TDR Targets

Basic information

Technical information

TDR Targets ID: 867035
Name: N-(2-methoxyethyl)-1-morpholin-4-ylsulfonylpi peridine-3-carboxamide
MW: 335.42 | Formula: C13H25N3O5S
H donors: 1 H acceptors: 3 LogP: -1.33 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COCCNC(=O)C1CCCN(C1)S(=O)(=O)N1CCOCC1
InChi: 1S/C13H25N3O5S/c1-20-8-4-14-13(17)12-3-2-5-16(11-12)22(18,19)15-6-9-21-10-7-15/h12H,2-11H2,1H3,(H,14,17)
InChiKey: DLKBYPGZWVIURP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(2-methoxyethyl)-1-morpholinosulfonyl-piperidine-3-carboxamide
N-(2-methoxyethyl)-1-morpholinosulfonyl-3-piperidinecarboxamide
N-(2-methoxyethyl)-1-morpholinosulfonyl-nipecotamide
N-(2-methoxyethyl)-1-morpholin-4-ylsulfonyl-piperidine-3-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0299	0.313	0.3112
Echinococcus granulosus	protein kinase c iota type	0.0299	0.313	0.4689
Schistosoma mansoni	voltage-gated potassium channel	0.0048	0.025	0.0375
Echinococcus granulosus	Protein kinase C brain isozyme	0.0299	0.313	0.4689
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0293	0.3056	0.3006
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0299	0.313	0.4689
Schistosoma mansoni	serine/threonine protein kinase	0.0299	0.313	0.4709
Loa Loa (eye worm)	hypothetical protein	0.0048	0.025	0.0225
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0165	0.1592	0.2366
Trichomonas vaginalis	AGC family protein kinase	0.0898	1	1
Entamoeba histolytica	protein kinase, putative	0.0898	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0299	0.313	0.3081
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0033	0.0076	0.0076
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.058	0.6351	1
Loa Loa (eye worm)	hypothetical protein	0.0143	0.1342	0.132
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0898	1	1
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0299	0.313	0.4689
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0033	0.0076	0.0051
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0033	0.0076	0.0114
Schistosoma mansoni	serine/threonine protein kinase	0.0299	0.313	0.4709
Echinococcus granulosus	voltage gated potassium channel	0.0048	0.025	0.0338
Echinococcus granulosus	hyperpolarization activated cyclic	0.0033	0.0076	0.0076
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0165	0.1592	0.2366
Schistosoma mansoni	serine/threonine protein kinase	0.0299	0.313	0.4709
Echinococcus granulosus	protein kinase C gamma type	0.0299	0.313	0.4689
Leishmania major	serine/threonine-protein kinase a, putative	0.0032	0.0071	1
Trichomonas vaginalis	AGC family protein kinase	0.0325	0.3425	0.3378
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0573	0.6277	0.9443
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0048	0.025	0.0338
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0033	0.0076	0.0076
Schistosoma mansoni	voltage-gated potassium channel	0.018	0.1765	0.2656
Brugia malayi	Protein kinase domain containing protein	0.0299	0.313	0.3112
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0299	0.313	0.4689
Schistosoma mansoni	serine/threonine protein kinase	0.0299	0.313	0.4709
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0606	0.6646	0.6622
Trichomonas vaginalis	AGC family protein kinase	0.0898	1	1
Brugia malayi	Hr1 repeat family protein	0.0299	0.313	0.3112
Trichomonas vaginalis	AGC family protein kinase	0.0898	1	1
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0165	0.1592	0.157
Trichomonas vaginalis	AGC family protein kinase	0.0299	0.313	0.3081
Echinococcus granulosus	NDR protein kinase	0.0299	0.313	0.4689
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0299	0.313	0.3112
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0048	0.025	0.0225
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0872	0.9705	0.9704
Schistosoma mansoni	serine/threonine-protein kinase	0.0606	0.6646	1
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0299	0.313	0.3112
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0154	0.1467	0.1406
Giardia lamblia	Kinase, AGC PKA	0.058	0.6351	0.5
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.058	0.6351	0.9554
Trichomonas vaginalis	AGC family protein kinase	0.0299	0.313	0.3081
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0033	0.0076	0.0005
Echinococcus multilocularis	serine threonine protein kinase	0.0299	0.313	0.4689
Schistosoma mansoni	voltage-gated potassium channel	0.0033	0.0076	0.0114
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0606	0.6646	0.6622
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0299	0.313	0.3112
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0033	0.0076	0.0114
Toxoplasma gondii	AGC kinase	0.0872	0.9705	1
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0026	0.0038
Echinococcus multilocularis	protein kinase c epsilon type	0.0299	0.313	0.4689
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0573	0.6277	0.9443
Echinococcus granulosus	serine:threonine protein kinase N2	0.0299	0.313	0.4689
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0299	0.313	0.4689
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0898	1	1
Schistosoma mansoni	atypical protein kinase C	0.0299	0.313	0.4709
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0165	0.1592	0.157
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.058	0.6351	0.9551
Echinococcus multilocularis	voltage gated potassium channel	0.0048	0.025	0.0338
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0033	0.0076	0.0076
Echinococcus multilocularis	Glutaredoxin protein 5	0.0573	0.6277	0.9443
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0033	0.0076	0.0076
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0033	0.0076	0.0005
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0026	0.0038
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0026	0.0038
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0032	0.0071	0.0072
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0299	0.313	0.4689
Schistosoma mansoni	serine/threonine protein kinase	0.0299	0.313	0.4709
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0299	0.313	0.3112
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0032	0.0071	1
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.058	0.6351	1
Echinococcus granulosus	nervana 2	0.0573	0.6277	0.9443
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0076	0.0051
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0033	0.0076	0.0076
Trypanosoma cruzi	Protein kinase B	0.0606	0.6646	1
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0033	0.0076	0.0051
Toxoplasma gondii	protein kinase domain-containing protein	0.0032	0.0071	0.0047
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0033	0.0076	0.0114
Entamoeba histolytica	protein kinase, putative	0.0299	0.313	0.3081
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0033	0.0076	0.0076
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0033	0.0076	0.0051
Trichomonas vaginalis	AGC family protein kinase	0.0898	1	1
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0033	0.0076	0.0076
Echinococcus granulosus	Glutaredoxin protein 5	0.0573	0.6277	0.9443
Echinococcus granulosus	serine/threonine protein kinase	0.0606	0.6646	1
Echinococcus granulosus	serine threonine protein kinase nrc	0.058	0.6351	0.9554
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0606	0.6646	1
Entamoeba histolytica	protein kinase 2, putative	0.058	0.6351	0.6325
Entamoeba histolytica	protein kinase, putative	0.0898	1	1
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0033	0.0076	0.0076
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0299	0.313	0.3112
Entamoeba histolytica	protein kinase, putative	0.0872	0.9705	0.9703
Echinococcus multilocularis	protein kinase c iota type	0.0299	0.313	0.4689
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0299	0.313	0.4689
Trichomonas vaginalis	AGC family protein kinase	0.0898	1	1
Schistosoma mansoni	voltage-gated potassium channel	0.018	0.1765	0.2656
Schistosoma mansoni	serine/threonine kinase	0.0299	0.313	0.4709
Schistosoma mansoni	voltage-gated potassium channel	0.0048	0.025	0.0375
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0154	0.1467	0.1406
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0033	0.0076	0.0114
Echinococcus multilocularis	nervana 2	0.0573	0.6277	0.9443
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0033	0.0076	0.0114
Trichomonas vaginalis	AGC family protein kinase	0.0898	1	1
Echinococcus multilocularis	rac serine:threonine kinase	0.0606	0.6646	1
Echinococcus granulosus	nervana 2	0.0573	0.6277	0.9443
Leishmania major	folate/biopterin transporter, putative	0.0032	0.0071	1
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0299	0.313	0.4689
Echinococcus multilocularis	nervana 2	0.0573	0.6277	0.9443
Brugia malayi	p70 ribosomal S6 kinase beta	0.0872	0.9705	0.9704
Echinococcus granulosus	protein kinase c epsilon type	0.0299	0.313	0.4689
Schistosoma mansoni	serine/threonine protein kinase	0.0299	0.313	0.4709
Schistosoma mansoni	serine/threonine protein kinase	0.0299	0.313	0.4709
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0299	0.313	0.4689
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0032	0.0071	0.0047
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0299	0.313	0.4689
Leishmania major	protein kinase, putative	0.0032	0.0071	1
Leishmania major	protein kinase, putative	0.0032	0.0071	1
Echinococcus granulosus	hyperpolarization activated cyclic	0.0033	0.0076	0.0076
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.058	0.6351	0.9554
Brugia malayi	protein kinase C II.	0.0299	0.313	0.3112
Schistosoma mansoni	serine/threonine-protein kinase	0.0606	0.6646	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0048	0.025	0.0338
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0033	0.0076	0.0076
Brugia malayi	Protein kinase domain containing protein	0.0299	0.313	0.3112
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0299	0.313	0.4689
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0032	0.0071	1
Trichomonas vaginalis	AGC family protein kinase	0.0898	1	1
Loa Loa (eye worm)	hypothetical protein	0.0299	0.313	0.3112

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 867035