Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0351 | 0.0448 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.5374 | 0.5833 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.2473 | 0.183 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.4049 | 0.4395 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.9213 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0059 | 0.7186 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.5374 | 0.4979 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.5374 | 0.5833 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.5374 | 0.4979 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.2473 | 0.2684 |
Schistosoma mansoni | bromodomain containing protein | 0.0062 | 0.7844 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.2473 | 0.3153 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.2814 | 0.3603 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.2814 | 0.3603 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.3262 | 0.3541 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0059 | 0.7186 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.3698 | 0.4014 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.3249 | 0.2673 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.