TDR Targets

Basic information

Technical information

TDR Targets ID: 869553
Name: 2-(4-ethoxyphenyl)-N-(pyridin-2-ylmethyl)imid azo[2,1-b][1,3]benzothiazole-6-carboxamide
MW: 428.506 | Formula: C24H20N4O2S
H donors: 1 H acceptors: 3 LogP: 5.03 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccc(cc1)c1cn2c(n1)sc1c2ccc(c1)C(=O)NCc1ccccn1
InChi: 1S/C24H20N4O2S/c1-2-30-19-9-6-16(7-10-19)20-15-28-21-11-8-17(13-22(21)31-24(28)27-20)23(29)26-14-18-5-3-4-12-25-18/h3-13,15H,2,14H2,1H3,(H,26,29)
InChiKey: UUFMGTWJERAATC-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

2-(4-ethoxyphenyl)-N-(2-pyridylmethyl)imidazo[2,1-b][1,3]benzothiazole-6-carboxamide
2-(4-ethoxyphenyl)-N-(2-pyridylmethyl)-6-imidazo[2,1-b][1,3]benzothiazolecarboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	para nitrobenzyl esterase	0.0045	0.1427	0.1427
Loa Loa (eye worm)	carboxylesterase	0.0045	0.1427	0.1427
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0045	0.1427	0.2758
Echinococcus granulosus	flap endonuclease 1	0.0026	0.0695	0.0695
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0433	0.102
Mycobacterium ulcerans	carboxylesterase, LipT	0.0045	0.1427	1
Plasmodium falciparum	glutathione reductase	0.0047	0.1519	1
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0433	0.0433
Loa Loa (eye worm)	flap endonuclease-1	0.0026	0.0695	0.0695
Loa Loa (eye worm)	hypothetical protein	0.0045	0.1427	0.1427
Echinococcus granulosus	acetylcholinesterase	0.0264	1	1
Echinococcus multilocularis	carboxylesterase 5A	0.0264	1	1
Loa Loa (eye worm)	thioredoxin reductase	0.0047	0.1519	0.1519
Echinococcus granulosus	dna polymerase eta	0.0019	0.0433	0.0433
Loa Loa (eye worm)	carboxylesterase	0.0264	1	1
Echinococcus multilocularis	dna polymerase eta	0.0019	0.0433	0.0433
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0045	0.1427	0.1427
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0016	0.032	0.0906
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0433	0.1763
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0019	0.0433	0.0943
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0433	0.0433
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0045	0.1427	0.1427
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0016	0.032	0.0906
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0016	0.032	0.032
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0433	0.1763
Echinococcus multilocularis	flap endonuclease 1	0.0026	0.0695	0.0695
Echinococcus granulosus	neuroligin	0.0045	0.1427	0.1427
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0045	0.1427	0.2758
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0047	0.1519	0.1519
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0433	0.0433
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.032	0.5
Toxoplasma gondii	thioredoxin reductase	0.0047	0.1519	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0433	0.1763
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0026	0.0695	0.3125
Trypanosoma brucei	unspecified product	0.0019	0.0433	0.1763
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0045	0.1427	0.1427
Echinococcus granulosus	BC026374 protein S09 family	0.0045	0.1427	0.1427
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0045	0.1427	0.1427
Loa Loa (eye worm)	acetylcholinesterase 1	0.0264	1	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0118	0.4315	0.4315
Echinococcus multilocularis	acetylcholinesterase	0.0264	1	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0045	0.1427	0.1427
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0012	0.0151	0.0151
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0026	0.0695	0.3125
Loa Loa (eye worm)	hypothetical protein	0.0045	0.1427	0.1427
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0016	0.032	0.032
Echinococcus multilocularis	neuroligin	0.0045	0.1427	0.1427
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.032	0.5
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0045	0.1427	1
Treponema pallidum	NADH oxidase	0.0016	0.032	0.5
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0433	0.102
Onchocerca volvulus		0.015	0.5546	1
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0119	0.4335	1
Trichomonas vaginalis	flap endonuclease-1, putative	0.0026	0.0695	0.3382
Brugia malayi	Flap endonuclease-1	0.0026	0.0695	0.0695
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0107	0.3868	0.8837
Mycobacterium tuberculosis	Probable dehydrogenase	0.0107	0.3868	0.8837
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0045	0.1427	0.1427
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0433	0.1763
Loa Loa (eye worm)	hypothetical protein	0.0045	0.1427	0.1427
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0433	0.0943
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0433	0.1763
Plasmodium vivax	flap endonuclease 1, putative	0.0026	0.0695	0.3125
Loa Loa (eye worm)	MH2 domain-containing protein	0.0118	0.4315	0.4315
Trichomonas vaginalis	DNA polymerase eta, putative	0.0019	0.0433	0.102
Brugia malayi	hypothetical protein	0.015	0.5546	0.5546
Loa Loa (eye worm)	hypothetical protein	0.0045	0.1427	0.1427
Schistosoma mansoni	acetylcholinesterase	0.0045	0.1427	0.1427
Plasmodium falciparum	thioredoxin reductase	0.0047	0.1519	1
Echinococcus granulosus	carboxylesterase 5A	0.0264	1	1
Brugia malayi	Carboxylesterase family protein	0.0045	0.1427	0.1427
Plasmodium falciparum	flap endonuclease 1	0.0026	0.0695	0.3125
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0045	0.1427	0.2758
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0107	0.3868	0.8837
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0019	0.0433	0.0281
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0433	0.1763
Leishmania major	trypanothione reductase	0.0047	0.1519	1
Leishmania major	DNA polymerase eta, putative	0.0019	0.0433	0.0943
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0016	0.032	0.032
Trypanosoma brucei	DNA polymerase eta, putative	0.0019	0.0433	0.1763
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0433	0.1763
Giardia lamblia	DINP protein human, muc B family	0.0019	0.0433	0.3017
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0016	0.032	0.0906
Brugia malayi	Carboxylesterase family protein	0.0045	0.1427	0.1427
Schistosoma mansoni	BC026374 protein (S09 family)	0.0045	0.1427	0.1427
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0045	0.1427	0.1427
Plasmodium vivax	glutathione reductase, putative	0.0047	0.1519	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0433	0.1763
Brugia malayi	Thioredoxin reductase	0.0047	0.1519	0.1519
Trypanosoma cruzi	DNA polymerase eta, putative	0.0019	0.0433	0.0943
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0433	0.1763
Brugia malayi	MH2 domain containing protein	0.0118	0.4315	0.4315
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0433	0.1763
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0433	0.0433
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0433	0.0943
Trichomonas vaginalis	spcc417.12 protein, putative	0.0045	0.1427	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0433	0.1763
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0016	0.032	0.5
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0019	0.0433	0.102
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0433	0.1763
Echinococcus multilocularis	acetylcholinesterase	0.0264	1	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0047	0.1519	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0119	0.4335	1
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0107	0.3868	0.8837
Mycobacterium tuberculosis	Probable reductase	0.0107	0.3868	0.8837
Loa Loa (eye worm)	hypothetical protein	0.0264	1	1
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0107	0.3868	0.8837
Brugia malayi	hypothetical protein	0.0045	0.1427	0.1427
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0433	0.0943
Loa Loa (eye worm)	hypothetical protein	0.015	0.5546	0.5546
Loa Loa (eye worm)	hypothetical protein	0.0045	0.1427	0.1427
Loa Loa (eye worm)	carboxylesterase	0.0045	0.1427	0.1427
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0016	0.032	0.0906
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0026	0.0695	0.3748
Brugia malayi	Carboxylesterase family protein	0.0045	0.1427	0.1427
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0264	1	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0433	0.1763
Schistosoma mansoni	flap endonuclease-1	0.0023	0.0598	0.0598
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0433	0.0433
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0012	0.0151	0.0151
Trypanosoma brucei	trypanothione reductase	0.0047	0.1519	1
Leishmania major	DNA polymerase kappa, putative	0.0019	0.0433	0.0943
Echinococcus granulosus	thioredoxin glutathione reductase	0.0047	0.1519	0.1519
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0433	0.0433
Plasmodium vivax	thioredoxin reductase, putative	0.0047	0.1519	1
Echinococcus granulosus	acetylcholinesterase	0.0264	1	1
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0047	0.1519	0.2985
Brugia malayi	Carboxylesterase family protein	0.0264	1	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0119	0.4335	1
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0026	0.0695	0.3125
Giardia lamblia	Flap structure-specific endonuclease	0.0026	0.0695	1
Schistosoma mansoni	gliotactin	0.0045	0.1427	0.1427
Entamoeba histolytica	Flap nuclease, putative	0.0026	0.0695	1
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.0433	0.0433
Loa Loa (eye worm)	hypothetical protein	0.0045	0.1427	0.1427
Schistosoma mansoni	DNA polymerase eta	0.0019	0.0433	0.0433
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0433	0.0943
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0016	0.032	0.032
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0433	0.0433
Loa Loa (eye worm)	glutathione reductase	0.0047	0.1519	0.1519
Brugia malayi	glutathione reductase	0.0047	0.1519	0.1519
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0119	0.4335	1
Echinococcus granulosus	para nitrobenzyl esterase	0.0045	0.1427	0.1427
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0019	0.0433	0.0281
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0433	0.0433
Loa Loa (eye worm)	hypothetical protein	0.0264	1	1
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0433	0.0433
Brugia malayi	Carboxylesterase family protein	0.0045	0.1427	0.1427
Loa Loa (eye worm)	hypothetical protein	0.0045	0.1427	0.1427

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 869553