Detailed information for compound 868568

Basic information

Technical information
  • TDR Targets ID: 868568
  • Name: 1-[2-imino-3-(2-piperidin-1-ylethyl)benzimida zol-1-yl]-3-(2-methoxyphenoxy)propan-2-ol
  • MW: 424.536 | Formula: C24H32N4O3
  • H donors: 1 H acceptors: 1 LogP: 2.92 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1OCC(Cn1c(=N)n(c2c1cccc2)CCN1CCCCC1)O
  • InChi: 1S/C24H32N4O3/c1-30-22-11-5-6-12-23(22)31-18-19(29)17-28-21-10-4-3-9-20(21)27(24(28)25)16-15-26-13-7-2-8-14-26/h3-6,9-12,19,25,29H,2,7-8,13-18H2,1H3
  • InChiKey: WBUOOXNMVHIUJT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[2-imino-3-[2-(1-piperidyl)ethyl]benzimidazol-1-yl]-3-(2-methoxyphenoxy)propan-2-ol
  • 1-[2-imino-3-[2-(1-piperidyl)ethyl]-1-benzimidazolyl]-3-(2-methoxyphenoxy)propan-2-ol
  • 1-[2-imino-3-(2-piperidinoethyl)benzimidazol-1-yl]-3-(2-methoxyphenoxy)propan-2-ol
  • STOCK4S-14153

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis GPCR, family 2 0.0012 0.0027 0.0027
Schistosoma mansoni hypothetical protein 0.0128 0.1949 0.2297
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0023 0.0207 0.4841
Loa Loa (eye worm) hypothetical protein 0.0012 0.0027 0.0075
Loa Loa (eye worm) cytochrome P450 family protein 0.0053 0.0703 0.1932
Schistosoma mansoni microtubule-associated protein tau 0.0522 0.8484 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0103 0.1531 0.2298
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0015 0.0073 0.1704
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.025 0.5844
Loa Loa (eye worm) hypothetical protein 0.0036 0.0428 0.1176
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0012 0.0027 0.0075
Trichomonas vaginalis modulator of drug activity B, putative 0.0103 0.1531 0.2298
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0023 0.0207 0.4841
Brugia malayi MH2 domain containing protein 0.0093 0.1373 0.3775
Toxoplasma gondii isocitrate dehydrogenase 0.0012 0.002 0.0887
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0412 0.666 1
Toxoplasma gondii isocitrate dehydrogenase 0.0012 0.002 0.0887
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0012 0.002 0.0746
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0035 0.0396 0.0396
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0023 0.0207 0.4841
Brugia malayi Cytochrome P450 family protein 0.003 0.0321 0.0882
Echinococcus granulosus dna polymerase eta 0.0035 0.0404 0.0476
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0027 0.0275 0.5
Trypanosoma cruzi DNA polymerase eta, putative 0.0025 0.0231 0.5719
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0035 0.0396 0.0396
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0073 0.1805
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0023 0.0207 0.4841
Trypanosoma cruzi DNA polymerase kappa, putative 0.0015 0.0073 0.1805
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0073 0.1805
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0023 0.0207 0.4841
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0012 0.002 0.0024
Echinococcus granulosus geminin 0.0128 0.1949 0.2297
Echinococcus granulosus GPCR family 2 0.0012 0.0027 0.0032
Entamoeba histolytica modulator of drug activity B homolog, putative 0.0103 0.1531 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0012 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0036 0.0428 0.1176
Loa Loa (eye worm) hypothetical protein 0.0027 0.0275 0.0755
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0023 0.0207 0.4841
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0023 0.0207 0.4841
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0023 0.0207 0.4841
Mycobacterium leprae Conserved hypothetical protein 0.0023 0.0207 0.4841
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0023 0.0207 0.4841
Trypanosoma brucei cytochrome P450, putative 0.003 0.0321 0.7946
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.1531 0.2298
Trichomonas vaginalis modulator of drug activity B, putative 0.0103 0.1531 0.2298
Trypanosoma cruzi DNA polymerase kappa, putative 0.0015 0.0073 0.1805
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.1531 0.2298
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0023 0.0207 0.4841
Brugia malayi AMP-binding enzyme family protein 0.0036 0.0428 0.1176
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0023 0.0207 0.4841
Plasmodium vivax acyl-CoA synthetase, putative 0.0027 0.0275 1
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0023 0.0207 0.4841
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0073 0.1805
Loa Loa (eye worm) hypothetical protein 0.0027 0.0275 0.0755
Trichomonas vaginalis modulator of drug activity B, putative 0.0103 0.1531 0.2298
Echinococcus multilocularis microtubule associated protein 2 0.0522 0.8484 0.8484
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0023 0.0207 0.4841
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0103 0.1531 0.2298
Trypanosoma cruzi DNA polymerase kappa, putative 0.0015 0.0073 0.1805
Leishmania major 4-coumarate:coa ligase-like protein 0.0036 0.0428 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0012 0.002 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0412 0.666 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0103 0.1531 0.2298
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.1531 0.2298
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0012 0.0027 0.0027
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0321 0.0882
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0012 0.002 0.0507
Trichomonas vaginalis conserved hypothetical protein 0.0412 0.666 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0073 0.1805
Echinococcus multilocularis geminin 0.0128 0.1949 0.1949
Schistosoma mansoni hypothetical protein 0.0012 0.0027 0.0032
Mycobacterium ulcerans DNA polymerase IV 0.0015 0.0073 0.1704
Trypanosoma brucei unspecified product 0.0015 0.0073 0.1805
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.1531 0.2298
Onchocerca volvulus Huntingtin homolog 0.0093 0.136 1
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0023 0.0207 0.4841
Loa Loa (eye worm) cytochrome P450 0.0023 0.0207 0.0569
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0039 0.047 0.1292
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0428 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0275 0.0755
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0036 0.0428 1
Mycobacterium ulcerans hypothetical protein 0.0036 0.0428 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0035 0.0396 0.0467
Brugia malayi Cytochrome P450 family protein 0.003 0.0321 0.0882
Schistosoma mansoni hypothetical protein 0.0027 0.0265 0.0312
Trichomonas vaginalis DNA polymerase eta, putative 0.0015 0.0073 0.0109
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0073 0.1805
Mycobacterium ulcerans acyl-CoA synthetase 0.0036 0.0428 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0073 0.1805
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0012 0.002 0.0479
Schistosoma mansoni DNA polymerase eta 0.0035 0.0404 0.0476
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0023 0.0207 0.4841
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0023 0.0207 0.4841
Loa Loa (eye worm) hypothetical protein 0.0036 0.0428 0.1176
Brugia malayi latrophilin 2 splice variant baaae 0.0027 0.0265 0.0728
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.1531 0.2298
Trypanosoma brucei DNA polymerase IV, putative 0.0015 0.0073 0.1805
Trichomonas vaginalis modulator of drug activity B, putative 0.0103 0.1531 0.2298
Echinococcus multilocularis muscleblind protein 0.023 0.3638 0.3638
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.025 0.5844
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0039 0.047 0.1292
Loa Loa (eye worm) transcription factor SMAD2 0.0093 0.1373 0.3775
Trichomonas vaginalis modulator of drug activity B, putative 0.0103 0.1531 0.2298
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0012 0.002 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0073 0.1805
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0023 0.0207 0.4841
Brugia malayi Latrophilin receptor protein 2 0.0012 0.0027 0.0075
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.025 0.5844
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0023 0.0207 0.4841
Loa Loa (eye worm) hypothetical protein 0.0027 0.0275 0.0755
Loa Loa (eye worm) isocitrate dehydrogenase 0.0012 0.002 0.0056
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0012 0.0027 0.0032
Trypanosoma cruzi cytochrome P450, putative 0.003 0.0321 0.7946
Brugia malayi AMP-binding enzyme family protein 0.0036 0.0428 0.1176
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0023 0.0207 0.4841
Mycobacterium leprae putative cytochrome p450 0.0023 0.0207 0.4841
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0023 0.0207 0.4841
Mycobacterium tuberculosis Conserved hypothetical protein 0.0015 0.0073 0.1704
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.025 0.5844
Trichomonas vaginalis modulator of drug activity B, putative 0.0103 0.1531 0.2298
Mycobacterium ulcerans DNA polymerase IV 0.0015 0.0073 0.1704
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0035 0.0396 0.1089
Trichomonas vaginalis modulator of drug activity B, putative 0.0103 0.1531 0.2298
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0023 0.0207 0.4841
Trypanosoma cruzi cytochrome P450, putative 0.003 0.0321 0.7946
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0035 0.0396 0.0467
Trichomonas vaginalis conserved hypothetical protein 0.0412 0.666 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0103 0.1531 0.2298
Echinococcus multilocularis neuropeptide s receptor 0.0349 0.5626 0.5626
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.003 0.0321 0.7502
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0035 0.0396 0.0467
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0023 0.0207 0.4841
Entamoeba histolytica hypothetical protein 0.0103 0.1531 1
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0023 0.0207 0.4841
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0023 0.0207 0.4841
Entamoeba histolytica iron-sulfur flavoprotein, putative 0.0103 0.1531 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0103 0.1531 0.2298
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0023 0.0207 0.5128
Leishmania major DNA polymerase eta, putative 0.0025 0.0231 0.5399
Trypanosoma cruzi DNA polymerase eta, putative 0.0035 0.0404 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0103 0.1531 0.2298
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0023 0.0207 0.4841
Trichomonas vaginalis modulator of drug activity B, putative 0.0103 0.1531 0.2298
Leishmania major DNA polymerase kappa, putative 0.0015 0.0073 0.1704
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0012 0.002 0.0746
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0023 0.0207 0.5128
Loa Loa (eye worm) CYP4Cod1 0.003 0.0321 0.0882
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0023 0.0207 0.4841
Giardia lamblia NADPH oxidoreductase, putative 0.0412 0.666 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0039 0.047 0.1292
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0073 0.1805
Loa Loa (eye worm) hypothetical protein 0.023 0.3638 1
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.1531 0.2298
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0023 0.0207 0.4841
Leishmania major DNA polymerase eta, putative 0.0035 0.0404 0.9441
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0012 0.0027 0.0032
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0012 0.002 0.0479
Trichomonas vaginalis conserved hypothetical protein 0.0309 0.4951 0.7435
Trichomonas vaginalis modulator of drug activity B, putative 0.0103 0.1531 0.2298
Trichomonas vaginalis modulator of drug activity B, putative 0.0103 0.1531 0.2298
Entamoeba histolytica acyl-coA synthetase, putative 0.0036 0.0428 0.2795
Echinococcus granulosus neuropeptide receptor A26 0.0349 0.5626 0.6632
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0012 0.002 0.0507
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0025 0.0231 1
Onchocerca volvulus Huntingtin homolog 0.0093 0.136 1
Echinococcus multilocularis dna polymerase kappa 0.0015 0.0073 0.0073
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0023 0.0207 0.4841
Loa Loa (eye worm) latrophilin receptor protein 2 0.0012 0.0027 0.0075
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0015 0.0073 0.02
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0412 0.666 1
Brugia malayi Muscleblind-like protein 0.023 0.3638 1
Schistosoma mansoni hypothetical protein 0.0023 0.0207 0.0244
Brugia malayi AMP-binding enzyme family protein 0.0036 0.0428 0.1176
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0023 0.0207 0.4841
Trichomonas vaginalis conserved hypothetical protein 0.0412 0.666 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0073 0.1805
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0103 0.1531 0.2298
Giardia lamblia NADPH oxidoreductase, putative 0.0412 0.666 1
Echinococcus granulosus muscleblind protein 0.023 0.3638 0.4288
Plasmodium falciparum acyl-CoA synthetase 0.0027 0.0275 1
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0023 0.0207 0.5128
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0012 0.002 0.002
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0015 0.0073 0.0073
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0015 0.0073 0.1704
Trichomonas vaginalis modulator of drug activity B, putative 0.0103 0.1531 0.2298
Echinococcus multilocularis muscleblind protein 1 0.023 0.3638 0.3638
Trichomonas vaginalis conserved hypothetical protein 0.0412 0.666 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0093 0.1373 0.3775
Trichomonas vaginalis conserved hypothetical protein 0.0412 0.666 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0073 0.1805
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0023 0.0207 0.4841
Loa Loa (eye worm) hypothetical protein 0.0039 0.047 0.1292
Brugia malayi hypothetical protein 0.0093 0.136 0.3738
Loa Loa (eye worm) hypothetical protein 0.0093 0.136 0.3738
Echinococcus granulosus microtubule associated protein 2 0.0522 0.8484 1
Onchocerca volvulus 0.0036 0.0428 0.3146
Entamoeba histolytica acyl-CoA synthetase, putative 0.0036 0.0428 0.2795
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0428 1
Schistosoma mansoni hypothetical protein 0.0012 0.0027 0.0032
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0023 0.0207 0.4841
Loa Loa (eye worm) hypothetical protein 0.0027 0.0275 0.0755
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0012 0.002 0.0507
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0036 0.0428 1
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0023 0.0207 0.4841
Schistosoma mansoni hypothetical protein 0.0012 0.0027 0.0032
Mycobacterium ulcerans acyl-CoA synthetase 0.0036 0.0428 1
Echinococcus multilocularis dna polymerase eta 0.0035 0.0404 0.0404
Trichomonas vaginalis conserved hypothetical protein 0.0412 0.666 1
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0023 0.0207 0.4841
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0035 0.0396 0.0467
Loa Loa (eye worm) hypothetical protein 0.0027 0.0265 0.0728
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0412 0.666 1
Schistosoma mansoni hypothetical protein 0.0012 0.0027 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.1531 0.2298
Trichomonas vaginalis conserved hypothetical protein 0.0412 0.666 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0012 0.002 0.002
Leishmania major cytochrome p450-like protein 0.003 0.0321 0.7502
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0275 0.6421
Trypanosoma brucei DNA polymerase IV, putative 0.0015 0.0073 0.1805
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0023 0.0207 0.5128
Trichomonas vaginalis modulator of drug activity B, putative 0.0103 0.1531 0.2298
Leishmania major cytochrome p450-like protein 0.0023 0.0207 0.4841
Schistosoma mansoni cytochrome P450 0.0023 0.0207 0.0244
Trichomonas vaginalis conserved hypothetical protein 0.0412 0.666 1
Leishmania major cytochrome p450-like protein 0.0023 0.0207 0.4841
Leishmania major 4-coumarate:coa ligase-like protein 0.0036 0.0428 1
Echinococcus multilocularis neuropeptide receptor A26 0.0349 0.5626 0.5626
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0036 0.0428 1
Trichomonas vaginalis FMN-dependent NADH-azoreductase, putative 0.0103 0.1531 0.2298
Loa Loa (eye worm) hypothetical protein 0.023 0.3638 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0012 0.002 0.0507
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0023 0.0207 0.4841
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0023 0.0207 0.4841
Toxoplasma gondii cytochrome p450 superfamily protein 0.0023 0.0207 0.8967
Brugia malayi cytochrome P450 0.0023 0.0207 0.0569
Trypanosoma brucei DNA polymerase eta, putative 0.0035 0.0404 1
Trichomonas vaginalis conserved hypothetical protein 0.0412 0.666 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0036 0.0428 0.2795
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0035 0.0396 0.1089
Leishmania major 4-coumarate:coa ligase-like protein 0.0036 0.0428 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0027 0.0275 0.6421
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0036 0.0428 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0015 0.0073 0.1805
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0036 0.0428 1
Echinococcus granulosus cytochrome P450 2K1 0.0023 0.0207 0.0244
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0023 0.0207 0.4841
Mycobacterium ulcerans acyl-CoA synthetase 0.0036 0.0428 1
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.1531 0.2298
Trichomonas vaginalis modulator of drug activity B, putative 0.0103 0.1531 0.2298
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0023 0.0207 0.4841
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0035 0.0396 0.0467
Trichomonas vaginalis conserved hypothetical protein 0.0412 0.666 1
Brugia malayi isocitrate dehydrogenase 0.0012 0.002 0.0056
Brugia malayi ImpB/MucB/SamB family protein 0.0035 0.0404 0.111
Loa Loa (eye worm) hypothetical protein 0.0035 0.0404 0.111
Trichomonas vaginalis conserved hypothetical protein 0.0412 0.666 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0103 0.1531 0.2298
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0015 0.0073 0.0086
Giardia lamblia NADPH oxidoreductase, putative 0.0412 0.666 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0012 0.002 0.002
Trypanosoma brucei DNA polymerase IV, putative 0.0015 0.0073 0.1805
Trichomonas vaginalis conserved hypothetical protein 0.0412 0.666 1
Loa Loa (eye worm) hypothetical protein 0.0093 0.136 0.3738
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0321 0.0882
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0012 0.0027 0.0027
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0036 0.0428 1
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0023 0.0207 0.4841
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.1531 0.2298
Entamoeba histolytica deoxycytidyl transferase, putative 0.0015 0.0073 0.0476
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0073 0.02
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0023 0.0207 0.4841
Schistosoma mansoni hypothetical protein 0.0128 0.1949 0.2297
Echinococcus granulosus dna polymerase kappa 0.0015 0.0073 0.0086
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0023 0.0207 0.4841
Echinococcus multilocularis 0.0023 0.0207 0.0207
Trichomonas vaginalis modulator of drug activity B, putative 0.0103 0.1531 0.2298
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0023 0.0207 0.4841
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0015 0.0073 0.0086
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0015 0.0073 0.0109
Schistosoma mansoni terminal deoxycytidyl transferase 0.0015 0.0073 0.0086
Echinococcus granulosus neuropeptide s receptor 0.0349 0.5626 0.6632
Brugia malayi Cytochrome P450 family protein 0.0053 0.0703 0.1932
Brugia malayi Isocitrate dehydrogenase 0.0012 0.002 0.0056
Brugia malayi Cytochrome P450 family protein 0.0023 0.0207 0.0569

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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