Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0846 | 0.3113 | 0.3098 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0275 | 0.0254 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0846 | 0.3113 | 0.4692 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.0846 | 0.3113 | 0.4675 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0846 | 0.3113 | 0.4675 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.1712 | 0.6634 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0101 | 0.0084 | 0.0126 |
Brugia malayi | Protein kinase domain containing protein | 0.0846 | 0.3113 | 0.3098 |
Trichomonas vaginalis | AGC family protein kinase | 0.254 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0846 | 0.3113 | 0.4692 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel alpha 3 | 0.0101 | 0.0084 | 0.0095 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.1642 | 0.6346 | 1 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0101 | 0.0084 | 0.0063 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0846 | 0.3113 | 0.4675 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.1642 | 0.6346 | 0.9565 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.1623 | 0.6272 | 0.9452 |
Entamoeba histolytica | protein kinase, putative | 0.254 | 1 | 1 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.1712 | 0.6634 | 1 |
Echinococcus granulosus | protein kinase c iota type | 0.0846 | 0.3113 | 0.4675 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.0846 | 0.3113 | 0.4675 |
Echinococcus granulosus | voltage gated potassium channel | 0.0148 | 0.0275 | 0.0384 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0512 | 0.1752 | 0.2617 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0101 | 0.0084 | 0.0049 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0846 | 0.3113 | 0.4675 |
Leishmania major | rac serine-threonine kinase, putative,protein kinase, putative | 0.0089 | 0.0034 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.254 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0846 | 0.3113 | 0.4675 |
Echinococcus multilocularis | nervana 2 | 0.1623 | 0.6272 | 0.9452 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0086 | 0.0021 | 0.0032 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0148 | 0.0275 | 0.0414 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0846 | 0.3113 | 0.3098 |
Trichomonas vaginalis | AGC family protein kinase | 0.0846 | 0.3113 | 0.3089 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.1623 | 0.6272 | 0.9452 |
Toxoplasma gondii | AGC kinase | 0.247 | 0.9712 | 1 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0101 | 0.0084 | 0.0126 |
Echinococcus multilocularis | protein kinase c iota type | 0.0846 | 0.3113 | 0.4675 |
Plasmodium falciparum | calcium-dependent protein kinase 7 | 0.0089 | 0.0034 | 0.0021 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0846 | 0.3113 | 0.3098 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.0846 | 0.3113 | 0.4675 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0084 | 0.0063 |
Trichomonas vaginalis | AGC family protein kinase | 0.254 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.254 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0148 | 0.0275 | 0.0254 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.0846 | 0.3113 | 0.4675 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.1623 | 0.6272 | 0.9452 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.1712 | 0.6634 | 0.6622 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.254 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0846 | 0.3113 | 0.4692 |
Loa Loa (eye worm) | hypothetical protein | 0.0846 | 0.3113 | 0.3098 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.247 | 0.9712 | 0.9712 |
Giardia lamblia | Kinase, AGC PKA | 0.1642 | 0.6346 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0444 | 0.1477 | 0.1459 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0086 | 0.0021 | 0.0032 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0558 | 0.1943 | 0.2928 |
Trypanosoma cruzi | Protein kinase B | 0.1712 | 0.6634 | 1 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel | 0.0101 | 0.0084 | 0.0095 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0846 | 0.3113 | 0.4675 |
Trichomonas vaginalis | serine/threonine-protein kinase sgk, putative | 0.0828 | 0.3039 | 0.3015 |
Echinococcus granulosus | NDR protein kinase | 0.0846 | 0.3113 | 0.4675 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.1712 | 0.6634 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0846 | 0.3113 | 0.4675 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0512 | 0.1752 | 0.1734 |
Brugia malayi | protein kinase C II. | 0.0846 | 0.3113 | 0.3098 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0148 | 0.0275 | 0.0384 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0101 | 0.0084 | 0.0095 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0101 | 0.0084 | 0.0063 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.1712 | 0.6634 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.254 | 1 | 1 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.1642 | 0.6346 | 0.9565 |
Entamoeba histolytica | protein kinase, putative | 0.254 | 1 | 1 |
Echinococcus granulosus | serine/threonine protein kinase | 0.1712 | 0.6634 | 1 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0101 | 0.0084 | 0.0095 |
Trichomonas vaginalis | AGC family protein kinase | 0.0846 | 0.3113 | 0.3089 |
Toxoplasma gondii | calcium dependent protein kinase CDPK7 | 0.0089 | 0.0034 | 0.0014 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0846 | 0.3113 | 0.4692 |
Leishmania major | folate/biopterin transporter, putative | 0.0089 | 0.0034 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0846 | 0.3113 | 0.4692 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0478 | 0.1615 | 0.1586 |
Trichomonas vaginalis | AGC family protein kinase | 0.254 | 1 | 1 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.1642 | 0.6346 | 0.9564 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0846 | 0.3113 | 0.4675 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0558 | 0.1943 | 0.2928 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.1642 | 0.6346 | 1 |
Echinococcus granulosus | potassium:sodium hyperpolarization activated | 0.0101 | 0.0084 | 0.0095 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0101 | 0.0084 | 0.0126 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0101 | 0.0084 | 0.0095 |
Leishmania major | serine/threonine-protein kinase a, putative | 0.0089 | 0.0034 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0846 | 0.3113 | 0.3089 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0512 | 0.1752 | 0.2617 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0148 | 0.0275 | 0.0384 |
Echinococcus multilocularis | potassium:sodium hyperpolarization activated | 0.0101 | 0.0084 | 0.0095 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0101 | 0.0084 | 0.0049 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0101 | 0.0084 | 0.0126 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0512 | 0.1752 | 0.1734 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0086 | 0.0021 | 0.0032 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.1623 | 0.6272 | 0.9452 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0846 | 0.3113 | 0.3098 |
Entamoeba histolytica | protein kinase 2, putative | 0.1642 | 0.6346 | 0.6333 |
Trichomonas vaginalis | AGC family protein kinase | 0.254 | 1 | 1 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.247 | 0.9712 | 0.9712 |
Echinococcus granulosus | nervana 2 | 0.1623 | 0.6272 | 0.9452 |
Leishmania major | protein kinase, putative | 0.0089 | 0.0034 | 1 |
Echinococcus granulosus | nervana 2 | 0.1623 | 0.6272 | 0.9452 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0101 | 0.0084 | 0.0095 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.1642 | 0.6346 | 0.9565 |
Schistosoma mansoni | atypical protein kinase C | 0.0846 | 0.3113 | 0.4692 |
Toxoplasma gondii | protein kinase domain-containing protein | 0.0089 | 0.0034 | 0.0014 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0846 | 0.3113 | 0.4675 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0846 | 0.3113 | 0.3098 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0846 | 0.3113 | 0.4675 |
Entamoeba histolytica | protein kinase, putative | 0.247 | 0.9712 | 0.9711 |
Echinococcus granulosus | protein kinase C gamma type | 0.0846 | 0.3113 | 0.4675 |
Brugia malayi | Protein kinase domain containing protein | 0.0846 | 0.3113 | 0.3098 |
Echinococcus granulosus | cyclic nucleotide gated cation channel alpha 3 | 0.0101 | 0.0084 | 0.0095 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0101 | 0.0084 | 0.0095 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0101 | 0.0084 | 0.0126 |
Leishmania major | protein kinase, putative,serine/threonine protein kinase, putative | 0.0089 | 0.0034 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0846 | 0.3113 | 0.4692 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0846 | 0.3113 | 0.4692 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0846 | 0.3113 | 0.3098 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0846 | 0.3113 | 0.4675 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0148 | 0.0275 | 0.0414 |
Trichomonas vaginalis | AGC family protein kinase | 0.0917 | 0.3401 | 0.3378 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0478 | 0.1615 | 0.1586 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0148 | 0.0275 | 0.0384 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0101 | 0.0084 | 0.0126 |
Brugia malayi | Hr1 repeat family protein | 0.0846 | 0.3113 | 0.3098 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.0846 | 0.3113 | 0.4675 |
Brugia malayi | Cyclic-nucleotide gated cation channel | 0.0101 | 0.0084 | 0.0063 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.1712 | 0.6634 | 0.6622 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0101 | 0.0084 | 0.0095 |
Echinococcus multilocularis | nervana 2 | 0.1623 | 0.6272 | 0.9452 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.254 | 1 | 1 |
Schistosoma mansoni | serine/threonine kinase | 0.0846 | 0.3113 | 0.4692 |
Trichomonas vaginalis | AGC family protein kinase | 0.0846 | 0.3113 | 0.3089 |
Leishmania major | protein kinase, putative | 0.0089 | 0.0034 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.