TDR Targets

Basic information

Technical information

TDR Targets ID: 867189
Name: N-(4-acetamidophenyl)-3-[(2-ethyl-3-oxo-4H-1, 4-benzothiazin-6-yl)sulfonyl]propanamide
MW: 461.554 | Formula: C21H23N3O5S2
H donors: 3 H acceptors: 5 LogP: 1.56 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCC1Sc2ccc(cc2NC1=O)S(=O)(=O)CCC(=O)Nc1ccc(cc1)NC(=O)C
InChi: 1S/C21H23N3O5S2/c1-3-18-21(27)24-17-12-16(8-9-19(17)30-18)31(28,29)11-10-20(26)23-15-6-4-14(5-7-15)22-13(2)25/h4-9,12,18H,3,10-11H2,1-2H3,(H,22,25)(H,23,26)(H,24,27)
InChiKey: MGBLZKGDTZDTFM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[4-[3-[(2-ethyl-3-keto-4H-1,4-benzothiazin-6-yl)sulfonyl]propanoylamino]phenyl]acetamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glycoprotein hormones, alpha polypeptide	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Toxoplasma gondii	intraflagellar transport protein 172, putative	glycoprotein hormones, alpha polypeptide	116 aa	94 aa	26.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Cytochrome P450 family protein	0.0049	0.1146	0.0337
Schistosoma mansoni	neuropeptide F-like receptor	0.0151	1	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0037	0.0132	0.0776
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0151	1	1
Schistosoma mansoni	cytochrome P450	0.0049	0.1146	0.1027
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0049	0.1146	0.5
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0151	1	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0151	1	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0049	0.1146	0.5
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Echinococcus granulosus	beta tubulin	0.0045	0.0837	0.0837
Echinococcus granulosus	tubulin subunit beta	0.0045	0.0837	0.0837
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0151	1	1
Echinococcus multilocularis	allatostatin A receptor	0.0151	1	1
Echinococcus granulosus	neuropeptides capa receptor	0.0151	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0049	0.1146	0.5
Echinococcus granulosus	sex peptide receptor	0.0151	1	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0045	0.0837	0.0837
Loa Loa (eye worm)	cytochrome P450 family protein	0.0125	0.7703	0.7493
Echinococcus granulosus	neuropeptide s receptor	0.0151	1	1
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0055	0.1699	0.179
Echinococcus multilocularis	tubulin beta 1 chain	0.0045	0.0837	0.0837
Schistosoma mansoni	histamine h1 receptor	0.0151	1	1
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0049	0.1146	0.064
Echinococcus granulosus	neuropeptide receptor A26	0.0151	1	1
Echinococcus multilocularis	g protein coupled receptor	0.0151	1	1
Echinococcus granulosus	serine/threonine protein kinase	0.0037	0.0132	0.0132
Trypanosoma cruzi	Protein kinase B	0.0037	0.0132	0.0233
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0151	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0151	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0045	0.0837	0.0837
Brugia malayi	Protein kinase domain containing protein	0.0055	0.1699	0.0941
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0151	1	1
Echinococcus multilocularis	fmrfamide receptor	0.0151	1	1
Echinococcus multilocularis	tubulin subunit beta	0.0045	0.0837	0.0837
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0151	1	1
Echinococcus granulosus	fmrfamide receptor	0.0151	1	1
Brugia malayi	hypothetical protein	0.0151	1	1
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0049	0.1146	0.5
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Onchocerca volvulus		0.0151	1	0.5
Loa Loa (eye worm)	cytochrome P450	0.0049	0.1146	0.0337
Schistosoma mansoni	biogenic amine receptor	0.0151	1	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0151	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0151	1	1
Brugia malayi	neuropeptide F receptor	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0151	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0055	0.1699	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0151	1	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0151	1	1
Brugia malayi	Serotonin receptor	0.0151	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0151	1	1
Echinococcus multilocularis	somatostatin receptor	0.0151	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0049	0.1146	0.5
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0151	1	0.5
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Giardia lamblia	Beta tubulin	0.0045	0.0837	1
Brugia malayi	cytochrome P450	0.0049	0.1146	0.0337
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0045	0.0837	0.0837
Schistosoma mansoni	amine GPCR	0.0151	1	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0151	1	1
Brugia malayi	Serotonin receptor	0.0151	1	1
Brugia malayi	hypothetical protein	0.0151	1	1
Leishmania major	cytochrome p450-like protein	0.0049	0.1146	0.064
Brugia malayi	sulfakinin receptor protein	0.0151	1	1
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0049	0.1146	0.4223
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Brugia malayi	hypothetical protein	0.0151	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0049	0.1146	0.5
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0151	1	1
Echinococcus granulosus	g protein coupled receptor	0.0151	1	1
Echinococcus granulosus	beta tubulin	0.0045	0.0837	0.0837
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Schistosoma mansoni	tubulin subunit beta	0.0045	0.0837	0.0715
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0054	0.1568	0.0797
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0049	0.1146	0.5
Brugia malayi	RE15519p	0.0151	1	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0151	1	1
Echinococcus multilocularis	sex peptide receptor	0.0151	1	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0151	1	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0151	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0049	0.1146	0.5
Echinococcus multilocularis	neuropeptide s receptor	0.0151	1	1
Giardia lamblia	Beta tubulin	0.0045	0.0837	1
Schistosoma mansoni	tubulin subunit beta	0.0045	0.0837	0.0715
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0151	1	1
Leishmania major	cytochrome p450-like protein	0.0049	0.1146	0.064
Loa Loa (eye worm)	CYP4Cod1	0.0101	0.5653	0.5256
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0049	0.1146	0.5
Schistosoma mansoni	amine GPCR	0.0151	1	1
Echinococcus multilocularis	serotonin receptor	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Entamoeba histolytica	protein kinase, putative	0.0055	0.1699	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Echinococcus multilocularis	rac serine:threonine kinase	0.0037	0.0132	0.0132
Echinococcus multilocularis	neuropeptides capa receptor	0.0151	1	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0151	1	1
Onchocerca volvulus		0.0151	1	0.5
Loa Loa (eye worm)	cytochrome P450 family protein	0.0101	0.5653	0.5256
Trichomonas vaginalis	AGC family protein kinase	0.0055	0.1699	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0151	1	1
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0049	0.1146	0.2026
Trichomonas vaginalis	AGC family protein kinase	0.0055	0.1699	1
Schistosoma mansoni	myosin xvIII	0.0151	1	1
Onchocerca volvulus		0.0151	1	0.5
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0101	0.5653	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Onchocerca volvulus		0.0151	1	0.5
Schistosoma mansoni	hypothetical protein	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Echinococcus granulosus	g-protein coupled receptor	0.0151	1	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Brugia malayi	Cytochrome P450 family protein	0.0101	0.5653	0.5256
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0049	0.1146	0.5
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0151	1	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0151	1	1
Toxoplasma gondii	AGC kinase	0.0054	0.1568	1
Echinococcus granulosus	neuropeptide Y receptor	0.0151	1	1
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0049	0.1146	0.5
Loa Loa (eye worm)	hypothetical protein	0.0052	0.14	0.0615
Schistosoma mansoni	opsin-like receptor	0.0151	1	1
Onchocerca volvulus		0.0151	1	0.5
Echinococcus granulosus	neuropeptide receptor	0.0151	1	1
Echinococcus granulosus	neuropeptide receptor	0.0151	1	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0151	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0151	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0045	0.0837	0.0837
Mycobacterium leprae	putative cytochrome p450	0.0049	0.1146	0.5
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Echinococcus granulosus	tubulin beta 1 chain	0.0045	0.0837	0.0837
Schistosoma mansoni	biogenic amine receptor	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Echinococcus granulosus	g protein coupled receptor	0.0151	1	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0151	1	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0151	1	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0045	0.0837	0.0837
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Brugia malayi	hypothetical protein	0.0151	1	1
Onchocerca volvulus		0.0151	1	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0151	1	1
Brugia malayi	hypothetical protein	0.0151	1	1
Echinococcus multilocularis		0.0049	0.1146	0.1146
Loa Loa (eye worm)	neuropeptide F receptor	0.0151	1	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0151	1	1
Echinococcus multilocularis	g-protein coupled receptor	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0151	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0049	0.1146	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0151	1	1
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0055	0.1699	0.0941
Echinococcus granulosus	tm gpcr rhodopsin	0.0151	1	1
Echinococcus multilocularis	beta tubulin	0.0045	0.0837	0.0837
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0151	1	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0151	1	1
Schistosoma mansoni	tubulin subunit beta	0.0045	0.0837	0.0715
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0151	1	1
Entamoeba histolytica	protein kinase, putative	0.0054	0.1568	0.9224
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0151	1	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0151	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0049	0.1146	0.5
Brugia malayi	AKH receptor	0.0151	1	1
Echinococcus granulosus	allatostatin A receptor	0.0151	1	1
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0049	0.1146	0.2026
Echinococcus multilocularis	G protein coupled receptor 139	0.0151	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0151	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0151	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0049	0.1146	0.5
Loa Loa (eye worm)	cytochrome P450 family protein	0.0101	0.5653	0.5256
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0151	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0045	0.0837	0.0837
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Brugia malayi	Cytochrome P450 family protein	0.0101	0.5653	0.5256
Brugia malayi	Cytochrome P450 family protein	0.0125	0.7703	0.7493
Brugia malayi	GnHR receptor homolog	0.0151	1	1
Echinococcus multilocularis	g protein coupled receptor	0.0151	1	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0045	0.0837	0.0837
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Echinococcus multilocularis	neuropeptide receptor	0.0151	1	1
Schistosoma mansoni	amine GPCR	0.0151	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0151	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0049	0.1146	0.5
Brugia malayi	G-protein coupled receptor	0.0151	1	1
Brugia malayi	Dopamine receptor	0.0151	1	1
Trypanosoma cruzi	cytochrome P450, putative	0.0101	0.5653	1
Echinococcus granulosus	g protein coupled receptor	0.0151	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0049	0.1146	0.5
Echinococcus multilocularis	Tubulin beta 2C chain	0.0045	0.0837	0.0837
Schistosoma mansoni	hypothetical protein	0.0151	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0049	0.1146	0.5
Schistosoma mansoni	opsin-like receptor	0.0151	1	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0151	1	1
Plasmodium vivax	tubulin beta chain, putative	0.0045	0.0837	1
Entamoeba histolytica	tubulin family protein	0.0045	0.0837	0.4927
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0151	1	1
Entamoeba histolytica	protein kinase, putative	0.0055	0.1699	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0151	1	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Brugia malayi	Melatonin receptor type 1A	0.0151	1	1
Schistosoma mansoni	hypothetical protein	0.0151	1	1
Onchocerca volvulus		0.0151	1	0.5
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0151	1	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0151	1	1
Brugia malayi	neuropeptide F receptor	0.0151	1	1
Mycobacterium leprae	Conserved hypothetical protein	0.0049	0.1146	0.5
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Echinococcus granulosus	tubulin beta 4A class IVa	0.0045	0.0837	0.0837
Brugia malayi	putative neuropeptide receptor NPR1	0.0151	1	1
Brugia malayi	G protein-coupled receptor	0.0151	1	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0151	1	1
Onchocerca volvulus		0.0151	1	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0151	1	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0151	1	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0151	1	1
Onchocerca volvulus		0.0151	1	0.5
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0151	1	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0037	0.0132	0.0776
Brugia malayi	p70 ribosomal S6 kinase beta	0.0054	0.1568	0.0797
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0049	0.1146	0.5
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0151	1	1
Schistosoma mansoni	neuropeptide receptor	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0151	1	1
Schistosoma mansoni	tubulin subunit beta	0.0045	0.0837	0.0715
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0151	1	1
Brugia malayi	Dopamine receptor protein 1	0.0151	1	1
Schistosoma mansoni	hypothetical protein	0.0151	1	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0151	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0151	1	1
Onchocerca volvulus		0.0151	1	0.5
Onchocerca volvulus		0.0151	1	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0045	0.0837	0.0837
Schistosoma mansoni	neuropeptide receptor	0.0151	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0055	0.1699	1
Loa Loa (eye worm)	TYRA-2 protein	0.0151	1	1
Brugia malayi	ORL1-like opioid receptor	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0151	1	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0151	1	1
Brugia malayi	Dopamine receptor protein 2	0.0151	1	1
Brugia malayi	hypothetical protein	0.0151	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0049	0.1146	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.0151	1	1
Plasmodium falciparum	tubulin beta chain	0.0045	0.0837	1
Onchocerca volvulus		0.0151	1	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0151	1	1
Schistosoma mansoni	tubulin subunit beta	0.0045	0.0837	0.0715
Trypanosoma cruzi	cytochrome P450, putative	0.0101	0.5653	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0151	1	1
Entamoeba histolytica	tubulin family protein	0.0045	0.0837	0.4927
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0151	1	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0151	1	1
Onchocerca volvulus		0.0151	1	0.5
Schistosoma mansoni	neuropeptide receptor	0.0151	1	1
Trypanosoma brucei	cytochrome P450, putative	0.0101	0.5653	1
Schistosoma mansoni	amine GPCR	0.0151	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0055	0.1699	1
Echinococcus multilocularis	beta tubulin	0.0045	0.0837	0.0837
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0049	0.1146	0.2026
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0151	1	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0151	1	1
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0037	0.0132	0.0233
Trichomonas vaginalis	AGC family protein kinase	0.0055	0.1699	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Schistosoma mansoni	hypothetical protein	0.0049	0.1146	0.1027
Echinococcus granulosus	serotonin receptor	0.0151	1	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0045	0.0837	0.0837
Echinococcus granulosus	orexin receptor type 2	0.0151	1	1
Echinococcus multilocularis	orexin receptor type 2	0.0151	1	1
Echinococcus granulosus	somatostatin receptor	0.0151	1	1
Echinococcus multilocularis	fmrfamide receptor	0.0151	1	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0151	1	1
Onchocerca volvulus		0.0151	1	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0151	1	1
Echinococcus granulosus	neuropeptide Y receptor	0.0151	1	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0151	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0055	0.1699	1
Brugia malayi	hypothetical protein	0.0151	1	1
Brugia malayi	putative neuropeptide receptor	0.0151	1	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Echinococcus granulosus	G protein coupled receptor 139	0.0151	1	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0045	0.0837	0.0837
Echinococcus granulosus	cytochrome P450 2K1	0.0049	0.1146	0.1146
Echinococcus multilocularis	neuropeptide receptor	0.0151	1	1
Giardia lamblia	Beta tubulin	0.0045	0.0837	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0151	1	1
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0049	0.1146	0.064
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0049	0.1146	0.5
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0151	1	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Schistosoma mansoni	opsin-like receptor	0.0151	1	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0151	1	1
Brugia malayi	follicle stimulating hormone receptor	0.0151	1	1
Schistosoma mansoni	biogenic amine receptor	0.0151	1	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Schistosoma mansoni	neuropeptide receptor	0.0151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0151	1	1
Echinococcus granulosus	hypothetical protein	0.0151	1	1
Schistosoma mansoni	amine GPCR	0.0151	1	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0151	1	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0151	1	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0151	1	1
Brugia malayi	hypothetical protein	0.0151	1	1
Echinococcus multilocularis	g protein coupled receptor	0.0151	1	1
Leishmania major	cytochrome p450-like protein	0.0101	0.5653	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0151	1	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0151	1	1
Onchocerca volvulus		0.0151	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0151	1	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0151	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0151	1	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0151	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0151	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0151	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0151	1	1
Brugia malayi	hypothetical protein	0.0151	1	1
Brugia malayi	larval opioid receptor	0.0151	1	1
Echinococcus multilocularis	serotonin receptor	0.0151	1	1
Onchocerca volvulus		0.0151	1	0.5
Onchocerca volvulus		0.0151	1	0.5
Schistosoma mansoni	tubulin subunit beta	0.0045	0.0837	0.0715
Loa Loa (eye worm)	G-protein coupled receptor	0.0151	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0151	1	1
Trypanosoma cruzi	beta tubulin, putative	0.0045	0.0837	0.1481
Brugia malayi	G-protein coupled receptor	0.0151	1	1
Schistosoma mansoni	adenoreceptor	0.0151	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.4467 uM	PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	6.5733 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	9.285 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1323147
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Bibliographic References

No literature references available for this target.

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Detailed information for compound 867189