Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0198 | 1 | 0.5 |
Schistosoma mansoni | ngng-dimethylarginine dimethylaminohydrolase | 0.017 | 0.7168 | 0.7168 |
Echinococcus multilocularis | ng dimethylarginine dimethylaminohydrolase | 0.017 | 0.7168 | 0.6327 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0198 | 1 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0198 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.7168 | 0.6327 |
Schistosoma mansoni | ngng-dimethylarginine dimethylaminohydrolase | 0.017 | 0.7168 | 0.7168 |
Trypanosoma cruzi | p450 reductase, putative | 0.0198 | 1 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0198 | 1 | 1 |
Leishmania major | cytochrome P450 reductase, putative | 0.0176 | 0.7709 | 0.1909 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0198 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0198 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0122 | 0.2291 | 0.2291 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0176 | 0.7709 | 0.5 |
Echinococcus granulosus | ng dimethylarginine dimethylaminohydrolase | 0.017 | 0.7168 | 0.6327 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0198 | 1 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0198 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0198 | 1 | 0.5 |
Brugia malayi | NG,NG-dimethylarginine dimethylaminohydrolase 1, putative | 0.017 | 0.7168 | 0.6327 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0198 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0198 | 1 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0198 | 1 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0198 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0122 | 0.2291 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0198 | 1 | 0.5 |
Leishmania major | p450 reductase, putative | 0.0198 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0198 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0176 | 0.7709 | 0.5 |
Onchocerca volvulus | 0.017 | 0.7168 | 0.5 | |
Trichomonas vaginalis | sulfite reductase, putative | 0.0198 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0198 | 1 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0198 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0198 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.