Detailed information for compound 867237

Basic information

Technical information
  • TDR Targets ID: 867237
  • Name: N-(2,4-dimethylphenyl)-2-(3-oxo-6-pyrrolidin- 1-ylsulfonyl-1,4-benzothiazin-4-yl)acetamide
  • MW: 459.582 | Formula: C22H25N3O4S2
  • H donors: 1 H acceptors: 4 LogP: 2.87 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1C)C)CN1C(=O)CSc2c1cc(cc2)S(=O)(=O)N1CCCC1
  • InChi: 1S/C22H25N3O4S2/c1-15-5-7-18(16(2)11-15)23-21(26)13-25-19-12-17(6-8-20(19)30-14-22(25)27)31(28,29)24-9-3-4-10-24/h5-8,11-12H,3-4,9-10,13-14H2,1-2H3,(H,23,26)
  • InChiKey: ZZUPTRBUXVJDKL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2,4-dimethylphenyl)-2-(3-oxo-6-1-pyrrolidinylsulfonyl-1,4-benzothiazin-4-yl)acetamide
  • N-(2,4-dimethylphenyl)-2-(3-keto-6-pyrrolidin-1-ylsulfonyl-1,4-benzothiazin-4-yl)acetamide
  • N-(2,4-dimethylphenyl)-2-(3-oxo-6-pyrrolidin-1-ylsulfonyl-1,4-benzothiazin-4-yl)ethanamide
  • E589-2551
  • NCGC00123375-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0054 0.0029 0.0684
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0356 0.0401 0.0656
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0012 0.0153
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0067 0.0045 0.1099
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.016 0.016 0.016
Schistosoma mansoni hypothetical protein 0.0069 0.0048 0.0046
Loa Loa (eye worm) hypothetical protein 0.007 0.0048 0.0048
Echinococcus multilocularis serine:threonine protein kinase N2 0.008 0.006 0.0073
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0672 0.079 0.0983
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0356 0.0401 0.0656
Toxoplasma gondii aspartyl protease ASP3 0.007 0.0048 0.114
Loa Loa (eye worm) hypothetical protein 0.0136 0.013 0.013
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0485 0.056 0.0696
Brugia malayi ADAM-TS Spacer 1 family protein 0.0136 0.013 0.013
Plasmodium vivax hypothetical protein, conserved 0.0099 0.0085 0.1681
Echinococcus granulosus nmda type glutamate receptor 0.015 0.0147 0.0146
Loa Loa (eye worm) hypothetical protein 0.0162 0.0162 0.0162
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0356 0.0401 1
Plasmodium falciparum plasmepsin VIII, putative 0.007 0.0048 0.0942
Loa Loa (eye worm) hypothetical protein 0.3176 0.3873 0.3873
Loa Loa (eye worm) subtilase 0.0356 0.0401 0.0401
Loa Loa (eye worm) hypothetical protein 0.0097 0.0081 0.0081
Onchocerca volvulus 0.0069 0.0048 0.0759
Schistosoma mansoni septate junction protein 0.004 0.0012 0.001
Loa Loa (eye worm) hypothetical protein 0.0062 0.0039 0.0039
Echinococcus multilocularis c Jun NH2 terminal kinase 0.026 0.0283 0.0351
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.007 0.0048 0.0047
Echinococcus granulosus adam 0.0467 0.0537 0.0536
Onchocerca volvulus 0.0356 0.0401 0.6564
Echinococcus granulosus protein kinase c epsilon type 0.0087 0.007 0.0068
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0083 0.0065 0.1591
Plasmodium falciparum subtilisin-like protease 3 0.0356 0.0401 0.8094
Plasmodium falciparum subtilisin-like protease 1 0.0356 0.0401 0.8094
Leishmania major sir2-family protein-like protein 0.0099 0.0085 0.001
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0091 0.0074 0.1813
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0091 0.0074 0.5
Schistosoma mansoni hypothetical protein 0.0062 0.0039 0.0037
Schistosoma mansoni furin-1 (S08 family) 0.3532 0.4311 0.431
Plasmodium vivax plasmepsin IV, putative 0.007 0.0048 0.0942
Mycobacterium tuberculosis Probable thioesterase TesA 0.0072 0.0051 0.1231
Schistosoma mansoni site-1 peptidase (S08 family) 0.0356 0.0401 0.04
Echinococcus granulosus fibrillin 2 0.0162 0.0162 0.0161
Trichomonas vaginalis conserved hypothetical protein 0.1612 0.1947 0.3196
Brugia malayi hypothetical protein 0.0305 0.0338 0.0338
Trichomonas vaginalis conserved hypothetical protein 0.0356 0.0401 0.0656
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0083 0.0065 0.1582
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0041 0.0013 0.0011
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0356 0.0401 0.0656
Mycobacterium ulcerans Type I modular polyketide synthase 0.0083 0.0065 0.1355
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0012 0.0153
Giardia lamblia Neurogenic locus notch-like protein 0.0162 0.0162 0.0408
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0059 0.0036 0.0034
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0119 0.0109 0.0107
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0356 0.0401 0.0656
Echinococcus multilocularis epidermal growth factor receptor 0.0452 0.0519 0.0646
Brugia malayi metalloprotease 0.0064 0.0042 0.0042
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0356 0.0401 0.0656
Schistosoma mansoni protein kinase 0.0134 0.0127 0.0126
Echinococcus multilocularis nmda type glutamate receptor 0.015 0.0147 0.0182
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0233 0.0249 0.0309
Echinococcus granulosus glutamate receptor subunit protein glur 0.0059 0.0036 0.0034
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0099 0.0085 0.0083
Brugia malayi hypothetical protein 0.0069 0.0048 0.0048
Schistosoma mansoni hypothetical protein 0.0286 0.0315 0.0313
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0099 0.0085 0.107
Plasmodium vivax plasmepsin V, putative 0.0433 0.0495 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.0084 0.0084
Plasmodium vivax hypothetical protein, conserved 0.0099 0.0084 0.1667
Echinococcus multilocularis integrin alpha ps 0.0597 0.0698 0.0869
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0013 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.1612 0.1947 0.3196
Schistosoma mansoni glutamate receptor NMDA 0.0119 0.0109 0.0107
Schistosoma mansoni hypothetical protein 0.007 0.0048 0.0047
Mycobacterium ulcerans oxidoreductase 0.0099 0.0084 0.1845
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0356 0.0401 0.0656
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0062 0.0039 0.0046
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0012 0.0017
Schistosoma mansoni hypothetical protein 0.0062 0.0039 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0012 0.0153
Trichomonas vaginalis WD repeat domain, putative 0.007 0.0048 0.0076
Loa Loa (eye worm) hypothetical protein 0.0069 0.0048 0.0048
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0041 0.0013 0.0014
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0485 0.056 0.0558
Onchocerca volvulus 0.007 0.0048 0.0765
Onchocerca volvulus 0.0526 0.061 1
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.008 0.0061 0.1499
Trypanosoma brucei SIR2-like protein 4, putative 0.0099 0.0085 0.107
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0099 0.0085 0.0083
Echinococcus multilocularis protein jagged 2 0.0162 0.0162 0.02
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0099 0.0084 0.1845
Brugia malayi EGF-like domain containing protein 0.0162 0.0162 0.0162
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.1612 0.1947 0.3196
Schistosoma mansoni glutamate receptor kainate 0.0101 0.0086 0.0085
Trichomonas vaginalis hypothetical protein 0.1612 0.1947 0.3196
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0119 0.0109 0.0107
Echinococcus multilocularis integrin alpha 3 0.0826 0.098 0.1221
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1968 0.2386 0.3916
Loa Loa (eye worm) reprolysin 0.0233 0.0249 0.0249
Loa Loa (eye worm) endoprotease bli-4 0.8153 1 1
Schistosoma mansoni glutamate receptor kainate 0.0101 0.0086 0.0085
Echinococcus granulosus glutamate receptor 2 0.0059 0.0035 0.0034
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0356 0.0401 0.0656
Loa Loa (eye worm) hypothetical protein 0.0064 0.0042 0.0042
Trypanosoma cruzi UDP-galactopyranose mutase 0.0099 0.0084 0.0923
Loa Loa (eye worm) WD40 repeat protein 0.007 0.0048 0.0048
Echinococcus granulosus neuroendocrine convertase 2 0.5144 0.6296 0.6295
Brugia malayi Integrin alpha cytoplasmic region family protein 0.077 0.091 0.091
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0233 0.0249 0.0248
Loa Loa (eye worm) hypothetical protein 0.0485 0.056 0.056
Mycobacterium leprae Probable polyketide synthase Pks1 0.0088 0.0071 0.1746
Loa Loa (eye worm) aspartic protease BmAsp-1 0.007 0.0048 0.0048
Brugia malayi transcriptional regulator, Sir2 family protein 0.0099 0.0085 0.0085
Onchocerca volvulus 0.008 0.0061 0.0984
Plasmodium vivax aspartyl protease, putative 0.007 0.0048 0.0942
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.007 0.0048 0.0076
Echinococcus granulosus protein will die slowly 0.007 0.0048 0.0047
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0672 0.079 1
Mycobacterium ulcerans Sir2-like regulatory protein 0.0099 0.0085 0.1863
Loa Loa (eye worm) apoptosis regulator protein 0.0062 0.0039 0.0039
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.026 0.0283 0.0283
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0356 0.0401 0.0656
Mycobacterium ulcerans thioesterase TesA 0.0072 0.0051 0.0994
Schistosoma mansoni SWI/SNF complex-related 0.0041 0.0013 0.0011
Loa Loa (eye worm) hypothetical protein 0.0485 0.056 0.056
Giardia lamblia Tenascin-X 0.0162 0.0162 0.0408
Echinococcus granulosus dna polymerase kappa 0.004 0.0012 0.001
Echinococcus multilocularis dna polymerase kappa 0.004 0.0012 0.0013
Schistosoma mansoni chromatin regulatory protein sir2 0.0099 0.0085 0.0083
Echinococcus multilocularis 0.6541 0.8015 1
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0099 0.0085 0.0921
Plasmodium vivax hypothetical protein, conserved 0.0099 0.0084 0.1667
Toxoplasma gondii subtilisin SUB11 0.0356 0.0401 0.9792
Toxoplasma gondii SWIRM domain-containing protein 0.0041 0.0013 0.028
Loa Loa (eye worm) hypothetical protein 0.0349 0.0392 0.0392
Brugia malayi hypothetical protein 0.1162 0.1392 0.1392
Schistosoma mansoni integrin alpha 0.1137 0.1363 0.1361
Echinococcus granulosus adam 17 protease 0.0097 0.0081 0.008
Echinococcus granulosus glutamate NMDA receptor subunit 0.0363 0.041 0.0408
Loa Loa (eye worm) TK/EGFR protein kinase 0.0452 0.0519 0.0519
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0356 0.0401 1
Loa Loa (eye worm) metalloprotease 0.0064 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0099 0.0085 0.0085
Entamoeba histolytica hypothetical protein 0.0047 0.002 0.0096
Echinococcus multilocularis protein will die slowly 0.007 0.0048 0.0058
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0356 0.0401 1
Loa Loa (eye worm) angiogenesis inhibito 0.0064 0.0042 0.0042
Echinococcus granulosus integrin alpha 3 0.0826 0.098 0.0978
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0356 0.0401 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0672 0.079 0.1294
Schistosoma mansoni protein kinase 0.0134 0.0127 0.0126
Echinococcus granulosus membrane bound transcription factor site 1 0.0356 0.0401 0.04
Schistosoma mansoni hypothetical protein 0.0062 0.0039 0.0037
Brugia malayi ADAMTS-like protease 0.0136 0.013 0.013
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0117 0.0106 0.0106
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1968 0.2386 0.3916
Plasmodium vivax aspartyl proteinase, putative 0.007 0.0048 0.0942
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0672 0.079 0.0788
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.007 0.0048 0.0047
Brugia malayi Probable ATP-dependent helicase DHX35 0.0032 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0356 0.0401 0.0401
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0043 0.0016 0.0354
Leishmania major subtilisin-like serine peptidase 0.0356 0.0401 0.4494
Trichomonas vaginalis conserved hypothetical protein 0.1612 0.1947 0.3196
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0085 0.0136
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.007 0.0048 0.0047
Loa Loa (eye worm) hypothetical protein 0.1162 0.1392 0.1392
Trypanosoma cruzi subtilisin peptidase 0.0356 0.0401 0.5003
Echinococcus granulosus glutamate receptor 2 0.0119 0.0109 0.0107
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0083 0.0065 0.1591
Plasmodium vivax aspartyl protease, putative 0.007 0.0048 0.0942
Echinococcus multilocularis glutamate receptor 2 0.0119 0.0109 0.0133
Loa Loa (eye worm) hypothetical protein 0.0162 0.0162 0.0162
Schistosoma mansoni chromatin regulatory protein sir2 0.0672 0.079 0.0788
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0099 0.0085 0.0196
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0119 0.0109 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.0356 0.0401 0.0656
Plasmodium vivax aspartyl protease, putative 0.007 0.0048 0.0942
Loa Loa (eye worm) hypothetical protein 0.0041 0.0013 0.0013
Brugia malayi AMP-binding enzyme family protein 0.008 0.0061 0.0061
Echinococcus multilocularis integrin beta 2 0.5579 0.683 0.8521
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0099 0.0084 0.1667
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0356 0.0401 0.04
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0099 0.0085 0.0921
Plasmodium falciparum plasmepsin IX 0.007 0.0048 0.0942
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0088 0.0071 0.1746
Mycobacterium ulcerans NAD-dependent deacetylase 0.0099 0.0085 0.1863
Entamoeba histolytica hypothetical protein, conserved 0.0099 0.0085 0.0921
Giardia lamblia Neurogenic locus Notch protein precursor 0.0162 0.0162 0.0408
Brugia malayi aspartic protease BmAsp-2, identical 0.007 0.0048 0.0048
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0059 0.0036 0.0034
Trypanosoma brucei unspecified product 0.0034 0.0004 0.0052
Loa Loa (eye worm) aspartic protease BmAsp-2 0.007 0.0048 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0356 0.0401 0.0656
Schistosoma mansoni glutamate receptor kainate 0.0101 0.0086 0.0085
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0134 0.0127 0.0126
Schistosoma mansoni integrin beta subunit 0.4417 0.54 0.54
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0375 0.0424 0.53
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0233 0.0249 0.0248
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0056 0.0031 0.0726
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0356 0.0401 0.0656
Schistosoma mansoni cathepsin D (A01 family) 0.007 0.0048 0.0047
Loa Loa (eye worm) hypothetical protein 0.0233 0.0249 0.0249
Mycobacterium leprae Polyketide synthase Pks13 0.0126 0.0117 0.2893
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0099 0.0084 0.0082
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0356 0.0401 0.0656
Toxoplasma gondii subtilisin SUB5 0.0356 0.0401 0.9792
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0099 0.0085 0.0103
Echinococcus multilocularis protein kinase c epsilon type 0.0087 0.007 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.1612 0.1947 0.3196
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0099 0.0085 0.1681
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0012 0.0153
Echinococcus multilocularis 0.0099 0.0084 0.0103
Loa Loa (eye worm) proprotein convertase 2 0.1968 0.2386 0.2386
Plasmodium falciparum plasmepsin IV 0.007 0.0048 0.0942
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0356 0.0401 0.0656
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0356 0.0401 0.0656
Onchocerca volvulus 0.0069 0.0048 0.0759
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0305 0.0338 0.0336
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0356 0.0401 0.0656
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0119 0.0109 0.0133
Loa Loa (eye worm) AMP-binding enzyme family protein 0.008 0.0061 0.0061
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0356 0.0401 1
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0099 0.0085 0.0932
Loa Loa (eye worm) hypothetical protein 0.0032 0.0002 0.0002
Toxoplasma gondii histone deacetylase SIR2-like 0.0099 0.0085 0.2033
Brugia malayi Eukaryotic aspartyl protease family protein 0.007 0.0048 0.0048
Echinococcus multilocularis fibrillin 1 0.0164 0.0164 0.0203
Toxoplasma gondii histone lysine-specific demethylase 0.0099 0.0084 0.2016
Loa Loa (eye worm) hypothetical protein 0.014 0.0134 0.0134
Loa Loa (eye worm) transcriptional regulator 0.0099 0.0085 0.0085
Mycobacterium ulcerans Type I modular polyketide synthase 0.0083 0.0065 0.1355
Echinococcus granulosus lysine specific histone demethylase 1A 0.0099 0.0084 0.0082
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0087 0.007 0.007
Mycobacterium ulcerans polyketide synthase 0.0083 0.0065 0.1355
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0099 0.0085 0.001
Plasmodium falciparum plasmepsin X 0.007 0.0048 0.0942
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0462 0.0531 0.053
Brugia malayi Stress-activated protein kinase jnk-1 0.026 0.0283 0.0283
Echinococcus multilocularis adam 0.0467 0.0537 0.0669
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0099 0.0084 0.1667
Brugia malayi Will die slowly protein 0.007 0.0048 0.0048
Trypanosoma brucei subtilisin peptidase 0.0356 0.0401 0.5079
Loa Loa (eye worm) hypothetical protein 0.0072 0.0051 0.0051
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0356 0.0401 0.0656
Onchocerca volvulus 0.007 0.0048 0.0764
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0012 0.0153
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0099 0.0085 0.0103
Toxoplasma gondii subtilisin SUB7 0.0356 0.0401 0.9792
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1968 0.2386 0.3916
Schistosoma mansoni chromatin regulatory protein sir2 0.0672 0.079 0.0788
Brugia malayi Kelch motif family protein 0.118 0.1416 0.1416
Schistosoma mansoni hypothetical protein 0.1612 0.1947 0.1946
Schistosoma mansoni site-1 peptidase (S08 family) 0.0356 0.0401 0.04
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0083 0.0065 0.1582
Schistosoma mansoni ATP-binding cassette transporter 0.0102 0.0088 0.0086
Echinococcus granulosus MAM 0.0069 0.0048 0.0046
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0356 0.0401 0.0656
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0356 0.0401 1
Giardia lamblia Tenascin-like 0.0162 0.0162 0.0408
Trichomonas vaginalis conserved hypothetical protein 0.1612 0.1947 0.3196
Brugia malayi Furin-like cysteine rich region family protein 0.0452 0.0519 0.0519
Mycobacterium ulcerans Type I modular polyketide synthase 0.0083 0.0065 0.1355
Loa Loa (eye worm) fatty acid synthase 0.0085 0.0067 0.0067
Loa Loa (eye worm) transcriptional regulator 0.0099 0.0085 0.0085
Echinococcus multilocularis protoporphyrinogen oxidase 0.0099 0.0084 0.0103
Onchocerca volvulus Fatty acid synthase homolog 0.0155 0.0153 0.2495
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0099 0.0084 0.1845
Loa Loa (eye worm) hypothetical protein 0.0069 0.0048 0.0048
Echinococcus multilocularis integrin alpha ps 0.066 0.0775 0.0965
Loa Loa (eye worm) DEAH box polypeptide 35 0.0032 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0136 0.013 0.013
Loa Loa (eye worm) kelch domain-containing protein family protein 0.118 0.1416 0.1416
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.007 0.0048 0.114
Mycobacterium tuberculosis Possible oxidoreductase 0.0099 0.0084 0.2059
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0062 0.0039 0.0926
Schistosoma mansoni dihydroceramide desaturase 0.0097 0.0081 0.008
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0085 0.0136
Plasmodium falciparum plasmepsin II 0.007 0.0048 0.0942
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0119 0.0109 0.0107
Toxoplasma gondii subtilisin SUB1 0.0356 0.0401 0.9792
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.007 0.0048 0.114
Brugia malayi amine oxidase, flavin-containing family protein 0.014 0.0134 0.0134
Schistosoma mansoni serine/threonine protein kinase 0.026 0.0283 0.0282
Brugia malayi aspartic protease BmAsp-1, identical 0.007 0.0048 0.0048
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0356 0.0401 0.04
Schistosoma mansoni chromatin regulatory protein sir2 0.0099 0.0085 0.0083
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0083 0.0065 0.1582
Loa Loa (eye worm) TK/ALK protein kinase 0.0069 0.0048 0.0048
Brugia malayi angiogenesis inhibito 0.0136 0.013 0.013
Toxoplasma gondii aspartyl protease ASP1 0.007 0.0048 0.114
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0099 0.0085 0.0932
Brugia malayi hypothetical protein 0.007 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0142 0.0137 0.0137
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0356 0.0401 1
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.007 0.0048 0.0047
Giardia lamblia Transcriptional regulator, Sir2 family 0.0099 0.0085 0.0196
Mycobacterium leprae Possible secreted protease 0.0356 0.0401 1
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0047 0.002 0.0259
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0363 0.041 0.0509
Trichomonas vaginalis conserved hypothetical protein 0.1612 0.1947 0.3196
Echinococcus multilocularis chromatin regulatory protein sir2 0.0672 0.079 0.0983
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0099 0.0084 0.1845
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0356 0.0401 0.0656
Brugia malayi Reprolysin 0.0136 0.013 0.013
Giardia lamblia High cysteine protein 0.0162 0.0162 0.0408
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0773 0.0915 0.1139
Schistosoma mansoni cathepsin D (A01 family) 0.007 0.0048 0.0047
Echinococcus granulosus integrin beta 2 0.5579 0.683 0.683
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.4977 0.609 0.6089
Schistosoma mansoni integrin alpha-ps 0.0597 0.0698 0.0696
Echinococcus granulosus lysine specific histone demethylase 1A 0.0485 0.056 0.0558
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0672 0.079 1
Toxoplasma gondii subtilisin SUB4 0.0356 0.0401 0.9792
Loa Loa (eye worm) hypothetical protein 0.0032 0.0002 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0356 0.0401 0.0656
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0099 0.0085 0.0103
Loa Loa (eye worm) hypothetical protein 0.0063 0.004 0.004
Toxoplasma gondii subtilisin SUB2 0.0356 0.0401 0.9792
Echinococcus multilocularis fibrillin 2 0.0162 0.0162 0.02
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0085 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.1612 0.1947 0.3196
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.015 0.0147 0.0182
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0356 0.0401 0.04
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0088 0.0071 0.1746
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0375 0.0424 0.53
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.1612 0.1947 0.3196
Brugia malayi NAD-dependent deacetylase SIRT1 0.0099 0.0085 0.0085
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0004 0.0052
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.8153 1 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0083 0.0065 0.1582
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0356 0.0401 0.0401
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0072 0.0051 0.1231
Schistosoma mansoni hypothetical protein 0.0069 0.0048 0.0046
Loa Loa (eye worm) transcriptional regulator 0.0672 0.079 0.079
Giardia lamblia Furin precursor putative serine protease 0.1612 0.1947 0.5294
Giardia lamblia Sirtuin type 2 0.0099 0.0085 0.0196
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0012 0.0153
Brugia malayi Glutamate receptor 1 precursor 0.0101 0.0086 0.0086
Toxoplasma gondii aspartyl protease ASP5 0.0363 0.0409 1
Schistosoma mansoni protein kinase 0.0134 0.0127 0.0126
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0068 0.0046 0.0045
Echinococcus multilocularis Furin 1 0.1968 0.2386 0.2975
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0088 0.0071 0.1524
Giardia lamblia hypothetical protein 0.0162 0.0162 0.0408
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0088 0.0071 0.1746
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0356 0.0401 0.0656
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0085 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0356 0.0401 0.0656
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.007 0.0048 0.0047
Brugia malayi Protein kinase domain containing protein 0.0032 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0162 0.0162 0.0162
Onchocerca volvulus 0.015 0.0147 0.2387
Brugia malayi Glutamate receptor 2 precursor 0.0101 0.0086 0.0086
Echinococcus multilocularis integrin alpha ps 0.0286 0.0315 0.0391
Schistosoma mansoni ADAMTS14 peptidase (M12 family) 0.0064 0.0042 0.004
Brugia malayi EGF-like domain containing protein 0.0162 0.0162 0.0162
Brugia malayi celfurPC protein 0.6541 0.8015 0.8015
Loa Loa (eye worm) acyl carrier protein 0.004 0.0011 0.0011
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0119 0.0109 0.0133
Mycobacterium tuberculosis Conserved hypothetical protein 0.0099 0.0084 0.2059
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1968 0.2386 0.3916
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0059 0.0036 0.0034
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0012 0.0153
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0012 0.0153
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0047 0.002 0.0108
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0012 0.0153
Echinococcus multilocularis glutamate receptor 2 0.0059 0.0035 0.0042
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0085 0.0136
Brugia malayi EGF-like domain containing protein 0.0162 0.0162 0.0162
Mycobacterium ulcerans polyketide synthase Pks9 0.0054 0.0029 0.0433
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0047 0.002 0.0108
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0233 0.0249 0.0248
Schistosoma mansoni serine/threonine protein kinase 0.0087 0.007 0.0068
Mycobacterium ulcerans polyketide synthase 0.0088 0.0071 0.1524
Toxoplasma gondii type I fatty acid synthase, putative 0.0088 0.0071 0.171
Schistosoma mansoni glutamate receptor AMPA 0.0101 0.0086 0.0085
Loa Loa (eye worm) glutamate receptor 1 0.0101 0.0086 0.0086
Trypanosoma cruzi UDP-galactopyranose mutase 0.0099 0.0084 0.0923
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0099 0.0085 0.1681
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0356 0.0401 0.0656
Brugia malayi SWIRM domain containing protein 0.0526 0.061 0.061
Loa Loa (eye worm) hypothetical protein 0.0374 0.0423 0.0423
Loa Loa (eye worm) hypothetical protein 0.0526 0.061 0.061
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0099 0.0084 0.1667
Trichomonas vaginalis conserved hypothetical protein 0.1612 0.1947 0.3196
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0035 0.0005 0.0094
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1968 0.2386 0.3916
Plasmodium falciparum plasmepsin I 0.007 0.0048 0.0942
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0066 0.0044 0.1064
Giardia lamblia Tenascin-37 0.0162 0.0162 0.0408
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0066 0.0044 0.0823
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0091 0.0074 0.1593
Brugia malayi protein kinase C II. 0.0087 0.007 0.007
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0083 0.0065 0.1355
Loa Loa (eye worm) hypothetical protein 0.077 0.091 0.091
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0054 0.0029 0.0433
Loa Loa (eye worm) glutamate receptor 2 0.0101 0.0086 0.0086
Onchocerca volvulus 0.0131 0.0124 0.2017
Echinococcus granulosus furin 0.8153 1 1
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.1612 0.1947 0.3196
Echinococcus granulosus disintegrin and metalloproteinase 0.0097 0.0081 0.008
Echinococcus multilocularis MAM 0.0069 0.0048 0.0058
Brugia malayi Pepsin A precursor 0.007 0.0048 0.0048
Leishmania major silent information regulator 2, putative 0.0672 0.079 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0071 0.005 0.0476
Brugia malayi neuroendocrine convertase 1 precursor 0.5144 0.6296 0.6296
Loa Loa (eye worm) hypothetical protein 0.0162 0.0162 0.0162
Trichomonas vaginalis hypothetical protein 0.0162 0.0162 0.0264
Brugia malayi Subtilase family protein 0.0356 0.0401 0.0401
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0099 0.0084 0.1667
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0085 0.0136
Brugia malayi hypothetical protein 0.0047 0.002 0.002
Onchocerca volvulus 0.007 0.0048 0.0764
Loa Loa (eye worm) hypothetical protein 0.0069 0.0048 0.0048
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0119 0.0109 0.0133
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0375 0.0424 0.5372
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.4977 0.609 1
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0126 0.0117 0.2893
Trichomonas vaginalis conserved hypothetical protein 0.1612 0.1947 0.3196
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.4977 0.609 0.7597
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0059 0.0036 0.0043
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.007 0.0048 0.0047
Schistosoma mansoni tyrosine kinase 0.0452 0.0519 0.0518
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0012 0.0017
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0356 0.0401 1
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0097 0.0081 0.01
Schistosoma mansoni chromatin regulatory protein sir2 0.0099 0.0085 0.0083
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0099 0.0085 0.2076
Mycobacterium ulcerans dehydrogenase 0.0099 0.0084 0.1845
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0013 0.0019
Schistosoma mansoni apoptosis regulator bax 0.0062 0.0039 0.0037
Echinococcus granulosus fibrillin 1 0.0164 0.0164 0.0162
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0059 0.0036 0.0043
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.4977 0.609 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1968 0.2386 0.3916
Brugia malayi transcriptional regulator, Sir2 family protein 0.0672 0.079 0.079
Schistosoma mansoni glutamate receptor AMPA 0.0101 0.0086 0.0085
Loa Loa (eye worm) sirtuin 4 0.0099 0.0085 0.0085
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0062 0.0039 0.0037
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0083 0.0065 0.1582
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0356 0.0401 0.5003
Loa Loa (eye worm) hypothetical protein 0.0047 0.002 0.002
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.1968 0.2386 0.2384
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0126 0.0117 0.2893
Brugia malayi Disintegrin family protein 0.0097 0.0081 0.0081
Loa Loa (eye worm) integrin alpha pat-2 0.1558 0.188 0.188
Loa Loa (eye worm) hypothetical protein 0.0032 0.0002 0.0002
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.007 0.0048 0.0058
Toxoplasma gondii aspartyl protease 0.007 0.0048 0.114
Echinococcus granulosus c-Jun N-terminal kinases 0.026 0.0283 0.0282
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0066 0.0044 0.0823
Schistosoma mansoni chromatin regulatory protein sir2 0.0099 0.0085 0.0083
Giardia lamblia Tenascin precursor 0.0162 0.0162 0.0408
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0356 0.0401 0.0656
Loa Loa (eye worm) hypothetical protein 0.054 0.0627 0.0627
Echinococcus granulosus serine:threonine protein kinase N2 0.0071 0.005 0.0048
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.007 0.0048 0.0047
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0162 0.0162 0.0264
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0088 0.0071 0.1524
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0356 0.0401 0.0498
Plasmodium vivax subtilisin-like serine protease, putative 0.0356 0.0401 0.8094
Brugia malayi Integrin beta pat-3 precursor 0.756 0.927 0.927
Brugia malayi Protein kinase domain containing protein 0.0069 0.0048 0.0048
Toxoplasma gondii hypothetical protein 0.0162 0.0162 0.3937
Loa Loa (eye worm) hypothetical protein 0.8153 1 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.007 0.0048 0.0047
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0062 0.0039 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.1612 0.1947 0.3196
Loa Loa (eye worm) hypothetical protein 0.007 0.0048 0.0048
Plasmodium falciparum plasmepsin VII 0.007 0.0048 0.0942
Toxoplasma gondii histone deacetylase SIR2 0.0099 0.0085 0.2033
Toxoplasma gondii subtilisin SUB12 0.0356 0.0401 0.9792
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0099 0.0085 0.0083
Schistosoma mansoni memapsin-2 (A01 family) 0.0884 0.1051 0.105
Loa Loa (eye worm) aspartyl protease 6 0.007 0.0048 0.0048
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0062 0.0039 0.0037
Loa Loa (eye worm) hypothetical protein 0.0851 0.101 0.101
Plasmodium falciparum protoporphyrinogen oxidase 0.0099 0.0084 0.1667
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0088 0.0071 0.1746
Loa Loa (eye worm) hypothetical protein 0.0099 0.0084 0.0084
Echinococcus granulosus epidermal growth factor receptor 0.0452 0.0519 0.0518
Echinococcus multilocularis glutamate receptor 2 0.0101 0.0086 0.0106
Giardia lamblia High cysteine membrane protein Group 2 0.3009 0.3667 1
Schistosoma mansoni integrin alpha-ps 0.0374 0.0423 0.0421
Plasmodium vivax aspartyl proteinase, putative 0.007 0.0048 0.0942
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0672 0.079 0.1294
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0356 0.0401 1
Echinococcus granulosus Furin 1 0.1968 0.2386 0.2384
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0099 0.0084 0.2059
Schistosoma mansoni amine oxidase 0.0099 0.0084 0.0082
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0085 0.0136
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0049 0.0023 0.0529
Brugia malayi hypothetical protein 0.007 0.0048 0.0048
Plasmodium falciparum plasmepsin III 0.007 0.0048 0.0942
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0091 0.0074 0.5
Brugia malayi EGF-like domain containing protein 0.0162 0.0162 0.0162
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0083 0.0065 0.0065
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.007 0.0048 0.0047
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0059 0.0036 0.0043
Mycobacterium ulcerans polyketide synthase Pks13 0.0126 0.0117 0.2701
Plasmodium falciparum plasmepsin VI 0.007 0.0048 0.0942
Giardia lamblia Hypothetical protein 0.0672 0.079 0.2125
Loa Loa (eye worm) integrin beta-2 0.756 0.927 0.927
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0012 0.0153
Loa Loa (eye worm) hypothetical protein 0.0051 0.0025 0.0025
Brugia malayi proprotein convertase 2 0.5144 0.6296 0.6296
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0356 0.0401 0.0656
Toxoplasma gondii type I fatty acid synthase, putative 0.0061 0.0038 0.089
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.007 0.0048 0.0047
Loa Loa (eye worm) hypothetical protein 0.0045 0.0018 0.0018
Toxoplasma gondii subtilisin SUB9 0.0356 0.0401 0.9792
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0356 0.0401 0.0656
Brugia malayi Integrin alpha pat-2 precursor 0.1137 0.1363 0.1363
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0773 0.0915 0.0913
Schistosoma mansoni hypothetical protein 0.0059 0.0036 0.0034
Brugia malayi transcriptional regulator, Sir2 family protein 0.0099 0.0085 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0356 0.0401 0.0656
Echinococcus multilocularis NMDA receptor 0.0059 0.0036 0.0043
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0088 0.0071 0.1746
Toxoplasma gondii subtilisin SUB6 0.0356 0.0401 0.9792
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0047 0.002 0.0096
Mycobacterium ulcerans thioesterase 0.0072 0.0051 0.0994
Echinococcus multilocularis disintegrin and metalloproteinase 0.0097 0.0081 0.01
Schistosoma mansoni chromatin regulatory protein sir2 0.0672 0.079 0.0788
Brugia malayi hypothetical protein 0.0099 0.0084 0.0084
Echinococcus multilocularis neuroendocrine convertase 2 0.5144 0.6296 0.7854
Plasmodium vivax NAD-dependent deacetylase, putative 0.0099 0.0085 0.1681
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0117 0.0106 0.0106
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0672 0.079 1
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.2541 0.3091 0.3089
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0085 0.0136
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0672 0.079 1
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0097 0.0081 0.008
Echinococcus granulosus integrin alpha ps 0.0286 0.0315 0.0313
Schistosoma mansoni amine oxidase 0.0099 0.0084 0.0082
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0356 0.0401 0.0401
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0672 0.079 1
Trichomonas vaginalis conserved hypothetical protein 0.1612 0.1947 0.3196
Plasmodium falciparum subtilisin-like protease 2 0.0356 0.0401 0.8094
Loa Loa (eye worm) hypothetical protein 0.007 0.0048 0.0048
Echinococcus granulosus integrin alpha ps 0.066 0.0775 0.0774
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0356 0.0401 0.0656
Chlamydia trachomatis protoporphyrinogen oxidase 0.0099 0.0084 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0356 0.0401 0.0656
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0134 0.0127 0.0157
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0085 0.0136
Plasmodium vivax subtilisin-like protease 1 0.0356 0.0401 0.8094
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0012 0.0153
Toxoplasma gondii subtilisin SUB8 0.0356 0.0401 0.9792
Echinococcus multilocularis membrane bound transcription factor site 1 0.0356 0.0401 0.0498
Onchocerca volvulus 0.0162 0.0162 0.2639
Giardia lamblia High cysteine protein 0.0162 0.0162 0.0408
Plasmodium vivax subtilisin-like protease 2, putative 0.0356 0.0401 0.8094
Mycobacterium ulcerans monoamine oxidase 0.0099 0.0084 0.1845
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0099 0.0084 0.2016
Schistosoma mansoni glutamate receptor NMDA 0.0363 0.041 0.0408
Brugia malayi SWIRM domain containing protein 0.0041 0.0013 0.0013
Plasmodium falciparum plasmepsin V 0.0433 0.0495 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0119 0.0109 0.0133
Echinococcus granulosus chromatin regulatory protein sir2 0.0672 0.079 0.0788
Toxoplasma gondii subtilisin SUB10 0.0356 0.0401 0.9792

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 4.4668 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 125.8925 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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