Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F) | 0.0242 | 0.1104 | 0.0663 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0097 | 0.0163 | 0.0496 |
Echinococcus multilocularis | CAAX prenyl protease 2 | 0.0089 | 0.0114 | 0.1034 |
Echinococcus multilocularis | NADH dehydrogenase (ubiquinone) flavoprotein 1 | 0.0242 | 0.1104 | 1 |
Entamoeba histolytica | CAAX prenyl protease family | 0.0089 | 0.0114 | 0.5 |
Schistosoma mansoni | single-minded | 0.0097 | 0.0163 | 0.0496 |
Mycobacterium tuberculosis | Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. | 0.1612 | 1 | 1 |
Echinococcus granulosus | NADH dehydrogenase ubiquinone flavoprotein 1 | 0.0242 | 0.1104 | 1 |
Echinococcus granulosus | NADH dehydrogenase subunit 1 | 0.0144 | 0.0472 | 0.4277 |
Mycobacterium ulcerans | NADH dehydrogenase I subunit F | 0.0242 | 0.1104 | 0.1104 |
Schistosoma mansoni | NADH-ubiquinone oxidoreductase | 0.0242 | 0.1104 | 1 |
Mycobacterium ulcerans | NADH dehydrogenase subunit H | 0.0144 | 0.0472 | 0.0472 |
Leishmania major | NADH-ubiquinone oxidoreductase, mitochondrial, putative | 0.0242 | 0.1104 | 1 |
Onchocerca volvulus | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial homolog | 0.013 | 0.0376 | 1 |
Giardia lamblia | Hypothetical protein | 0.0089 | 0.0114 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | NADH dehydrogenase I subunit F | 0.0242 | 0.1104 | 1 |
Brugia malayi | hypoxia-induced factor 1 | 0.0299 | 0.1479 | 0.9006 |
Brugia malayi | PAS domain containing protein | 0.0097 | 0.0163 | 0.0994 |
Trypanosoma brucei | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial, putative | 0.0242 | 0.1104 | 1 |
Brugia malayi | NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial precursor | 0.0242 | 0.1104 | 0.6721 |
Trypanosoma cruzi | NADH-ubiquinone oxidoreductase, mitochondrial, putative | 0.0242 | 0.1104 | 1 |
Trichomonas vaginalis | NADH-ubiquinone oxidoreductase flavoprotein, putative | 0.0242 | 0.1104 | 1 |
Echinococcus granulosus | CAAX prenyl protease 2 | 0.0089 | 0.0114 | 0.1034 |
Trypanosoma brucei | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | 0.0242 | 0.1104 | 1 |
Trichomonas vaginalis | NADH-ubiquinone oxidoreductase flavoprotein, putative | 0.0242 | 0.1104 | 1 |
Brugia malayi | CAAX amino terminal protease family protein | 0.0089 | 0.0114 | 0.0695 |
Schistosoma mansoni | hypothetical protein | 0.0144 | 0.0472 | 0.3616 |
Brugia malayi | hypothetical protein | 0.0325 | 0.1642 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0325 | 0.1642 | 1 |
Trypanosoma cruzi | NADH-ubiquinone oxidoreductase, mitochondrial, putative | 0.0242 | 0.1104 | 1 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0299 | 0.1479 | 0.8932 |
Loa Loa (eye worm) | NADH-ubiquinone oxidoreductase 51 kDa subunit | 0.0242 | 0.1104 | 0.6476 |
Mycobacterium ulcerans | proteasome PrcA | 0.1612 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.