Detailed information for compound 868130

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 437.919 | Formula: C24H24ClN3O3
  • H donors: 1 H acceptors: 3 LogP: 5.32 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1ccccc1NC(=O)c1nc(n2c1CCCCC2)c1ccc(cc1)Cl
  • InChi: 1S/C24H24ClN3O3/c1-2-31-24(30)18-8-5-6-9-19(18)26-23(29)21-20-10-4-3-7-15-28(20)22(27-21)16-11-13-17(25)14-12-16/h5-6,8-9,11-14H,2-4,7,10,15H2,1H3,(H,26,29)
  • InChiKey: RBSLYIYMPOAGJT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Possible arylsulfatase AtsD (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0009 0.0054 0.0195
Mycobacterium tuberculosis Conserved hypothetical protein 0.0015 0.0215 0.0771
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0621 0.091
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0096 0.0068
Brugia malayi 6-phosphofructokinase 0.0115 0.2785 0.4442
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0013 0.0154 0.1702
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0096 0.004
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.006 0.0004
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.162 0.5733
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0013 0.0154 0.0361
Loa Loa (eye worm) hypothetical protein 0.0011 0.0096 0.0049
Schistosoma mansoni ap endonuclease 0.0015 0.0218 0.0203
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0096 0.0068
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0096 0.0068
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0343 0.036
Brugia malayi Cyclic-nucleotide gated cation channel 0.0014 0.0174 0.0194
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0096 0.0068
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0862 0.0811
Echinococcus granulosus axis inhibition protein axin 0.002 0.0343 0.0288
Schistosoma mansoni hypothetical protein 0.0318 0.8028 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0015 0.0218 0.0783
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.094 0.324
Brugia malayi 6-phosphofructokinase 0.0115 0.2785 0.4442
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0096 0.0068
Schistosoma mansoni lipoxygenase 0.0058 0.1326 0.1593
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0035 0.071 0.2395
Trichomonas vaginalis ap endonuclease, putative 0.0015 0.0218 0.0263
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0013 0.0154 0.0099
Echinococcus multilocularis expressed protein 0.0035 0.0731 0.0679
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.094 0.324
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0096 0.004
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0395 0.1241
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0009 0.0056 0.0003
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.0343 0.0464
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0272 0.0792
Schistosoma mansoni 60S ribosomal protein L21 0.0011 0.0102 0.0057
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0115 0.2785 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0604 0.0551
Schistosoma mansoni regulator of G protein signaling 0.002 0.0343 0.036
Echinococcus granulosus 6 phosphofructokinase 0.0115 0.2785 0.2744
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0343 0.0288
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0096 0.005
Toxoplasma gondii peptidylprolyl isomerase 0.0035 0.071 1
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0014 0.0174 0.0118
Loa Loa (eye worm) hypothetical protein 0.0018 0.0284 0.0273
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0358 0.0303
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0015 0.0215 0.0191
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0096 0.004
Loa Loa (eye worm) hypothetical protein 0.0009 0.0056 0.0002
Giardia lamblia Sgs1 DNA helicase, putative 0.0009 0.006 0.0108
Brugia malayi N-terminal motif family protein 0.0009 0.0056 0.0003
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0358 0.5219
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0013 0.0154 0.0361
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0058 0.1326 0.1277
Loa Loa (eye worm) hypothetical protein 0.0021 0.0358 0.0361
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.094 0.324
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0402 0.0559
Brugia malayi steroid hormone receptor 0.0011 0.0096 0.0068
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0096 0.0068
Entamoeba histolytica hypothetical protein 0.002 0.0343 0.0798
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0358 0.0303
Trypanosoma brucei unspecified product 0.0011 0.0092 0.0133
Trypanosoma brucei unspecified product 0.0036 0.076 0.258
Brugia malayi exodeoxyribonuclease III family protein 0.0015 0.0218 0.0267
Mycobacterium ulcerans regulatory protein 0.0009 0.0056 0.0007
Entamoeba histolytica hypothetical protein 0.002 0.0343 0.0798
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0096 0.0068
Brugia malayi nuclear hormone receptor 0.0011 0.0096 0.0068
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0402 0.0559
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0621 0.8644
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0343 0.047
Echinococcus multilocularis thyroid hormone receptor alpha 0.0144 0.3529 0.3493
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.071 0.2395
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.006 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0343 0.0464
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0013 0.0154 0.0361
Brugia malayi hypothetical protein 0.0021 0.0358 0.0494
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0215 0.0261
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.007 0.162 0.1573
Leishmania major DNA polymerase kappa, putative 0.0022 0.0395 0.1241
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.007 0.162 0.5733
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.0009 0.0056 0.0003
Schistosoma mansoni ap endonuclease 0.0015 0.0218 0.0203
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0096 0.0068
Loa Loa (eye worm) 6-phosphofructokinase 0.0115 0.2785 0.3244
Onchocerca volvulus 0.0251 0.628 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0009 0.0056 0.0201
Echinococcus multilocularis voltage gated potassium channel 0.002 0.0338 0.0283
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0096 0.005
Schistosoma mansoni coup transcription factor 0.0011 0.0096 0.005
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0065 0.1489 0.2305
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.094 0.324
Brugia malayi follicle stimulating hormone receptor 0.0248 0.6202 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.002 0.0338 0.0283
Toxoplasma gondii isocitrate dehydrogenase 0.0013 0.0154 0.1506
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0343 0.036
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.094 0.324
Echinococcus multilocularis RUN 0.0021 0.0358 0.0303
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0011 0.0097 0.015
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0096 0.004
Loa Loa (eye worm) hypothetical protein 0.002 0.0343 0.0343
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.162 0.5733
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0343 0.047
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0009 0.0056 0.0003
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.0131 0.0123
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.0214 0.2725
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.007 0.162 0.2548
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0634 0.0725
Schistosoma mansoni loxhd1 0.0021 0.0358 0.0379
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0131 0.0275
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0015 0.0218 0.0594
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.2785 1
Onchocerca volvulus 0.0011 0.0096 0.0067
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0621 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0096 0.004
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.094 0.324
Echinococcus multilocularis dna polymerase eta 0.0015 0.0215 0.016
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0096 0.0068
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0058 0.1326 0.1277
Mycobacterium ulcerans hypothetical protein 0.0009 0.0056 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0272 0.0792
Plasmodium vivax SET domain protein, putative 0.0032 0.0634 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0358 0.0361
Echinococcus granulosus hyperpolarization activated cyclic 0.0014 0.0174 0.0118
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.0009 0.0056 0.0003
Mycobacterium ulcerans transmembrane transport protein 0.0009 0.0056 0.0007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0634 0.0725
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0009 0.0056 0.0201
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0115 0.2785 1
Onchocerca volvulus 0.0021 0.0358 0.0488
Brugia malayi PXA domain containing protein 0.002 0.0343 0.047
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0015 0.0218 0.0594
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0014 0.0174 0.0118
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.2785 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0343 0.0343
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0096 0.004
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0015 0.0218 0.2803
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0009 0.0056 0.0002
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0343 0.0288
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0096 0.0049
Brugia malayi nuclear receptor NHR-88 0.0011 0.0096 0.0068
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0013 0.0154 0.0361
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0343 0.036
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.028 0.028
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0634 0.0725
Echinococcus multilocularis expressed protein 0.0395 1 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0343 0.0464
Echinococcus granulosus axis inhibition protein axin 0.002 0.0343 0.0288
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0013 0.0154 0.0099
Brugia malayi hypothetical protein 0.0129 0.314 0.5019
Mycobacterium ulcerans hypothetical protein 0.0009 0.0056 0.0007
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.0621 0.2071
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0015 0.0215 0.0199
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0174 0.0147
Loa Loa (eye worm) hypothetical protein 0.0033 0.0668 0.0729
Loa Loa (eye worm) hypothetical protein 0.002 0.0343 0.0343
Entamoeba histolytica deoxycytidyl transferase, putative 0.0015 0.0215 0.0316
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.006 0.0007
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0343 0.047
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0621 1
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0343 0.036
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.002 0.0338 0.0461
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0015 0.0218 0.2892
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0012 0.0123 0.1018
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.2785 0.4385
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0621 0.1847
Mycobacterium tuberculosis Possible hydrolase 0.0009 0.0054 0.0195
Schistosoma mansoni DNA helicase recq1 0.0009 0.006 0.0005
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0634 0.0725
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0668 0.2242
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.2785 0.4385
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0343 0.0343
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0097 0.015
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0056 0.0003
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0096 0.005
Mycobacterium tuberculosis Conserved protein 0.0009 0.0056 0.0201
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0015 0.0215 0.016
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0395 0.1418
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0358 0.0303
Loa Loa (eye worm) hypothetical protein 0.0009 0.006 0.0007
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0015 0.0218 0.0594
Echinococcus multilocularis isocitrate dehydrogenase 0.0013 0.0154 0.0099
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0035 0.0731 0.1101
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0634 0.8847
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0035 0.0731 0.0804
Treponema pallidum exodeoxyribonuclease (exoA) 0.0015 0.0218 0.0594
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.006 0.0004
Mycobacterium ulcerans hypothetical protein 0.0009 0.0056 0.0007
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0009 0.0056 0.0003
Loa Loa (eye worm) RGS-3 protein 0.002 0.0343 0.0343
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0096 0.005
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0014 0.0174 0.0142
Schistosoma mansoni thyroid hormone receptor 0.0144 0.3529 0.4357
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0014 0.0174 0.0192
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.007 0.162 0.1861
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0343 0.047
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0343 0.0288
Echinococcus multilocularis dna polymerase kappa 0.0043 0.094 0.0889
Schistosoma mansoni hypothetical protein 0.0318 0.8028 1
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0343 0.0288
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0621 0.8644
Loa Loa (eye worm) hypothetical protein 0.0011 0.0096 0.0049
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0343 0.036
Schistosoma mansoni polycystin 1-related 0.0021 0.0358 0.0379
Loa Loa (eye worm) phosphofructokinase 0.0115 0.2785 0.3244
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0096 0.0049
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.2785 1
Brugia malayi Pre-SET motif family protein 0.022 0.5496 0.8852
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0009 0.0056 0.0003
Schistosoma mansoni hypothetical protein 0.0021 0.0358 0.0379
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.094 0.324
Loa Loa (eye worm) hypothetical protein 0.002 0.0343 0.0343
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0035 0.071 0.2395
Mycobacterium ulcerans hypothetical protein 0.0009 0.0056 0.0007
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.0009 0.0056 0.0201
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0011 0.0097 0.0628
Brugia malayi Isocitrate dehydrogenase 0.0013 0.0154 0.0163
Echinococcus multilocularis geminin 0.0318 0.8028 0.8016
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0621 1
Schistosoma mansoni lipoxygenase 0.0021 0.0358 0.0379
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0358 0.0361
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0043 0.094 0.1423
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0096 0.0068
Onchocerca volvulus 0.0021 0.0358 0.0488
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0343 0.0288
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0096 0.0068
Loa Loa (eye worm) hypothetical protein 0.002 0.0343 0.0343
Schistosoma mansoni rab6-interacting 0.0021 0.0358 0.0379
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0215 0.0261
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0343 0.0288
Trypanosoma cruzi DNA polymerase eta, putative 0.0015 0.0215 0.0582
Loa Loa (eye worm) hypothetical protein 0.006 0.1371 0.1564
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.094 0.324
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.094 0.324
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0621 0.091
Trichomonas vaginalis ap endonuclease, putative 0.0015 0.0218 0.0263
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0621 0.091
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0634 0.0581
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0131 0.0275
Schistosoma mansoni 6-phosphofructokinase 0.0115 0.2785 0.3423
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0014 0.0174 0.0142
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0668 0.2242
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0343 0.0343
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0343 0.036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0096 0.0049
Mycobacterium ulcerans 6-phosphofructokinase 0.0115 0.2785 1
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0621 0.091
Brugia malayi phosphofructokinase 0.0115 0.2785 0.4442
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0209 0.2339
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0097 0.015
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.094 0.324
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0013 0.0154 0.0099
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0015 0.0218 0.0328
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0014 0.0174 0.0118
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0343 0.0288
Mycobacterium tuberculosis Possible arylsulfatase AtsA (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0009 0.0054 0.0195
Brugia malayi ecdysteroid receptor 0.0011 0.0096 0.0068
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0402 0.0348
Leishmania major DNA polymerase eta, putative 0.0015 0.0215 0.0582
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0343 0.0288
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0358 0.0303
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0395 0.1241
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0013 0.0154 0.0555
Echinococcus granulosus expressed protein 0.0035 0.0731 0.0679
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0096 0.0067
Trichomonas vaginalis set domain proteins, putative 0.0251 0.628 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0014 0.0174 0.0192
Giardia lamblia CAMP-dependent protein kinase regulatory chain 0.0009 0.0056 0.0033
Loa Loa (eye worm) hypothetical protein 0.0009 0.0056 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0343 0.0464
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0015 0.0218 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0096 0.0049
Schistosoma mansoni DNA polymerase eta 0.0015 0.0215 0.0199
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0248 0.6202 0.7303
Schistosoma mansoni voltage-gated potassium channel 0.0076 0.1771 0.2151
Schistosoma mansoni voltage-gated potassium channel 0.0076 0.1771 0.2151
Echinococcus granulosus dna polymerase kappa 0.0043 0.094 0.0889
Schistosoma mansoni regulator of G protein signaling 0.002 0.0343 0.036
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0096 0.004
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0096 0.0068
Trichomonas vaginalis rotamase, putative 0.0035 0.0731 0.1087
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.094 0.324
Brugia malayi PXA domain containing protein 0.002 0.0343 0.047
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0096 0.004
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0343 0.0288
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0069 0.1607 0.2526
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0009 0.006 0.0076
Schistosoma mansoni rab6-interacting 0.0021 0.0358 0.0379
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.162 0.5733
Echinococcus granulosus dna polymerase eta 0.0015 0.0215 0.016
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.094 0.324
Mycobacterium ulcerans transcriptional regulatory protein 0.0009 0.0056 0.0007
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0621 0.091
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.006 0.0066
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0343 0.047
Schistosoma mansoni DNA helicase recq5 0.0009 0.006 0.0005
Onchocerca volvulus 0.0032 0.0634 0.0932
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.094 0.3244
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0096 0.0049
Loa Loa (eye worm) hypothetical protein 0.0015 0.0215 0.0191
Mycobacterium tuberculosis Conserved hypothetical protein 0.0009 0.0056 0.0201
Loa Loa (eye worm) hypothetical protein 0.002 0.0343 0.0343
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0096 0.005
Trichomonas vaginalis rotamase, putative 0.0035 0.071 0.1053
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0621 0.091
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0013 0.0154 0.0361
Schistosoma mansoni rotamase 0.0035 0.0731 0.0847
Entamoeba histolytica hypothetical protein 0.002 0.0343 0.0798
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0621 0.8644
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0133 0.3253 0.3215
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0096 0.0068
Schistosoma mansoni axis inhibition protein axin 0.002 0.0343 0.036
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0096 0.004
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.094 0.324
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0014 0.0174 0.0118
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0343 0.0288
Loa Loa (eye worm) RecQ helicase 0.0023 0.0402 0.0413
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0343 0.0288
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.007 0.162 0.1962
Loa Loa (eye worm) hypothetical protein 0.0011 0.0096 0.0049
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0096 0.005
Schistosoma mansoni hypothetical protein 0.0055 0.1231 0.1473
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0069 0.1607 0.1844
Loa Loa (eye worm) hypothetical protein 0.0336 0.8472 1
Brugia malayi hypothetical protein 0.002 0.0343 0.047
Trypanosoma brucei DNA polymerase IV, putative 0.0036 0.076 0.258
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0343 0.0464
Trypanosoma brucei unspecified product 0.0011 0.0092 0.0133
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0096 0.0068
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.006 0.001
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0096 0.0068
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0009 0.0056 0.0003
Onchocerca volvulus 0.0009 0.0056 0.0003
Mycobacterium tuberculosis Probable sulfatase 0.0009 0.0054 0.0195
Trichomonas vaginalis DNA polymerase eta, putative 0.0043 0.094 0.1423
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0013 0.0154 0.1742
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.2785 0.4385
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.006 0.0004
Echinococcus multilocularis hyperpolarization activated cyclic 0.0014 0.0174 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0096 0.0068
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0014 0.0174 0.0118
Brugia malayi polk-prov protein 0.0033 0.0668 0.0998
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0009 0.0056 0.0003
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0115 0.2785 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0015 0.0218 0.0163
Brugia malayi Pre-SET motif family protein 0.0032 0.0634 0.0944
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0343 0.0464
Schistosoma mansoni thyroid hormone receptor 0.0144 0.3529 0.4357
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0621 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0096 0.005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0096 0.0049
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0015 0.0218 0.0594
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0358 0.5342
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0096 0.0049
Trypanosoma brucei DNA polymerase eta, putative 0.0015 0.0215 0.0582
Toxoplasma gondii isocitrate dehydrogenase 0.0013 0.0154 0.1506
Schistosoma mansoni regulator of G protein signaling 0.002 0.0343 0.036
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0014 0.0174 0.0118
Loa Loa (eye worm) hypothetical protein 0.002 0.0338 0.0337
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0013 0.0154 0.0123
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0096 0.004
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0096 0.005
Loa Loa (eye worm) 6-phosphofructokinase 0.0115 0.2785 0.3244
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0096 0.004
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0343 0.0288
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.0009 0.0056 0.0201
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0621 0.9771
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0621 1
Schistosoma mansoni axis inhibition protein axin 0.002 0.0343 0.036
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.006 0.001
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0102 0.0057
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0065 0.1489 0.2305
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0343 0.0464
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0097 0.015
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0338 0.0353
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0096 0.005
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0174 0.0147
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0634 0.0581
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0402 0.0566
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0343 0.0288
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0013 0.0154 0.0099
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0096 0.004
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.0009 0.0056 0.0201
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0014 0.0174 0.0118
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0174 0.0147
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.094 0.324
Echinococcus granulosus transcription factor Dp 1 0.004 0.0862 0.0811
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0013 0.0154 0.0099
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0015 0.0218 0.0163
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.071 0.2395
Schistosoma mansoni regulator of G protein signaling 0.002 0.0343 0.036
Echinococcus multilocularis hyperpolarization activated cyclic 0.0014 0.0174 0.0118
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0621 0.9771
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.2785 0.4385
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0343 0.047
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0096 0.004
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0096 0.0067
Loa Loa (eye worm) hypothetical protein 0.0032 0.0634 0.0689
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.007 0.162 0.5613
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0343 0.0288
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0096 0.004
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0634 0.0581
Loa Loa (eye worm) hypothetical protein 0.0011 0.0096 0.0049
Brugia malayi isocitrate dehydrogenase 0.0013 0.0154 0.0163
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0014 0.0174 0.0147
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0015 0.0218 0.06
Brugia malayi Doublecortin family protein 0.0021 0.0358 0.0494
Schistosoma mansoni 6-phosphofructokinase 0.0115 0.2785 0.3423
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0343 0.0288
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0343 0.036
Loa Loa (eye worm) hypothetical protein 0.0014 0.0174 0.0142
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0343 0.0343
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0343 0.0288
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0096 0.004
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0115 0.2785 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0272 0.0792
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0131 0.0275
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0015 0.0218 0.2869
Toxoplasma gondii exonuclease III APE 0.0015 0.0218 0.248
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0358 0.0303
Brugia malayi Egg laying defective protein 4 0.0009 0.0056 0.0003
Echinococcus granulosus hyperpolarization activated cyclic 0.0014 0.0174 0.0118
Loa Loa (eye worm) hypothetical protein 0.0011 0.0096 0.0049
Giardia lamblia DINP protein human, muc B family 0.0022 0.0395 0.6009
Echinococcus granulosus voltage gated potassium channel 0.002 0.0338 0.0283
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.007 0.162 0.1573
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0096 0.0049
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0096 0.0067
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0338 0.0353
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.094 0.324
Leishmania major ATP-dependent phosphofructokinase 0.0115 0.2785 1
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0343 0.0288
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.006 0.0066
Loa Loa (eye worm) hypothetical protein 0.0011 0.0096 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0731 0.1087
Schistosoma mansoni regulator of G protein signaling 0.002 0.0343 0.036
Loa Loa (eye worm) isocitrate dehydrogenase 0.0013 0.0154 0.0119
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0035 0.071 0.218
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0069 0.1607 0.1559
Loa Loa (eye worm) hypothetical protein 0.0011 0.0096 0.0049
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0096 0.005
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.094 0.3244
Echinococcus granulosus RUN 0.0021 0.0358 0.0303
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0014 0.0174 0.0147
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0331 0.4874
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0115 0.2785 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0096 0.0049
Schistosoma mansoni hypothetical protein 0.0133 0.3253 0.4011
Brugia malayi hypothetical protein 0.0021 0.0358 0.0494
Schistosoma mansoni terminal deoxycytidyl transferase 0.0015 0.0215 0.0199
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0015 0.0218 0.0195
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0069 0.1607 0.1559
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0015 0.0215 0.016
Echinococcus granulosus bloom syndrome protein 0.0023 0.0402 0.0348
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0621 0.091
Loa Loa (eye worm) AGC/PKG protein kinase 0.0009 0.0056 0.0002
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.002 0.0338 0.0283
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0133 0.3253 0.3215
Echinococcus granulosus geminin 0.0318 0.8028 0.8016
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0358 0.0303
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.022 0.5496 0.6465
Echinococcus multilocularis 6 phosphofructokinase 0.0115 0.2785 0.2744
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0343 0.0343
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0096 0.004
Brugia malayi hypothetical protein 0.002 0.0343 0.047
Onchocerca volvulus 0.0009 0.0056 0.0003
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0174 0.0147
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0096 0.004

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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