Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0256 | 0.0919 | 1 |
Mycobacterium ulcerans | pantoate--beta-alanine ligase | 0.2436 | 1 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0717 | 0.2839 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0314 | 0.116 | 1 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.079 | 0.3146 | 1 |
Onchocerca volvulus | 0.0047 | 0.005 | 0.5 | |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0148 | 0.0472 | 0.3871 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.005 | 0.0175 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0314 | 0.116 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.005 | 0.0175 |
Schistosoma mansoni | hypothetical protein | 0.019 | 0.0646 | 0.2276 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0717 | 0.2839 | 0.9023 |
Brugia malayi | hypothetical protein | 0.023 | 0.0814 | 0.8857 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0 | 0.5 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0314 | 0.116 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.023 | 0.0814 | 0.2587 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.019 | 0.0646 | 0.2054 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0717 | 0.2839 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0256 | 0.0919 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0054 | 0.0078 | 0.0358 |
Schistosoma mansoni | hypothetical protein | 0.019 | 0.0646 | 0.2276 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.005 | 0.0541 |
Mycobacterium tuberculosis | Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | 0.2436 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0314 | 0.116 | 1 |
Toxoplasma gondii | pantoate-beta-alanine ligase | 0.2436 | 1 | 1 |
Echinococcus granulosus | geminin | 0.019 | 0.0646 | 0.2276 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0148 | 0.0472 | 0.3871 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.023 | 0.0814 | 0.2867 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0256 | 0.0919 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.04 mg kg-1 | In vivo antihistaminic activity after 1 hour of subcutaneous administration using 48/80 lethality test in rat. | ChEMBL. | 3934387 |
ED50 (functional) | = 0.31 mg kg-1 | In vivo antihistaminic activity after 2 hours of oral administration using 48/80 lethality test in rat . | ChEMBL. | 3934387 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.