Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1335 | 0.7936 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1269 | 0.7227 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.1016 | 0.4509 | 0.249 |
Mycobacterium ulcerans | thymidylate synthase | 0.1269 | 0.7227 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1335 | 0.7936 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.1269 | 0.7227 | 1 |
Onchocerca volvulus | 0.1269 | 0.7227 | 1 | |
Onchocerca volvulus | Matrilysin homolog | 0.0932 | 0.3607 | 0.4991 |
Brugia malayi | hypothetical protein | 0.0604 | 0.0087 | 0.012 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1335 | 0.7936 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1335 | 0.7936 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0604 | 0.0087 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0932 | 0.3607 | 0.4991 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1335 | 0.7936 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.1528 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1269 | 0.7227 | 1 |
Brugia malayi | thymidylate synthase | 0.1269 | 0.7227 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.1269 | 0.7227 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1335 | 0.7936 | 0.5 |
Brugia malayi | Matrixin family protein | 0.1016 | 0.4509 | 0.6239 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.