Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0145 | 0 | 0.5 |
Plasmodium falciparum | histone deacetylase 1 | 0.0145 | 0 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.046 | 0.3774 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.046 | 0.3774 | 1 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0404 | 0.31 | 0.31 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0404 | 0.31 | 0.31 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0404 | 0.31 | 0.31 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0404 | 0.31 | 0.31 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.046 | 0.3774 | 1 |
Schistosoma mansoni | patched 1 | 0.0404 | 0.31 | 0.31 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.046 | 0.3774 | 1 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0145 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0981 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0404 | 0.31 | 0.8215 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0404 | 0.31 | 0.31 |
Echinococcus multilocularis | protein dispatched 1 | 0.0404 | 0.31 | 0.31 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0981 | 1 | 1 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0145 | 0 | 0.5 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0404 | 0.31 | 0.31 |
Loa Loa (eye worm) | hypothetical protein | 0.0404 | 0.31 | 0.31 |
Echinococcus multilocularis | protein patched | 0.0404 | 0.31 | 0.31 |
Brugia malayi | CHE-14 protein | 0.0404 | 0.31 | 0.31 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0981 | 1 | 0.5 |
Entamoeba histolytica | histone deacetylase, putative | 0.0145 | 0 | 0.5 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0981 | 1 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0404 | 0.31 | 0.31 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0981 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0981 | 1 | 1 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0981 | 1 | 1 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0981 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0981 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.