Detailed information for compound 86876

Basic information

Technical information
  • TDR Targets ID: 86876
  • Name: Maytansine
  • MW: 692.196 | Formula: C34H46ClN3O10
  • H donors: 2 H acceptors: 5 LogP: 2.9 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: CO[C@@H]1/C=C/C=C(\C)/Cc2cc(OC)c(c(c2)N(C(=O)C[C@@H]([C@]2([C@H]([C@@H]([C@@H]3C[C@@]1(O)NC(=O)O3)C)O2)C)OC(=O)[C@@H](N(C(=O)C)C)C)C)Cl
  • InChi: 1S/C34H46ClN3O10/c1-18-11-10-12-26(45-9)34(43)17-25(46-32(42)36-34)19(2)30-33(5,48-30)27(47-31(41)20(3)37(6)21(4)39)16-28(40)38(7)23-14-22(13-18)15-24(44-8)29(23)35/h10-12,14-15,19-20,25-27,30,43H,13,16-17H2,1-9H3,(H,36,42)/b12-10+,18-11+/t19-,20+,25+,26-,27+,30+,33+,34+/m1/s1
  • InChiKey: WKPWGQKGSOKKOO-RSFHAFMBSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • 35846-53-8
  • BRN 5417399
  • EINECS 252-754-7
  • L-Alanine, N-acetyl-N-methyl-, 11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo(19.3.1.110,14.03,5)hexacosa-10,12,14(26),16,18-pentaen-6-yl ester, (1S-(1R*,2S*,3R*,5R*,6R*,16E,18E,20S*,21R*))-
  • Maitansina [INN-Spanish]
  • Maitansine
  • Maitansinum [INN-Latin]
  • C10606
  • N-Acetyl-N-methyl-L-alanine(1S-(1R*,2S*,3R*,5R*,6R*,16E,18E,20S*,21R*))-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethy-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo(19.3.1.1(sup 10,14).0(sup 3,5))hexacosa-10,12,14(26),16,18-pentaen-6-yl ester
  • NSC 153858
  • NSC-153858
  • LMPK01000021
  • NCI60_001090
  • NSC153858
  • Maytansine (USAN)
  • Maytansin
  • D04864
  • Maytansine [USAN]

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major epsilon tubulin, putative Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major delta tubulin, putative Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major gamma-tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major zeta tubulin, putative Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Babesia bovis tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi beta-tubulin, identical Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin subunit TubB Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium vivax tubulin gamma chain, putative Get druggable targets OG5_127652 All targets in OG5_127652
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma cruzi zeta tubulin, putative Get druggable targets OG5_145938 All targets in OG5_145938
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium yoelii tubulin beta chain Get druggable targets OG5_130726 All targets in OG5_130726
Plasmodium falciparum tubulin epsilon chain, putative Get druggable targets OG5_130726 All targets in OG5_130726
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium knowlesi alpha-tubulin II, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin epsilon chain Get druggable targets OG5_130726 All targets in OG5_130726
Echinococcus granulosus tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin gamma 1 chain Get druggable targets OG5_127652 All targets in OG5_127652
Echinococcus multilocularis hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium yoelii tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium falciparum tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Schistosoma japonicum ko:K10391 tubulin epsilon, putative Get druggable targets OG5_130726 All targets in OG5_130726
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein Get druggable targets OG5_130726 All targets in OG5_130726
Trypanosoma brucei gambiense zeta tubulin Get druggable targets OG5_145938 All targets in OG5_145938
Toxoplasma gondii beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major gamma-tubulin Get druggable targets OG5_127652 All targets in OG5_127652
Cryptosporidium hominis alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin alpha-3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin gamma chain, putative Get druggable targets OG5_130726 All targets in OG5_130726
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein Get druggable targets OG5_143817 All targets in OG5_143817
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania donovani epsilon tubulin, putative Get druggable targets OG5_130726 All targets in OG5_130726
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum ko:K10389 tubulin gamma, putative Get druggable targets OG5_127652 All targets in OG5_127652
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma cruzi tubulin delta chain Get druggable targets OG5_143817 All targets in OG5_143817
Echinococcus granulosus alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis epsilon tubulin, putative Get druggable targets OG5_130726 All targets in OG5_130726
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin, beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium hominis beta-catenin-like repeat protein Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium parvum gamma tubulin Get druggable targets OG5_127652 All targets in OG5_127652
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-7 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi Tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis zeta tubulin, putative Get druggable targets OG5_145938 All targets in OG5_145938
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania donovani tubulin delta chain Get druggable targets OG5_143817 All targets in OG5_143817
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Entamoeba histolytica tubulin alpha-1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Neospora caninum tubulin epsilon chain, putative Get druggable targets OG5_130726 All targets in OG5_130726
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium knowlesi tubulin epsilon chain, putative Get druggable targets OG5_130726 All targets in OG5_130726
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium berghei tubulin epsilon chain, putative Get druggable targets OG5_130726 All targets in OG5_130726
Loa Loa (eye worm) alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium vivax tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei epsilon tubulin Get druggable targets OG5_130726 All targets in OG5_130726
Entamoeba histolytica tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei gambiense gamma tubulin Get druggable targets OG5_127652 All targets in OG5_127652
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07374 tubulin alpha, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei gambiense alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi Tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma congolense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin gamma 1 chain Get druggable targets OG5_127652 All targets in OG5_127652
Cryptosporidium hominis gamma-tubulin Get druggable targets OG5_127652 All targets in OG5_127652
Leishmania mexicana zeta tubulin, putative Get druggable targets OG5_145938 All targets in OG5_145938
Plasmodium vivax tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major epsilon tubulin, putative Get druggable targets OG5_130726 All targets in OG5_130726
Schistosoma japonicum Tubulin beta-4 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei zeta tubulin Get druggable targets OG5_145938 All targets in OG5_145938
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense epsilon tubulin Get druggable targets OG5_130726 All targets in OG5_130726
Babesia bovis tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium berghei alpha tubulin 2 Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium yoelii Tubulin/FtsZ family, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus peroxisome assembly protein 26 Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma cruzi beta tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis gamma-tubulin Get druggable targets OG5_127652 All targets in OG5_127652
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma congolense alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium knowlesi tubulin gamma chain, putative Get druggable targets OG5_127652 All targets in OG5_127652
Brugia malayi alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium berghei tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei zeta tubulin, putative Get druggable targets OG5_145938 All targets in OG5_145938
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta-1 tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium parvum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi Tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum ko:K07374 tubulin alpha, putative Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium yoelii tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii alpha tubulin TUBA1 Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Theileria parva Tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis peroxisome assembly protein 26 Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum gamma-tubulin Get druggable targets OG5_127652 All targets in OG5_127652
Plasmodium yoelii tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Theileria parva tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium knowlesi alpha tubulin, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania donovani tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin subunit TubB Get druggable targets OG5_126605 All targets in OG5_126605
Candida albicans cytoskeletal structural protein Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Babesia bovis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Babesia bovis tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Neospora caninum tubulin delta chain, putative Get druggable targets OG5_143817 All targets in OG5_143817
Loa Loa (eye worm) tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma cruzi tubulin delta chain Get druggable targets OG5_143817 All targets in OG5_143817
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Giardia lamblia Gamma tubulin Get druggable targets OG5_127652 All targets in OG5_127652
Leishmania infantum beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii alpha-tubulin I, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis delta tubulin, putative Get druggable targets OG5_143817 All targets in OG5_143817
Echinococcus granulosus tubulin beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium parvum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma cruzi zeta tubulin, putative Get druggable targets OG5_145938 All targets in OG5_145938
Trichomonas vaginalis tubulin gamma chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Theileria parva tubulin gamma chain, putative Get druggable targets OG5_127652 All targets in OG5_127652
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major zeta tubulin, putative Get druggable targets OG5_145938 All targets in OG5_145938
Trypanosoma cruzi alpha tubulin, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania donovani zeta tubulin, putative Get druggable targets OG5_145938 All targets in OG5_145938
Trypanosoma congolense tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Neospora caninum Beta-tubulin, related Get druggable targets OG5_127652 All targets in OG5_127652
Trichomonas vaginalis tubulin alpha chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma congolense epsilon tubulin Get druggable targets OG5_130726 All targets in OG5_130726
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma congolense zeta tubulin Get druggable targets OG5_145938 All targets in OG5_145938
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Giardia lamblia Epsilon tubulin Get druggable targets OG5_130726 All targets in OG5_130726
Trypanosoma brucei gambiense delta tubulin, putative Get druggable targets OG5_143817 All targets in OG5_143817
Plasmodium vivax tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin gamma chain, putative Get druggable targets OG5_127652 All targets in OG5_127652
Theileria parva tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta-tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Brugia malayi Tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Candida albicans gamma tubulin-like protein Get druggable targets OG5_127652 All targets in OG5_127652
Brugia malayi Tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium berghei alpha tubulin 1 Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit gamma Get druggable targets OG5_127652 All targets in OG5_127652
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium berghei tubulin gamma chain, putative Get druggable targets OG5_127652 All targets in OG5_127652
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin alpha-2/alpha-4 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin beta-4 chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin alpha-1C chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana gamma-tubulin Get druggable targets OG5_127652 All targets in OG5_127652
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum delta tubulin, putative Get druggable targets OG5_143817 All targets in OG5_143817
Echinococcus multilocularis tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium falciparum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin, putative Get druggable targets OG5_127652 All targets in OG5_127652
Leishmania infantum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania donovani alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium falciparum alpha tubulin 1 Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi tubulin alpha chain - mouse Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum epsilon tubulin, putative Get druggable targets OG5_130726 All targets in OG5_130726
Trypanosoma cruzi tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana epsilon tubulin, putative Get druggable targets OG5_130726 All targets in OG5_130726
Trypanosoma cruzi epsilon tubulin, putative Get druggable targets OG5_130726 All targets in OG5_130726
Trypanosoma congolense tubulin delta chain Get druggable targets OG5_143817 All targets in OG5_143817
Leishmania mexicana alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin beta-2A chain Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) alpha-tubulin isotype 2 Get druggable targets OG5_126605 All targets in OG5_126605
Giardia lamblia Alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium vivax tubulin epsilon chain, putative Get druggable targets OG5_130726 All targets in OG5_130726
Plasmodium falciparum alpha tubulin 2 Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit epsilon Get druggable targets OG5_130726 All targets in OG5_130726
Leishmania infantum zeta tubulin, putative Get druggable targets OG5_145938 All targets in OG5_145938
Candida albicans gamma tubulin-like protein Get druggable targets OG5_127652 All targets in OG5_127652
Trypanosoma brucei epsilon tubulin Get druggable targets OG5_130726 All targets in OG5_130726
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii tubulin, putative Get druggable targets OG5_130726 All targets in OG5_130726
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma cruzi epsilon tubulin, putative Get druggable targets OG5_130726 All targets in OG5_130726
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major delta tubulin, putative Get druggable targets OG5_143817 All targets in OG5_143817
Trypanosoma brucei tubulin delta chain Get druggable targets OG5_143817 All targets in OG5_143817
Leishmania mexicana Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin epsilon chain Get druggable targets OG5_130726 All targets in OG5_130726
Neospora caninum tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin epsilon chain, putative gamma-tubulin 447 aa 479 aa 28.2 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Trypanosoma brucei epsilon tubulin epsilon tubulin, putative 470 aa 488 aa 68.0 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni tubulin subunit delta 0.0161 0.0274 0.1202
Echinococcus multilocularis muscleblind protein 0.0154 0.026 0.026
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0006 0.0053
Loa Loa (eye worm) hypothetical protein 0.0056 0.0076 0.0527
Loa Loa (eye worm) patched family protein 0.0033 0.0032 0.0208
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0067 0.0582
Loa Loa (eye worm) hypothetical protein 0.0057 0.0077 0.0533
Leishmania major delta tubulin, putative 0.0363 0.0654 0.5695
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0053
Brugia malayi hypothetical protein 0.0033 0.0032 0.0229
Leishmania major alpha tubulin 0.0471 0.0858 0.7472
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.0208
Echinococcus granulosus calpain A 0.0066 0.0095 0.0418
Echinococcus granulosus lysosomal alpha glucosidase 0.035 0.0629 0.2765
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0075 0.0112 0.0974
Giardia lamblia Beta tubulin 0.0625 0.1148 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0053
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0075 0.0112 0.0974
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0511 0.0933 0.8127
Trichomonas vaginalis tubulin gamma chain, putative 0.0384 0.0694 0.6046
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.0192 0.7007
Schistosoma mansoni intermediate filament proteins 0.0056 0.0076 0.0334
Leishmania major beta tubulin 0.0625 0.1148 1
Trypanosoma brucei beta tubulin 0.0625 0.1148 1
Trypanosoma brucei beta tubulin 0.0625 0.1148 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.028 0.0497 0.3588
Giardia lamblia Sgs1 DNA helicase, putative 0.0045 0.0055 0.0477
Schistosoma mansoni alpha tubulin 0.0471 0.0858 0.377
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0006 0.0006
Plasmodium falciparum tubulin delta chain, putative 0.0161 0.0274 0.2383
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0029 0.0024 0.021
Loa Loa (eye worm) hypothetical protein 0.0057 0.0077 0.0533
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0079 0.0118 0.4325
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.0001 0.0006
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0414 0.0751 0.5422
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.0047 0.0407
Trypanosoma brucei alpha tubulin 0.0471 0.0858 0.7472
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0006 0.0025
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.0208
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0022 0.0012 0.0085
Leishmania major kinesin, putative 0.0019 0.0005 0.0045
Giardia lamblia Delta tubulin 0.0161 0.0274 0.2383
Loa Loa (eye worm) patched family protein 0.0033 0.0032 0.0208
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0076 0.0113 0.2084
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0029 0.0024 0.021
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0022 0.0012 0.0102
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0012 0.0102
Loa Loa (eye worm) apoptosis regulator protein 0.0086 0.0132 0.0932
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0006 0.0053
Loa Loa (eye worm) hypothetical protein 0.0283 0.0504 0.3623
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0006 0.0049
Brugia malayi cytochrome P450 0.0079 0.0118 0.0854
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.0192 0.7007
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.0169 0.6193
Brugia malayi Bromodomain containing protein 0.0078 0.0118 0.0848
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0075 0.0112 0.0491
Echinococcus multilocularis Niemann Pick C1 protein 0.0776 0.1434 0.1434
Plasmodium vivax tubulin gamma chain, putative 0.0384 0.0694 0.6046
Leishmania major beta tubulin 0.0625 0.1148 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0414 0.0751 0.5422
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.0113 0.2084
Schistosoma mansoni smad1 5 8 and 0.0025 0.0017 0.0073
Plasmodium vivax delta tubulin, putative 0.0161 0.0274 0.2383
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.009 0.0784
Schistosoma mansoni tubulin subunit gamma 0.0384 0.0694 0.3051
Trichomonas vaginalis ap endonuclease, putative 0.006 0.0083 0.0726
Loa Loa (eye worm) alpha-tubulin 0.0471 0.0858 0.6181
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0131 0.0217 0.0217
Loa Loa (eye worm) sirtuin 4 0.0075 0.0112 0.0786
Echinococcus multilocularis tubulin alpha chain 0.0471 0.0858 0.0858
Trypanosoma brucei alpha tubulin 0.0471 0.0858 0.7472
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.0082 0.0082
Trichomonas vaginalis DNA helicase recq, putative 0.0058 0.008 0.0695
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.0001 0.0001
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0022 0.0012 0.043
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0006 0.0223
Brugia malayi tubulin alpha chain - mouse 0.0471 0.0858 0.6189
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.0169 0.6193
Echinococcus granulosus tubulin subunit beta 0.0625 0.1148 0.5045
Schistosoma mansoni lipoxygenase 0.0086 0.0131 0.0577
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.008 0.0553
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0053
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.0208
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0096 0.0151 0.0665
Entamoeba histolytica hypothetical protein 0.0186 0.0321 0.2766
Treponema pallidum ATP-dependent DNA helicase 0.0023 0.0013 0.0476
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0625 0.1148 0.1148
Leishmania major beta tubulin 0.0625 0.1148 1
Toxoplasma gondii cytochrome p450 superfamily protein 0.0079 0.0118 0.1031
Echinococcus multilocularis tubulin beta 1 chain 0.0625 0.1148 0.1148
Brugia malayi AMP-binding enzyme family protein 0.0076 0.0113 0.0816
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0024 0.021
Echinococcus multilocularis zinc finger protein 0.0023 0.0013 0.0013
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0078 0.0116 0.0817
Brugia malayi MH2 domain containing protein 0.0025 0.0017 0.0121
Echinococcus granulosus beta tubulin 0.0625 0.1148 0.5045
Trypanosoma brucei trypanothione reductase 0.0046 0.0057 0.0499
Loa Loa (eye worm) cytochrome P450 family protein 0.0118 0.0192 0.1366
Loa Loa (eye worm) hypothetical protein 0.0086 0.0132 0.0932
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.0208
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.028 0.0497 0.2186
Toxoplasma gondii patched family protein 0.0033 0.0032 0.0277
Brugia malayi calpain family protein 1 0.0063 0.0089 0.0642
Loa Loa (eye worm) hypothetical protein 0.0063 0.0089 0.0621
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0086 0.0132 0.058
Echinococcus granulosus calpain 5 0.0019 0.0005 0.0023
Trichomonas vaginalis tubulin gamma chain, putative 0.0384 0.0693 0.6039
Echinococcus granulosus tubulin beta 1 chain 0.0625 0.1148 0.5045
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0038
Echinococcus multilocularis calpain 5 0.0019 0.0005 0.0005
Echinococcus granulosus survival motor neuron protein 1 0.0751 0.1386 0.6091
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.001 0.0042
Plasmodium vivax patched family protein, putative 0.0033 0.0032 0.0277
Leishmania major alpha tubulin 0.0471 0.0858 0.7472
Loa Loa (eye worm) calpain 0.0019 0.0005 0.0015
Loa Loa (eye worm) CYP4Cod1 0.0118 0.0192 0.1366
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0079 0.0118 0.2181
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0013 0.0113
Loa Loa (eye worm) RecQ helicase 0.0109 0.0176 0.1249
Echinococcus multilocularis lysosomal alpha glucosidase 0.035 0.0629 0.0629
Echinococcus multilocularis Tubulin alpha 1 chain 0.0471 0.0858 0.0858
Echinococcus granulosus expressed conserved protein 0.051 0.0932 0.4097
Schistosoma mansoni tubulin subunit alpha 0.0471 0.0858 0.377
Echinococcus multilocularis smad 0.0025 0.0017 0.0017
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0006 0.0022
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0012 0.043
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0217 0.0952
Brugia malayi MH1 domain containing protein 0.0025 0.0017 0.0121
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0011 0.008
Loa Loa (eye worm) hypothetical protein 0.0414 0.0751 0.5412
Echinococcus multilocularis lysosomal alpha glucosidase 0.035 0.0629 0.0629
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0078 0.0116 0.101
Plasmodium vivax NAD-dependent deacetylase, putative 0.0075 0.0112 0.0974
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0021 0.0092
Trypanosoma cruzi epsilon tubulin, putative 0.0384 0.0693 0.6039
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.0208
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0012 0.0085
Echinococcus granulosus dnaJ subfamily B 0.0829 0.1534 0.6743
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0073 0.0107 0.0935
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0076 0.0113 0.2084
Entamoeba histolytica recQ family DNA helicase 0.0023 0.0013 0.0069
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.0208
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.035 0.0629 0.4527
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0511 0.0933 0.0933
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.0192 0.6873
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0552 0.101 0.444
Schistosoma mansoni tubulin subunit beta 0.0161 0.0274 0.1202
Schistosoma mansoni alpha-glucosidase 0.0301 0.0537 0.2361
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0075 0.0112 0.0974
Schistosoma mansoni chromatin regulatory protein sir2 0.0075 0.0112 0.0491
Entamoeba histolytica hypothetical protein 0.0186 0.0321 0.2766
Echinococcus multilocularis beta tubulin 0.0625 0.1148 0.1148
Brugia malayi Pre-SET motif family protein 0.0064 0.009 0.0649
Schistosoma mansoni tubulin subunit beta 0.0625 0.1148 0.5045
Loa Loa (eye worm) patched family protein 0.0033 0.0032 0.0208
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0079 0.0118 0.4325
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0001 0.0006
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0058 0.008 0.0695
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0079 0.0118 0.4325
Leishmania major beta tubulin 0.0625 0.1148 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0005 0.0045
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0005 0.0045
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0006 0.0206
Toxoplasma gondii hypothetical protein 0.0033 0.0032 0.0277
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0086 0.0132 0.058
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0006 0.0053
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0013 0.0058
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0075 0.0112 0.0112
Echinococcus multilocularis survival motor neuron protein 1 0.0751 0.1386 0.1386
Trypanosoma cruzi kinesin, putative 0.0019 0.0005 0.0045
Trichomonas vaginalis tubulin alpha chain, putative 0.0625 0.1148 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0625 0.1148 1
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0079 0.0118 0.2181
Echinococcus multilocularis dnaJ subfamily B 0.0829 0.1534 0.1534
Echinococcus granulosus Tubulin alpha 1 chain 0.0471 0.0858 0.377
Echinococcus granulosus histone lysine methyltransferase setb 0.0081 0.0122 0.0537
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.006 0.0083 0.0726
Loa Loa (eye worm) transcriptional regulator 0.0075 0.0112 0.0786
Brugia malayi Smad1 0.0025 0.0017 0.0121
Giardia lamblia Transcriptional regulator, Sir2 family 0.0075 0.0112 0.0974
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.009 0.009
Echinococcus granulosus neuropeptide receptor A26 0.0473 0.0862 0.3788
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0076 0.0527
Echinococcus granulosus tubulin alpha 1C chain 0.0471 0.0858 0.377
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.0208
Loa Loa (eye worm) hypothetical protein 0.0076 0.0113 0.0796
Leishmania major epsilon tubulin, putative 0.0384 0.0693 0.6039
Loa Loa (eye worm) hypothetical protein 0.0019 0.0006 0.0022
Brugia malayi intermediate filament protein 0.0056 0.0076 0.0548
Echinococcus multilocularis calpain family protein 1, d 0.0044 0.0053 0.0053
Loa Loa (eye worm) histone methyltransferase 0.002 0.0008 0.0036
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0081 0.0122 0.0122
Trichomonas vaginalis conserved hypothetical protein 0.0161 0.0274 0.2383
Entamoeba histolytica acyl-coA synthetase, putative 0.0076 0.0113 0.0944
Brugia malayi hypothetical protein 0.002 0.0008 0.006
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0075 0.0112 0.0974
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0006 0.0053
Echinococcus multilocularis geminin 0.1222 0.2275 0.2275
Trichomonas vaginalis alpha-glucosidase, putative 0.0078 0.0116 0.101
Loa Loa (eye worm) hypothetical protein 0.0026 0.0019 0.0115
Trichomonas vaginalis tubulin alpha chain, putative 0.019 0.0329 0.2863
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0088 0.0763
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0047 0.0407
Leishmania major 4-coumarate:coa ligase-like protein 0.0076 0.0113 0.0985
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0012 0.0085
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0281 0.0499 0.3585
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0053
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0067 0.0582
Echinococcus multilocularis calpain 7 (C02 family) 0.0019 0.0005 0.0005
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0079 0.0118 0.4325
Leishmania major sir2-family protein-like protein 0.0075 0.0112 0.0974
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0131 0.0217 0.0954
Onchocerca volvulus 0.0033 0.0032 0.0261
Echinococcus granulosus calpain A 0.0019 0.0005 0.0023
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0193 0.0334 0.2912
Loa Loa (eye worm) hypothetical protein 0.0057 0.0077 0.0533
Echinococcus granulosus tubulin alpha 3 chain 0.0471 0.0858 0.377
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0012 0.0217
Echinococcus multilocularis 0.0079 0.0118 0.0118
Giardia lamblia Alpha-tubulin 0.0471 0.0858 0.7472
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.0208
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0131 0.0217 0.1566
Schistosoma mansoni ap endonuclease 0.006 0.0083 0.0366
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0075 0.0112 0.0974
Schistosoma mansoni hypothetical protein 0.0283 0.0504 0.2215
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0079 0.0118 0.4325
Trichomonas vaginalis tubulin epsilon chain, putative 0.0161 0.0274 0.2383
Echinococcus multilocularis Tubulin beta 2C chain 0.0625 0.1148 0.1148
Brugia malayi Muscleblind-like protein 0.0154 0.026 0.1875
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.0208
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0005 0.0045
Toxoplasma gondii tubulin, putative 0.0032 0.003 0.0264
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0076 0.0113 0.2084
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0001 0.0006
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.0082 0.0082
Toxoplasma gondii alpha-tubulin I, putative 0.0471 0.0858 0.7472
Leishmania major alpha tubulin 0.0471 0.0858 0.7472
Brugia malayi Cytochrome P450 family protein 0.0079 0.0118 0.0854
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0012 0.043
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0006 0.0053
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0079 0.0118 0.4325
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0471 0.0858 0.7472
Toxoplasma gondii beta-1 tubulin, putative 0.0625 0.1148 1
Schistosoma mansoni polycystin 1-related 0.002 0.0008 0.0036
Loa Loa (eye worm) glutaminase 2 0.0304 0.0543 0.3901
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.0192 0.7007
Loa Loa (eye worm) hypothetical protein 0.0027 0.0021 0.0129
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0075 0.0112 0.0933
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0038 0.0038
Leishmania major glycosyl hydrolase-like protein 0.0029 0.0024 0.021
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.006 0.0083 0.0726
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.0208
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.0208
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0088 0.1613
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.006 0.0083 0.3046
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0057 0.0077 1
Brugia malayi jmjC domain containing protein 0.006 0.0082 0.0595
Entamoeba histolytica acyl-CoA synthetase, putative 0.0076 0.0113 0.0944
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0012 0.0102
Schistosoma mansoni hypothetical protein 0.0131 0.0217 0.0954
Brugia malayi calpain 5 0.0019 0.0005 0.0037
Trichomonas vaginalis tubulin alpha chain, putative 0.019 0.0329 0.2863
Echinococcus granulosus GPCR family 2 0.0131 0.0217 0.0954
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.028 0.0497 0.2186
Brugia malayi Trypsin family protein 0.0096 0.0151 0.1092
Giardia lamblia Beta tubulin 0.0625 0.1148 1
Loa Loa (eye worm) alpha-tubulin 0.0471 0.0858 0.6181
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0079 0.0118 0.2181
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.0208
Plasmodium vivax glutathione reductase, putative 0.0046 0.0057 0.0499
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0511 0.0933 0.8127
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.006 0.0083 0.0726
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0079 0.0118 0.4325
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0075 0.0112 0.0491
Echinococcus granulosus Smad4 0.0025 0.0017 0.0073
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0067 0.0582
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0088 0.3199
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0076 0.0113 0.2084
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0079 0.0118 0.2181
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0075 0.0112 0.0974
Loa Loa (eye worm) hypothetical protein 0.0131 0.0217 0.1547
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0075 0.0112 0.0974
Echinococcus multilocularis RUN 0.002 0.0008 0.0008
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0363 0.0654 0.5695
Brugia malayi PHD-finger family protein 0.0028 0.0023 0.0166
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0057 0.0057
Echinococcus multilocularis protein dispatched 1 0.0266 0.0472 0.0472
Onchocerca volvulus 0.0497 0.0908 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0089 0.0621
Trypanosoma cruzi zeta tubulin, putative 0.0498 0.0909 0.7919
Brugia malayi Patched family protein 0.0033 0.0032 0.0229
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0075 0.0112 0.0974
Loa Loa (eye worm) hypothetical protein 0.0044 0.0053 0.0365
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0079 0.0118 0.1031
Trichomonas vaginalis alpha-glucosidase, putative 0.0078 0.0116 0.101
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0012 0.0102
Echinococcus granulosus muscleblind protein 0.0154 0.026 0.1142
Trypanosoma cruzi tubulin delta chain 0.0363 0.0654 0.5695
Leishmania major beta tubulin 0.0625 0.1148 1
Mycobacterium leprae putative cytochrome p450 0.0079 0.0118 0.4071
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0075 0.0112 0.0112
Brugia malayi glutaminase DH11.1 0.0304 0.0543 0.3915
Schistosoma mansoni hypothetical protein 0.0225 0.0394 0.173
Plasmodium vivax tubulin alpha chain, putative 0.0471 0.0858 0.7472
Brugia malayi Niemann-Pick C1 protein precursor 0.0543 0.0994 0.7175
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0024 0.021
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0126 0.0207 0.091
Trichomonas vaginalis tubulin, putative 0.0625 0.1148 1
Leishmania major alpha tubulin 0.0471 0.0858 0.7472
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0012 0.0102
Loa Loa (eye worm) hypothetical protein 0.0026 0.0019 0.0115
Onchocerca volvulus 0.0064 0.009 0.0908
Schistosoma mansoni lamin 0.0056 0.0076 0.0334
Echinococcus granulosus tubulin alpha 3 chain 0.0471 0.0858 0.377
Brugia malayi hypothetical protein 0.0751 0.1386 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0006 0.0006
Leishmania major silent information regulator 2, putative 0.0511 0.0933 0.8127
Echinococcus multilocularis hypothetical protein 0.0471 0.0858 0.0858
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0006 0.0053
Leishmania major cytochrome p450-like protein 0.0079 0.0118 0.1031
Schistosoma mansoni hypothetical protein 0.0225 0.0394 0.173
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.028 0.0497 0.2186
Echinococcus multilocularis neuropeptide receptor A26 0.0473 0.0862 0.0862
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0022 0.0012 0.043
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0075 0.0112 0.4085
Loa Loa (eye worm) hypothetical protein 0.0038 0.0042 0.0283
Brugia malayi Cytochrome P450 family protein 0.0118 0.0192 0.1385
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0096 0.0151 0.0665
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.0208
Loa Loa (eye worm) calpain family protein 1 0.0044 0.0053 0.0365
Onchocerca volvulus 0.0056 0.0076 0.0751
Schistosoma mansoni glutaminase 0.0304 0.0543 0.2384
Loa Loa (eye worm) hypothetical protein 0.0543 0.0994 0.7169
Echinococcus granulosus Tubulin beta 2C chain 0.0625 0.1148 0.5045
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0045 0.0055 0.0241
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0071 0.2593
Loa Loa (eye worm) glutaminase 0.0304 0.0543 0.3901
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0012 0.0102
Leishmania major beta tubulin 0.0625 0.1148 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0078 0.0116 0.101
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0088 0.0385
Brugia malayi hypothetical protein 0.0033 0.0032 0.0229
Loa Loa (eye worm) hypothetical protein 0.0075 0.0112 0.0786
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0.0039 0.1029
Leishmania major cytochrome p450-like protein 0.0079 0.0118 0.1031
Echinococcus granulosus Tubulin beta 2C chain 0.0625 0.1148 0.5045
Plasmodium falciparum tubulin beta chain 0.0625 0.1148 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0511 0.0933 0.41
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0067 0.0582
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0012 0.043
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.0082 0.0362
Loa Loa (eye worm) hypothetical protein 0.0286 0.0508 0.3654
Trichomonas vaginalis tubulin, putative 0.019 0.0329 0.2863
Plasmodium vivax tubulin epsilon chain, putative 0.0384 0.0693 0.6039
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0047 0.0407
Leishmania major alpha tubulin 0.0471 0.0858 0.7472
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.006 0.0083 0.0083
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0005 0.0045
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0006 0.0113
Echinococcus granulosus tubulin subunit TubB 0.0471 0.0858 0.377
Brugia malayi protein C24B5.3 0.0033 0.0032 0.0229
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0075 0.0112 0.0933
Brugia malayi hypothetical protein 0.0127 0.021 0.1513
Leishmania major hypothetical protein, conserved 0.0052 0.0067 0.0582
Echinococcus multilocularis tubulin alpha chain 0.0471 0.0858 0.0858
Trypanosoma brucei SIR2-like protein 4, putative 0.0075 0.0112 0.0974
Echinococcus multilocularis tubulin alpha 0.0351 0.0633 0.0633
Mycobacterium leprae cell division protein FtsZ 0.0161 0.0274 1
Entamoeba histolytica recQ family helicase, putative 0.0022 0.0011 0.0054
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0116 0.101
Echinococcus granulosus tubulin epsilon chain 0.0384 0.0693 0.3047
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.0047 0.0862
Trypanosoma brucei glucosidase, putative 0.0078 0.0116 0.101
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0022 0.0012 0.0217
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0022 0.0012 0.0217
Onchocerca volvulus 0.0022 0.0012 0.0038
Schistosoma mansoni chromatin regulatory protein sir2 0.0511 0.0933 0.41
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0024 0.021
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.0208
Leishmania major beta tubulin 0.0625 0.1148 1
Echinococcus granulosus Tubulin beta 2C chain 0.0625 0.1148 0.5045
Brugia malayi Cell division protein ftsZ 0.0161 0.0274 0.1974
Schistosoma mansoni smad1 5 8 and 0.0025 0.0017 0.0073
Toxoplasma gondii propionate-CoA ligase 0.0022 0.0012 0.0102
Onchocerca volvulus 0.0058 0.008 0.0791
Entamoeba histolytica hypothetical protein 0.0186 0.0321 0.2766
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.006 0.0083 0.0726
Echinococcus granulosus tubulin delta chain 0.0161 0.0274 0.1202
Leishmania major beta tubulin 0.0625 0.1148 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0122 0.0862
Mycobacterium ulcerans cell division protein FtsZ 0.0161 0.0274 0.5043
Echinococcus granulosus dna polymerase kappa 0.0019 0.0006 0.0027
Schistosoma mansoni cpg binding protein 0.0058 0.008 0.0349
Loa Loa (eye worm) TAR-binding protein 0.0131 0.0217 0.1545
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0058 0.008 0.0695
Echinococcus multilocularis Tubulin beta 2C chain 0.0625 0.1148 0.1148
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.0113 0.2084
Trypanosoma brucei kinesin, putative 0.0019 0.0005 0.0045
Echinococcus multilocularis Niemann Pick C1 protein 0.0543 0.0994 0.0994
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0075 0.0112 0.0974
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0006 0.0008
Leishmania major beta tubulin 0.0625 0.1148 1
Schistosoma mansoni hypothetical protein 0.0023 0.0013 0.0058
Loa Loa (eye worm) hypothetical protein 0.0186 0.0321 0.2297
Trypanosoma brucei beta tubulin 0.0625 0.1148 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0006 0.0049
Mycobacterium ulcerans acetyl-CoA synthetase 0.0022 0.0012 0.0217
Echinococcus granulosus cpg binding protein 0.0063 0.0089 0.0393
Loa Loa (eye worm) MH2 domain-containing protein 0.0366 0.066 0.4753
Trypanosoma brucei zeta tubulin, putative 0.0498 0.0909 0.7919
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0067 0.0582
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0079 0.0118 0.4325
Echinococcus multilocularis hypothetical protein 0.0019 0.0005 0.0005
Brugia malayi transcriptional regulator, Sir2 family protein 0.0511 0.0933 0.6732
Loa Loa (eye worm) cytochrome P450 family protein 0.0249 0.0439 0.3153
Schistosoma mansoni patched 1 0.0233 0.0409 0.1799
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.0113 0.2084
Brugia malayi CHE-14 protein 0.0233 0.0409 0.2954
Schistosoma mansoni tubulin subunit beta 0.0625 0.1148 0.5045
Schistosoma mansoni lipoxygenase 0.0123 0.0201 0.0882
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.009 0.0396
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0012 0.043
Schistosoma mansoni tubulin subunit alpha 0.0161 0.0274 0.1202
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0006 0.0113
Mycobacterium ulcerans glutaminase 0.0304 0.0543 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.0047 0.171
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0086 0.0132 0.0132
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0153 0.0259 0.1865
Schistosoma mansoni alpha tubulin 0.0471 0.0858 0.377
Entamoeba histolytica recQ family helicase, putative 0.0058 0.008 0.0653
Onchocerca volvulus 0.0033 0.0032 0.0261
Loa Loa (eye worm) oxidoreductase 0.0022 0.0012 0.0063
Onchocerca volvulus Huntingtin homolog 0.0127 0.021 0.2239
Plasmodium vivax tubulin beta chain, putative 0.0625 0.1148 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0078 0.0116 0.101
Brugia malayi jmjC domain containing protein 0.0065 0.0092 0.0666
Schistosoma mansoni hypothetical protein 0.0186 0.0321 0.1412
Mycobacterium ulcerans NAD-dependent deacetylase 0.0075 0.0112 0.206
Trichomonas vaginalis ap endonuclease, putative 0.006 0.0083 0.0726
Echinococcus granulosus tubulin alpha 0.0351 0.0633 0.278
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0414 0.0751 0.5412
Echinococcus multilocularis Tubulin alpha 1 chain 0.0471 0.0858 0.0858
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0351 0.0633 0.551
Loa Loa (eye worm) hypothetical protein 0.0044 0.0053 0.0365
Echinococcus granulosus lysine specific demethylase 5A 0.0065 0.0092 0.0406
Loa Loa (eye worm) RNA binding protein 0.0131 0.0217 0.1545
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0086 0.0132 0.0132
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0017 0.0017
Giardia lamblia Alpha-tubulin 0.0471 0.0858 0.7472
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0161 0.0274 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0006 0.0027
Brugia malayi MH2 domain containing protein 0.0366 0.066 0.4764
Leishmania major 4-coumarate:coa ligase-like protein 0.0076 0.0113 0.0985
Schistosoma mansoni tubulin subunit alpha 0.0471 0.0858 0.377
Brugia malayi Tubulin alpha-2 chain 0.0471 0.0858 0.6189
Schistosoma mansoni apoptosis regulator bax 0.0086 0.0132 0.058
Giardia lamblia Sirtuin type 2 0.0075 0.0112 0.0974
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0006 0.0027
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0079 0.0118 0.4325
Echinococcus granulosus tubulin alpha chain 0.0471 0.0858 0.377
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0277 0.0492 0.4258
Brugia malayi TAR-binding protein 0.0131 0.0217 0.1563
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0008 0.0008
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0076 0.0113 0.3868
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0053
Loa Loa (eye worm) transcriptional regulator 0.0075 0.0112 0.0786
Trypanosoma brucei tubulin gamma chain 0.0384 0.0694 0.6046
Schistosoma mansoni cpg binding protein 0.0063 0.0089 0.0393
Brugia malayi glutathione reductase 0.0046 0.0057 0.0413
Echinococcus granulosus peroxisome assembly protein 26 0.0471 0.0858 0.377
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0002 0.0008
Echinococcus multilocularis GPCR, family 2 0.0131 0.0217 0.0217
Brugia malayi Patched family protein 0.0033 0.0032 0.0229
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0027 0.017
Onchocerca volvulus 0.0022 0.0012 0.0038
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0006 0.0053
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0005 0.0045
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0017 0.0017
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.006 0.0083 0.0726
Loa Loa (eye worm) hypothetical protein 0.0233 0.0409 0.2939
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0437 0.0794 0.5723
Trichomonas vaginalis tubulin beta chain, putative 0.0625 0.1148 1
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0002 0.0008
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0047 0.0206
Schistosoma mansoni tubulin subunit beta 0.0625 0.1148 0.5045
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.006 0.0083 0.0366
Entamoeba histolytica tubulin gamma chain 0.0384 0.0694 0.6029
Loa Loa (eye worm) hypothetical protein 0.0057 0.0077 0.0533
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0045 0.0055 0.0477
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0233 0.0409 0.2939
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0024 0.021
Brugia malayi Patched family protein 0.0033 0.0032 0.0229
Onchocerca volvulus 0.0033 0.0032 0.0261
Brugia malayi Patched family protein 0.0033 0.0032 0.0229
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0022 0.0012 0.0217
Echinococcus granulosus dna polymerase eta 0.0019 0.0006 0.0027
Brugia malayi beta-tubulin, identical 0.0625 0.1148 0.8283
Echinococcus multilocularis tubulin alpha chain 0.0471 0.0858 0.0858
Loa Loa (eye worm) tubulin gamma chain 0.0384 0.0694 0.4997
Loa Loa (eye worm) calpain 5 0.0019 0.0005 0.0015
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0012 0.0063
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0005 0.0045
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0075 0.0112 0.0974
Echinococcus granulosus microtubule associated protein 2 0.0717 0.1322 0.581
Giardia lamblia DINP protein human, muc B family 0.0019 0.0006 0.0053
Echinococcus granulosus Tubulin alpha 1 chain 0.0471 0.0858 0.377
Trichomonas vaginalis tubulin alpha chain, putative 0.0351 0.0633 0.551
Brugia malayi Patched related family protein 4 0.0033 0.0032 0.0229
Brugia malayi Glycosyl hydrolases family 31 protein 0.035 0.0629 0.4539
Schistosoma mansoni jumonji domain containing protein 0.006 0.0082 0.0362
Trichomonas vaginalis alpha-glucosidase, putative 0.0078 0.0116 0.101
Loa Loa (eye worm) doublecortin family protein 0.002 0.0008 0.0038
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0543 0.0994 0.8657
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0012 0.0217
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.006 0.0083 0.3046
Echinococcus multilocularis tubulin delta chain 0.0161 0.0274 0.0274
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.028 0.0497 0.2186
Schistosoma mansoni acetyl-CoA synthetase 0.0022 0.0012 0.0052
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0079 0.0118 0.2181
Leishmania major DNA polymerase eta, putative 0.0019 0.0006 0.0053
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0081 0.0122 0.0537
Brugia malayi Myosin head containing protein 0.0033 0.0032 0.0229
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0006 0.0049
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0075 0.0112 0.0974
Entamoeba histolytica tubulin family protein 0.0625 0.1148 1
Trichomonas vaginalis tubulin beta chain, putative 0.0471 0.0858 0.7472
Echinococcus multilocularis tubulin epsilon chain 0.0384 0.0693 0.0693
Schistosoma mansoni hypothetical protein 0.0131 0.0217 0.0954
Echinococcus granulosus neuropeptide s receptor 0.0473 0.0862 0.3788
Loa Loa (eye worm) hypothetical protein 0.0046 0.0056 0.0387
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.0063
Schistosoma mansoni loxhd1 0.002 0.0008 0.0036
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.0208
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0045 0.0055 0.0477
Onchocerca volvulus 0.0044 0.0053 0.0502
Schistosoma mansoni calpain-7 (C02 family) 0.0019 0.0005 0.0023
Brugia malayi Tubulin gamma chain 0.0384 0.0694 0.5008
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.006 0.0083 0.0726
Trichomonas vaginalis DNA helicase recq, putative 0.0109 0.0176 0.1531
Echinococcus multilocularis tubulin alpha 1C chain 0.0471 0.0858 0.0858
Schistosoma mansoni calpain (C02 family) 0.0019 0.0005 0.0023
Schistosoma mansoni inositol monophosphatase 0.0041 0.0047 0.0206
Echinococcus granulosus intermediate filament protein 0.0056 0.0076 0.0334
Toxoplasma gondii beta tubulin 0.0625 0.1148 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.0208
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0079 0.0118 0.4325
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0079 0.0118 0.2181
Schistosoma mansoni chromatin regulatory protein sir2 0.0075 0.0112 0.0491
Onchocerca volvulus 0.0033 0.0032 0.0261
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0079 0.0118 0.4325
Schistosoma mansoni rab6-interacting 0.002 0.0008 0.0036
Trypanosoma brucei alpha tubulin 0.0471 0.0858 0.7472
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0012 0.0217
Loa Loa (eye worm) tubulin alpha 2 0.031 0.0554 0.3983
Brugia malayi alpha-tubulin 0.0471 0.0858 0.6189
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.0208
Toxoplasma gondii thioredoxin reductase 0.0046 0.0057 0.0499
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0057 0.0499
Schistosoma mansoni chromatin regulatory protein sir2 0.0075 0.0112 0.0491
Schistosoma mansoni tubulin subunit beta 0.0625 0.1148 0.5045
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0047 0.0407
Entamoeba histolytica tubulin alpha-1 chain 0.0471 0.0858 0.7461
Mycobacterium leprae Conserved hypothetical protein 0.0079 0.0118 0.4071
Brugia malayi transcriptional regulator, Sir2 family protein 0.0075 0.0112 0.0806
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0053
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0012 0.0217
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0006 0.0049
Onchocerca volvulus 0.0076 0.0113 0.1164
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0088 0.0385
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0079 0.0118 0.2181
Onchocerca volvulus 0.0022 0.0012 0.0038
Brugia malayi RNA recognition motif domain containing protein 0.0131 0.0217 0.1563
Toxoplasma gondii exonuclease III APE 0.006 0.0083 0.0726
Brugia malayi RNA binding protein 0.0131 0.0217 0.1563
Brugia malayi AMP-binding enzyme family protein 0.0076 0.0113 0.0816
Schistosoma mansoni rab6-interacting 0.002 0.0008 0.0036
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0088 0.0088
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0019 0.0081
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0022 0.0012 0.0217
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0022 0.0012 0.0217
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0076 0.0113 0.4132
Schistosoma mansoni inositol monophosphatase 0.0041 0.0047 0.0206
Schistosoma mansoni alpha tubulin 0.0471 0.0858 0.377
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0006 0.0049
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0006 0.0041
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0012 0.0085
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0277 0.0492 0.4258
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0217 0.0952
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0079 0.0118 0.2181
Entamoeba histolytica acyl-CoA synthetase, putative 0.0076 0.0113 0.0944
Echinococcus multilocularis tubulin gamma 1 chain 0.0384 0.0694 0.0694
Brugia malayi hypothetical protein 0.0186 0.0321 0.2318
Trypanosoma brucei epsilon tubulin 0.0384 0.0693 0.6039
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0022 0.0012 0.0058
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.0063
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0006 0.0006
Schistosoma mansoni chromatin regulatory protein sir2 0.0075 0.0112 0.0491
Giardia lamblia Hypothetical protein 0.0511 0.0933 0.8127
Loa Loa (eye worm) tubulin beta chain 0.0625 0.1148 0.8279
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.0208
Schistosoma mansoni lamin 0.0056 0.0076 0.0334
Echinococcus multilocularis lamin 0.0056 0.0076 0.0076
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0022 0.0012 0.043
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0013 0.0113
Loa Loa (eye worm) hypothetical protein 0.0127 0.021 0.1495
Brugia malayi MH1 domain containing protein 0.0025 0.0017 0.0121
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0075 0.0112 0.0491
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0006 0.0025
Echinococcus granulosus Tubulin beta 2C chain 0.0625 0.1148 0.5045
Trichomonas vaginalis tubulin epsilon chain, putative 0.0625 0.1148 1
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0022 0.0012 0.043
Trypanosoma cruzi cytochrome P450, putative 0.0118 0.0192 0.1672
Echinococcus granulosus beta tubulin 0.0625 0.1148 0.5045
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0022 0.0012 0.0012
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0045 0.0055 0.0395
Mycobacterium ulcerans Sir2-like regulatory protein 0.0075 0.0112 0.206
Leishmania major zeta tubulin, putative 0.0498 0.0909 0.7919
Loa Loa (eye worm) hypothetical protein 0.0041 0.0047 0.0315
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0079 0.0118 0.4325
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0008 0.0036
Echinococcus multilocularis tubulin alpha chain 0.0471 0.0858 0.0858
Echinococcus granulosus tubulin gamma 1 chain 0.0384 0.0694 0.3051
Brugia malayi Patched family protein 0.0033 0.0032 0.0229
Toxoplasma gondii histone lysine methyltransferase SET1 0.0115 0.0187 0.1625
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0079 0.0118 0.2181
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0079 0.0118 0.4325
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.0208
Brugia malayi Patched family protein 0.0033 0.0032 0.0229
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0096 0.0151 0.1313
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0006 0.0049
Leishmania major beta tubulin 0.0625 0.1148 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0005 0.0045
Brugia malayi hypothetical protein 0.0033 0.0032 0.0229
Trypanosoma brucei beta tubulin 0.0351 0.0633 0.551
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0012 0.0085
Entamoeba histolytica hypothetical protein, conserved 0.0075 0.0112 0.0933
Loa Loa (eye worm) hypothetical protein 0.0076 0.0113 0.0796
Leishmania major beta tubulin 0.0625 0.1148 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0077 0.0533
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0012 0.0102
Trichomonas vaginalis maltase-glucoamylase, putative 0.0078 0.0116 0.101
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0022 0.0012 0.043
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0083 0.0366
Trichomonas vaginalis tubulin gamma chain, putative 0.0161 0.0274 0.2383
Brugia malayi Patched family protein 0.0033 0.0032 0.0229
Schistosoma mansoni hypothetical protein 0.0153 0.0259 0.1136
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0022 0.0012 0.0217
Brugia malayi Tubulin beta chain 0.0161 0.0274 0.1974
Brugia malayi Tubulin beta chain 0.019 0.0329 0.2371
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0029 0.0024 0.0166
Loa Loa (eye worm) hypothetical protein 0.0055 0.0074 0.0513
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0079 0.0118 0.1031
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0067 0.0582
Brugia malayi transcriptional regulator, Sir2 family protein 0.0075 0.0112 0.0806
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0019 0.0005 0.0045
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0079 0.0118 0.4325
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0079 0.0118 0.2181
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0022 0.0012 0.043
Echinococcus multilocularis musashi 0.0056 0.0076 0.0076
Schistosoma mansoni hypothetical protein 0.0086 0.0132 0.058
Schistosoma mansoni hypothetical protein 0.0829 0.1534 0.6743
Brugia malayi AMP-binding enzyme family protein 0.0076 0.0113 0.0816
Brugia malayi Patched family protein 0.0033 0.0032 0.0229
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0057 0.0077 0.1415
Trichomonas vaginalis tubulin beta chain, putative 0.0471 0.0858 0.7472
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0006 0.0053
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0002 0.0002
Echinococcus multilocularis calpain 0.0019 0.0005 0.0005
Trichomonas vaginalis tubulin beta chain, putative 0.019 0.0329 0.2863
Leishmania major alpha tubulin 0.0471 0.0858 0.7472
Schistosoma mansoni Smad4 0.0025 0.0017 0.0073
Onchocerca volvulus Protein patched homolog 0.0033 0.0032 0.0261
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0079 0.0118 0.4325
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0006 0.0223
Brugia malayi Patched family protein 0.0033 0.0032 0.0229
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0002 0.0008
Plasmodium vivax acyl-CoA synthetase, putative 0.0057 0.0077 0.0669
Brugia malayi Pre-SET motif family protein 0.0437 0.0794 0.5732
Echinococcus granulosus lamin dm0 0.0056 0.0076 0.0334
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0005 0.0045
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0029 0.0024 0.021
Schistosoma mansoni tubulin subunit epsilon 0.0384 0.0693 0.3047
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0001 0.0001
Trypanosoma cruzi kinesin, putative 0.0019 0.0005 0.0045
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0118 0.0192 0.3538
Entamoeba histolytica tubulin alpha chain, putative 0.0471 0.0858 0.7461
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0022 0.0012 0.0102
Brugia malayi Tubulin alpha chain 0.0161 0.0274 0.1974
Brugia malayi Inositol-1 0.0041 0.0047 0.0338
Echinococcus granulosus cytochrome P450 2K1 0.0079 0.0118 0.052
Plasmodium falciparum glutathione reductase 0.0046 0.0057 0.0499
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0012 0.0102
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0217 0.0952
Trichomonas vaginalis tubulin beta chain, putative 0.0471 0.0858 0.7472
Brugia malayi Latrophilin receptor protein 2 0.0131 0.0217 0.1566
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0186 0.0321 0.1412
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0029 0.0024 0.021
Treponema pallidum exodeoxyribonuclease (exoA) 0.006 0.0083 0.3046
Echinococcus multilocularis Smad4 0.0025 0.0017 0.0017
Plasmodium falciparum lipid/sterol:H+ symporter 0.0033 0.0032 0.0277
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0038 0.0165
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0006 0.0049
Leishmania major DNA polymerase kappa, putative 0.0019 0.0006 0.0053
Loa Loa (eye worm) cytochrome P450 0.0079 0.0118 0.0834
Loa Loa (eye worm) tubulin alpha 2 0.031 0.0554 0.3983
Loa Loa (eye worm) BEN-1 protein 0.0625 0.1148 0.8279
Loa Loa (eye worm) patched family protein 0.0033 0.0032 0.0208
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0079 0.0118 0.4325
Schistosoma mansoni smad1 5 8 and 0.0025 0.0017 0.0073
Leishmania major alpha tubulin 0.0471 0.0858 0.7472
Loa Loa (eye worm) hypothetical protein 0.0277 0.0492 0.3534
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0006 0.0006
Brugia malayi hypothetical protein 0.0033 0.0032 0.0234
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.028 0.0497 0.0497
Trichomonas vaginalis conserved hypothetical protein 0.0233 0.0409 0.3567
Schistosoma mansoni ap endonuclease 0.006 0.0083 0.0366
Leishmania major beta tubulin 0.0625 0.1148 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.0208
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.0208
Schistosoma mansoni blooms syndrome DNA helicase 0.0086 0.0132 0.0582
Schistosoma mansoni DNA helicase recq1 0.0045 0.0055 0.0241
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0071 0.2593
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0079 0.0118 0.2181
Loa Loa (eye worm) hypothetical protein 0.0096 0.0151 0.1073
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0075 0.0112 0.0974
Echinococcus multilocularis neuropeptide s receptor 0.0473 0.0862 0.0862
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.001 0.001
Schistosoma mansoni cytochrome P450 0.0079 0.0118 0.052
Echinococcus multilocularis sterol regulatory element binding protein 0.0233 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.0208
Trypanosoma brucei antigen, putative 0.0019 0.0005 0.0045
Brugia malayi calpain family protein 1 0.0063 0.0089 0.0642
Trichomonas vaginalis tubulin epsilon chain, putative 0.0471 0.0858 0.7472
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0006 0.0019
Brugia malayi Patched family protein 0.0033 0.0032 0.0229
Entamoeba histolytica tubulin family protein 0.0625 0.1148 1
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0161 0.0274 0.2383
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.028 0.0497 0.0497
Trichomonas vaginalis DNA helicase recq1, putative 0.0109 0.0176 0.1531
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0012 0.0217
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0053
Brugia malayi Patched related family protein 12 0.0033 0.0032 0.0229
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.0169 0.6193
Onchocerca volvulus 0.0153 0.0259 0.2781
Schistosoma mansoni tubulin subunit alpha 0.0471 0.0858 0.377
Loa Loa (eye worm) hypothetical protein 0.0154 0.026 0.1857
Loa Loa (eye worm) tubulin beta-4 chain 0.0625 0.1148 0.8279
Schistosoma mansoni microtubule-associated protein tau 0.0717 0.1322 0.581
Echinococcus granulosus Tubulin beta 2C chain 0.0625 0.1148 0.5045
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0075 0.0112 0.0974
Brugia malayi Bromodomain containing protein 0.0038 0.0042 0.0303
Loa Loa (eye worm) glutathione reductase 0.0046 0.0057 0.0392
Leishmania major beta tubulin 0.0625 0.1148 1
Trichomonas vaginalis glutaminase, putative 0.0304 0.0543 0.4726
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0131 0.0217 0.0954
Echinococcus multilocularis cpg binding protein 0.0063 0.0089 0.0089
Brugia malayi Tubulin beta-1 chain 0.0625 0.1148 0.8283
Echinococcus granulosus tubulin alpha chain 0.0471 0.0858 0.377
Trichomonas vaginalis tubulin epsilon chain, putative 0.0625 0.1148 1
Trypanosoma cruzi alpha tubulin, putative 0.0471 0.0858 0.7472
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0022 0.0012 0.0217
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0511 0.0933 0.41
Trypanosoma cruzi cytochrome P450, putative 0.0118 0.0192 0.1672
Schistosoma mansoni DNA helicase recq5 0.0045 0.0055 0.0241
Schistosoma mansoni hypothetical protein 0.0079 0.0118 0.052
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0078 0.0116 0.101
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0075 0.0112 0.0974
Trypanosoma brucei alpha tubulin 0.0471 0.0858 0.7472
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0066 0.0095 0.0095
Brugia malayi Cytochrome P450 family protein 0.0118 0.0192 0.1385
Leishmania major trypanothione reductase 0.0046 0.0057 0.0499
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0075 0.0112 0.0974
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0079 0.0118 0.4325
Leishmania major alpha tubulin 0.0471 0.0858 0.7472
Schistosoma mansoni alpha-glucosidase 0.0301 0.0537 0.2361
Leishmania major beta tubulin 0.0625 0.1148 1
Trichomonas vaginalis tubulin alpha chain, putative 0.019 0.0329 0.2863
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0012 0.0217
Echinococcus multilocularis dna polymerase eta 0.0019 0.0006 0.0006
Echinococcus granulosus bloom syndrome protein 0.0109 0.0176 0.0773
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.0208
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0281 0.0499 0.4345
Toxoplasma gondii beta-tubulin, putative 0.0625 0.1148 1
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0217 0.0952
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0006 0.0049
Echinococcus multilocularis protein patched 0.0233 0.0409 0.0409
Echinococcus multilocularis Tubulin beta 2C chain 0.0625 0.1148 0.1148
Echinococcus granulosus tubulin beta 4A class IVa 0.0625 0.1148 0.5045
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0076 0.0548
Echinococcus multilocularis Tubulin beta 2C chain 0.0625 0.1148 0.1148
Trypanosoma cruzi tubulin delta chain 0.0363 0.0654 0.5695
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0078 0.0116 0.097
Plasmodium falciparum tubulin gamma chain 0.0384 0.0694 0.6046
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0047 0.0407
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0005 0.0045
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0079 0.0118 0.4325
Brugia malayi Patched family protein 0.0033 0.0032 0.0229
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0092 0.0646
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0116 0.101
Loa Loa (eye worm) hypothetical protein 0.0096 0.0151 0.1073
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0076 0.0113 0.4132
Leishmania major cytochrome p450-like protein 0.0118 0.0192 0.1672
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0081 0.0122 0.0537
Trypanosoma brucei glycosyl hydrolase-like protein 0.0029 0.0024 0.021
Schistosoma mansoni hypothetical protein 0.002 0.0008 0.0036
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.0208
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.028 0.0497 0.3574
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0079 0.0118 0.1031
Echinococcus granulosus tubulin alpha 1C chain 0.0471 0.0858 0.377
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.031 0.0554 0.4825
Echinococcus granulosus chromatin regulatory protein sir2 0.0511 0.0933 0.41
Loa Loa (eye worm) cytochrome P450 family protein 0.0118 0.0192 0.1366
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.0169 0.6022
Loa Loa (eye worm) hypothetical protein 0.0071 0.0103 0.0725
Trichomonas vaginalis tubulin, putative 0.019 0.0329 0.2863
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0005 0.0045
Loa Loa (eye worm) tubulin beta-1 chain 0.0625 0.1148 0.8279
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0058 0.008 0.0695
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0005 0.0045
Leishmania major beta tubulin 0.0625 0.1148 1
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0029 0.0024 0.0176
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0008 0.0035
Loa Loa (eye worm) hypothetical protein 0.0023 0.0013 0.0072
Brugia malayi MH2 domain containing protein 0.0025 0.0017 0.0121
Echinococcus multilocularis calpain A 0.0066 0.0095 0.0095
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0079 0.0118 0.2181
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0092 0.0406
Entamoeba histolytica exodeoxyribonuclease III, putative 0.006 0.0083 0.0684
Loa Loa (eye worm) alpha-tubulin isotype 2 0.031 0.0554 0.3983
Loa Loa (eye worm) hypothetical protein 0.0029 0.0024 0.0153
Toxoplasma gondii patched family protein 0.0033 0.0032 0.0277
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0019 0.0019
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0012 0.0217
Brugia malayi hypothetical protein 0.0052 0.0067 0.0482
Brugia malayi hypothetical protein 0.0033 0.0032 0.0229
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0086 0.0132 0.0952
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0066 0.0095 0.0418
Trypanosoma brucei unspecified product 0.0019 0.0006 0.0053
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0057 0.0392
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0006 0.0044
Echinococcus granulosus Tubulin alpha 1 chain 0.0471 0.0858 0.377
Toxoplasma gondii alpha tubulin TUBA1 0.0471 0.0858 0.7472
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0511 0.0933 0.8127
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0131 0.0217 0.0217
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0022 0.0011 0.0099
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.019 0.0329 0.2863
Onchocerca volvulus Protein patched homolog 0.0033 0.0032 0.0261
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0047 0.0407
Brugia malayi Glycosyl hydrolases family 31 protein 0.0029 0.0024 0.0174
Loa Loa (eye worm) tubulin alpha-2 chain 0.0471 0.0858 0.6181
Mycobacterium ulcerans hypothetical protein 0.0076 0.0113 0.2084
Onchocerca volvulus 0.0096 0.0151 0.159
Schistosoma mansoni tubulin subunit beta 0.0625 0.1148 0.5045
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0005 0.0045
Toxoplasma gondii histone deacetylase SIR2-like 0.0075 0.0112 0.0974
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0053
Brugia malayi Patched family protein 0.0033 0.0032 0.0229
Leishmania major gamma-tubulin 0.0384 0.0694 0.6046
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0075 0.0112 0.0974
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0067 0.0582
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0005 0.0045
Trypanosoma brucei beta tubulin 0.0625 0.1148 1
Echinococcus granulosus tubulin alpha chain 0.0471 0.0858 0.377
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0006 0.0053
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0079 0.0118 0.1031
Schistosoma mansoni smad 0.0025 0.0017 0.0073
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0088 0.0385
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0008 0.0008
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0045 0.0055 0.0055
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0079 0.0118 0.2181
Echinococcus multilocularis tubulin subunit beta 0.0625 0.1148 0.1148
Schistosoma mansoni calpain C (C02 family) 0.0019 0.0005 0.0023
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0066 0.0095 0.0418
Trichomonas vaginalis maltase-glucoamylase, putative 0.0029 0.0024 0.021
Trichomonas vaginalis tubulin beta chain, putative 0.0471 0.0858 0.7472
Echinococcus multilocularis muscleblind protein 1 0.0154 0.026 0.026
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0006 0.0053
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0008 0.0036
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.006 0.0083 0.0581
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0006 0.0006
Toxoplasma gondii patched family protein 0.0033 0.0032 0.0277
Entamoeba histolytica hypothetical protein 0.0186 0.0321 0.2766
Brugia malayi Thioredoxin reductase 0.0046 0.0057 0.0413
Loa Loa (eye worm) hypothetical protein 0.0154 0.026 0.1857
Loa Loa (eye worm) hypothetical protein 0.0045 0.0055 0.0374
Schistosoma mansoni cpg binding protein 0.0063 0.0089 0.0393
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0022 0.0012 0.0085
Brugia malayi Patched family protein 0.0033 0.0032 0.0229
Schistosoma mansoni hypothetical protein 0.1222 0.2275 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0017 0.0073
Loa Loa (eye worm) patched family protein 0.0033 0.0032 0.0208
Plasmodium falciparum tubulin epsilon chain, putative 0.0384 0.0693 0.6039
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0017 0.0099
Brugia malayi protein C24B5.3 0.0033 0.0032 0.0229
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0079 0.0118 0.2181
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0079 0.0118 0.4325
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.0208
Loa Loa (eye worm) hypothetical protein 0.0471 0.0858 0.6181
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.0169 0.6193
Loa Loa (eye worm) latrophilin receptor protein 2 0.0131 0.0217 0.1547
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0008 0.0072
Plasmodium vivax acetyl-CoA synthetase, putative 0.0022 0.0012 0.0102
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0013 0.0113
Loa Loa (eye worm) tubulin alpha chain 0.0471 0.0858 0.6181
Onchocerca volvulus 0.0086 0.0132 0.138
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0006 0.0027
Brugia malayi Doublecortin family protein 0.002 0.0008 0.006
Brugia malayi latrophilin 2 splice variant baaae 0.0283 0.0504 0.3637
Plasmodium vivax SET domain protein, putative 0.0064 0.009 0.0784
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0006 0.0053
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0078 0.0116 0.097
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0088 0.0763
Loa Loa (eye worm) BEN-1 protein 0.0625 0.1148 0.8279
Brugia malayi Patched related family protein 10 0.0033 0.0032 0.0229
Loa Loa (eye worm) calpain family protein 1 0.0063 0.0089 0.0621
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0017 0.0099
Echinococcus multilocularis peroxisome assembly protein 26 0.0471 0.0858 0.0858
Giardia lamblia Beta tubulin 0.0625 0.1148 1
Schistosoma mansoni survival motor neuron protein 0.0153 0.0259 0.1136
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0012 0.0102
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0045 0.0055 0.0241
Onchocerca volvulus 0.0033 0.0032 0.0261
Toxoplasma gondii patched family protein 0.0033 0.0032 0.0277
Echinococcus granulosus calpain 0.0019 0.0005 0.0023
Echinococcus granulosus lamin 0.0056 0.0076 0.0334
Brugia malayi Tubulin alpha-2 chain 0.0471 0.0858 0.6189
Schistosoma mansoni alpha glucosidase 0.0078 0.0116 0.051
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0022 0.0012 0.0052
Echinococcus multilocularis tubulin alpha 3 chain 0.0471 0.0858 0.0858
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0005 0.0045
Onchocerca volvulus 0.0033 0.0032 0.0261
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0045 0.0055 0.0477
Trypanosoma brucei cytochrome P450, putative 0.0118 0.0192 0.1672
Echinococcus granulosus tar DNA binding protein 0.0131 0.0217 0.0952
Echinococcus granulosus zinc finger protein 0.0023 0.0013 0.0057
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0079 0.0118 0.4325
Brugia malayi NAD-dependent deacetylase SIRT1 0.0075 0.0112 0.0806
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0217 0.0952
Trypanosoma cruzi zeta tubulin, putative 0.0498 0.0909 0.7919
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0186 0.0321 0.0321
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0131 0.0217 0.1545
Brugia malayi Cytochrome P450 family protein 0.0249 0.0439 0.3168
Loa Loa (eye worm) hypothetical protein 0.0076 0.0113 0.0796
Schistosoma mansoni hypothetical protein 0.0086 0.0132 0.058
Echinococcus granulosus geminin 0.1222 0.2275 1
Toxoplasma gondii histone deacetylase SIR2 0.0075 0.0112 0.0974
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0019 0.0005 0.0045
Loa Loa (eye worm) hypothetical protein 0.0127 0.021 0.1495
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0071 0.2593
Trichomonas vaginalis tubulin epsilon chain, putative 0.0471 0.0858 0.7472
Leishmania major alpha tubulin 0.0471 0.0858 0.7472
Onchocerca volvulus 0.0202 0.0351 0.3809
Plasmodium falciparum alpha tubulin 1 0.0471 0.0858 0.7472
Echinococcus granulosus sterol regulatory element binding protein 0.0233 0.0409 0.1799
Brugia malayi Patched family protein 0.0033 0.0032 0.0229
Echinococcus granulosus neutral alpha glucosidase AB 0.0078 0.0116 0.051
Echinococcus multilocularis tubulin alpha 1C chain 0.0471 0.0858 0.0858
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.0208
Schistosoma mansoni calpain-7 (C02 family) 0.0019 0.0005 0.0023
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0511 0.0933 0.8127
Brugia malayi calpain 7 0.0019 0.0005 0.0037
Echinococcus granulosus calpain 7 C02 family 0.0019 0.0005 0.0023
Plasmodium vivax calpain, putative 0.0019 0.0005 0.0045
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0017 0.0073
Echinococcus granulosus Niemann Pick C1 protein 0.0543 0.0994 0.4371
Brugia malayi Bloom's syndrome protein homolog 0.0109 0.0176 0.1268
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0017 0.0073
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0022 0.0012 0.043
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0112 0.0974
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0038
Plasmodium falciparum acyl-CoA synthetase 0.0057 0.0077 0.0669
Leishmania major beta tubulin 0.0625 0.1148 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0012 0.0217
Loa Loa (eye worm) beta-tubulin 0.0625 0.1148 0.8279
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0012 0.0102
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0022 0.0012 0.0102
Loa Loa (eye worm) hypothetical protein 0.0052 0.0067 0.0461
Echinococcus multilocularis tar DNA binding protein 0.0131 0.0217 0.0217
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0076 0.0113 0.3868
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0086 0.0132 0.058
Schistosoma mansoni hypothetical protein 0.0086 0.0132 0.058
Echinococcus multilocularis tubulin alpha 3 chain 0.0471 0.0858 0.0858
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0024 0.021
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0131 0.0217 0.0954
Onchocerca volvulus 0.0033 0.0032 0.0261
Loa Loa (eye worm) tubulin alpha-3 chain 0.0281 0.0499 0.3585
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0047 0.0047
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0012 0.0102
Trypanosoma brucei epsilon tubulin 0.0384 0.0693 0.6039
Brugia malayi exodeoxyribonuclease III family protein 0.006 0.0083 0.0601
Brugia malayi hypothetical protein 0.002 0.0008 0.006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.028 0.0497 0.2186
Trichomonas vaginalis alpha-glucosidase, putative 0.0078 0.0116 0.101
Echinococcus multilocularis expressed conserved protein 0.051 0.0932 0.0932
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0079 0.0118 0.2181
Giardia lamblia Epsilon tubulin 0.0193 0.0334 0.2912
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0057 0.0077 0.2807
Schistosoma mansoni hypothetical protein 0.0225 0.0394 0.173
Schistosoma mansoni hypothetical protein 0.0021 0.0009 0.0038
Schistosoma mansoni zinc finger protein 0.0023 0.0013 0.0057
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0089 0.0089
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.006 0.0083 0.1536
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0057 0.2092
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.0208
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0005 0.0045
Leishmania major 4-coumarate:coa ligase-like protein 0.0076 0.0113 0.0985
Brugia malayi Patched protein homolog 1 0.0033 0.0032 0.0229
Onchocerca volvulus Huntingtin homolog 0.0127 0.021 0.2239
Loa Loa (eye worm) Smad1 0.0025 0.0017 0.0099
Echinococcus multilocularis chromatin regulatory protein sir2 0.0511 0.0933 0.0933
Loa Loa (eye worm) tubulin beta chain 0.0161 0.0274 0.1957
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0006 0.0006
Plasmodium falciparum thioredoxin reductase 0.0046 0.0057 0.0499
Brugia malayi Patched family protein 0.0033 0.0032 0.0229
Echinococcus multilocularis tubulin alpha chain 0.0471 0.0858 0.0858
Loa Loa (eye worm) hypothetical protein 0.031 0.0554 0.3983
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0047 0.0407
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0039 0.1414
Trypanosoma brucei tubulin delta chain 0.0363 0.0654 0.5695
Loa Loa (eye worm) transcriptional regulator 0.0511 0.0933 0.6724
Trypanosoma brucei epsilon tubulin 0.0351 0.0633 0.551
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0066 0.0095 0.0418
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0057 0.0499
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0079 0.0118 0.2181
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0047 0.0407
Brugia malayi CXXC zinc finger family protein 0.0058 0.008 0.0574
Schistosoma mansoni tubulin subunit beta 0.0625 0.1148 0.5045
Echinococcus granulosus Niemann Pick C1 protein 0.0776 0.1434 0.6303
Echinococcus multilocularis lamin dm0 0.0056 0.0076 0.0076
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0008 0.0008
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0045 0.0055 0.0374
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0079 0.0118 0.2181
Leishmania major alpha tubulin 0.0471 0.0858 0.7472
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0074 0.0109 0.095
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0089 0.039
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0008 0.0072
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0053
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0063 0.0089 0.0391
Loa Loa (eye worm) transcription factor SMAD2 0.0366 0.066 0.4753
Mycobacterium tuberculosis Cell division protein FtsZ 0.0161 0.0274 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0123 0.0201 0.0882
Echinococcus granulosus tubulin alpha chain 0.0471 0.0858 0.377
Leishmania major beta tubulin 0.0625 0.1148 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0471 0.0858 0.0858
Echinococcus granulosus tubulin alpha chain 0.0471 0.0858 0.377
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0027 0.0192
Schistosoma mansoni Mername-AA248 (C02 family) 0.0019 0.0005 0.0023
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.0208
Schistosoma mansoni bromodomain containing protein 0.0067 0.0095 0.042
Echinococcus multilocularis tubulin subunit TubB 0.0471 0.0858 0.0858
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.0013 0.0057
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.006 0.0083 0.0726
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0005 0.0045
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0006 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0053
Schistosoma mansoni chromatin regulatory protein sir2 0.0511 0.0933 0.41
Echinococcus multilocularis bloom syndrome protein 0.0109 0.0176 0.0176
Loa Loa (eye worm) inositol-1 0.0041 0.0047 0.0316
Echinococcus multilocularis microtubule associated protein 2 0.0717 0.1322 0.1322
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.0047 0.0364
Schistosoma mansoni hypothetical protein 0.1222 0.2275 1
Trichomonas vaginalis tubulin beta chain, putative 0.0471 0.0858 0.7472
Loa Loa (eye worm) tubulin alpha 2 0.0119 0.0195 0.1387
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0071 0.2593
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0075 0.0112 0.0112
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0088 0.1613
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0511 0.0933 0.8119
Trypanosoma cruzi epsilon tubulin, putative 0.0384 0.0693 0.6039
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0019 0.0006 0.0216
Loa Loa (eye worm) hypothetical protein 0.0751 0.1386 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0078 0.0116 0.0837
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0511 0.0933 0.8119
Trichomonas vaginalis tubulin, putative 0.0194 0.0335 0.292
Giardia lamblia Gamma tubulin 0.0384 0.0694 0.6046
Leishmania major alpha tubulin 0.0471 0.0858 0.7472
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0005 0.0045
Plasmodium vivax tubulin alpha chain, putative 0.0471 0.0858 0.7472
Echinococcus granulosus Protein patched homolog 1 0.0233 0.0409 0.1799
Onchocerca volvulus 0.019 0.0329 0.356
Brugia malayi Tubulin alpha chain 0.0471 0.0858 0.6189
Loa Loa (eye worm) hypothetical protein 0.0039 0.0043 0.0291
Echinococcus granulosus RUN 0.002 0.0008 0.0036
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.0208
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0088 0.1613
Echinococcus multilocularis Tubulin beta 2C chain 0.0625 0.1148 0.1148
Loa Loa (eye worm) tubulin alpha chain 0.0471 0.0858 0.6181
Onchocerca volvulus 0.0022 0.0012 0.0038
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0006 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0161 0.0274 0.2383
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0064 0.009 0.0396
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0008 0.0036
Plasmodium falciparum alpha tubulin 2 0.0471 0.0858 0.7472
Schistosoma mansoni transcription factor LCR-F1 0.0186 0.0321 0.1412
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.0169 0.6193
Schistosoma mansoni hypothetical protein 0.0225 0.0394 0.173
Echinococcus multilocularis neutral alpha glucosidase AB 0.0078 0.0116 0.0116
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0022 0.0012 0.0217
Trichomonas vaginalis set domain proteins, putative 0.0497 0.0908 0.791
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0006 0.0049
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.0208
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.0208
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0012 0.0063
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0076 0.0527
Brugia malayi tubulin alpha-2 chain 0.0471 0.0858 0.6189
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0045 0.0055 0.0395
Schistosoma mansoni hypothetical protein 0.0131 0.0217 0.0954
Trypanosoma brucei alpha tubulin, putative 0.019 0.0329 0.2863
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0079 0.0118 0.2181
Trichomonas vaginalis alpha-glucosidase, putative 0.0078 0.0116 0.101
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0079 0.0118 0.2181
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0019 0.0081
Leishmania major alpha glucosidase II subunit, putative 0.0078 0.0116 0.101
Brugia malayi isocitrate dehydrogenase 0.0019 0.0006 0.0041
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0045 0.0055 0.0055
Onchocerca volvulus 0.0056 0.0076 0.0751
Trichomonas vaginalis tubulin beta chain, putative 0.0471 0.0858 0.7472
Trypanosoma brucei zeta tubulin 0.0498 0.0909 0.7919
Leishmania major alpha tubulin 0.0471 0.0858 0.7472
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0079 0.0118 0.1031
Trypanosoma cruzi tubulin gamma chain 0.0384 0.0694 0.6046
Echinococcus multilocularis beta tubulin 0.0625 0.1148 0.1148
Leishmania major beta tubulin 0.0625 0.1148 1
Echinococcus granulosus alpha tubulin 0.0471 0.0858 0.377
Echinococcus granulosus smad 0.0025 0.0017 0.0073
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0022 0.0012 0.0102
Treponema pallidum cell division protein FtsZ 0.0161 0.0274 1
Mycobacterium tuberculosis Probable reductase 0.0106 0.0169 0.6193
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0009 0.0041
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0092 0.0406
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0008 0.0008
Loa Loa (eye worm) tubulin beta-2A chain 0.0625 0.1148 0.8279
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.0208
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0511 0.0933 0.8127
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0057 0.0252
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0123 0.0201 0.0201
Schistosoma mansoni DNA polymerase eta 0.0019 0.0006 0.0027
Trypanosoma cruzi beta tubulin, putative 0.0625 0.1148 1
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0079 0.0118 0.2181

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) = -0.4 g Toxicity in PS mouse allografted with mouse P388 cells assessed as change in body weight at 100 ug/kg relative to control ChEMBL. 563462
ED50 (functional) = 0.0000061 ug ml-1 Cytotoxicity against human KB cells ChEMBL. 563462
ED50 (functional) = 0.51 ug ml-1 Cytotoxicity against human KB cells ChEMBL. 7130986
IC50 (functional) = 0.03 nM Cytotoxicity against human SK-Br-3 cell line by clonogenic plating efficiency assay after 72 hrs ChEMBL. 16821799
IC50 (functional) = 0.034 nM Cytotoxicity against human KB cell line by clonogenic plating efficiency assay after 72 hrs ChEMBL. 16821799
IC50 (functional) = 0.037 nM Cytotoxicity against human A375 cell line by clonogenic plating efficiency assay after 72 hrs ChEMBL. 16821799
IC50 (functional) = 0.04 nM Cytotoxicity against human A431 cell line by clonogenic plating efficiency assay after 72 hrs ChEMBL. 16821799
IC50 (functional) = 0.044 nM Cytotoxicity against human MCF7 cell line by clonogenic plating efficiency assay after 72 hrs ChEMBL. 16821799
IC50 (ADMET) > 0.1 nM Cytotoxicity against human SW620 cell line by clonogenic plating efficiency assay after 72 hrs ChEMBL. 16821799
IC50 (functional) = 0.1 nM Cytotoxicity against human Ovcar3 cell line by clonogenic plating efficiency assay after 72 hrs ChEMBL. 16821799
IC50 (functional) = 0.16 nM Cytotoxicity against human A549 cell line by clonogenic plating efficiency assay after 72 hrs ChEMBL. 16821799
IC50 (ADMET) = 0.75 nM Cytotoxicity against human HCT15 cell line by clonogenic plating efficiency assay after 72 hrs ChEMBL. 16821799
IC50 (binding) > 200 ug ml-1 Inhibition of HIV1 RT ChEMBL. 1710653
Inhibition (binding) Inhibition of brain tubulin polymerization (unknown origin) at 37 degC by spectrophotometry ChEMBL. 563462
Log CR (functional) = 1.23 Cross resistance profile versus L1210/R71 cells. ChEMBL. 2362268
Log CR (functional) = 2.85 Effect on cross resistance of CCRF-CEM cells resistant to vincristine. ChEMBL. 2362268
logD (ADMET) = 1.99 Partition coefficient (logD7.4) ChEMBL. 2362268

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 16821799

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Targets
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 26882  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 26953  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 29919  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 25756  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 29777  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 25113  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 29099  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 28601  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 24472  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 21739  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 28044  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 21309  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 24440  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 20919  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 22594  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 23453  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 21545  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 29554  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 29031  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 23905  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 21179  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 25450  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 22205  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 27459  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 26961  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 22252  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 23996  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 23078  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 20827  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 28024  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 28324  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 26882  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 26953  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 29919  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 25756  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 29777  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 25113  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 29099  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 28601  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 24472  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 21739  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 28044  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 21309  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 24440  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 20919  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 22594  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 23453  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 21545  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 29554  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 29031  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 23905  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 21179  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 25450  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 22205  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 27459  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 26961  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 22252  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 23996  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 23078  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 20827  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 28024  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 28324  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

4 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.