TDR Targets

Basic information

Technical information

TDR Targets ID: 869467
Name: [2-(4-fluorophenyl)imidazo[2,1-b][1,3]benzoth iazol-6-yl]-[4-(4-fluorophenyl)piperazin-1-yl ]methanone
MW: 474.525 | Formula: C26H20F2N4OS
H donors: 0 H acceptors: 2 LogP: 6.2 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(cc1)N1CCN(CC1)C(=O)c1ccc2c(c1)sc1n2cc(n1)c1ccc(cc1)F
InChi: 1S/C26H20F2N4OS/c27-19-4-1-17(2-5-19)22-16-32-23-10-3-18(15-24(23)34-26(32)29-22)25(33)31-13-11-30(12-14-31)21-8-6-20(28)7-9-21/h1-10,15-16H,11-14H2
InChiKey: BYIDRAIKSVXTHF-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

[2-(4-fluorophenyl)-6-imidazo[2,1-b][1,3]benzothiazolyl]-[4-(4-fluorophenyl)-1-piperazinyl]methanone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0088	0.013	0.0254
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0922	0.5133	1
Trypanosoma cruzi	subtilisin peptidase	0.0088	0.013	0.5
Mycobacterium leprae	Possible secreted protease	0.0088	0.013	0.5
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.056	0.2963	0.5772
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0088	0.013	0.0254
Trichomonas vaginalis	conserved hypothetical protein	0.04	0.2	0.3897
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.056	0.2963	0.5772
Echinococcus multilocularis	Mastin	0.0075	0.005	0.0064
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0088	0.013	0.0254
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.056	0.2963	0.5772
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.016	0.0562	0.0562
Echinococcus multilocularis	glycoprotein Antigen 5	0.0075	0.005	0.0064
Toxoplasma gondii	subtilisin SUB8	0.0088	0.013	0.5
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0088	0.013	0.0254
Schistosoma mansoni	furin-1 (S08 family)	0.0899	0.4997	0.4997
Echinococcus multilocularis		0.1333	0.76	0.9706
Schistosoma mansoni	tyrosine kinase	0.0308	0.1448	0.1448
Mycobacterium ulcerans	membrane-anchored serine protease (mycosin), MycP4	0.0088	0.013	0.5
Mycobacterium leprae	PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5)	0.0088	0.013	0.5
Onchocerca volvulus		0.0326	0.1555	0.9973
Echinococcus granulosus	Mastin	0.0075	0.005	0.005
Giardia lamblia	Furin precursor putative serine protease	0.0472	0.2432	1
Trichomonas vaginalis	conserved hypothetical protein	0.04	0.2	0.3897
Toxoplasma gondii	subtilisin SUB6	0.0088	0.013	0.5
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0088	0.013	0.0254
Echinococcus granulosus	enteropeptidase	0.0075	0.005	0.005
Trichomonas vaginalis	conserved hypothetical protein	0.04	0.2	0.3897
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0088	0.013	0.0254
Onchocerca volvulus		0.0088	0.013	0.0836
Plasmodium vivax	subtilisin-like protease 1	0.0088	0.013	0.5
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0088	0.013	0.0254
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4)	0.0088	0.013	0.5
Echinococcus granulosus	Furin 1	0.056	0.2963	0.2963
Onchocerca volvulus		0.0072	0.0033	0.021
Trichomonas vaginalis	hypothetical protein	0.04	0.2	0.3897
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.013	0.0254
Brugia malayi	celfurPC protein	0.1333	0.76	0.76
Plasmodium vivax	subtilisin-like serine protease, putative	0.0088	0.013	0.5
Schistosoma mansoni	tripeptidyl-peptidase II (S08 family)	0.0088	0.013	0.013
Echinococcus granulosus	peptidase s8 s53 subtilisin kexin sedolisin	0.0088	0.013	0.013
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0088	0.013	0.0254
Loa Loa (eye worm)	hypothetical protein	0.1733	1	1
Echinococcus granulosus	rho-associated protein kinase 1	0.0326	0.156	0.156
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.1733	1	1
Echinococcus granulosus	neuroendocrine convertase 2	0.1371	0.783	0.783
Echinococcus multilocularis	rho associated protein kinase	0.0326	0.156	0.1992
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.056	0.2963	0.5772
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0088	0.013	0.013
Plasmodium falciparum	subtilisin-like protease 1	0.0088	0.013	0.5
Trypanosoma cruzi	serine peptidase, clan SB, family S8-like protein	0.0088	0.013	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.04	0.2	0.3897
Toxoplasma gondii	subtilisin SUB2	0.0088	0.013	0.5
Echinococcus granulosus	membrane bound transcription factor site 1	0.0088	0.013	0.013
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.0032	0.0063
Brugia malayi	Integrin beta pat-3 precursor	0.0304	0.1425	0.1425
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.056	0.2963	0.5772
Toxoplasma gondii	subtilisin SUB12	0.0088	0.013	0.5
Echinococcus granulosus	integrin beta 2	0.0225	0.0952	0.0952
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0088	0.013	0.0254
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0075	0.005	0.005
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3)	0.0088	0.013	0.5
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.056	0.2963	0.2963
Loa Loa (eye worm)	proprotein convertase 2	0.056	0.2963	0.2963
Trypanosoma brucei	subtilisin peptidase	0.0088	0.013	0.5
Mycobacterium tuberculosis	Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5)	0.0088	0.013	0.5
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0088	0.013	0.0254
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.013	0.0254
Echinococcus multilocularis	neuroendocrine convertase 2	0.1371	0.783	1
Trichomonas vaginalis	conserved hypothetical protein	0.04	0.2	0.3897
Toxoplasma gondii	subtilisin SUB7	0.0088	0.013	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.04	0.2	0.3897
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.056	0.2963	0.5772
Toxoplasma gondii	subtilisin SUB5	0.0088	0.013	0.5
Trichomonas vaginalis	proprotein convertase subtilisin/kexin type, putative	0.0472	0.2432	0.4739
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0088	0.013	0.0254
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0088	0.013	0.0254
Brugia malayi	neuroendocrine convertase 1 precursor	0.1648	0.949	0.949
Plasmodium falciparum	subtilisin-like protease 2	0.0088	0.013	0.5
Onchocerca volvulus		0.0326	0.156	1
Trichomonas vaginalis	leucine-rich repeat protein, BspA family	0.04	0.2	0.3897
Schistosoma mansoni	hypothetical protein	0.04	0.2	0.2
Echinococcus granulosus	furin	0.1733	1	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0922	0.5133	1
Echinococcus multilocularis	integrin beta 2	0.0225	0.0952	0.1216
Echinococcus multilocularis	enteropeptidase	0.0075	0.005	0.0064
Brugia malayi	Subtilase family protein	0.0088	0.013	0.013
Leishmania major	subtilisin-like serine peptidase	0.0088	0.013	0.5
Plasmodium falciparum	subtilisin-like protease 3	0.0088	0.013	0.5
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0088	0.013	0.0254
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.016	0.0562	0.1096
Toxoplasma gondii	subtilisin SUB10	0.0088	0.013	0.5
Echinococcus multilocularis	membrane bound transcription factor site 1	0.0088	0.013	0.0166
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0308	0.1448	0.1448
Echinococcus granulosus	glycoprotein Antigen 5	0.0075	0.005	0.005
Trichomonas vaginalis	conserved hypothetical protein	0.04	0.2	0.3897
Trichomonas vaginalis	conserved hypothetical protein	0.04	0.2	0.3897
Brugia malayi	Protein kinase domain containing protein	0.1014	0.5688	0.5688
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0088	0.013	0.0254
Toxoplasma gondii	subtilisin SUB1	0.0088	0.013	0.5
Toxoplasma gondii	subtilisin SUB9	0.0088	0.013	0.5
Trichomonas vaginalis	neuroendocrine convertase 2 precursor, putative	0.0472	0.2432	0.4739
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0088	0.013	0.0254
Echinococcus multilocularis	epidermal growth factor receptor	0.0308	0.1448	0.1849
Trichomonas vaginalis	conserved hypothetical protein	0.04	0.2	0.3897
Loa Loa (eye worm)	AGC/DMPK/ROCK protein kinase	0.1014	0.5688	0.5688
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0088	0.013	0.0254
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.013	0.0254
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0088	0.013	0.0254
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0088	0.013	0.0254
Toxoplasma gondii	subtilisin SUB4	0.0088	0.013	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.04	0.2	0.3897
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0088	0.013	0.0254
Brugia malayi	Membrane-bound transcription factor site-1 protease precursor	0.0088	0.013	0.013
Echinococcus multilocularis	Peptidase S8 S53, subtilisin kexin sedolisin	0.0088	0.013	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0088	0.013	0.013
Loa Loa (eye worm)	endoprotease bli-4	0.1733	1	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0088	0.013	0.0254
Echinococcus multilocularis	Furin 1	0.056	0.2963	0.3784
Schistosoma mansoni	serine/threonine protein kinase	0.0326	0.156	0.156
Brugia malayi	proprotein convertase 2	0.1371	0.783	0.783
Mycobacterium ulcerans	membrane-anchored mycosin MycP3	0.0088	0.013	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.04	0.2	0.3897
Loa Loa (eye worm)	subtilase	0.0088	0.013	0.013
Mycobacterium leprae	PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3)	0.0088	0.013	0.5
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0088	0.013	0.0254
Echinococcus granulosus	epidermal growth factor receptor	0.0308	0.1448	0.1448
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0088	0.013	0.0254
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.0922	0.5133	0.5133
Mycobacterium ulcerans	proline rich membrane-anchored mycosin MycP5	0.0088	0.013	0.5
Trypanosoma brucei	serine peptidase, clan SB, family S8-like protein	0.0088	0.013	0.5
Loa Loa (eye worm)	hypothetical protein	0.0883	0.4899	0.4899
Toxoplasma gondii	subtilisin SUB11	0.0088	0.013	0.5
Brugia malayi	Furin-like cysteine rich region family protein	0.0308	0.1448	0.1448
Loa Loa (eye worm)	integrin beta-2	0.0304	0.1425	0.1425
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0088	0.013	0.013
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.0922	0.5133	0.6556
Brugia malayi	Hypothetical subtilase-type proteinase F21H12.6 in chromosome II	0.0088	0.013	0.013
Loa Loa (eye worm)	hypothetical protein	0.0349	0.1693	0.1693
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0088	0.013	0.0254
Plasmodium vivax	subtilisin-like protease 2, putative	0.0088	0.013	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.013	0.0254
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0088	0.013	0.5
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0088	0.013	0.5
Schistosoma mansoni	integrin beta subunit	0.0179	0.0675	0.0675
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.013	0.0254
Mycobacterium tuberculosis	Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like)	0.0088	0.013	0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 869467