Detailed information for compound 869227

Basic information

Technical information
  • TDR Targets ID: 869227
  • Name: N-(2-methoxyphenyl)-3-[(3-oxo-4H-1,4-benzothi azin-6-yl)sulfonyl]propanamide
  • MW: 406.476 | Formula: C18H18N2O5S2
  • H donors: 2 H acceptors: 4 LogP: 1.43 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1NC(=O)CCS(=O)(=O)c1ccc2c(c1)NC(=O)CS2
  • InChi: 1S/C18H18N2O5S2/c1-25-15-5-3-2-4-13(15)19-17(21)8-9-27(23,24)12-6-7-16-14(10-12)20-18(22)11-26-16/h2-7,10H,8-9,11H2,1H3,(H,19,21)(H,20,22)
  • InChiKey: OKLKBMCTAQTCIU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[(3-keto-4H-1,4-benzothiazin-6-yl)sulfonyl]-N-(2-methoxyphenyl)propionamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus fibrillin 2 0.0061 0.0107 0.0099
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0026 0.0028 0.055
Schistosoma mansoni hypothetical protein 0.0022 0.0019 0.0011
Onchocerca volvulus 0.0061 0.0107 0.2419
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0196 0.0415 0.0662
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.002 0.0013 0.0196
Plasmodium vivax subtilisin-like protease 1 0.0196 0.0415 1
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0047 0.0075 0.0066
Echinococcus multilocularis tissue type plasminogen activator 0.0018 0.0009 0.0001
Toxoplasma gondii subtilisin SUB5 0.0196 0.0415 1
Brugia malayi amine oxidase, flavin-containing family protein 0.0019 0.0012 0.0003
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1085 0.2437 0.3974
Loa Loa (eye worm) hypothetical protein 0.0041 0.0062 0.0055
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0196 0.0415 0.0408
Trichomonas vaginalis conserved hypothetical protein 0.0889 0.199 0.3242
Echinococcus multilocularis 0.352 0.7978 1
Onchocerca volvulus 0.0022 0.0019 0.0261
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0021 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0889 0.199 0.3242
Brugia malayi angiogenesis inhibito 0.0053 0.0089 0.008
Echinococcus granulosus integrin alpha ps 0.0138 0.0282 0.0274
Onchocerca volvulus 0.0043 0.0066 0.141
Loa Loa (eye worm) endoprotease bli-4 0.4408 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0889 0.199 0.3242
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0061 0.0107 0.0157
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0196 0.0415 0.0408
Giardia lamblia High cysteine protein 0.0061 0.0107 0.0264
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0196 0.0415 1
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.02 0.0424 1
Toxoplasma gondii subtilisin SUB8 0.0196 0.0415 1
Mycobacterium leprae Polyketide synthase Pks13 0.0037 0.0052 0.1142
Loa Loa (eye worm) hypothetical protein 0.0025 0.0025 0.0017
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0028 0.0668
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0196 0.0415 0.0408
Brugia malayi EGF-like domain containing protein 0.0061 0.0107 0.0098
Toxoplasma gondii type I fatty acid synthase, putative 0.0018 0.0008 0.0086
Brugia malayi Protein kinase domain containing protein 0.0022 0.0019 0.0011
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0196 0.0415 0.0662
Loa Loa (eye worm) metalloprotease 0.0025 0.0025 0.0017
Loa Loa (eye worm) fatty acid synthase 0.0024 0.0023 0.0016
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1085 0.2437 0.3974
Toxoplasma gondii subtilisin SUB6 0.0196 0.0415 1
Trichomonas vaginalis conserved hypothetical protein 0.0196 0.0415 0.0662
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.02 0.0424 1
Onchocerca volvulus 0.0072 0.0133 0.3053
Giardia lamblia Tenascin precursor 0.0061 0.0107 0.0264
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0196 0.0415 0.0662
Loa Loa (eye worm) hypothetical protein 0.0067 0.012 0.0112
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2702 0.6116 1
Echinococcus granulosus neuroendocrine convertase 2 0.2792 0.6321 0.6318
Echinococcus granulosus membrane bound transcription factor site 1 0.0196 0.0415 0.0408
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0196 0.0415 0.0662
Toxoplasma gondii subtilisin SUB12 0.0196 0.0415 1
Schistosoma mansoni furin-1 (S08 family) 0.1903 0.4298 0.4294
Loa Loa (eye worm) hypothetical protein 0.0196 0.0415 0.0408
Trichomonas vaginalis conserved hypothetical protein 0.0889 0.199 0.3242
Brugia malayi EGF-like domain containing protein 0.0061 0.0107 0.0098
Echinococcus multilocularis integrin alpha ps 0.0066 0.0118 0.0139
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0196 0.0415 1
Echinococcus granulosus fibrillin 1 0.0063 0.011 0.0103
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0011 0.006
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0889 0.199 0.3242
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0011 0.0004
Brugia malayi ADAMTS-like protease 0.0053 0.0089 0.008
Toxoplasma gondii type I fatty acid synthase, putative 0.0026 0.0028 0.0566
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0067 0.012 0.0112
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0196 0.0415 0.0662
Mycobacterium ulcerans polyketide synthase 0.0026 0.0028 0.055
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0026 0.0028 0.055
Loa Loa (eye worm) reprolysin 0.0091 0.0174 0.0167
Loa Loa (eye worm) hypothetical protein 0.0067 0.012 0.0112
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0011 0.006
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0196 0.0415 0.0662
Schistosoma mansoni site-1 peptidase (S08 family) 0.0196 0.0415 0.0408
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0028 0.055
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0025 0.0024 0.0584
Brugia malayi Reprolysin 0.0053 0.0089 0.008
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0025 0.0024 0.0584
Toxoplasma gondii hypothetical protein 0.0061 0.0107 0.2493
Loa Loa (eye worm) hypothetical protein 0.0053 0.0089 0.0081
Loa Loa (eye worm) hypothetical protein 0.1707 0.3852 0.3847
Loa Loa (eye worm) hypothetical protein 0.0072 0.0131 0.0124
Loa Loa (eye worm) hypothetical protein 0.0241 0.0518 0.051
Plasmodium falciparum subtilisin-like protease 1 0.0196 0.0415 1
Schistosoma mansoni serine/threonine protein kinase 0.0232 0.0496 0.0489
Trichomonas vaginalis conserved hypothetical protein 0.0889 0.199 0.3242
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0024 0.0464
Brugia malayi Stress-activated protein kinase jnk-1 0.0232 0.0496 0.0488
Trichomonas vaginalis conserved hypothetical protein 0.0196 0.0415 0.0662
Brugia malayi metalloprotease 0.0025 0.0025 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0889 0.199 0.3242
Toxoplasma gondii subtilisin SUB2 0.0196 0.0415 1
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.2702 0.6116 0.6113
Echinococcus granulosus tissue type plasminogen activator 0.0018 0.0009 0.0001
Brugia malayi EGF-like domain containing protein 0.0061 0.0107 0.0098
Schistosoma mansoni integrin alpha 0.0308 0.0668 0.0661
Loa Loa (eye worm) hypothetical protein 0.0577 0.1281 0.1274
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0021 0.0013
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0196 0.0415 0.0662
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.2702 0.6116 0.7665
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0196 0.0415 0.0662
Echinococcus granulosus epidermal growth factor receptor 0.0287 0.062 0.0613
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0091 0.0174 0.0167
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0011 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0196 0.0415 0.0662
Plasmodium vivax subtilisin-like serine protease, putative 0.0196 0.0415 1
Toxoplasma gondii subtilisin SUB10 0.0196 0.0415 1
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.4408 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0889 0.199 0.3242
Giardia lamblia hypothetical protein 0.0061 0.0107 0.0264
Giardia lamblia Neurogenic locus Notch protein precursor 0.0061 0.0107 0.0264
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0225 0.0481 0.0474
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0232 0.0496 0.0613
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0011
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0011 0.014
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0025 0.0024 0.0016
Echinococcus multilocularis integrin beta 2 0.2751 0.6228 0.7804
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0037 0.0052 0.1254
Brugia malayi SWIRM domain containing protein 0.0072 0.0133 0.0124
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.002 0.0014 0.0337
Echinococcus multilocularis disintegrin and metalloproteinase 0.0038 0.0054 0.0058
Schistosoma mansoni hypothetical protein 0.0066 0.0118 0.0111
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0011 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0196 0.0415 0.0662
Mycobacterium ulcerans polyketide synthase Pks13 0.0037 0.0052 0.1142
Brugia malayi celfurPC protein 0.352 0.7978 0.7976
Giardia lamblia Furin precursor putative serine protease 0.0889 0.199 0.5444
Loa Loa (eye worm) proprotein convertase 2 0.1085 0.2437 0.2431
Brugia malayi proprotein convertase 2 0.2792 0.6321 0.6318
Onchocerca volvulus Fatty acid synthase homolog 0.0044 0.0069 0.1496
Echinococcus multilocularis integrin alpha 3 0.0236 0.0505 0.0623
Schistosoma mansoni site-1 peptidase (S08 family) 0.0196 0.0415 0.0408
Trichomonas vaginalis conserved hypothetical protein 0.0196 0.0415 0.0662
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0196 0.0415 1
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0196 0.0415 1
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0196 0.0415 0.0407
Echinococcus granulosus integrin alpha 3 0.0236 0.0505 0.0497
Giardia lamblia Neurogenic locus notch-like protein 0.0061 0.0107 0.0264
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0196 0.0415 0.0662
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.002 0.0013 0.0196
Loa Loa (eye worm) subtilase 0.0196 0.0415 0.0408
Schistosoma mansoni dihydroceramide desaturase 0.0038 0.0054 0.0046
Giardia lamblia Tenascin-37 0.0061 0.0107 0.0264
Echinococcus granulosus disintegrin and metalloproteinase 0.0038 0.0054 0.0046
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0196 0.0415 0.0662
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0021 0.0015 0.0236
Loa Loa (eye worm) TK/ALK protein kinase 0.0022 0.0019 0.0011
Brugia malayi Furin-like cysteine rich region family protein 0.0287 0.062 0.0612
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1085 0.2437 0.3974
Loa Loa (eye worm) hypothetical protein 0.0061 0.0107 0.0099
Loa Loa (eye worm) hypothetical protein 0.4408 1 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0011
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0011 0.0003
Brugia malayi Disintegrin family protein 0.0038 0.0054 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0889 0.199 0.3242
Mycobacterium tuberculosis Probable thioesterase TesA 0.0021 0.0015 0.0358
Trichomonas vaginalis conserved hypothetical protein 0.0889 0.199 0.3242
Brugia malayi hypothetical protein 0.0022 0.0019 0.0011
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0196 0.0415 0.0662
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0196 0.0415 0.0662
Giardia lamblia High cysteine membrane protein Group 2 0.1617 0.3647 1
Mycobacterium ulcerans thioesterase 0.0021 0.0015 0.0236
Loa Loa (eye worm) hypothetical protein 0.0061 0.0107 0.0099
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0233 0.0497 0.0489
Schistosoma mansoni integrin alpha-ps 0.0072 0.0131 0.0124
Toxoplasma gondii subtilisin SUB7 0.0196 0.0415 1
Echinococcus multilocularis Furin 1 0.1085 0.2437 0.3048
Echinococcus multilocularis protein jagged 2 0.0061 0.0107 0.0124
Loa Loa (eye worm) TK/EGFR protein kinase 0.0287 0.062 0.0613
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0024 0.0464
Schistosoma mansoni integrin beta subunit 0.2174 0.4915 0.4911
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0011 0.006
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0196 0.0415 0.0662
Loa Loa (eye worm) TK/ROR protein kinase 0.0018 0.0009 0.0001
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0889 0.199 0.3242
Schistosoma mansoni hypothetical protein 0.0018 0.0009 0.0001
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0024 0.0464
Loa Loa (eye worm) hypothetical protein 0.017 0.0354 0.0347
Loa Loa (eye worm) hypothetical protein 0.0066 0.0118 0.0111
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0018 0.0008 0.0203
Brugia malayi Integrin beta pat-3 precursor 0.3735 0.8467 0.8466
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0011 0.0059
Loa Loa (eye worm) hypothetical protein 0.0038 0.0054 0.0046
Echinococcus granulosus adam 17 protease 0.0038 0.0054 0.0046
Echinococcus granulosus furin 0.4408 1 1
Brugia malayi neuroendocrine convertase 1 precursor 0.2792 0.6321 0.6318
Toxoplasma gondii subtilisin SUB1 0.0196 0.0415 1
Plasmodium falciparum subtilisin-like protease 2 0.0196 0.0415 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0196 0.0415 0.0662
Echinococcus multilocularis epidermal growth factor receptor 0.0287 0.062 0.0768
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0011
Echinococcus granulosus adam 0.018 0.0377 0.0369
Trichomonas vaginalis conserved hypothetical protein 0.0889 0.199 0.3242
Toxoplasma gondii subtilisin SUB4 0.0196 0.0415 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1085 0.2437 0.3974
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0025 0.0024 0.0464
Trichomonas vaginalis conserved hypothetical protein 0.0889 0.199 0.3242
Toxoplasma gondii kringle domain-containing protein 0.0018 0.0009 0.0098
Loa Loa (eye worm) integrin alpha pat-2 0.0474 0.1047 0.104
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.0021 0.0495
Leishmania major subtilisin-like serine peptidase 0.0196 0.0415 1
Brugia malayi Kelch motif family protein 0.0581 0.1289 0.1282
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0196 0.0415 0.0511
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0196 0.0415 0.9787
Loa Loa (eye worm) hypothetical protein 0.0053 0.0089 0.0081
Brugia malayi hypothetical protein 0.0119 0.0238 0.023
Echinococcus multilocularis MAM 0.0022 0.0019 0.0014
Brugia malayi EGF-like domain containing protein 0.0061 0.0107 0.0098
Brugia malayi ADAM-TS Spacer 1 family protein 0.0053 0.0089 0.008
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0232 0.0496 0.0489
Plasmodium falciparum subtilisin-like protease 3 0.0196 0.0415 1
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0038 0.0054 0.0046
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.0015
Onchocerca volvulus 0.006 0.0105 0.2376
Schistosoma mansoni ADAMTS14 peptidase (M12 family) 0.0025 0.0025 0.0017
Echinococcus multilocularis integrin alpha ps 0.0138 0.0282 0.0344
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2702 0.6116 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0196 0.0415 0.0662
Loa Loa (eye worm) hypothetical protein 0.0233 0.0497 0.049
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0196 0.0415 0.0407
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0196 0.0415 1
Schistosoma mansoni hypothetical protein 0.0022 0.0019 0.0011
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0024 0.0584
Echinococcus granulosus Furin 1 0.1085 0.2437 0.2431
Echinococcus granulosus c-Jun N-terminal kinases 0.0232 0.0496 0.0489
Mycobacterium ulcerans thioesterase TesA 0.0021 0.0015 0.0236
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1085 0.2437 0.3974
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.002 0.0013 0.0196
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0028 0.055
Loa Loa (eye worm) hypothetical protein 0.0028 0.0032 0.0024
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0011 0.0059
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0011 0.0003
Echinococcus granulosus integrin alpha ps 0.0066 0.0118 0.0111
Loa Loa (eye worm) hypothetical protein 0.0061 0.0107 0.0099
Echinococcus multilocularis integrin alpha ps 0.0138 0.0282 0.0344
Loa Loa (eye worm) hypothetical protein 0.0061 0.0107 0.0099
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0196 0.0415 0.0662
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0024 0.0023 0.0543
Echinococcus multilocularis fibrillin 2 0.0061 0.0107 0.0124
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0119 0.0238 0.0231
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0026 0.0028 0.0668
Mycobacterium ulcerans polyketide synthase 0.0025 0.0024 0.0464
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0196 0.0415 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0133 0.0125
Toxoplasma gondii subtilisin SUB11 0.0196 0.0415 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0196 0.0415 0.0662
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0024 0.0023 0.0543
Onchocerca volvulus 0.0196 0.0415 1
Brugia malayi Subtilase family protein 0.0196 0.0415 0.0407
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.124 0.279 0.2785
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0011 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0196 0.0415 0.0662
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0038 0.0054 0.0058
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0889 0.199 0.3242
Trichomonas vaginalis conserved hypothetical protein 0.0196 0.0415 0.0662
Echinococcus granulosus neuropeptides capa receptor 0.022 0.0469 0.0461
Echinococcus multilocularis neuropeptides capa receptor 0.022 0.0469 0.0578
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.02 0.0424 1
Echinococcus multilocularis neuroendocrine convertase 2 0.2792 0.6321 0.7921
Trichomonas vaginalis hypothetical protein 0.0889 0.199 0.3242
Brugia malayi hypothetical protein 0.0577 0.1281 0.1273
Echinococcus granulosus MAM 0.0022 0.0019 0.0011
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0196 0.0415 1
Onchocerca volvulus 0.0022 0.0019 0.0261
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0067 0.012 0.0141
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0024 0.0464
Echinococcus multilocularis membrane bound transcription factor site 1 0.0196 0.0415 0.0511
Trypanosoma brucei subtilisin peptidase 0.0196 0.0415 0.9786
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0004
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0581 0.1289 0.1283
Toxoplasma gondii subtilisin SUB9 0.0196 0.0415 1
Loa Loa (eye worm) angiogenesis inhibito 0.0025 0.0025 0.0017
Giardia lamblia High cysteine protein 0.0061 0.0107 0.0264
Plasmodium vivax subtilisin-like protease 2, putative 0.0196 0.0415 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0011 0.5
Schistosoma mansoni ap endonuclease 0.0019 0.0011 0.0003
Mycobacterium leprae Probable polyketide synthase Pks1 0.0026 0.0028 0.055
Schistosoma mansoni ap endonuclease 0.0019 0.0011 0.0003
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0196 0.0415 0.0662
Schistosoma mansoni hypothetical protein 0.0889 0.199 0.1984
Mycobacterium leprae Possible secreted protease 0.0196 0.0415 1
Brugia malayi Integrin alpha pat-2 precursor 0.0308 0.0668 0.066
Trypanosoma cruzi subtilisin peptidase 0.0196 0.0415 0.9787
Schistosoma mansoni tyrosine kinase 0.0287 0.062 0.0613
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0196 0.0415 0.0662
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0091 0.0174 0.0167
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0011 0.0264
Echinococcus multilocularis adam 0.018 0.0377 0.0463
Echinococcus multilocularis fibrillin 1 0.0076 0.0141 0.0167
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0091 0.0174 0.0167
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.1085 0.2437 0.2431
Giardia lamblia Tenascin-X 0.0061 0.0107 0.0264
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0196 0.0415 0.0662
Schistosoma mansoni integrin alpha-ps 0.0138 0.0282 0.0274
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0196 0.0415 1
Giardia lamblia Tenascin-like 0.0061 0.0107 0.0264
Onchocerca volvulus 0.0023 0.0021 0.0296
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0196 0.0415 0.0662
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0025 0.0024 0.0464
Echinococcus granulosus lysine specific histone demethylase 1A 0.0067 0.012 0.0112
Trichomonas vaginalis conserved hypothetical protein 0.0196 0.0415 0.0662
Loa Loa (eye worm) integrin beta-2 0.3735 0.8467 0.8466
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1085 0.2437 0.3974
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0091 0.0174 0.0209
Loa Loa (eye worm) hypothetical protein 0.0091 0.0174 0.0167
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0037 0.0052 0.1254
Toxoplasma gondii exonuclease III APE 0.0019 0.0011 0.0157
Echinococcus granulosus integrin beta 2 0.2751 0.6228 0.6225
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0196 0.0415 1
Trichomonas vaginalis hypothetical protein 0.0061 0.0107 0.0157
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0026 0.0028 0.0668

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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