Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | DNA helicase recq, putative | 0.0048 | 0.1357 | 0.0848 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0048 | 0.1357 | 0.0848 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0063 | 0.19 | 1 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0063 | 0.19 | 0.724 |
Schistosoma mansoni | DNA helicase recq5 | 0.002 | 0.0348 | 0.0087 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0048 | 0.1357 | 0.1046 |
Loa Loa (eye worm) | glutaminase | 0.029 | 1 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0083 | 0.2616 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.1276 | 0.4754 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0035 | 0.0904 | 0.0368 |
Trichomonas vaginalis | glutaminase, putative | 0.029 | 1 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0083 | 0.2616 | 0.9817 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0035 | 0.0875 | 0.3231 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0084 | 0.2658 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0084 | 0.2658 | 1 |
Trypanosoma brucei | DNA damage repair protein, putative | 0.0017 | 0.0263 | 0.0909 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.002 | 0.0348 | 0.052 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0084 | 0.2658 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0084 | 0.2658 | 0.246 |
Trypanosoma brucei | chrX additional, unordered contigs | 0.0017 | 0.0263 | 0.0909 |
Trypanosoma brucei | unspecified product | 0.0039 | 0.1026 | 0.3805 |
Giardia lamblia | DINP protein human, muc B family | 0.0063 | 0.19 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0084 | 0.2658 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0044 | 0.1228 | 0.4574 |
Trichomonas vaginalis | rotamase, putative | 0.0035 | 0.0875 | 0.0337 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1002 | 0.6073 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1002 | 0.6073 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0056 | 0.165 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.0084 | 0.2658 | 1 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.002 | 0.0348 | 0.0961 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1271 | 0.0956 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1002 | 0.0759 |
Schistosoma mansoni | DNA polymerase eta | 0.0083 | 0.2616 | 0.2416 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0056 | 0.165 | 0.1349 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0084 | 0.2658 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.0063 | 0.19 | 0.724 |
Echinococcus granulosus | expressed protein | 0.0035 | 0.0904 | 0.2409 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0038 | 0.0995 | 0.0753 |
Leishmania major | DNA polymerase kappa, putative | 0.0017 | 0.0263 | 0.0924 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0084 | 0.2658 | 1 |
Loa Loa (eye worm) | glutaminase 2 | 0.029 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0084 | 0.2658 | 0.2225 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.4864 | 0.4679 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0017 | 0.0263 | 0.0909 |
Wolbachia endosymbiont of Brugia malayi | parvulin-like peptidyl-prolyl isomerase, PPID | 0.0011 | 0.0023 | 0.5 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0026 | 0.0557 | 0.2024 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0084 | 0.2658 | 1 |
Entamoeba histolytica | recQ family helicase, putative | 0.0026 | 0.0557 | 0.3373 |
Brugia malayi | hypothetical protein | 0.0038 | 0.1002 | 0.0678 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0032 | 0.0787 | 0.6405 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.1276 | 0.4754 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0084 | 0.2658 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.1002 | 0.2832 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.1002 | 0.0759 |
Entamoeba histolytica | Flap nuclease, putative | 0.0028 | 0.0625 | 0.3791 |
Loa Loa (eye worm) | Pin1-type peptidyl-prolyl cis-trans isomerase | 0.0035 | 0.0904 | 0.0577 |
Schistosoma mansoni | rotamase | 0.0035 | 0.0904 | 0.0659 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0017 | 0.0263 | 0.0909 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0063 | 0.19 | 0.7123 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0084 | 0.2658 | 0.246 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0017 | 0.0263 | 0.2139 |
Leishmania major | DNA polymerase eta, putative | 0.0044 | 0.1228 | 0.4648 |
Schistosoma mansoni | flap endonuclease-1 | 0.0025 | 0.0531 | 0.0275 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0084 | 0.2658 | 1 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0026 | 0.0557 | 0.2057 |
Trichomonas vaginalis | rotamase, putative | 0.0035 | 0.0904 | 0.0368 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0084 | 0.2658 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0083 | 0.2616 | 0.9839 |
Trypanosoma brucei | unspecified product | 0.0039 | 0.1026 | 0.3805 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0056 | 0.165 | 0.1425 |
Brugia malayi | polk-prov protein | 0.0046 | 0.1271 | 0.0956 |
Plasmodium falciparum | flap endonuclease 1 | 0.0028 | 0.0625 | 0.4096 |
Trypanosoma brucei | DNA damage repair protein, putative | 0.0017 | 0.0263 | 0.0909 |
Leishmania major | flap endonuclease-1 (FEN-1), putative | 0.0028 | 0.0625 | 0.2323 |
Schistosoma mansoni | glutaminase | 0.029 | 1 | 1 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0028 | 0.0625 | 0.0073 |
Leishmania major | peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative | 0.0035 | 0.0875 | 0.3284 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0042 | 0.1148 | 1 |
Plasmodium vivax | flap endonuclease 1, putative | 0.0028 | 0.0625 | 0.6745 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0056 | 0.165 | 0.5637 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0056 | 0.165 | 0.1349 |
Toxoplasma gondii | flap structure-specific endonuclease 1, putative | 0.0028 | 0.0625 | 0.5092 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0084 | 0.2658 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1002 | 0.6073 |
Echinococcus multilocularis | expressed protein | 0.0035 | 0.0904 | 0.2409 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.1271 | 0.4734 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.002 | 0.0348 | 0.2832 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase/rotamase, putative | 0.0035 | 0.0875 | 0.3231 |
Trypanosoma cruzi | DNA damage repair protein, putative | 0.0017 | 0.0263 | 0.0909 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0084 | 0.2658 | 0.2225 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0084 | 0.2658 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0017 | 0.0263 | 0.0909 |
Loa Loa (eye worm) | flap endonuclease-1 | 0.0028 | 0.0625 | 0.0288 |
Echinococcus multilocularis | bloom syndrome protein | 0.0048 | 0.1357 | 0.4369 |
Echinococcus granulosus | dna polymerase eta | 0.0083 | 0.2616 | 0.9817 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.1271 | 0.4734 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0084 | 0.2658 | 1 |
Trypanosoma cruzi | DNA damage repair protein, putative | 0.0017 | 0.0263 | 0.0909 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0083 | 0.2616 | 0.2349 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.2616 | 0.2349 |
Echinococcus granulosus | bloom syndrome protein | 0.0048 | 0.1357 | 0.4369 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.1276 | 0.4754 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0017 | 0.0263 | 0.0909 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0084 | 0.2658 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.002 | 0.0348 | 0.2832 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0077 | 0.2408 | 0.9051 |
Loa Loa (eye worm) | RecQ helicase | 0.0048 | 0.1357 | 0.1046 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0056 | 0.165 | 0.1425 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0035 | 0.0875 | 0.3231 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.0028 | 0.0625 | 0.2286 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0083 | 0.2616 | 0.9839 |
Toxoplasma gondii | peptidylprolyl isomerase | 0.0035 | 0.0875 | 0.7121 |
Toxoplasma gondii | BRCA1 C Terminus (BRCT) domain-containing protein | 0.0024 | 0.0513 | 0.4175 |
Brugia malayi | Flap endonuclease-1 | 0.0028 | 0.0625 | 0.0288 |
Trypanosoma brucei | unspecified product | 0.0077 | 0.2408 | 0.9051 |
Toxoplasma gondii | PPIC-type PPIASE domain-containing protein | 0.0011 | 0.0023 | 0.019 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0056 | 0.165 | 0.5637 |
Mycobacterium ulcerans | glutaminase | 0.029 | 1 | 1 |
Brugia malayi | Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 | 0.0035 | 0.0904 | 0.0577 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.1002 | 0.2832 |
Leishmania major | DNA damage repair protein, putative | 0.0017 | 0.0263 | 0.0924 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0084 | 0.2658 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1002 | 0.6073 |
Echinococcus multilocularis | dna polymerase kappa | 0.0084 | 0.2658 | 1 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0044 | 0.1228 | 1 |
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.0028 | 0.0625 | 0.2286 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, putative | 0.0035 | 0.0875 | 0.5301 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0026 | 0.0557 | 0.2024 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0032 | 0.0801 | 1 |
Schistosoma mansoni | DNA helicase recq1 | 0.002 | 0.0348 | 0.0087 |
Echinococcus multilocularis | flap endonuclease 1 | 0.0028 | 0.0625 | 0.1202 |
Echinococcus granulosus | flap endonuclease 1 | 0.0028 | 0.0625 | 0.1202 |
Giardia lamblia | Flap structure-specific endonuclease | 0.0028 | 0.0625 | 0.2215 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.