TDR Targets

Basic information

Technical information

TDR Targets ID: 867837
Name: 2-[3-[(2-methylphenyl)amino]imidazo[1,2-a]pyr imidin-2-yl]phenol
MW: 316.357 | Formula: C19H16N4O
H donors: 2 H acceptors: 3 LogP: 4.66 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccccc1Nc1c(nc2n1cccn2)c1ccccc1O
InChi: 1S/C19H16N4O/c1-13-7-2-4-9-15(13)21-18-17(14-8-3-5-10-16(14)24)22-19-20-11-6-12-23(18)19/h2-12,21,24H,1H3
InChiKey: WCCWXLMCMWEHHE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[3-[(2-methylphenyl)amino]-2-imidazo[1,2-a]pyrimidinyl]phenol
EU-0058129

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	RNA binding protein	0.0062	0.0944	0.0944
Brugia malayi	nuclear hormone receptor family member odr-7	0.003	0.0158	0.0158
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0063	0.0968	0.0968
Brugia malayi	conserved hypotetical protein	0.003	0.0158	0.0158
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0063	0.0968	0.0968
Brugia malayi	Nuclear hormone receptor-like 1	0.0063	0.0968	0.0968
Loa Loa (eye worm)	hypothetical protein	0.003	0.0158	0.0158
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.0944	0.0944
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0063	0.0968	0.1895
Schistosoma mansoni	nuclear hormone receptor	0.0063	0.0968	0.1895
Plasmodium falciparum	histone acetyltransferase GCN5	0.0038	0.0356	0.5
Brugia malayi	nuclear receptor RXR	0.0033	0.0245	0.0245
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0063	0.0968	0.0968
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0063	0.0968	0.0968
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0245	0.0245
Echinococcus granulosus	FTZ F1 alpha	0.0063	0.0968	0.1895
Brugia malayi	ecdysone receptor	0.003	0.0158	0.0158
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0063	0.0968	0.0968
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0063	0.0968	0.0968
Echinococcus multilocularis	Protein lozenge	0.0054	0.076	0.1407
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0065	0.1009	0.199
Echinococcus multilocularis	transcription factor Dp 1	0.0037	0.0346	0.0439
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0065	0.1009	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0063	0.0968	0.0968
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0063	0.0968	0.0968
Schistosoma mansoni	thyroid hormone receptor	0.0187	0.3997	0.8976
Echinococcus multilocularis	hormone sensitive lipase	0.0205	0.4435	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0063	0.0968	0.1895
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0063	0.0968	0.1895
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0968	0.0968
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0968	0.0968
Brugia malayi	ecdysteroid receptor	0.0063	0.0968	0.0968
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0063	0.0968	0.0968
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0065	0.1009	0.1009
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0063	0.0968	0.1895
Brugia malayi	Steroid receptor seven-up type 2	0.0063	0.0968	0.0968
Loa Loa (eye worm)	nuclear hormone receptor	0.003	0.0158	0.0158
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0033	0.0245	0.0203
Brugia malayi	nuclear hormone receptor	0.003	0.0158	0.0158
Brugia malayi	Nuclear hormone receptor-like 1	0.0033	0.0245	0.0245
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0033	0.0245	0.0203
Brugia malayi	TAR-binding protein	0.0062	0.0944	0.0944
Entamoeba histolytica	hypothetical protein	0.007	0.115	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0063	0.0968	0.1895
Schistosoma mansoni	hormone-sensitive lipase (S09 family)	0.0205	0.4435	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0063	0.0968	0.0968
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0245	0.0245
Loa Loa (eye worm)	steroid hormone receptor	0.0063	0.0968	0.0968
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0968	0.0968
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0944	0.1837
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.003	0.0158	0.0158
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0124	0.2463	0.5389
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.007	0.115	0.2319
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0063	0.0968	0.1895
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0065	0.1009	0.199
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0968	0.0968
Brugia malayi	nuclear receptor NHR-88	0.0063	0.0968	0.0968
Schistosoma mansoni	hormone-sensitive lipase (S09 family)	0.0205	0.4435	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0158	0.0158
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0063	0.0968	0.1895
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0124	0.2463	0.5389
Onchocerca volvulus	Protein ultraspiracle homolog	0.0063	0.0968	0.0968
Brugia malayi	RNA binding protein	0.0062	0.0944	0.0944
Brugia malayi	hypothetical protein	0.0033	0.0245	0.0245
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0	0.5
Echinococcus multilocularis	geminin	0.0165	0.3471	0.7748
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0041	0.0439	0.5
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0433	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0063	0.0968	0.0968
Onchocerca volvulus		0.003	0.0158	0.0158
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0063	0.0968	0.0968
Schistosoma mansoni	RAR-like nuclear receptor	0.0063	0.0968	0.1895
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0	0.5
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0033	0.0245	0.0203
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0063	0.0968	0.1895
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0136	0.2755	0.6073
Echinococcus granulosus	hormone sensitive lipase	0.0205	0.4435	1
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.014	0.2851	0.6297
Onchocerca volvulus		0.003	0.0158	0.0158
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0063	0.0968	0.0968
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0063	0.0968	0.1895
Loa Loa (eye worm)	hypothetical protein	0.003	0.0158	0.0158
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0	0.5
Echinococcus granulosus	transcription factor Dp 1	0.0037	0.0346	0.0439
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0063	0.0968	0.1895
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0063	0.0968	0.1895
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0247	0.0247
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0041	0.0439	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0063	0.0968	0.0968
Echinococcus granulosus	geminin	0.0165	0.3471	0.7748
Brugia malayi	hypothetical protein	0.003	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0245	0.0245
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0624	0.0624
Entamoeba histolytica	hypothetical protein	0.007	0.115	1
Brugia malayi	hypothetical protein	0.003	0.0158	0.0158
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0065	0.1009	0.1009
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0944	0.1837
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0968	0.0968
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.003	0.0158	0.0158
Loa Loa (eye worm)	acetyltransferase	0.014	0.2851	0.2851
Echinococcus granulosus	tar DNA binding protein	0.0062	0.0944	0.1837
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0944	0.1837
Mycobacterium ulcerans	hypothetical protein	0.0023	0	0.5
Onchocerca volvulus		0.0433	1	1
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.1009	0.5
Brugia malayi	acetyltransferase, GNAT family protein	0.014	0.2851	0.2851
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0041	0.0439	0.0657
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0944	0.1837
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0063	0.0968	0.1895
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0063	0.0968	0.0968
Loa Loa (eye worm)	hypothetical protein	0.003	0.0158	0.0158
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.0944	0.0944
Giardia lamblia	Histone acetyltransferase GCN5	0.0038	0.0356	0.5
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.0944	0.0944
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.1009	0.5
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.003	0.0158	0.0158
Onchocerca volvulus	Bile acid receptor homolog	0.0063	0.0968	0.0968
Onchocerca volvulus		0.0063	0.0968	0.0968
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.007	0.115	0.2319
Loa Loa (eye worm)	hypothetical protein	0.003	0.0158	0.0158
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0063	0.0968	0.0968
Loa Loa (eye worm)	hypothetical protein	0.003	0.0158	0.0158
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0041	0.0439	0.5
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0041	0.0439	0.5
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0041	0.0439	0.5
Echinococcus granulosus	ecdysone induced protein 78C	0.0063	0.0968	0.1895
Brugia malayi	photoreceptor-specific nuclear receptor	0.0063	0.0968	0.0968
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0	0.5
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0063	0.0968	0.1895
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0063	0.0968	0.0968
Brugia malayi	nuclear receptor NHR-88	0.003	0.0158	0.0158
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.0944	0.1837
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0247	0.0247
Brugia malayi	orphan nuclear receptor NR2E1	0.003	0.0158	0.0158
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0063	0.0968	0.1895
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0063	0.0968	0.1895
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0063	0.0968	0.0968
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0063	0.0968	0.1895
Schistosoma mansoni	lozenge	0.0054	0.076	0.1407
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0624	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0245	0.0245
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0624	0.0624
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0944	0.1837
Schistosoma mansoni	hypothetical protein	0.007	0.115	0.2319
Brugia malayi	steroid hormone receptor	0.0063	0.0968	0.0968
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0	0.5
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.014	0.2851	0.6297
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0065	0.1009	0.8776
Loa Loa (eye worm)	hypothetical protein	0.0205	0.4435	0.4435
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0033	0.0245	0.0245
Brugia malayi	hypothetical protein	0.007	0.115	0.115
Loa Loa (eye worm)	runx1	0.0054	0.076	0.076
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0065	0.1009	0.199
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0187	0.3997	0.8976
Echinococcus multilocularis	FTZ F1 alpha	0.0063	0.0968	0.1895
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0063	0.0968	0.0968
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0968	0.0968
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0063	0.0968	0.1895
Schistosoma mansoni	coup transcription factor	0.0063	0.0968	0.1895
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0624	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0433	1	1
Brugia malayi	nuclear receptor NHR-67	0.003	0.0158	0.0158
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0063	0.0968	0.1895
Loa Loa (eye worm)	hypothetical protein	0.003	0.0158	0.0158
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0033	0.0245	0.0203
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.003	0.0158	0.0158
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.1009	0.5
Loa Loa (eye worm)	nuclear receptor NHR-67	0.003	0.0158	0.0158
Schistosoma mansoni	hypothetical protein	0.0165	0.3471	0.7748
Brugia malayi	nuclear receptor RXR	0.003	0.0158	0.0158
Brugia malayi	tailless protein	0.003	0.0158	0.0158
Brugia malayi	Nuclear hormone receptor E75	0.003	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.003	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.003	0.0158	0.0158
Schistosoma mansoni	hypothetical protein	0.0165	0.3471	0.7748
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0033	0.0245	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0968	0.0968
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0	0.5
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0063	0.0968	0.1895
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0063	0.0968	0.0968
Brugia malayi	nuclear hormone receptor	0.0063	0.0968	0.0968
Schistosoma mansoni	hormone-sensitive lipase (S09 family)	0.0205	0.4435	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0158	0.0158
Entamoeba histolytica	acetyltransferase, GNAT family	0.0038	0.0356	0.3092
Schistosoma mansoni	transcription factor LCR-F1	0.007	0.115	0.2319
Loa Loa (eye worm)	hypothetical protein	0.003	0.0158	0.0158
Schistosoma mansoni	hypothetical protein	0.0124	0.2463	0.5389
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0245	0.0245
Entamoeba histolytica	hypothetical protein	0.007	0.115	1
Schistosoma mansoni	thyroid hormone receptor	0.0187	0.3997	0.8976
Brugia malayi	hypothetical protein	0.0033	0.0245	0.0245
Echinococcus multilocularis	ecdysone induced protein 78C	0.0063	0.0968	0.1895
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0063	0.0968	0.0968
Loa Loa (eye worm)	hypothetical protein	0.003	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.003	0.0158	0.0158
Brugia malayi	Nuclear hormone receptor E75	0.003	0.0158	0.0158
Schistosoma mansoni	hypothetical protein	0.0033	0.0247	0.0209
Loa Loa (eye worm)	DR-78	0.003	0.0158	0.0158
Entamoeba histolytica	hypothetical protein	0.007	0.115	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0968	0.0968
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0063	0.0968	0.1895
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0063	0.0968	0.1895
Brugia malayi	nuclear hormone receptor family member nhr-6	0.003	0.0158	0.0158

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 867837