TDR Targets

Basic information

Technical information

TDR Targets ID: 869817
Name: N-ethyl-1-(2-ethyl2,3-dihydro-1,4-benzoxazine -4-carbonyl)piperidine-4-carboxamide
MW: 345.436 | Formula: C19H27N3O3
H donors: 1 H acceptors: 2 LogP: 2.14 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCNC(=O)C1CCN(CC1)C(=O)N1CC(CC)Oc2c1cccc2
InChi: 1S/C19H27N3O3/c1-3-15-13-22(16-7-5-6-8-17(16)25-15)19(24)21-11-9-14(10-12-21)18(23)20-4-2/h5-8,14-15H,3-4,9-13H2,1-2H3,(H,20,23)
InChiKey: MYWPFNNABGGNIY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-ethyl-1-[(2-ethyl-2,3-dihydro-1,4-benzoxazin-4-yl)-oxomethyl]-4-piperidinecarboxamide
N-ethyl-1-(2-ethyl2,3-dihydro-1,4-benzoxazine-4-carbonyl)isonipecotamide
N-ethyl-1-[(2-ethyl-2,3-dihydro-1,4-benzoxazin-4-yl)carbonyl]piperidine-4-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	tight junction protein ZO 3	0.0016	0.0041	0.0041
Echinococcus multilocularis	protein lin 7 B	0.0016	0.0041	0.0041
Brugia malayi	Steroid receptor seven-up type 2	0.0012	0.0002	0.0004
Schistosoma mansoni	hypothetical protein	0.0016	0.0041	0.0067
Schistosoma mansoni	cell polarity protein	0.0016	0.0041	0.0067
Echinococcus granulosus	3'partial\|membrane associated guanylate kinase ww and pdz	0.0016	0.0041	0.0067
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0016	0.0041	0.0067
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.0577	0.6156	1
Echinococcus multilocularis		0.0016	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0041	0.0067
Schistosoma mansoni	hypothetical protein	0.0016	0.0041	0.0067
Echinococcus granulosus	Na:H exchange regulatory cofactor NHE RF2	0.0016	0.0041	0.0067
Schistosoma mansoni	tight junction protein	0.0016	0.0041	0.0067
Brugia malayi	Shank2E	0.0016	0.0041	0.0067
Schistosoma mansoni	diflavin oxidoreductase	0.0286	0.2989	0.4855
Echinococcus multilocularis	peregrin	0.0035	0.0253	0.0253
Onchocerca volvulus		0.0016	0.0041	0.0707
Entamoeba histolytica	type A flavoprotein, putative	0.0221	0.2274	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0012	0.0002	0.0004
Schistosoma mansoni	hypothetical protein	0.0016	0.0041	0.0067
Brugia malayi	diaphorase	0.0066	0.0584	0.0949
Echinococcus granulosus	membrane associated guanylate kinase ww and pdz	0.0016	0.0041	0.0067
Brugia malayi	FAD binding domain containing protein	0.0356	0.3752	0.6094
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0012	0.0002	0.0002
Trichomonas vaginalis	sulfite reductase, putative	0.0577	0.6156	1
Echinococcus multilocularis	membrane associated guanylate kinase ww and pdz	0.0016	0.0041	0.0041
Schistosoma mansoni	multiple pdz domain protein	0.0016	0.0041	0.0067
Plasmodium falciparum	S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative	0.0221	0.2274	0.3694
Echinococcus multilocularis	PDZ and LIM domain protein Zasp	0.0016	0.0041	0.0041
Echinococcus granulosus	Microtubule-associated serine/threonine-protein kinase	0.0016	0.0041	0.0067
Brugia malayi	PDZ domain containing protein	0.0016	0.0041	0.0067
Echinococcus multilocularis	SH3 and multiple ankyrin repeat domains protein	0.0016	0.0041	0.0041
Schistosoma mansoni	lim domain	0.0016	0.0041	0.0067
Brugia malayi	Synapse defective protein 1	0.0016	0.0041	0.0067
Onchocerca volvulus		0.0066	0.0584	1
Schistosoma mansoni	cell polarity protein	0.0016	0.0041	0.0067
Loa Loa (eye worm)	DIX domain-containing protein	0.0016	0.0041	0.0067
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0002	0.0002
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0703	0.1142
Echinococcus granulosus	jumonji domain containing protein	0.0049	0.0403	0.0655
Echinococcus multilocularis	segment polarity protein dishevelled	0.0016	0.0041	0.0041
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0012	0.0002	0.0002
Loa Loa (eye worm)	FAD binding domain-containing protein	0.0356	0.3752	0.6094
Brugia malayi	Partitioning defective-6 homolog alpha	0.0016	0.0041	0.0067
Echinococcus multilocularis	MAGUK p55 subfamily	0.0016	0.0041	0.0041
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0012	0.0002	0.0004
Echinococcus multilocularis	NADPH dependent diflavin oxidoreductase 1	0.0577	0.6156	0.6156
Echinococcus granulosus	cytochrome b5 reductase 4	0.0066	0.0584	0.0949
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0703	0.1142
Echinococcus granulosus	MAGUK p55 subfamily	0.0016	0.0041	0.0067
Echinococcus multilocularis	partitioning defective 3	0.0016	0.0041	0.0041
Brugia malayi	interleukin-16	0.0016	0.0041	0.0067
Echinococcus granulosus	NADPH cytochrome P450 reductase	0.0577	0.6156	1
Echinococcus granulosus	partitioning defective 3	0.0016	0.0041	0.0067
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0002	0.0004
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0703	0.1142
Echinococcus granulosus	methionine synthase reductase	0.0356	0.3752	0.6094
Echinococcus multilocularis	SH3 and multiple ankyrin repeat domains protein	0.0016	0.0041	0.0041
Brugia malayi	RNA binding protein	0.0076	0.0703	0.1142
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0002	0.0004
Loa Loa (eye worm)	X11 protein	0.0016	0.0041	0.0067
Echinococcus multilocularis	disks large 3	0.0016	0.0041	0.0041
Trypanosoma cruzi	p450 reductase, putative	0.0577	0.6156	1
Schistosoma mansoni	syntenin	0.0016	0.0041	0.0067
Brugia malayi	gopc protein	0.0016	0.0041	0.0067
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0221	0.2274	0.3694
Schistosoma mansoni	multiple pdz domain protein	0.0016	0.0041	0.0067
Onchocerca volvulus	Bile acid receptor homolog	0.0012	0.0002	0.0038
Echinococcus multilocularis	peripheral plasma membrane protein CASK	0.0016	0.0041	0.0041
Schistosoma mansoni	ATP-dependent RNA Helicase	0.0016	0.0041	0.0067
Brugia malayi	gamma-syntrophin-like protein SYN2	0.0016	0.0041	0.0067
Schistosoma mansoni	hypothetical protein	0.0016	0.0041	0.0067
Plasmodium falciparum	NADH-cytochrome b5 reductase, putative	0.0066	0.0584	0.0949
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0012	0.0002	0.0038
Echinococcus granulosus	amyloid beta A4 protein	0.0016	0.0041	0.0067
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0002	0.0004
Loa Loa (eye worm)	guanylate kinase	0.0016	0.0041	0.0067
Trypanosoma cruzi	Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative	0.0221	0.2274	0.3033
Echinococcus multilocularis	pdz domain containing protein	0.0016	0.0041	0.0041
Schistosoma mansoni	discs large	0.0016	0.0041	0.0067
Plasmodium vivax	ferredoxin--NADP reductase, putative	0.0066	0.0584	0.0949
Schistosoma mansoni	dishevelled	0.0016	0.0041	0.0067
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0012	0.0002	0.0004
Schistosoma mansoni	jumonji domain containing protein	0.0092	0.0868	0.141
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0002	0.0004
Echinococcus multilocularis	SH3 and multiple ankyrin repeat domains protein	0.0016	0.0041	0.0041
Echinococcus granulosus	NADH cytochrome b5 reductase 3	0.0066	0.0584	0.0949
Echinococcus granulosus	PDZ and LIM domain protein Zasp	0.0016	0.0041	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0041	0.0067
Echinococcus granulosus	PRKCA binding protein	0.0016	0.0041	0.0067
Echinococcus granulosus	multiple pdz domain protein	0.0016	0.0041	0.0067
Leishmania major	cytochrome P450 reductase, putative	0.0511	0.5442	0.8717
Loa Loa (eye worm)	cytochrome b5 reductase 4	0.0066	0.0584	0.0949
Schistosoma mansoni	sh3 and multiple ankyrin repeat domains protein 12 (shank12)	0.0016	0.0041	0.0067
Loa Loa (eye worm)	RNA binding protein	0.0076	0.0703	0.1142
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0041	0.0067
Schistosoma mansoni	membrane associated guanylate kinase inverted related	0.0016	0.0041	0.0067
Mycobacterium tuberculosis	Possible oxygenase	0.0066	0.0584	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0012	0.0002	0.0004
Echinococcus granulosus	PDZ and LIM domain protein Zasp	0.0016	0.0041	0.0067
Plasmodium falciparum	nitric oxide synthase, putative	0.0577	0.6156	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0041	0.0067
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0002	0.0004
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.0343	0.0343
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0012	0.0002	0.0002
Schistosoma mansoni	multiple pdz domain protein	0.0016	0.0041	0.0067
Leishmania major	hypothetical protein, conserved	0.0221	0.2274	0.3033
Schistosoma mansoni	discs lost-related	0.0016	0.0041	0.0067
Loa Loa (eye worm)	PDZ domain-containing protein	0.0016	0.0041	0.0067
Brugia malayi	9ORF binding protein 1	0.0016	0.0041	0.0067
Echinococcus granulosus	ecdysone induced protein 78C	0.0012	0.0002	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0041	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0041	0.0067
Echinococcus granulosus	disks large 3	0.0016	0.0041	0.0067
Brugia malayi	PDZ domain containing protein	0.0016	0.0041	0.0067
Echinococcus granulosus	disks large 1	0.0016	0.0041	0.0067
Schistosoma mansoni	coup transcription factor	0.0012	0.0002	0.0004
Plasmodium falciparum	NADPH--cytochrome P450 reductase, putative	0.0221	0.2274	0.3694
Brugia malayi	syntenin	0.0016	0.0041	0.0067
Brugia malayi	Guanylate kinase family protein	0.0016	0.0041	0.0067
Schistosoma mansoni	MAGUK homolog	0.0016	0.0041	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0002	0.0004
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0035	0.0253	0.0253
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0002	0.0004
Echinococcus multilocularis	microtubule associated serine:threonine protein	0.0016	0.0041	0.0041
Brugia malayi	hypothetical protein	0.0016	0.0041	0.0067
Trypanosoma cruzi	NADPH-dependent FMN/FAD containing oxidoreductase, putative	0.0577	0.6156	1
Onchocerca volvulus		0.0016	0.0041	0.0707
Brugia malayi	Bromodomain containing protein	0.0035	0.0253	0.0411
Brugia malayi	hypothetical protein	0.0016	0.0041	0.0067
Echinococcus multilocularis	segment polarity protein dishevelled	0.0016	0.0041	0.0041
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0012	0.0002	0.0004
Loa Loa (eye worm)	peripheral plasma membrane protein CASK	0.0016	0.0041	0.0067
Echinococcus multilocularis	55 kDa erythrocyte membrane protein	0.0016	0.0041	0.0041
Schistosoma mansoni	hypothetical protein	0.0016	0.0041	0.0067
Trypanosoma brucei	NADPH--cytochrome P450 reductase, putative	0.0577	0.6156	1
Brugia malayi	PDZ-domain protein scribble	0.0016	0.0041	0.0067
Loa Loa (eye worm)	steroid hormone receptor	0.0012	0.0002	0.0004
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0012	0.0002	0.0004
Echinococcus granulosus	multiple pdz domain protein	0.0016	0.0041	0.0067
Toxoplasma gondii	flavodoxin domain-containing protein	0.0286	0.2989	1
Schistosoma mansoni	dishevelled	0.0016	0.0041	0.0067
Schistosoma mansoni	cell polarity protein	0.0016	0.0041	0.0067
Echinococcus granulosus	multiple pdz domain protein	0.0016	0.0041	0.0067
Onchocerca volvulus		0.0016	0.0041	0.0707
Loa Loa (eye worm)	9ORF binding protein 1	0.0016	0.0041	0.0067
Echinococcus granulosus	peripheral plasma membrane protein CASK	0.0016	0.0041	0.0067
Toxoplasma gondii	ferredoxin NADP+ oxidoreductase FNR	0.0066	0.0584	0.1954
Treponema pallidum	flavodoxin	0.0221	0.2274	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0041	0.0067
Echinococcus multilocularis	multiple pdz domain protein	0.0016	0.0041	0.0041
Echinococcus multilocularis	membrane associated guanylate kinase, WW and PDZ	0.0016	0.0041	0.0041
Brugia malayi	steroid hormone receptor	0.0012	0.0002	0.0004
Brugia malayi	jmjC domain containing protein	0.0043	0.0334	0.0542
Brugia malayi	abnormal cell lineage protein 10 (Protein lin-10), putative	0.0016	0.0041	0.0067
Echinococcus granulosus	segment polarity protein dishevelled	0.0016	0.0041	0.0067
Schistosoma mansoni	5-methyl tetrahydrofolate-homocysteine methyltransferase reductase	0.0356	0.3752	0.6094
Schistosoma mansoni	cell polarity protein	0.0016	0.0041	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0002	0.0004
Loa Loa (eye worm)	PX domain-containing protein	0.0016	0.0041	0.0067
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0016	0.0041	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0041	0.0067
Loa Loa (eye worm)	guanylate kinase	0.0016	0.0041	0.0067
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0221	0.2274	0.3694
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0002	0.0004
Brugia malayi	Hypothetical 13.5 kDa protein C45G9.7 in chromosome III	0.0016	0.0041	0.0067
Trypanosoma brucei	NADPH--cytochrome P450 reductase, putative	0.0577	0.6156	1
Brugia malayi	Neurabin protein 1	0.0016	0.0041	0.0067
Loa Loa (eye worm)	hypothetical protein	0.006	0.0527	0.0856
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0002	0.0004
Echinococcus multilocularis	rho guanine nucleotide exchange factor 12	0.0016	0.0041	0.0041
Echinococcus multilocularis	glutamate receptor interacting protein 1	0.0016	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0041	0.0067
Brugia malayi	photoreceptor-specific nuclear receptor	0.0012	0.0002	0.0004
Brugia malayi	jmjC domain containing protein	0.0115	0.1126	0.1829
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0012	0.0002	0.0004
Onchocerca volvulus	Big bang homolog	0.0016	0.0041	0.0707
Echinococcus multilocularis	MAGUK p55 subfamily	0.0016	0.0041	0.0041
Plasmodium vivax	oxidoreductase NAD-binding domain containing protein	0.0066	0.0584	0.0949
Echinococcus granulosus	tight junction protein ZO 3	0.0016	0.0041	0.0067
Schistosoma mansoni	nuclear hormone receptor	0.0012	0.0002	0.0004
Schistosoma mansoni	hypothetical protein	0.0016	0.0041	0.0067
Echinococcus granulosus	glutamate receptor interacting protein 1	0.0016	0.0041	0.0067
Schistosoma mansoni	multiple pdz domain protein	0.0016	0.0041	0.0067
Loa Loa (eye worm)	jmjC domain-containing protein	0.0073	0.0662	0.1075
Toxoplasma gondii	NADH-cytochrome b5 reductase 1, putative	0.0066	0.0584	0.1954
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0002	0.0004
Echinococcus granulosus	Rho GTPase activating protein 21	0.0016	0.0041	0.0067
Schistosoma mansoni	amyloid beta A4 protein related	0.0016	0.0041	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0041	0.0067
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0703	0.1142
Mycobacterium ulcerans	formate dehydrogenase H FdhF	0.0577	0.6156	1
Echinococcus multilocularis	PDZ and LIM domain protein Zasp	0.0016	0.0041	0.0041
Onchocerca volvulus		0.0016	0.0041	0.0707
Schistosoma mansoni	hypothetical protein	0.0016	0.0041	0.0067
Brugia malayi	Patj homolog	0.0016	0.0041	0.0067
Schistosoma mansoni	lin-7-like proteins	0.0016	0.0041	0.0067
Echinococcus multilocularis	protein piccolo	0.0016	0.0041	0.0041
Brugia malayi	PX domain containing protein	0.0016	0.0041	0.0067
Echinococcus granulosus	cytochrome b5 reductase 4	0.0066	0.0584	0.0949
Echinococcus granulosus	MAGUK p55 subfamily	0.0016	0.0041	0.0067
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.0703	0.1142
Chlamydia trachomatis	sulfite reductase	0.0356	0.3752	1
Echinococcus granulosus	MAGUK p55 subfamily	0.0016	0.0041	0.0067
Brugia malayi	TAR-binding protein	0.0076	0.0703	0.1142
Entamoeba histolytica	type A flavoprotein, putative	0.0221	0.2274	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0002	0.0004
Leishmania major	NADPH-cytochrome p450 reductase-like protein	0.0577	0.6156	1
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0221	0.2274	0.3694
Echinococcus granulosus	membrane associated guanylate kinase ww and pdz	0.0016	0.0041	0.0067
Echinococcus granulosus	cell polarity protein	0.0016	0.0041	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0041	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0253	0.0411
Echinococcus multilocularis	lysine specific demethylase 5A	0.0043	0.0334	0.0334
Schistosoma mansoni	PDZ domain protein	0.0016	0.0041	0.0067
Brugia malayi	hypothetical protein	0.0016	0.0041	0.0067
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0012	0.0002	0.0002
Echinococcus multilocularis	cell polarity protein leucine rich repeat	0.0016	0.0041	0.0041
Echinococcus granulosus	membrane associated guanylate kinase, WW and PDZ	0.0016	0.0041	0.0067
Schistosoma mansoni	membrane associated guanylate kinase inverted related	0.0016	0.0041	0.0067
Schistosoma mansoni	hypothetical protein	0.0016	0.0041	0.0067
Echinococcus multilocularis	amyloid beta A4 protein	0.0016	0.0041	0.0041
Echinococcus multilocularis	pdz domain containing protein	0.0016	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0002	0.0004
Brugia malayi	PDZ domain containing protein	0.0016	0.0041	0.0067
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0012	0.0002	0.0004
Echinococcus granulosus	rho guanine nucleotide exchange factor 12	0.0016	0.0041	0.0067
Echinococcus multilocularis	PRKCA binding protein	0.0016	0.0041	0.0041
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0002	0.0004
Brugia malayi	Guanylate kinase family protein	0.0016	0.0041	0.0067
Brugia malayi	PDZ domain	0.0016	0.0041	0.0067
Loa Loa (eye worm)	gopc protein	0.0016	0.0041	0.0067
Schistosoma mansoni	protein kinase C alpha binding protein	0.0016	0.0041	0.0067
Echinococcus granulosus	55 kDa erythrocyte membrane protein	0.0016	0.0041	0.0067
Schistosoma mansoni	cytochrome B5	0.0066	0.0584	0.0949
Brugia malayi	RasGEF domain containing protein	0.0016	0.0041	0.0067
Schistosoma mansoni	memapsin-2 (A01 family)	0.0299	0.3126	0.5078
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0115	0.1126	0.1126
Echinococcus multilocularis	cytochrome b5 reductase 4	0.0066	0.0584	0.0584
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0012	0.0002	0.0004
Echinococcus granulosus	syndecan binding protein syntenin	0.0016	0.0041	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0041	0.0067
Loa Loa (eye worm)	PDZ-domain-containing protein scribble	0.0016	0.0041	0.0067
Echinococcus multilocularis	Na(+):H(+) exchange regulatory cofactor NHE RF2	0.0016	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0041	0.0067
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0221	0.2274	0.3694
Echinococcus granulosus	FTZ F1 alpha	0.0012	0.0002	0.0004
Echinococcus multilocularis	PDZ and LIM domain protein Zasp	0.0016	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0041	0.0067
Loa Loa (eye worm)	PAR-6 protein	0.0016	0.0041	0.0067
Echinococcus multilocularis	NADH cytochrome b5 reductase 3	0.0066	0.0584	0.0584
Brugia malayi	hypothetical protein	0.0043	0.0343	0.0557
Brugia malayi	PDZ domain	0.0016	0.0041	0.0067
Schistosoma mansoni	hypothetical protein	0.0016	0.0041	0.0067
Echinococcus granulosus	lysine specific demethylase 5A	0.0043	0.0334	0.0542
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0041	0.0067
Echinococcus multilocularis	beta 1 syntrophin	0.0016	0.0041	0.0041
Schistosoma mansoni	RAR-like nuclear receptor	0.0012	0.0002	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0041	0.0067
Echinococcus granulosus	beta 1 syntrophin	0.0016	0.0041	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0041	0.0067
Schistosoma mansoni	sap-97	0.0016	0.0041	0.0067
Echinococcus granulosus	PHD finger protein rhinoceros	0.0035	0.0253	0.0411
Trypanosoma brucei	NADPH-dependent diflavin oxidoreductase 1	0.0577	0.6156	1
Plasmodium falciparum	ferredoxin--NADP reductase	0.0066	0.0584	0.0949
Loa Loa (eye worm)	diaphorase	0.0066	0.0584	0.0949
Echinococcus granulosus	SH3 and multiple ankyrin repeat domains protein	0.0016	0.0041	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0041	0.0067
Echinococcus granulosus	ligand of numb protein x 2	0.0016	0.0041	0.0067
Giardia lamblia	Nitric oxide synthase, inducible	0.0511	0.5442	1
Loa Loa (eye worm)	PHD-finger family protein	0.0035	0.0253	0.0411
Loa Loa (eye worm)	cell junction protein LIN-7	0.0016	0.0041	0.0067
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.0703	0.1142
Trichomonas vaginalis	NADPH fad oxidoreductase, putative	0.0511	0.5442	0.8839
Trypanosoma cruzi	NADPH--cytochrome P450 reductase, putative	0.0221	0.2274	0.3033
Entamoeba histolytica	type A flavoprotein, putative	0.0221	0.2274	1
Schistosoma mansoni	hypothetical protein	0.0035	0.0253	0.0411
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0002	0.0002
Brugia malayi	nuclear receptor NHR-88	0.0012	0.0002	0.0004
Brugia malayi	hypothetical protein	0.0016	0.0041	0.0067
Toxoplasma gondii	flavodoxin domain-containing protein	0.0286	0.2989	1
Brugia malayi	Abnormal embryonic partitioning of cytoplasm protein 3	0.0016	0.0041	0.0067
Echinococcus granulosus	peregrin	0.0035	0.0253	0.0411
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0012	0.0002	0.0004
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0703	0.1142
Echinococcus granulosus	protein lin 7 B	0.0016	0.0041	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0577	0.6156	1
Schistosoma mansoni	hypothetical protein	0.0016	0.0041	0.0067
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0002	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0041	0.0067
Echinococcus multilocularis	pdz domain containing protein	0.0016	0.0041	0.0041
Schistosoma mansoni	syntrophin	0.0016	0.0041	0.0067
Echinococcus multilocularis	syndecan binding protein (syntenin)	0.0016	0.0041	0.0041
Schistosoma mansoni	pdz and lim domain protein	0.0016	0.0041	0.0067
Entamoeba histolytica	type A flavoprotein, putative	0.0221	0.2274	1
Onchocerca volvulus		0.0016	0.0041	0.0707
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0016	0.0041	0.0067
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.0703	0.1142
Schistosoma mansoni	leucine-rich repeat protein	0.0016	0.0041	0.0067
Schistosoma mansoni	NADPH flavin oxidoreductase	0.0291	0.3037	0.4933
Plasmodium vivax	NADPH-cytochrome p450 reductase, putative	0.0577	0.6156	1
Echinococcus multilocularis	PDZ domain containing protein GIPC3	0.0016	0.0041	0.0041
Onchocerca volvulus		0.0016	0.0041	0.0707
Onchocerca volvulus	Alhambra homolog	0.0035	0.0253	0.4332
Brugia malayi	DIX domain containing protein	0.0016	0.0041	0.0067
Echinococcus granulosus	tar DNA binding protein	0.0076	0.0703	0.1142
Echinococcus granulosus	segment polarity protein dishevelled	0.0016	0.0041	0.0067
Brugia malayi	C2 domain containing protein	0.0016	0.0041	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0041	0.0067
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0012	0.0002	0.0004
Plasmodium vivax	flavodoxin domain containing protein	0.0511	0.5442	0.8839
Loa Loa (eye worm)	flavodoxin family protein	0.0221	0.2274	0.3694
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0016	0.0041	0.0067
Brugia malayi	microtubule-associated serine/threonine protein kinase 2 (MAST2)	0.0016	0.0041	0.0067
Plasmodium falciparum	phd finger protein, putative	0.0035	0.0253	0.0411
Entamoeba histolytica	type A flavoprotein, putative	0.0221	0.2274	1
Trypanosoma cruzi	Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative	0.0221	0.2274	0.3033
Schistosoma mansoni	NADH-cytochrome B5 reductase	0.0066	0.0584	0.0949
Echinococcus multilocularis	jumonji domain containing protein	0.0049	0.0403	0.0403
Brugia malayi	PHD-finger family protein	0.0035	0.0253	0.0411
Echinococcus multilocularis	FTZ F1 alpha	0.0012	0.0002	0.0002
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0012	0.0002	0.0004
Schistosoma mansoni	hypothetical protein	0.0016	0.0041	0.0067
Schistosoma mansoni	regulator of G protein signaling	0.0016	0.0041	0.0067
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0002	0.0004
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0016	0.0041	0.0041
Schistosoma mansoni	pdz domain containing protein	0.0016	0.0041	0.0067
Echinococcus granulosus	pdz domain containing protein	0.0016	0.0041	0.0067
Brugia malayi	Peripheral plasma membrane protein CASK	0.0016	0.0041	0.0067
Schistosoma mansoni	hypothetical protein	0.0016	0.0041	0.0067
Echinococcus granulosus	Partitioning defective 3 protein B	0.0016	0.0041	0.0067
Onchocerca volvulus		0.0016	0.0041	0.0707
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0041	0.0067
Brugia malayi	ecdysteroid receptor	0.0012	0.0002	0.0004
Schistosoma mansoni	MAGUK homolog	0.0016	0.0041	0.0067
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0012	0.0002	0.0004
Toxoplasma gondii	PHD-finger domain-containing protein	0.0035	0.0253	0.0846
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0012	0.0002	0.0004
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0035	0.0253	0.0411
Leishmania major	p450 reductase, putative	0.0577	0.6156	1
Onchocerca volvulus	Segment polarity protein dishevelled homolog	0.0016	0.0041	0.0707
Brugia malayi	Cytochrome b5-like Heme/Steroid binding domain containing protein	0.0066	0.0584	0.0949
Mycobacterium tuberculosis	Probable oxidoreductase	0.0066	0.0584	0.5
Schistosoma mansoni	leucine-rich repeat protein	0.0016	0.0041	0.0067
Echinococcus multilocularis	pdz domain containing protein	0.0016	0.0041	0.0041
Brugia malayi	flavodoxin family protein	0.0221	0.2274	0.3694
Brugia malayi	hypothetical protein	0.0016	0.0041	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0002	0.0004
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.0343	0.0557
Echinococcus granulosus	pdz domain containing protein	0.0016	0.0041	0.0067
Giardia lamblia	Flavohemoprotein lateral transfer candidate	0.0066	0.0584	0.0638
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0012	0.0002	0.0004
Brugia malayi	flavodoxin family protein	0.0577	0.6156	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0012	0.0002	0.0004
Loa Loa (eye worm)	FAD binding domain-containing protein	0.0577	0.6156	1
Echinococcus granulosus	pdz domain containing protein	0.0016	0.0041	0.0067
Schistosoma mansoni	afadin (af-6 protein)	0.0016	0.0041	0.0067
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0012	0.0002	0.0004
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0253	0.0411
Echinococcus granulosus	SH3 and multiple ankyrin repeat domains protein	0.0016	0.0041	0.0067
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0115	0.1126	0.1829
Echinococcus granulosus	partitioning defective 3	0.0016	0.0041	0.0067
Onchocerca volvulus		0.0016	0.0041	0.0707
Echinococcus granulosus	NADPH dependent diflavin oxidoreductase 1	0.0577	0.6156	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0012	0.0002	0.0004
Giardia lamblia	Hypothetical protein	0.0511	0.5442	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0041	0.0067
Schistosoma mansoni	membrane associated guanylate kinase inverted related	0.0016	0.0041	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0041	0.0067
Echinococcus multilocularis	multiple pdz domain protein	0.0016	0.0041	0.0041
Onchocerca volvulus	Arc homolog	0.0016	0.0041	0.0707
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0041	0.0067
Onchocerca volvulus		0.0016	0.0041	0.0707
Echinococcus multilocularis	partitioning defective protein 6	0.0016	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0041	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0041	0.0067
Mycobacterium tuberculosis	Possible electron transfer protein FdxB	0.0066	0.0584	0.5
Schistosoma mansoni	cytochrome P450 reductase	0.0577	0.6156	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0012	0.0002	0.0004
Mycobacterium tuberculosis	Hypothetical oxidoreductase	0.0066	0.0584	0.5
Loa Loa (eye worm)	jmjC domain-containing protein	0.0043	0.0334	0.0542
Echinococcus granulosus	SH3 and multiple ankyrin repeat domains protein	0.0016	0.0041	0.0067
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0012	0.0002	0.0004
Brugia malayi	Ferm domain	0.0016	0.0041	0.0067
Trypanosoma brucei	NADPH-cytochrome p450 reductase, putative	0.0577	0.6156	1
Echinococcus multilocularis	multiple pdz domain protein	0.0016	0.0041	0.0041
Schistosoma mansoni	hypothetical protein	0.0043	0.0343	0.0557
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0012	0.0002	0.0004
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0043	0.0334	0.0542
Onchocerca volvulus	Protein ultraspiracle homolog	0.0012	0.0002	0.0038
Echinococcus granulosus	myeloid:lymphoid or mixed lineage leukemia	0.0016	0.0041	0.0067
Schistosoma mansoni	multiple pdz domain protein	0.0016	0.0041	0.0067
Loa Loa (eye worm)	AGC/MAST/MAST protein kinase	0.0016	0.0041	0.0067
Brugia malayi	PDZ domain containing protein	0.0016	0.0041	0.0067
Trypanosoma brucei	S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative	0.0221	0.2274	0.3033
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0041	0.0067
Echinococcus multilocularis	partitioning defective 3	0.0016	0.0041	0.0041
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0012	0.0002	0.0004
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0012	0.0002	0.0004
Brugia malayi	cell junction protein LIN-7	0.0016	0.0041	0.0067
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.0002	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0041	0.0067
Schistosoma mansoni	rab3 interacting molecule (rim)-related	0.0016	0.0041	0.0067
Echinococcus multilocularis	ecdysone induced protein 78C	0.0012	0.0002	0.0002
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0012	0.0002	0.0004
Echinococcus multilocularis	MAGUK p55 subfamily	0.0016	0.0041	0.0041
Brugia malayi	Syntrophin-1	0.0016	0.0041	0.0067
Brugia malayi	FAD binding domain containing protein	0.0577	0.6156	1
Schistosoma mansoni	pdz domain containing protein	0.0016	0.0041	0.0067
Echinococcus granulosus	neurabin 1	0.0016	0.0041	0.0067
Echinococcus multilocularis	NADPH cytochrome P450 reductase	0.0577	0.6156	0.6156
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.0703	0.0703
Echinococcus multilocularis	Rho GTPase activating protein 21	0.0016	0.0041	0.0041
Onchocerca volvulus		0.0016	0.0041	0.0707
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0012	0.0002	0.0002
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.0343	0.0557
Toxoplasma gondii	PHD-finger domain-containing protein	0.0035	0.0253	0.0846
Echinococcus multilocularis	myeloid:lymphoid or mixed lineage leukemia	0.0016	0.0041	0.0041
Echinococcus granulosus	pdz domain containing protein	0.0016	0.0041	0.0067
Echinococcus multilocularis	ligand of numb protein x 2	0.0016	0.0041	0.0041
Brugia malayi	Protein-tyrosine phosphatase 1	0.0016	0.0041	0.0067
Chlamydia trachomatis	Na(+)-translocating NADH-quinone reductase subunit F	0.0066	0.0584	0.1463
Brugia malayi	rho guanine nucleotide exchange factor 12	0.0016	0.0041	0.0067
Brugia malayi	hypothetical protein	0.0016	0.0041	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0041	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0002	0.0004
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0016	0.0041	0.0067
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0012	0.0002	0.0004
Plasmodium vivax	hypothetical protein, conserved	0.0221	0.2274	0.3694
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.0577	0.6156	1
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0016	0.0041	0.0041
Echinococcus multilocularis	disks large 1	0.0016	0.0041	0.0041
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0043	0.0334	0.0542
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0041	0.0067
Mycobacterium tuberculosis	Probable monooxygenase	0.0066	0.0584	0.5
Echinococcus multilocularis	methionine synthase reductase	0.0356	0.3752	0.3752
Loa Loa (eye worm)	syntrophin-1	0.0016	0.0041	0.0067
Onchocerca volvulus		0.0012	0.0002	0.0038
Echinococcus multilocularis	neurabin 1	0.0016	0.0041	0.0041
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0002	0.0004
Onchocerca volvulus		0.0016	0.0041	0.0707
Schistosoma mansoni	maguk P55 subfamily member 35	0.0016	0.0041	0.0067
Schistosoma mansoni	Patj homolog	0.0016	0.0041	0.0067
Brugia malayi	nuclear hormone receptor	0.0012	0.0002	0.0004
Echinococcus multilocularis	glutamate receptor interacting protein 1	0.0016	0.0041	0.0041
Schistosoma mansoni	maguk P55 subfamily member 26	0.0016	0.0041	0.0067
Brugia malayi	protein kinase C-binding protein PICK1	0.0016	0.0041	0.0067
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0016	0.0041	0.0067
Schistosoma mansoni	retinoic acid receptor RXR	0.0012	0.0002	0.0004
Echinococcus multilocularis	Partitioning defective 3 protein B	0.0016	0.0041	0.0041
Echinococcus granulosus	PDZ and LIM domain protein Zasp	0.0016	0.0041	0.0067

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 869817