Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0056 | 0.0097 | 0.0131 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0147 | 0.3128 | 0.5 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0166 | 0.3793 | 0.0967 |
Brugia malayi | thymidylate synthase | 0.0104 | 0.1705 | 0.2291 |
Loa Loa (eye worm) | thymidylate synthase | 0.0104 | 0.1705 | 0.2291 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0147 | 0.3128 | 0.2963 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0147 | 0.3128 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0185 | 0.4423 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0166 | 0.3793 | 0.3175 |
Schistosoma mansoni | survival motor neuron protein | 0.0056 | 0.0097 | 0.057 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0352 | 1 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0275 | 0.7442 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0104 | 0.1705 | 0.2291 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0166 | 0.3793 | 0.3643 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0147 | 0.3128 | 0.5 |
Onchocerca volvulus | 0.0104 | 0.1705 | 1 | |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0147 | 0.3128 | 0.2444 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.0905 | 0.5306 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0104 | 0.1705 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0352 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0275 | 0.7442 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0104 | 0.1705 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0104 | 0.1705 | 0.2291 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.7442 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0275 | 0.7442 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0185 | 0.4423 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0352 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.0097 | 0.057 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.