Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Histone deacetylase family protein | 0.0403 | 0.1621 | 0.3882 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.1038 | 0.1791 |
Plasmodium falciparum | histone deacetylase 2 | 0.0403 | 0.1621 | 1 |
Trichomonas vaginalis | NADH-ubiquinone oxidoreductase flavoprotein, putative | 0.0669 | 0.3324 | 1 |
Echinococcus multilocularis | NADH dehydrogenase (ubiquinone) flavoprotein 1 | 0.0669 | 0.3324 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0403 | 0.1621 | 0.3882 |
Trypanosoma cruzi | NADH-ubiquinone oxidoreductase, mitochondrial, putative | 0.0669 | 0.3324 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0403 | 0.1621 | 0.3882 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0403 | 0.1621 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0411 | 0.1672 | 0.4067 |
Trichomonas vaginalis | NADH-ubiquinone oxidoreductase flavoprotein, putative | 0.0669 | 0.3324 | 1 |
Leishmania major | histone deacetylase, putative | 0.0403 | 0.1621 | 0.3882 |
Loa Loa (eye worm) | hypothetical protein | 0.0303 | 0.0987 | 0.1606 |
Trypanosoma cruzi | NADH-ubiquinone oxidoreductase, mitochondrial, putative | 0.0669 | 0.3324 | 1 |
Brugia malayi | hypothetical protein | 0.034 | 0.1222 | 0.2449 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0403 | 0.1621 | 0.3882 |
Plasmodium vivax | histone deacetylase, putative | 0.0403 | 0.1621 | 1 |
Echinococcus granulosus | NADH dehydrogenase ubiquinone flavoprotein 1 | 0.0669 | 0.3324 | 1 |
Mycobacterium tuberculosis | Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. | 0.1713 | 1 | 1 |
Schistosoma mansoni | NADH-ubiquinone oxidoreductase | 0.0669 | 0.3324 | 1 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0411 | 0.1672 | 0.4067 |
Entamoeba histolytica | histone deacetylase, putative | 0.0234 | 0.054 | 0.5 |
Brugia malayi | NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial precursor | 0.0669 | 0.3324 | 1 |
Echinococcus granulosus | histone deacetylase | 0.0403 | 0.1621 | 0.3882 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0314 | 0.1053 | 0.1844 |
Wolbachia endosymbiont of Brugia malayi | NADH dehydrogenase I subunit F | 0.0669 | 0.3324 | 1 |
Plasmodium falciparum | histone deacetylase, putative | 0.0403 | 0.1621 | 1 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0403 | 0.1621 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0403 | 0.1621 | 0.3882 |
Loa Loa (eye worm) | NADH-ubiquinone oxidoreductase 51 kDa subunit | 0.0669 | 0.3324 | 1 |
Giardia lamblia | Histone deacetylase | 0.0234 | 0.054 | 0.5 |
Trypanosoma brucei | histone deacetylase 3 | 0.0403 | 0.1621 | 0.3882 |
Mycobacterium ulcerans | NADH dehydrogenase subunit H | 0.0317 | 0.1071 | 0.1071 |
Echinococcus granulosus | histone deacetylase 6 | 0.0403 | 0.1621 | 0.3882 |
Loa Loa (eye worm) | hypothetical protein | 0.034 | 0.1222 | 0.2449 |
Echinococcus multilocularis | histone deacetylase | 0.0403 | 0.1621 | 0.3882 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0403 | 0.1621 | 0.3882 |
Treponema pallidum | nitrogen fixation protein (rnfC) | 0.0149 | 0 | 0.5 |
Mycobacterium ulcerans | proteasome PrcA | 0.1713 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase | 0.0403 | 0.1621 | 0.3882 |
Leishmania major | NADH-ubiquinone oxidoreductase, mitochondrial, putative | 0.0669 | 0.3324 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0403 | 0.1621 | 0.3882 |
Echinococcus granulosus | histone deacetylase 7 | 0.0403 | 0.1621 | 0.3882 |
Echinococcus granulosus | NADH dehydrogenase subunit 1 | 0.0317 | 0.1071 | 0.1909 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0403 | 0.1621 | 0.3882 |
Echinococcus granulosus | histone deacetylase 6 | 0.0411 | 0.1672 | 0.4067 |
Brugia malayi | hypoxia-induced factor 1 | 0.0314 | 0.1053 | 0.1844 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0403 | 0.1621 | 0.3882 |
Onchocerca volvulus | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial homolog | 0.0359 | 0.1339 | 0.5 |
Mycobacterium ulcerans | NADH dehydrogenase I subunit F | 0.0669 | 0.3324 | 0.3324 |
Trypanosoma brucei | histone deacetylase 4 | 0.0403 | 0.1621 | 0.3882 |
Schistosoma mansoni | hypothetical protein | 0.0317 | 0.1071 | 0.1909 |
Trypanosoma brucei | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial, putative | 0.0669 | 0.3324 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0403 | 0.1621 | 0.3882 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0403 | 0.1621 | 0.3882 |
Brugia malayi | Histone deacetylase family protein | 0.0403 | 0.1621 | 0.3882 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F) | 0.0669 | 0.3324 | 0.3324 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H) | 0.0317 | 0.1071 | 0.1071 |
Trypanosoma brucei | histone deacetylase, putative | 0.0403 | 0.1621 | 0.3882 |
Leishmania major | histone deacetylase, putative | 0.0403 | 0.1621 | 0.3882 |
Trypanosoma brucei | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | 0.0669 | 0.3324 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.