TDR Targets

Basic information

Technical information

TDR Targets ID: 869985
Name: 1-(2-ethyl-6-methyl2,3-dihydro-1,4-benzoxazin e-4-carbonyl)-N-[2-(4-methylsulfanylphenyl)et hyl]piperidine-4-carboxamide
MW: 481.65 | Formula: C27H35N3O3S
H donors: 1 H acceptors: 2 LogP: 4.6 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCC1Oc2ccc(cc2N(C1)C(=O)N1CCC(CC1)C(=O)NCCc1ccc(cc1)SC)C
InChi: 1S/C27H35N3O3S/c1-4-22-18-30(24-17-19(2)5-10-25(24)33-22)27(32)29-15-12-21(13-16-29)26(31)28-14-11-20-6-8-23(34-3)9-7-20/h5-10,17,21-22H,4,11-16,18H2,1-3H3,(H,28,31)
InChiKey: ODHDWUVSWCPWRY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-(2-ethyl-6-methyl-2,3-dihydro-1,4-benzoxazine-4-carbonyl)-N-[2-(4-methylsulfanylphenyl)ethyl]piperidine-4-carboxamide
1-[(2-ethyl-6-methyl-2,3-dihydro-1,4-benzoxazin-4-yl)-oxomethyl]-N-[2-[4-(methylthio)phenyl]ethyl]-4-piperidinecarboxamide
1-(2-ethyl-6-methyl-2,3-dihydro-1,4-benzoxazine-4-carbonyl)-N-[2-[4-(methylthio)phenyl]ethyl]isonipecotamide
1-[(2-ethyl-6-methyl-2,3-dihydro-1,4-benzoxazin-4-yl)carbonyl]-N-[2-(4-methylsulfanylphenyl)ethyl]piperidine-4-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0159	0.2414	0.2409
Mycobacterium tuberculosis	Probable transcriptional regulatory protein	0.024	0.3813	0.5
Brugia malayi	Sex muscle abnormal protein 5	0.0031	0.0199	0.0448
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0135	0.1998	0.8279
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0655	0.1516
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0117	0.0258
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0655	0.1516
Onchocerca volvulus		0.0085	0.1119	1
Schistosoma mansoni	tyrosine kinase	0.0036	0.0276	0.1143
Loa Loa (eye worm)	cysteine protease	0.0085	0.1119	0.26
Echinococcus granulosus	tyrosine protein kinase HCK	0.0128	0.1869	0.1863
Schistosoma mansoni	growth factor receptor-bound protein	0.0031	0.0199	0.0822
Mycobacterium ulcerans	two component transcriptional regulatory protein DevR	0.024	0.3813	1
Onchocerca volvulus	Cathepsin F homolog	0.0085	0.1119	1
Brugia malayi	Papain family cysteine protease containing protein	0.0045	0.0439	0.101
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0159	0.2414	0.2409
Schistosoma mansoni	cathepsin F (C01 family)	0.0085	0.1119	0.4635
Schistosoma mansoni	adapter molecule crk	0.0031	0.0199	0.0822
Leishmania major	p450 reductase, putative	0.003	0.0169	0.014
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0031	0.0199	0.0448
Brugia malayi	FAD binding domain containing protein	0.003	0.0169	0.0378
Entamoeba histolytica	cysteine protease, putative	0.0045	0.0439	0.2319
Trypanosoma cruzi	cysteine peptidase, putative	0.0085	0.1119	0.2404
Echinococcus multilocularis	NADPH dependent diflavin oxidoreductase 1	0.003	0.0169	0.0162
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0267	0.4283	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0045	0.0439	0.1817
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0159	0.2414	0.2409
Plasmodium vivax	vivapain-2	0.0085	0.1119	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0144	0.2145	0.2139
Entamoeba histolytica	cysteine proteinase, putative	0.0085	0.1119	0.5972
Trypanosoma cruzi	cysteine peptidase, putative	0.0085	0.1119	0.2404
Loa Loa (eye worm)	TK protein kinase	0.0128	0.1869	0.4354
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0085	0.1119	1
Loa Loa (eye worm)	cathepsin B	0.0055	0.0601	0.1389
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0027	0.0117	0.0258
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0055	0.0601	0.2488
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0085	0.1119	1
Plasmodium vivax	NADPH-cytochrome p450 reductase, putative	0.003	0.0169	0.0581
Echinococcus multilocularis	cysteine protease	0.0085	0.1119	0.1113
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.003	0.0169	0.0124
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0126	0.1842	0.4291
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0085	0.1119	1
Schistosoma mansoni	tyrosine kinase	0.0159	0.2414	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0085	0.1119	0.1113
Brugia malayi	Cathepsin L-like precursor	0.0085	0.1119	0.26
Entamoeba histolytica	cysteine protease, putative	0.0045	0.0439	0.2319
Mycobacterium tuberculosis	Possible nitrate/nitrite response transcriptional regulatory protein NarL	0.024	0.3813	0.5
Leishmania major	NADPH-cytochrome p450 reductase-like protein	0.003	0.0169	0.014
Entamoeba histolytica	cysteine protease, putative	0.0045	0.0439	0.2319
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0085	0.1119	0.2309
Loa Loa (eye worm)	hypothetical protein	0.0137	0.202	0.4707
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0085	0.1119	1
Trypanosoma cruzi	p450 reductase, putative	0.003	0.0169	0.0124
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0159	0.2414	0.2409
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0159	0.2414	0.2409
Entamoeba histolytica	cysteine proteinase, putative	0.0058	0.0655	0.3481
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0085	0.1119	0.1113
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0055	0.0601	0.1161
Onchocerca volvulus	Cathepsin L homolog	0.0085	0.1119	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0085	0.1119	0.2309
Mycobacterium ulcerans	putative regulatory protein	0.024	0.3813	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0045	0.0439	0.0656
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0085	0.1119	1
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0031	0.0199	0.0192
Schistosoma mansoni	tyrosine kinase	0.002	0.0007	0.0028
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0144	0.2145	0.2139
Entamoeba histolytica	cysteine proteinase, putative	0.0045	0.0439	0.2319
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0135	0.1998	0.8279
Schistosoma mansoni	cathepsin F (C01 family)	0.0058	0.0655	0.2713
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0085	0.1119	1
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0159	0.2414	0.2409
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0045	0.0439	0.0656
Echinococcus granulosus	tyrosine kinase	0.0144	0.2145	0.2139
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0085	0.1119	0.2309
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0085	0.1119	1
Entamoeba histolytica	cysteine protease, putative	0.0045	0.0439	0.2319
Echinococcus multilocularis	c src tyrosine kinase	0.0036	0.0276	0.0269
Brugia malayi	Cathepsin L-like precursor	0.0058	0.0655	0.1516
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0135	0.1998	0.8279
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0045	0.0439	0.3257
Giardia lamblia	Cathepsin B precursor	0.0055	0.0601	1
Brugia malayi	Variant SH3 domain containing protein	0.0031	0.0199	0.0448
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0085	0.1119	0.2309
Schistosoma mansoni	tyrosine kinase	0.0159	0.2414	1
Loa Loa (eye worm)	hypothetical protein	0.0085	0.1119	0.26
Schistosoma mansoni	cathepsin s	0.0027	0.0117	0.0485
Leishmania major	cathepsin L-like protease	0.0085	0.1119	0.2417
Onchocerca volvulus		0.0085	0.1119	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0045	0.0439	0.0772
Echinococcus multilocularis	cathepsin b	0.0135	0.1998	0.1993
Schistosoma mansoni	growth factor receptor-bound protein	0.0031	0.0199	0.0822
Echinococcus granulosus	cathepsin b	0.0135	0.1998	0.1993
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0036	0.0276	0.0269
Plasmodium vivax	vivapain-2	0.0085	0.1119	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0597	1	1
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0027	0.0117	0.0258
Loa Loa (eye worm)	FAD binding domain-containing protein	0.003	0.0169	0.0378
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0036	0.0276	0.0269
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0085	0.1119	1
Loa Loa (eye worm)	SRC-1	0.0159	0.2414	0.5629
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0045	0.0439	0.1817
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0045	0.0439	0.0772
Leishmania major	cathepsin L-like protease	0.0085	0.1119	0.2417
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0031	0.0199	0.0822
Leishmania major	cathepsin L-like protease	0.0085	0.1119	0.2417
Entamoeba histolytica	cysteine protease, putative	0.0045	0.0439	0.2319
Echinococcus granulosus	cathepsin L cysteine protease	0.0045	0.0439	0.0432
Onchocerca volvulus		0.0085	0.1119	1
Leishmania major	cathepsin L-like protease	0.0085	0.1119	0.2417
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0159	0.2414	0.2409
Loa Loa (eye worm)	fibroinase	0.0085	0.1119	0.26
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0085	0.1119	0.26
Entamoeba histolytica	cysteine proteinase, putative	0.0045	0.0439	0.2319
Brugia malayi	cathepsin B-like cysteine proteinase	0.0135	0.1998	0.4657
Mycobacterium leprae	PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN	0.024	0.3813	0.5
Echinococcus granulosus	NADPH dependent diflavin oxidoreductase 1	0.003	0.0169	0.0162
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0036	0.0276	0.0269
Brugia malayi	Variant SH3 domain containing protein	0.0031	0.0199	0.0448
Brugia malayi	Tyrosine-protein kinase abl-1	0.0036	0.0276	0.0629
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0055	0.0601	0.105
Entamoeba histolytica	cysteine protease, putative	0.0085	0.1119	0.5972
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0058	0.0655	0.5402
Brugia malayi	Cathepsin L-like precursor	0.0085	0.1119	0.26
Echinococcus multilocularis	cathepsin b	0.0135	0.1998	0.1993
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0159	0.2414	0.2409
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0085	0.1119	0.1113
Schistosoma mansoni	cytochrome P450 reductase	0.003	0.0169	0.0699
Entamoeba histolytica	cysteine proteinase, putative	0.0085	0.1119	0.5972
Trypanosoma cruzi	cysteine protease, putative	0.0045	0.0439	0.0772
Brugia malayi	Cathepsin L-like precursor	0.0085	0.1119	0.26
Mycobacterium tuberculosis	Possible two component transcriptional regulatory protein (probably LuxR-family)	0.024	0.3813	0.5
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0055	0.0601	0.1176
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0085	0.1119	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0027	0.0117	0.0258
Schistosoma mansoni	nck2/grb4	0.0031	0.0199	0.0822
Echinococcus granulosus	tyrosine protein kinase Blk	0.0144	0.2145	0.2139
Brugia malayi	follicle stimulating hormone receptor	0.0126	0.1842	0.4291
Schistosoma mansoni	hypothetical protein	0.0108	0.1519	0.6291
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0085	0.1119	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0159	0.2414	0.2409
Echinococcus granulosus	cathepsin l1	0.0085	0.1119	0.1113
Loa Loa (eye worm)	hypothetical protein	0.003	0.0169	0.0378
Brugia malayi	Cathepsin L-like precursor	0.0058	0.0655	0.1516
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0085	0.1119	1
Echinococcus multilocularis	cathepsin L	0.0045	0.0439	0.0432
Echinococcus multilocularis	cysteine protease	0.0085	0.1119	0.1113
Toxoplasma gondii	cathepsin CPL	0.0085	0.1119	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0085	0.1119	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0159	0.2414	0.2409
Trichomonas vaginalis	sulfite reductase, putative	0.003	0.0169	0.0581
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0159	0.2414	0.2409
Echinococcus granulosus	NADPH cytochrome P450 reductase	0.003	0.0169	0.0162
Leishmania major	cysteine peptidase A (CPA)	0.0085	0.1119	0.2417
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0144	0.2145	0.2139
Echinococcus granulosus	cathepsin b	0.0135	0.1998	0.1993
Brugia malayi	SRC-1	0.0159	0.2414	0.5629
Brugia malayi	cathepsin L-like precursor	0.0058	0.0655	0.1516
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0085	0.1119	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0085	0.1119	0.1113
Onchocerca volvulus		0.0085	0.1119	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0045	0.0439	0.1817
Echinococcus granulosus	cysteine protease	0.0045	0.0439	0.0432
Entamoeba histolytica	cysteine proteinase 2	0.0045	0.0439	0.2319
Entamoeba histolytica	cysteine protease, putative	0.0045	0.0439	0.2319
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0085	0.1119	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0144	0.2145	0.2139
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0655	0.1516
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0031	0.0199	0.0448
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0055	0.0601	0.4864
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0085	0.1119	1
Brugia malayi	Cathepsin L-like precursor	0.0085	0.1119	0.26
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0085	0.1119	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0135	0.1998	0.8279
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0159	0.2414	0.2409
Leishmania major	cathepsin L-like protease	0.0085	0.1119	0.2417
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0085	0.1119	0.26
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0139	0.2067	0.2062
Brugia malayi	Cathepsin L-like precursor	0.0085	0.1119	0.26
Brugia malayi	protein-tyrosine kinase	0.0144	0.2145	0.4999
Onchocerca volvulus	Cathepsin L homolog	0.0085	0.1119	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0117	0.0258
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0199	0.0448
Brugia malayi	flavodoxin family protein	0.003	0.0169	0.0378
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0045	0.0439	0.3257
Trypanosoma cruzi	cruzipain precursor, putative	0.0085	0.1119	0.2404
Schistosoma mansoni	tyrosine kinase	0.002	0.0007	0.0028
Leishmania major	cathepsin L-like protease	0.0085	0.1119	0.2417
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0159	0.2414	0.2409
Trypanosoma cruzi	cysteine proteinase, putative	0.0045	0.0439	0.0772
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0085	0.1119	0.2309
Schistosoma mansoni	tyrosine kinase	0.0036	0.0276	0.1143
Giardia lamblia	Cathepsin B precursor	0.0055	0.0601	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0085	0.1119	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0085	0.1119	0.1113
Leishmania major	C-8 sterol isomerase-like protein	0.0267	0.4283	1
Onchocerca volvulus		0.0058	0.0655	0.5829
Trypanosoma brucei	RNA helicase, putative	0.0108	0.1519	0.3281
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0117	0.0258
Plasmodium vivax	vivapain-3	0.0045	0.0439	0.3257
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0139	0.2067	0.2062
Entamoeba histolytica	protein kinase, putative	0.0128	0.1869	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0085	0.1119	0.2309
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0085	0.1119	0.2309
Trypanosoma cruzi	cysteine proteinase, putative	0.0045	0.0439	0.0772
Mycobacterium tuberculosis	Possible transcriptional regulatory protein	0.024	0.3813	0.5
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0159	0.2414	0.2409
Brugia malayi	Papain family cysteine protease containing protein	0.0085	0.1119	0.26
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0159	0.2414	0.2409
Entamoeba histolytica	cysteine protease, putative	0.0045	0.0439	0.2319
Mycobacterium ulcerans	two component transcriptional regulator	0.024	0.3813	1
Entamoeba histolytica	cysteine protease, putative	0.0045	0.0439	0.2319
Entamoeba histolytica	cysteine protease, putative	0.0045	0.0439	0.2319
Entamoeba histolytica	cysteine protease, putative	0.0045	0.0439	0.2319
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0085	0.1119	0.2309
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0085	0.1119	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0085	0.1119	0.2404
Entamoeba histolytica	cysteine proteinase, putative	0.0045	0.0439	0.2319
Entamoeba histolytica	cysteine protease, putative	0.0045	0.0439	0.2319
Entamoeba histolytica	cysteine protease, putative	0.0045	0.0439	0.2319
Trypanosoma cruzi	cysteine peptidase, putative	0.0085	0.1119	0.2404
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0058	0.0655	0.1516
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0159	0.2414	0.2409
Plasmodium vivax	unspecified product	0.0027	0.0117	0.007
Echinococcus multilocularis	cathepsin L cysteine protease	0.0085	0.1119	0.1113
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0085	0.1119	1
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.0267	0.4283	1
Loa Loa (eye worm)	hypothetical protein	0.0267	0.4283	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0085	0.1119	1
Echinococcus granulosus	cathepsin L	0.0045	0.0439	0.0432
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0085	0.1119	1
Brugia malayi	Cathepsin L-like precursor	0.0085	0.1119	0.26
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0058	0.0655	0.1291
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0085	0.1119	1
Loa Loa (eye worm)	ctsf protein	0.0085	0.1119	0.26
Loa Loa (eye worm)	hypothetical protein	0.0135	0.1998	0.4657
Leishmania major	cathepsin L-like protease	0.0085	0.1119	0.2417
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0128	0.1869	0.1863
Onchocerca volvulus		0.0085	0.1119	1
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.003	0.0169	0.0124
Mycobacterium tuberculosis	Probable transcriptional regulatory protein (LuxR-family)	0.024	0.3813	0.5
Mycobacterium ulcerans	hypothetical protein	0.024	0.3813	1
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0117	0.0258
Loa Loa (eye worm)	TK protein kinase	0.0144	0.2145	0.4999
Echinococcus granulosus	c src tyrosine kinase	0.0036	0.0276	0.0269
Onchocerca volvulus		0.0085	0.1119	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0036	0.0276	0.1143
Entamoeba histolytica	cysteine proteinase, putative	0.0045	0.0439	0.2319
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0058	0.0655	0.5402
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0085	0.1119	1
Echinococcus granulosus	cathepsin l1	0.0058	0.0655	0.0649
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0267	0.4283	1
Echinococcus granulosus	NCK adaptor protein	0.0031	0.0199	0.0192
Plasmodium vivax	vivapain-1	0.0045	0.0439	0.3257
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0085	0.1119	1
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0159	0.2414	0.2409
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0085	0.1119	0.2309
Echinococcus multilocularis	NCK adaptor protein	0.0031	0.0199	0.0192
Trypanosoma cruzi	NADPH-dependent FMN/FAD containing oxidoreductase, putative	0.003	0.0169	0.0124
Giardia lamblia	Cathepsin B precursor	0.0055	0.0601	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0085	0.1119	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0085	0.1119	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0085	0.1119	1
Echinococcus granulosus	growth factor receptor bound protein 2	0.0031	0.0199	0.0192
Schistosoma mansoni	cathepsin F (C01 family)	0.0085	0.1119	0.4635
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0085	0.1119	0.2309
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0135	0.1998	0.4516
Mycobacterium tuberculosis	Probable transcriptional regulatory protein (probably LuxR/UhpA-family)	0.024	0.3813	0.5
Onchocerca volvulus		0.0085	0.1119	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0045	0.0439	0.2319
Brugia malayi	Papain family cysteine protease containing protein	0.0045	0.0439	0.101
Plasmodium vivax	unspecified product	0.0045	0.0439	0.3257
Echinococcus multilocularis	NADPH cytochrome P450 reductase	0.003	0.0169	0.0162
Entamoeba histolytica	cysteine protease, putative	0.0045	0.0439	0.2319
Mycobacterium ulcerans	nitrate/nitrite response regulator protein NarL	0.024	0.3813	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0085	0.1119	0.2309
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0045	0.0439	0.2841
Leishmania major	cathepsin L-like protease	0.0085	0.1119	0.2417
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0085	0.1119	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 869985