Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0661 | 0.0798 | 0.3267 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.2565 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.1001 | 0.2444 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0661 | 0.0798 | 0.3267 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0661 | 0.0798 | 0.3267 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0661 | 0.0798 | 0.3267 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.1001 | 0.2444 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.1001 | 0.2444 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.1001 | 0.2444 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0661 | 0.0798 | 0.3267 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.2565 | 1 | 1 |
Leishmania major | dihydroorotate dehydrogenase | 0.2565 | 1 | 0.5 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.0661 | 0.0798 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.1001 | 0.2444 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.2565 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0661 | 0.0798 | 0.3267 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.2565 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0661 | 0.0798 | 0.3267 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0661 | 0.0798 | 0.3267 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.1001 | 0.2444 | 0.5 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0661 | 0.0798 | 0.3267 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0661 | 0.0798 | 0.3267 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.2565 | 1 | 1 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.2565 | 1 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.2565 | 1 | 1 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.2565 | 1 | 1 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.2565 | 1 | 0.5 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.1001 | 0.2444 | 1 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.2565 | 1 | 0.5 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.1001 | 0.2444 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0661 | 0.0798 | 0.3267 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0661 | 0.0798 | 0.3267 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.0661 | 0.0798 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0661 | 0.0798 | 0.3267 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0661 | 0.0798 | 0.3267 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.2565 | 1 | 0.5 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.2565 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.1001 | 0.2444 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0661 | 0.0798 | 0.3267 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.1001 | 0.2444 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.1001 | 0.2444 | 0.5 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0661 | 0.0798 | 0.3267 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.0661 | 0.0798 | 0.5 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.2565 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.