Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acetyltransferase | 0.0154 | 0.5131 | 0.5436 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0041 | 0.0967 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0268 | 0.937 | 0.9929 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0032 | 0.0623 | 0.0623 |
Brugia malayi | nuclear hormone receptor | 0.0032 | 0.0623 | 0.0623 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0032 | 0.0623 | 0.066 |
Brugia malayi | nuclear receptor NHR-88 | 0.0032 | 0.0623 | 0.0623 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0041 | 0.0967 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0032 | 0.0623 | 0.1118 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0032 | 0.0623 | 0.0623 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0041 | 0.0967 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0032 | 0.0623 | 0.1118 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0061 | 0.0064 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0032 | 0.0623 | 0.1118 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0154 | 0.5131 | 0.9205 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0061 | 0.0064 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.017 | 0.1629 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0044 | 0.1046 | 1 |
Brugia malayi | polk-prov protein | 0.0033 | 0.0653 | 0.0653 |
Schistosoma mansoni | coup transcription factor | 0.0032 | 0.0623 | 0.1118 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0032 | 0.0623 | 0.1118 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0032 | 0.0623 | 0.0623 |
Leishmania major | DNA polymerase kappa, putative | 0.0022 | 0.0259 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0032 | 0.0623 | 0.0623 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0018 | 0.0083 | 0.0792 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0061 | 0.0061 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0032 | 0.0623 | 0.066 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0032 | 0.0623 | 0.0623 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0061 | 0.0064 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0032 | 0.0623 | 0.0623 |
Brugia malayi | steroid hormone receptor | 0.0032 | 0.0623 | 0.0623 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0032 | 0.0623 | 0.1254 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0032 | 0.0623 | 0.1254 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0044 | 0.1046 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0017 | 0.0061 | 0.0122 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.017 | 0.6567 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0032 | 0.0623 | 0.066 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0032 | 0.0623 | 0.0623 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0044 | 0.1046 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.027 | 0.9438 | 0.9438 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0032 | 0.0623 | 0.066 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0033 | 0.0653 | 0.6246 |
Brugia malayi | ecdysteroid receptor | 0.0032 | 0.0623 | 0.0623 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0061 | 0.0064 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0032 | 0.0623 | 0.1254 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0045 | 0.1107 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0166 | 0.5574 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0045 | 0.1107 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0032 | 0.0623 | 0.1118 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0032 | 0.0623 | 0.066 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0037 | 0.0786 | 0.7519 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0032 | 0.0623 | 0.1118 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0017 | 0.0061 | 0.0109 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0017 | 0.0061 | 0.0109 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0134 | 0.4382 | 0.7861 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0032 | 0.0623 | 0.0623 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.017 | 0.1761 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0032 | 0.0623 | 0.066 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0032 | 0.0623 | 0.1118 |
Trypanosoma brucei | unspecified product | 0.0037 | 0.0786 | 0.7519 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0044 | 0.1046 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0044 | 0.1046 | 0.9346 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0044 | 0.1046 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0032 | 0.0623 | 0.1118 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0032 | 0.0623 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0623 | 0.066 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0154 | 0.5131 | 0.5131 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0044 | 0.1046 | 0.9346 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.0259 | 0.2481 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0032 | 0.0623 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0032 | 0.0623 | 0.1118 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0134 | 0.4382 | 0.8815 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.017 | 0.0306 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0032 | 0.0623 | 0.1118 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0044 | 0.1046 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0623 | 0.066 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0032 | 0.0623 | 0.0623 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0032 | 0.0623 | 0.0623 |
Echinococcus multilocularis | dna polymerase kappa | 0.0044 | 0.1046 | 0.1876 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.017 | 0.017 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.017 | 0.0343 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.017 | 0.0306 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0032 | 0.0623 | 0.1118 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0032 | 0.0623 | 0.1118 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0623 | 0.066 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0032 | 0.0623 | 0.1254 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0032 | 0.0623 | 0.1118 |
Brugia malayi | nuclear receptor RXR | 0.0017 | 0.0061 | 0.0061 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0022 | 0.0259 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0032 | 0.0623 | 0.1254 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.017 | 0.0181 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0044 | 0.1046 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0044 | 0.1046 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0045 | 0.1107 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.027 | 0.9438 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0032 | 0.0623 | 0.1118 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0022 | 0.0259 | 1 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0045 | 0.1107 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.0044 | 0.1046 | 0.2104 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0653 | 0.0692 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0032 | 0.0623 | 0.1254 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.017 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0032 | 0.0623 | 0.1118 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0018 | 0.0083 | 0.0792 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0032 | 0.0623 | 0.0623 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0061 | 0.0064 |
Schistosoma mansoni | hypothetical protein | 0.0134 | 0.4382 | 0.7861 |
Schistosoma mansoni | thyroid hormone receptor | 0.0166 | 0.5574 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0032 | 0.0623 | 0.0623 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0623 | 0.066 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0018 | 0.0083 | 0.0792 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0033 | 0.0653 | 0.6246 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0032 | 0.0623 | 0.1254 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0044 | 0.1046 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0044 | 0.1046 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0032 | 0.0623 | 0.1118 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0032 | 0.0623 | 0.066 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0044 | 0.1046 | 1 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0154 | 0.5131 | 0.9205 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0061 | 0.0061 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0044 | 0.1046 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0032 | 0.0623 | 0.0623 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0032 | 0.0623 | 0.1118 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0032 | 0.0623 | 0.1254 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0623 | 0.066 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.017 | 0.0306 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0623 | 0.066 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0032 | 0.0623 | 0.1118 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0032 | 0.0623 | 0.066 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0044 | 0.1046 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0.017 | 0.6567 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0017 | 0.0061 | 0.0109 |
Giardia lamblia | DINP protein human, muc B family | 0.0022 | 0.0259 | 0.1117 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.017 | 0.1629 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0045 | 0.1107 | 0.2227 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0044 | 0.1046 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0166 | 0.5574 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0044 | 0.1046 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0044 | 0.1046 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0149 | 0.4971 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.017 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0032 | 0.0623 | 0.1254 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0623 | 0.066 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0032 | 0.0623 | 0.0623 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0032 | 0.0623 | 0.0623 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0623 | 0.066 |
Onchocerca volvulus | 0.0032 | 0.0623 | 0.5 | |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0032 | 0.0623 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.027 | 0.9438 | 0.9438 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.017 | 0.1629 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0044 | 0.1046 | 1 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0045 | 0.1107 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.