, putative	0.0051	0.0204	1
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3)	0.0035	0.001	0.5
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0051	0.0204	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0032	0.0032
Echinococcus multilocularis	c4b binding protein beta chain	0.0064	0.0372	0.0466
Schistosoma mansoni	cercarial elastase (S01 family)	0.004	0.0076	0.0076
Schistosoma mansoni	hypothetical protein	0.004	0.0076	0.0076
Toxoplasma gondii	rhoptry neck protein RON1	0.0064	0.0372	0.7911
Echinococcus multilocularis	membrane bound transcription factor site 1	0.0035	0.001	0.0013
Loa Loa (eye worm)	hypothetical protein	0.004	0.0076	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0032	0.0032
Echinococcus granulosus	collagen alpha 1VII chain	0.0037	0.0032	0.0032
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.004	0.0076	0.0076
Echinococcus granulosus	glycoprotein Antigen 5	0.004	0.0076	0.0076
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.004	0.0076	0.0076
Toxoplasma gondii	von Willebrand factor type A domain-containing protein	0.0037	0.0032	0.0488
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0037	0.0032	0.0032
Onchocerca volvulus		0.0209	0.2209	0.667
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4)	0.0035	0.001	0.5
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0032	0.0032
Loa Loa (eye worm)	WD40 repeat protein	0.0209	0.2209	0.2209
Plasmodium vivax	SET domain protein, putative	0.0071	0.0468	1
Echinococcus multilocularis	glycoprotein Antigen 5	0.004	0.0076	0.0095
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0188	0.0188
Echinococcus granulosus	histone lysine n methyltransferase setd8	0.0071	0.0468	0.0468
Onchocerca volvulus		0.0064	0.0372	0.1123
Loa Loa (eye worm)	hypothetical protein	0.0323	0.3657	0.3657
Echinococcus multilocularis	transmembrane protease serine 3	0.004	0.0076	0.0095
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0037	0.0032	0.0032
Brugia malayi	von Willebrand factor type A domain containing protein	0.0037	0.0032	0.0032
Brugia malayi	Zona pellucida-like domain containing protein	0.0037	0.0032	0.0032
Mycobacterium leprae	PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5)	0.0035	0.001	0.5
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.004	0.0076	0.0095
Mycobacterium leprae	Possible secreted protease	0.0035	0.001	0.5
Schistosoma mansoni	hypothetical protein	0.0037	0.0032	0.0032
Treponema pallidum	hypothetical protein	0.0037	0.0032	0.5
Plasmodium falciparum	SET domain protein, putative	0.0071	0.0468	1
Onchocerca volvulus		0.0037	0.0032	0.0098
Loa Loa (eye worm)	hypothetical protein	0.004	0.0076	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0372	0.0372
Onchocerca volvulus		0.004	0.0076	0.0229
Trichomonas vaginalis	proprotein convertase subtilisin/kexin type, putative	0.0159	0.1583	0.2667
Echinococcus granulosus	membrane bound transcription factor site 1	0.0035	0.001	0.001
Onchocerca volvulus		0.004	0.0076	0.0229
Trichomonas vaginalis	conserved hypothetical protein	0.0159	0.1583	0.2667
Echinococcus granulosus	protein will die slowly	0.0209	0.2209	0.2209
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0188	0.0188
Trichomonas vaginalis	leucine-rich repeat protein, BspA family	0.0159	0.1583	0.2667
Brugia malayi	Hypothetical subtilase-type proteinase F21H12.6 in chromosome II	0.0035	0.001	0.001
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.0195	0.2029	0.2029
Onchocerca volvulus		0.004	0.0076	0.0229
Trichomonas vaginalis	cyclin A, putative	0.0051	0.0204	0.0329
Trichomonas vaginalis	conserved hypothetical protein	0.0159	0.1583	0.2667
Brugia malayi	neuroendocrine convertase 1 precursor	0.0518	0.6122	0.6122
Onchocerca volvulus		0.0051	0.0204	0.0617
Echinococcus multilocularis	cyclin B	0.0051	0.0204	0.0256
Trichomonas vaginalis	ubiquitin-conjugating enzyme E2, putative	0.0037	0.0032	0.0038
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0824	1	1
Loa Loa (eye worm)	von Willebrand factor domain-containing protein	0.0037	0.0032	0.0032
Brugia malayi	celfurPC protein	0.0664	0.7981	0.7981
Brugia malayi	Subtilase family protein	0.0035	0.001	0.001
Brugia malayi	Trypsin family protein	0.004	0.0076	0.0076
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.004	0.0076	0.0076
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0195	0.2029	0.3423
Brugia malayi	hypothetical protein	0.0064	0.0372	0.0372
Loa Loa (eye worm)	hypothetical protein	0.0296	0.3311	0.3311
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0102	0.0862	0.0862
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0032	0.0032
Schistosoma mansoni	cercarial elastase (S01 family)	0.004	0.0076	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0188	0.0188
Brugia malayi	Will die slowly protein	0.0209	0.2209	0.2209
Schistosoma mansoni	dihydropyridine-sensitive l-type calcium channel	0.0037	0.0032	0.0032
Onchocerca volvulus		0.0296	0.3311	1
Plasmodium falciparum	apical sushi protein	0.0064	0.0372	0.7911
Brugia malayi	hypothetical protein	0.0064	0.0372	0.0372
Schistosoma mansoni	hypothetical protein	0.0037	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0468	0.0468
Trichomonas vaginalis	conserved hypothetical protein	0.0159	0.1583	0.2667
Echinococcus granulosus	Furin 1	0.0195	0.2029	0.2029
Echinococcus multilocularis	Peptidase S8 S53, subtilisin kexin sedolisin	0.0035	0.001	0.0013
Plasmodium vivax	thrombospondin-related anonymous protein	0.0037	0.0032	0.0488
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0195	0.2029	0.3423
Onchocerca volvulus		0.0037	0.0032	0.0098
Loa Loa (eye worm)	endoprotease bli-4	0.0824	1	1
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0102	0.0862	0.0862
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0372	0.0372
Plasmodium falciparum	circumsporozoite- and TRAP-related protein	0.0037	0.0032	0.0488
Loa Loa (eye worm)	CUTiclin-Like family member	0.0037	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0372	0.0372
Echinococcus granulosus	voltage dependent calcium channel subunit	0.0037	0.0032	0.0032
Onchocerca volvulus		0.0037	0.0032	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0372	0.0372
Echinococcus granulosus	G protein coupled receptor kinase 1	0.0092	0.0727	0.0727
Brugia malayi	GCC2 and GCC3 family protein	0.0064	0.0372	0.0372
Loa Loa (eye worm)	pregnancy-associated plasma protein-E	0.0064	0.0372	0.0372
Onchocerca volvulus		0.0064	0.0372	0.1123
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.004	0.0076	0.0095
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0051	0.0204	1
Brugia malayi	von Willebrand factor type A domain containing protein	0.0037	0.0032	0.0032
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.0092	0.0727	0.0911
Trichomonas vaginalis	hypothetical protein	0.0159	0.1583	0.2667
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0195	0.2029	0.3423
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0501	0.5907	1
Echinococcus multilocularis	neuroendocrine convertase 2	0.0518	0.6122	0.7671
Onchocerca volvulus		0.0064	0.0372	0.1123
Brugia malayi	von Willebrand factor type A domain containing protein	0.0037	0.0032	0.0032
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.0501	0.5907	0.5907
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0032	0.0032
Schistosoma mansoni	cercarial elastase (S01 family)	0.004	0.0076	0.0076
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0032	0.0488
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.004	0.0076	0.0076
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0035	0.001	0.001
Echinococcus multilocularis	histone lysine n methyltransferase setd8	0.0071	0.0468	0.0586
Onchocerca volvulus		0.0037	0.0032	0.0098
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.004	0.0076	0.0076
Schistosoma mansoni	histone-lysine n-methyltransferase seto7	0.0071	0.0468	0.0468
Echinococcus granulosus	furin	0.0824	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0159	0.1583	0.2667
Trichomonas vaginalis	cyclin B, putative	0.0051	0.0204	0.0329
Trichomonas vaginalis	cyclin B, putative	0.0051	0.0204	0.0329
Brugia malayi	hypothetical protein	0.0064	0.0372	0.0372
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0102	0.0862	0.1079
Loa Loa (eye worm)	trypsin family protein	0.004	0.0076	0.0076
Brugia malayi	hypothetical protein	0.0064	0.0372	0.0372
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.03	0.3369	0.3369
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0204	0.0204
Schistosoma mansoni	cercarial elastase (S01 family)	0.004	0.0076	0.0076
Trichomonas vaginalis	conserved hypothetical protein	0.0159	0.1583	0.2667
Giardia lamblia	Furin precursor putative serine protease	0.0159	0.1583	0.4258
Brugia malayi	Membrane-bound transcription factor site-1 protease precursor	0.0035	0.001	0.001
Trichomonas vaginalis	cyclin B, putative	0.0051	0.0204	0.0329
Schistosoma mansoni	furin-1 (S08 family)	0.0358	0.4103	0.4103
Brugia malayi	hypothetical protein	0.0064	0.0372	0.0372
Schistosoma mansoni	hypothetical protein	0.0159	0.1583	0.1583
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0035	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0032	0.0032
Toxoplasma gondii	histone lysine methyltransferase SET8	0.0071	0.0468	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0188	0.0188
Brugia malayi	Protein set-1	0.0071	0.0468	0.0468
Loa Loa (eye worm)	proprotein convertase 2	0.0195	0.2029	0.2029
Schistosoma mansoni	cercarial elastase (S01 family)	0.004	0.0076	0.0076
Brugia malayi	von Willebrand factor type A domain containing protein	0.0037	0.0032	0.0032
Onchocerca volvulus		0.0037	0.0032	0.0098
Echinococcus granulosus	Mastin	0.004	0.0076	0.0076
Schistosoma mansoni	serine/threonine protein kinase	0.0102	0.0862	0.0862
Loa Loa (eye worm)	hypothetical protein	0.0296	0.3311	0.3311
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0372	0.0372
Onchocerca volvulus		0.004	0.0076	0.0229
Plasmodium vivax	von Willebrand factor A domain-related protein, putative	0.0037	0.0032	0.0488
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0032	0.0032
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.004	0.0076	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.004	0.0076	0.0076
Toxoplasma gondii	microneme protein MIC2	0.0037	0.0032	0.0488
Echinococcus granulosus	enteropeptidase	0.004	0.0076	0.0076
Onchocerca volvulus		0.0062	0.0353	0.1066
Schistosoma mansoni	cercarial elastase (S01 family)	0.004	0.0076	0.0076
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0195	0.2029	0.3423
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0032	0.0032
Echinococcus multilocularis	voltage dependent calcium channel subunit	0.0037	0.0032	0.0041
Schistosoma mansoni	hypothetical protein	0.004	0.0076	0.0076
Schistosoma mansoni	cercarial elastase (S01 family)	0.004	0.0076	0.0076
Entamoeba histolytica	cyclin, putative	0.0051	0.0204	1
Trypanosoma cruzi	cyclin 6, putative	0.0051	0.0204	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0296	0.3311	0.3311
Brugia malayi	pregnancy-associated plasma protein-A	0.0064	0.0372	0.0372
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0195	0.2029	0.3423
Brugia malayi	proprotein convertase 2	0.0518	0.6122	0.6122
Giardia lamblia	High cysteine membrane protein Group 2	0.0306	0.3442	1
Onchocerca volvulus		0.0064	0.0372	0.1123
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0372	0.0372
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0372	0.0372
Schistosoma mansoni	cercarial elastase (S01 family)	0.004	0.0076	0.0076
Schistosoma mansoni	cercarial elastase (S01 family)	0.004	0.0076	0.0076
Echinococcus granulosus	c4b binding protein beta chain	0.0064	0.0372	0.0372
Onchocerca volvulus		0.0255	0.2799	0.8454
Mycobacterium tuberculosis	Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like)	0.0035	0.001	0.5
Schistosoma mansoni	cyclin B	0.0051	0.0204	0.0204
Brugia malayi	Sushi domain	0.0064	0.0372	0.0372
Plasmodium vivax	apical sushi protein, putative	0.0064	0.0372	0.7911
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0032	0.0032
Brugia malayi	von Willebrand factor type A domain containing protein	0.0037	0.0032	0.0032
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0051	0.0204	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0032	0.0032
Mycobacterium leprae	PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3)	0.0035	0.001	0.5
Loa Loa (eye worm)	von Willebrand factor type A domain-containing protein	0.0037	0.0032	0.0032
Echinococcus multilocularis	Mastin	0.004	0.0076	0.0095
Trichomonas vaginalis	cyclins, putative	0.0051	0.0204	0.0329
Brugia malayi	hypothetical protein	0.004	0.0076	0.0076
Schistosoma mansoni	cercarial elastase (S01 family)	0.004	0.0076	0.0076
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0051	0.0204	1
Schistosoma mansoni	c4b-binding protein beta chain	0.0064	0.0372	0.0372
Brugia malayi	Trypsin-like protease protein 5	0.004	0.0076	0.0076
Plasmodium vivax	circumsporozoite- and TRAP-related protein, putative	0.0037	0.0032	0.0488
Loa Loa (eye worm)	hypothetical protein	0.0824	1	1
Trichomonas vaginalis	neuroendocrine convertase 2 precursor, putative	0.0159	0.1583	0.2667
Plasmodium falciparum	von Willebrand factor A domain-related protein	0.0037	0.0032	0.0488
Trichomonas vaginalis	conserved hypothetical protein	0.0159	0.1583	0.2667
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0035	0.001	0.001
Echinococcus granulosus	peptidase s8 s53 subtilisin kexin sedolisin	0.0035	0.001	0.001
Brugia malayi	hypothetical protein	0.0037	0.0032	0.0032
Onchocerca volvulus		0.0064	0.0372	0.1123
Trichomonas vaginalis	conserved hypothetical protein	0.0159	0.1583	0.2667
Echinococcus granulosus	neuroendocrine convertase 2	0.0518	0.6122	0.6122
Trichomonas vaginalis	WD repeat domain, putative	0.0209	0.2209	0.3728
Trichomonas vaginalis	cyclins, putative	0.0051	0.0204	0.0329
Plasmodium falciparum	thrombospondin-related anonymous protein	0.0037	0.0032	0.0488
Trypanosoma cruzi	cyclin, putative	0.0051	0.0204	1
Brugia malayi	von Willebrand factor type A domain containing protein	0.0037	0.0032	0.0032
Brugia malayi	hypothetical protein	0.0064	0.0372	0.0372
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0032	0.0032
Echinococcus multilocularis	collagen alpha 1(VII) chain	0.0037	0.0032	0.0041

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	1.2589 uM	PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.6891 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1401581
Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 866934