Detailed information for compound 866942

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 430.974 | Formula: C20H19ClN4OS2
  • H donors: 1 H acceptors: 3 LogP: 5.92 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1nnc(c2n1c1cc(sc1c2)C)SCC(=O)Nc1ccc(cc1Cl)C
  • InChi: 1S/C20H19ClN4OS2/c1-4-18-23-24-20(16-9-17-15(25(16)18)8-12(3)28-17)27-10-19(26)22-14-6-5-11(2)7-13(14)21/h5-9H,4,10H2,1-3H3,(H,22,26)
  • InChiKey: WXWNKTJGTDZHBR-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus multilocularis smad 0.0032 0.0099 0.0256
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0038 0.0129 0.2569
Trypanosoma brucei trypanothione reductase 0.013 0.0624 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0045 0.0167 0.2682
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0045 0.0167 0.0147
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.0129 0.109
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0045 0.0167 0.2682
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0255 0.0672
Schistosoma mansoni alpha glucosidase 0.0037 0.0126 0.0328
Trypanosoma cruzi trypanothione reductase, putative 0.013 0.0624 1
Echinococcus multilocularis dna polymerase kappa 0.0057 0.0233 0.0612
Mycobacterium ulcerans DNA polymerase IV 0.0057 0.0233 0.0213
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0045 0.0167 0.0438
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.0208 0.3339
Onchocerca volvulus Huntingtin homolog 0.0127 0.0606 0.3777
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.022 0.0753
Loa Loa (eye worm) hypothetical protein 0.003 0.0087 0.0352
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0021 0.0331
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0108 0.028
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0126 0.1062
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0007 0.0012
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0126 0.1062
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0033 0.0103 0.0416
Toxoplasma gondii NADPH-glutathione reductase 0.0045 0.0167 0.0561
Plasmodium vivax ataxin-2 like protein, putative 0.0076 0.0333 0.5238
Loa Loa (eye worm) hypothetical protein 0.0312 0.1605 0.6472
Brugia malayi hypothetical protein 0.0108 0.0504 0.2031
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0021 0.0331
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0045 0.0167 0.2682
Echinococcus granulosus smad 0.0032 0.0099 0.0256
Schistosoma mansoni microtubule-associated protein tau 0.0713 0.3761 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0057 0.0233 0.196
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0045 0.0167 0.2682
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.003 0.0589
Entamoeba histolytica deoxycytidyl transferase, putative 0.0057 0.0233 0.4622
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.0208 0.3339
Trypanosoma brucei chrX additional, unordered contigs 0.0018 0.0021 0.0331
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0038 0.0129 0.2569
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0007 0.0012
Onchocerca volvulus 0.003 0.0087 0.0543
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0126 0.202
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.003
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0208 0.1754
Brugia malayi MH2 domain containing protein 0.0475 0.248 1
Leishmania major DNA polymerase eta, putative 0.0082 0.0368 0.59
Brugia malayi hypothetical protein 0.0127 0.0606 0.2444
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1345 0.716 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0329 0.1698 0.2357
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0087 0.0224
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0208 0.3339
Entamoeba histolytica hypothetical protein 0.0108 0.0504 1
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0255 0.103
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.003 0.0476
Brugia malayi MH1 domain containing protein 0.0032 0.0099 0.04
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0045 0.0167 0.2682
Plasmodium vivax thioredoxin reductase, putative 0.013 0.0624 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.013 0.0627 0.166
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0078 0.0347 0.0916
Plasmodium vivax SET domain protein, putative 0.003 0.0087 0.1214
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0078 0.0347 0.14
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0087 0.0224
Brugia malayi MH2 domain containing protein 0.0014 0.0003 0.0012
Brugia malayi Glycosyl hydrolases family 31 protein 0.0168 0.0831 0.335
Loa Loa (eye worm) RNA binding protein 0.0061 0.0255 0.103
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.0208 0.0547
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0007 0.003
Leishmania major hypothetical protein, conserved 0.0076 0.0333 0.5337
Brugia malayi MH2 domain containing protein 0.0032 0.0099 0.04
Trypanosoma brucei unspecified product 0.0057 0.0233 0.373
Trichomonas vaginalis DNA polymerase eta, putative 0.0057 0.0233 0.196
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0007 0.0012
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0021 0.0331
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0126 0.1062
Echinococcus granulosus GPCR family 2 0.0015 0.0007 0.0012
Toxoplasma gondii thioredoxin reductase 0.013 0.0624 0.222
Trypanosoma cruzi DNA polymerase kappa, putative 0.0057 0.0233 0.373
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0089 0.0406 1
Loa Loa (eye worm) hypothetical protein 0.0127 0.0606 0.2444
Trypanosoma brucei DNA polymerase eta, putative 0.0082 0.0368 0.59
Plasmodium vivax DNA repair protein REV1, putative 0.0018 0.0021 0.0126
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1872 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0126 0.1062
Brugia malayi CXXC zinc finger family protein 0.0028 0.0078 0.0314
Loa Loa (eye worm) MH1 domain-containing protein 0.0014 0.0003 0.0012
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0255 0.0672
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0179 0.047
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0013 0.0208
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0528 0.2765 1
Onchocerca volvulus 0.0235 0.1188 0.7401
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.0129 0.109
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0045 0.0167 0.2526
Echinococcus multilocularis cpg binding protein 0.003 0.0087 0.0222
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0126 0.202
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0045 0.0167 0.2682
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1872 1 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0168 0.0831 0.2203
Schistosoma mansoni smad 0.0032 0.0099 0.0256
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0108 0.028
Echinococcus granulosus TGF beta signal transducer SmadC 0.0032 0.0099 0.0256
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0333 0.5337
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0329 0.1698 0.2357
Echinococcus multilocularis dna polymerase eta 0.0082 0.0368 0.0972
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0007 0.0012
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0078 0.0347 0.0916
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0126 0.2503
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0185 0.0746
Loa Loa (eye worm) hypothetical protein 0.0033 0.0103 0.0415
Brugia malayi Thioredoxin reductase 0.013 0.0624 0.2517
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0126 0.0328
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0086
Schistosoma mansoni hypothetical protein 0.0108 0.0504 0.1333
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0013 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0137 0.22
Trypanosoma brucei glucosidase, putative 0.0037 0.0126 0.202
Loa Loa (eye worm) MH2 domain-containing protein 0.0032 0.0099 0.04
Trypanosoma brucei DNA polymerase IV, putative 0.0057 0.0233 0.373
Trypanosoma brucei DNA damage repair protein, putative 0.0018 0.0021 0.0331
Schistosoma mansoni hypothetical protein 0.0015 0.0007 0.0012
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0045 0.0167 0.0438
Trypanosoma cruzi DNA damage repair protein, putative 0.0018 0.0021 0.0331
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0126 0.1062
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0233 0.373
Brugia malayi Pre-SET motif family protein 0.003 0.0087 0.0352
Trichomonas vaginalis set domain proteins, putative 0.0235 0.1188 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0126 0.202
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0078 0.02
Trichomonas vaginalis MYB3r3, putative 0.0038 0.0129 0.109
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0208 0.1754
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0045 0.0167 0.2682
Trypanosoma brucei unspecified product 0.0039 0.0137 0.22
Trypanosoma cruzi DNA polymerase kappa, putative 0.0057 0.0233 0.373
Brugia malayi hypothetical protein 0.0049 0.0189 0.076
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.003 0.012
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0021 0.0331
Trypanosoma brucei protein kinase, putative 0.0053 0.0208 0.3339
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.003 0.0071
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.0208 0.0547
Plasmodium falciparum thioredoxin reductase 0.0045 0.0167 0.2526
Loa Loa (eye worm) thioredoxin reductase 0.013 0.0624 0.2517
Echinococcus granulosus Smad4 0.0032 0.0099 0.0256
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.003 0.0235
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.0208 0.071
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0045 0.0167 0.2526
Trypanosoma cruzi DNA polymerase eta, putative 0.0082 0.0368 0.59
Brugia malayi Pre-SET motif family protein 0.0206 0.1035 0.4174
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0233 0.373
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0045 0.0167 0.2682
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0179 0.047
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0087 0.0224
Mycobacterium tuberculosis Probable dehydrogenase 0.0296 0.152 0.2108
Brugia malayi hypothetical protein 0.0312 0.1605 0.6472
Schistosoma mansoni cpg binding protein 0.0028 0.0078 0.0199
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.003 0.0009
Schistosoma mansoni smad1 5 8 and 0.0032 0.0099 0.0256
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0032 0.0099 0.0256
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0179 0.047
Mycobacterium ulcerans DNA polymerase IV 0.0057 0.0233 0.0213
Brugia malayi MH1 domain containing protein 0.0018 0.0021 0.0086
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0032 0.0099 0.0256
Brugia malayi RNA binding protein 0.0061 0.0255 0.103
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0255 0.067
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0087 0.0224
Loa Loa (eye worm) MH2 domain-containing protein 0.0475 0.248 1
Schistosoma mansoni DNA polymerase eta 0.0082 0.0368 0.0972
Trichomonas vaginalis MYB, putative 0.0038 0.013 0.1098
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0185 0.0746
Echinococcus granulosus geminin 0.0674 0.3551 0.9442
Giardia lamblia DINP protein human, muc B family 0.0057 0.0233 0.5511
Trichomonas vaginalis C-MYB, putative 0.0038 0.0129 0.109
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.0208 0.0547
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0126 0.1062
Schistosoma mansoni cpg binding protein 0.003 0.0087 0.0222
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.003 0.0071
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0013 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0233 0.373
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.003 0.025
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0126 0.0509
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0007 0.003
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.0831 0.2203
Trypanosoma cruzi DNA damage repair protein, putative 0.0018 0.0021 0.0331
Loa Loa (eye worm) hypothetical protein 0.0048 0.0185 0.0746
Loa Loa (eye worm) Smad1 0.0032 0.0099 0.04
Brugia malayi MH2 domain containing protein 0.0032 0.0099 0.04
Entamoeba histolytica hypothetical protein 0.0108 0.0504 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0233 0.373
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.003 0.0274
Trichomonas vaginalis pc-MYB2, putative 0.0038 0.0129 0.109
Entamoeba histolytica hypothetical protein 0.0108 0.0504 1
Echinococcus granulosus cpg binding protein 0.003 0.0087 0.0222
Plasmodium falciparum thioredoxin reductase 0.013 0.0624 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0045 0.0167 0.0561
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0087 0.027
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0018 0.0021 0.0028
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0137 0.22
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0012
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0108 0.0504 0.1333
Toxoplasma gondii LsmAD domain-containing protein 0.0076 0.0333 0.1163
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0296 0.152 0.2108
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0021 0.0331
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0013 0.0208
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0045 0.0167 0.0147
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0156 0.2501
Brugia malayi glutathione reductase 0.013 0.0624 0.2517
Brugia malayi isocitrate dehydrogenase 0.0016 0.0013 0.0052
Trypanosoma brucei unspecified product 0.0039 0.0137 0.22
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0179 0.0723
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.0129 0.109
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0089 0.0406 0.1427
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0013 0.0208
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0296 0.152 0.2108
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0045 0.0167 0.2682
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0033 0.0103 0.0416
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0057 0.0233 0.373
Echinococcus multilocularis GPCR, family 2 0.0015 0.0007 0.0012
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.003 0.0274
Loa Loa (eye worm) hypothetical protein 0.0076 0.0333 0.1343
Schistosoma mansoni alpha-glucosidase 0.0145 0.0705 0.1867
Trypanosoma cruzi DNA polymerase kappa, putative 0.0057 0.0233 0.373
Schistosoma mansoni smad1 5 8 and 0.0032 0.0099 0.0256
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0045 0.0167 0.2526
Schistosoma mansoni hypothetical protein 0.0015 0.0007 0.0012
Echinococcus granulosus microtubule associated protein 2 0.0713 0.3761 1
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1345 0.716 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0045 0.0167 0.0675
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.003 0.012
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0045 0.0167 0.2682
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0255 0.103
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0126 0.1062
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.003 0.0476
Trichomonas vaginalis MYB72, putative 0.0038 0.0129 0.109
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.0208 0.4876
Schistosoma mansoni smad1 5 8 and 0.0032 0.0099 0.0256
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0126 0.2503
Entamoeba histolytica hypothetical protein 0.0108 0.0504 1
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0014 0.0003 0.0018
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0333 0.5238
Toxoplasma gondii exonuclease III APE 0.0019 0.003 0.0061
Loa Loa (eye worm) hypothetical protein 0.0127 0.0606 0.2444
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.0129 0.109
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0296 0.152 0.2108
Echinococcus multilocularis Smad4 0.0032 0.0099 0.0256
Trichomonas vaginalis mercuric reductase, putative 0.0045 0.0167 0.1409
Schistosoma mansoni hypothetical protein 0.0015 0.0007 0.0012
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0057 0.0233 0.0308
Giardia lamblia Myb 1-like protein 0.0038 0.013 0.2849
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0018 0.0021 0.0028
Schistosoma mansoni transcription factor LCR-F1 0.0108 0.0504 0.1333
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0528 0.2765 0.2642
Brugia malayi mothers against decapentaplegic homolog 3 0.0014 0.0003 0.0012
Echinococcus granulosus thioredoxin glutathione reductase 0.013 0.0627 0.166
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.003 0.0476
Brugia malayi polk-prov protein 0.0018 0.0021 0.0083
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.0208 0.084
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.0208 0.3339
Trypanosoma brucei PAB1-binding protein , putative 0.0076 0.0333 0.5337
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0045 0.0167 0.2682
Loa Loa (eye worm) hypothetical protein 0.0089 0.0406 0.1636
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0233 0.373
Trypanosoma brucei DNA polymerase IV, putative 0.0057 0.0233 0.373
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0087 0.0224
Onchocerca volvulus 0.0028 0.0078 0.0485
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0126 0.1062
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0057 0.0233 0.0939
Trypanosoma brucei DNA damage repair protein, putative 0.0018 0.0021 0.0331
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.0831 0.2203
Brugia malayi hypothetical protein 0.0076 0.0333 0.1343
Loa Loa (eye worm) MH1 domain-containing protein 0.0032 0.0099 0.04
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.0208 0.0547
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0126 0.1062
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.003 0.0023
Schistosoma mansoni ap endonuclease 0.0019 0.003 0.0071
Loa Loa (eye worm) nuclear factor I 0.0018 0.0021 0.0086
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0089 0.0406 0.1072
Brugia malayi ImpB/MucB/SamB family protein 0.0057 0.0233 0.0939
Plasmodium falciparum glutathione reductase 0.0045 0.0167 0.2526
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0013 0.0027
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0013 0.0208
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0057 0.0233 0.0612
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0103 0.0415
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0255 0.0672
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0126 0.0509
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0045 0.0167 0.2682
Trichomonas vaginalis C-MYB, putative 0.0038 0.0129 0.109
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.013 0.0624 0.0855
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0185 0.0746
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0233 0.373
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0233 0.373
Schistosoma mansoni hypothetical protein 0.0034 0.0108 0.028
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0255 0.103
Onchocerca volvulus 0.0097 0.0449 0.2797
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0087 0.0224
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0045 0.0167 0.0438
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0045 0.0167 0.2526
Echinococcus granulosus mothers against decapentaplegic 5 0.0032 0.0099 0.0256
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.1035 0.4174
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0333 0.5238
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0208 0.0547
Leishmania major DNA polymerase kappa, putative 0.0057 0.0233 0.373
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0255 0.0672
Leishmania major DNA damage repair protein, putative 0.0018 0.0021 0.0331
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0137 0.22
Echinococcus multilocularis mothers against decapentaplegic 5 0.0032 0.0099 0.0256
Schistosoma mansoni DNA polymerase IV / kappa 0.0018 0.0021 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0233 0.373
Schistosoma mansoni hypothetical protein 0.0674 0.3551 0.9442
Schistosoma mansoni hypothetical protein 0.0674 0.3551 0.9442
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0013 0.0027
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0333 0.5337
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0021 0.0331
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0296 0.152 0.2108
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0013 0.0027
Trypanosoma cruzi trypanothione reductase, putative 0.0045 0.0167 0.2682
Treponema pallidum NADH oxidase 0.0045 0.0167 0.0138
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.013 0.1098
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0255 0.0672
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0038 0.013 0.0426
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0013 0.0027
Brugia malayi MAP kinase sur-1 0.0053 0.0208 0.084
Echinococcus multilocularis microtubule associated protein 2 0.0713 0.3761 1
Loa Loa (eye worm) transcription factor SMAD2 0.0475 0.248 1
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0038 0.0129 0.2569
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0045 0.0167 0.0216
Echinococcus granulosus tar DNA binding protein 0.0061 0.0255 0.0672
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.0208 0.3339
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0108 0.0504 0.1333
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0179 0.0723
Schistosoma mansoni ap endonuclease 0.0019 0.003 0.0071
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0179 0.047
Trypanosoma cruzi DNA polymerase kappa, putative 0.0057 0.0233 0.373
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0007 0.003
Leishmania major DNA polymerase eta, putative 0.0043 0.0156 0.2501
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0233 0.373
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.003 0.0476
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0089 0.0406 0.1072
Brugia malayi MH1 domain containing protein 0.0018 0.0021 0.0086
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0089 0.0406 0.1072
Schistosoma mansoni hypothetical protein 0.0033 0.0103 0.0266
Loa Loa (eye worm) MH2 domain-containing protein 0.0014 0.0003 0.0012
Trypanosoma brucei DNA polymerase IV, putative 0.0057 0.0233 0.373
Brugia malayi TAR-binding protein 0.0061 0.0255 0.103
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0528 0.2765 0.2209
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.0129 0.109
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0038 0.0129 0.2569
Onchocerca volvulus Huntingtin homolog 0.0127 0.0606 0.3777
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0208 0.3339
Brugia malayi ImpB/MucB/SamB family protein 0.0082 0.0368 0.1485
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0087 0.0224
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0057 0.0233 0.0612
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0179 0.047
Schistosoma mansoni Smad4 0.0032 0.0099 0.0256
Schistosoma mansoni cpg binding protein 0.003 0.0087 0.0222
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.0129 0.109
Giardia lamblia NADH oxidase lateral transfer candidate 0.0045 0.0167 0.3811
Leishmania major trypanothione reductase 0.013 0.0624 1
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.013 0.1098
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0045 0.0167 0.0138
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0043 0.0156 0.052
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0045 0.0167 0.0138
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0528 0.2765 0.275
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0208 0.1754
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0329 0.1698 0.0315
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0208 0.1754
Onchocerca volvulus 0.0312 0.1605 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.0208 0.3339
Plasmodium falciparum DNA repair protein REV1, putative 0.0018 0.0021 0.0126
Loa Loa (eye worm) hypothetical protein 0.0082 0.0368 0.1485
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0078 0.0347 0.14
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0038 0.0129 0.2569
Plasmodium vivax glutathione reductase, putative 0.013 0.0624 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0045 0.0167 0.2682
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0013 0.0027
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0089 0.0406 0.1072
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0045 0.0167 0.2682
Mycobacterium tuberculosis Probable reductase 0.0296 0.152 0.2108
Schistosoma mansoni terminal deoxycytidyl transferase 0.0057 0.0233 0.0612
Brugia malayi Smad1 0.0032 0.0099 0.04
Schistosoma mansoni hypothetical protein 0.0015 0.0007 0.0012
Trichomonas vaginalis glutathione reductase, putative 0.0045 0.0167 0.1409
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0126 0.0411
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0168 0.0831 0.335
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0089 0.0406 0.1072
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0013 0.0208
Plasmodium falciparum glutathione reductase 0.013 0.0624 1
Echinococcus granulosus dna polymerase eta 0.0082 0.0368 0.0972
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0045 0.0167 0.2682
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0078 0.0314
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0045 0.0167 0.2682
Mycobacterium tuberculosis Conserved hypothetical protein 0.0057 0.0233 0.0308
Schistosoma mansoni alpha-glucosidase 0.0145 0.0705 0.1867
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0013 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0233 0.373
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0179 0.047
Echinococcus multilocularis geminin 0.0674 0.3551 0.9442
Brugia malayi MH1 domain containing protein 0.0032 0.0099 0.04
Echinococcus granulosus dna polymerase kappa 0.0057 0.0233 0.0612
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0255 0.0672
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0045 0.0167 0.0147
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1872 1 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0126 0.0328
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.003 0.025
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0013 0.0027
Loa Loa (eye worm) glutathione reductase 0.013 0.0624 0.2517
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0057 0.0233 0.0612
Mycobacterium tuberculosis Probable oxidoreductase 0.0329 0.1698 0.2357
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0179 0.047
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0083
Leishmania major DNA polymerase kappa, putative 0.0018 0.0021 0.0331
Trichomonas vaginalis pc-MYB2, putative 0.0038 0.0129 0.109

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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