Detailed information for compound 870971

Basic information

Technical information
  • TDR Targets ID: 870971
  • Name: 3-cyclopentyl-2-sulfanylidene-1H-quinazolin-4 -one
  • MW: 246.328 | Formula: C13H14N2OS
  • H donors: 1 H acceptors: 1 LogP: 2.5 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=c1[nH]c2ccccc2c(=O)n1C1CCCC1
  • InChi: 1S/C13H14N2OS/c16-12-10-7-3-4-8-11(10)14-13(17)15(12)9-5-1-2-6-9/h3-4,7-9H,1-2,5-6H2,(H,14,17)
  • InChiKey: ROEAWMSBZLHPSX-UHFFFAOYSA-N  

Network

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Synonyms

  • 3-cyclopentyl-2-thioxo-1H-quinazolin-4-one
  • T0516-5926
  • 3-Cyclopentyl-2-sulfanyl-4(3H)-quinazolinone
  • Oprea1_504242
  • NSC176289
  • ZINC00292399
  • ZINC00316656
  • IVK/8027420
  • 3-Cyclopentyl-2-mercapto-3H-quinazolin-4-one
  • BAS 00718584
  • AJ-292/37095006
  • Oprea1_374398
  • ChemDiv3_012440
  • Quinazolin-4(3H)-one, 3-cyclopentyl-2-mercapto-
  • Oprea1_013173

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1313 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0319 0.3697
Trichomonas vaginalis ferritin, putative 0.0008 0.0024 0.0087
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0242 0.0305
Schistosoma mansoni ferritin 0.0008 0.0024 0.0274
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0035 0.0234
Brugia malayi nuclear receptor NHR-88 0.001 0.0035 0.0234
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0187 0.2171
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.0913 0.6032
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0319 1
Echinococcus multilocularis smad 0.0008 0.0025 0.0791
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0035 0.0412
Loa Loa (eye worm) hypothetical protein 0.0038 0.0251 0.1655
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1313 1 1
Schistosoma mansoni apoferritin-2 0.0008 0.0024 0.0274
Schistosoma mansoni smad 0.0008 0.0025 0.0292
Schistosoma mansoni hypothetical protein 0.0011 0.0044 0.0515
Mycobacterium tuberculosis Conserved protein 0.0038 0.0251 0.0318
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0251 0.0318
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0251 0.7862
Brugia malayi Thioredoxin reductase 0.0037 0.0242 0.1597
Schistosoma mansoni cpg binding protein 0.0028 0.0174 0.2019
Leishmania major hypothetical protein, conserved 0.0025 0.0148 0.4673
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0319 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0187 0.5872
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0234
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0251 0.0318
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0251 0.2907
Echinococcus granulosus FTZ F1 alpha 0.001 0.0035 0.1113
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0242 0.1597
Loa Loa (eye worm) glutathione reductase 0.0037 0.0242 0.1597
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0251 0.1655
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0234
Echinococcus multilocularis cpg binding protein 0.003 0.0186 0.5843
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.0913 0.6032
Loa Loa (eye worm) hypothetical protein 0.0038 0.0251 0.1655
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.0943 0.717 1
Onchocerca volvulus 0.0038 0.0251 0.1271
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.0602 0.081
Schistosoma mansoni ferritin light chain 0.0008 0.0024 0.0274
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0025 0.0166
Brugia malayi steroid hormone receptor 0.001 0.0035 0.0234
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.037 0.2791 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0009 0.0032 0.0211
Loa Loa (eye worm) hypothetical protein 0.003 0.0187 0.1236
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0174 0.5469
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0035 0.1113
Schistosoma mansoni ferritin 0.0008 0.0024 0.0274
Echinococcus granulosus Smad4 0.0008 0.0025 0.0791
Leishmania major trypanothione reductase 0.0037 0.0242 0.9547
Trichomonas vaginalis C-MYB, putative 0.0009 0.0032 0.0134
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.0602 0.081
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0251 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0035 0.0412
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0035 0.0412
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0035 0.0234
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0251 0.0318
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0035 0.0234
Echinococcus granulosus ferritin 0.0008 0.0024 0.0742
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0035 0.0234
Schistosoma mansoni thyroid hormone receptor 0.001 0.0035 0.0412
Trichomonas vaginalis pc-MYB2, putative 0.0009 0.0032 0.0134
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0187 0.2171
Brugia malayi MH1 domain containing protein 0.0008 0.0025 0.0166
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0251 0.2907
Brugia malayi hypothetical protein 0.0025 0.0148 0.0977
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0148 0.4673
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0022 0.0676
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0251 1
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0035 0.1113
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0251 0.0318
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0009 0.0032 0.0136
Leishmania major hypothetical protein, conserved 0.0038 0.0251 1
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0035 0.0412
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0058 1
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0251 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0035 0.0234
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0058 0.1815
Loa Loa (eye worm) Smad1 0.0008 0.0025 0.0166
Mycobacterium tuberculosis Conserved protein 0.0038 0.0251 0.0318
Echinococcus multilocularis Smad4 0.0008 0.0025 0.0791
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0035 0.0234
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0174 0.1149
Schistosoma mansoni ferritin 0.0008 0.0024 0.0274
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0187 0.5872
Onchocerca volvulus 0.003 0.0187 0.0896
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.0674 0.091
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0246 0.7706
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0035 0.0234
Trichomonas vaginalis MYB3r3, putative 0.0009 0.0032 0.0134
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0243 0.1815 0.2506
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0234
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0148 0.4894
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0035 0.0234
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.0602 0.081
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.0602 0.081
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0035 0.1085
Trichomonas vaginalis MYB72, putative 0.0009 0.0032 0.0134
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0246 0.7706
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0319 0.3697
Onchocerca volvulus 0.0028 0.0174 0.0819
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0035 0.0412
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0234
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0234
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0035 0.0412
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0251 0.0318
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0025 0.0292
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0035 0.1113
Trichomonas vaginalis C-MYB, putative 0.0009 0.0032 0.0134
Schistosoma mansoni nuclear hormone receptor 0.001 0.0035 0.0412
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0234
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0058 0.1815
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0035 0.0234
Schistosoma mansoni ferritin 0.0008 0.0024 0.0274
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0058 0.0093
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0319 0.2105
Brugia malayi MH1 domain containing protein 0.0008 0.0025 0.0166
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0058 0.0034
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0251 0.0227
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0009 0.0032 0.5
Schistosoma mansoni smad1 5 8 and 0.0008 0.0025 0.0292
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.0674 0.091
Loa Loa (eye worm) hypothetical protein 0.0038 0.0251 0.1655
Plasmodium falciparum thioredoxin reductase 0.0037 0.0242 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0035 0.0234
Schistosoma mansoni ferritin light chain 0.0008 0.0024 0.0274
Mycobacterium tuberculosis Conserved protein 0.0038 0.0251 0.0318
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0025 0.0791
Schistosoma mansoni apoferritin-2 0.0008 0.0024 0.0274
Trichomonas vaginalis set domain proteins, putative 0.0231 0.1728 1
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.037 0.2791 0.3872
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0187 0.2171
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.0602 0.081
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0035 0.1113
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0035 0.1113
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0035 0.0234
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0058 0.0671
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0187 0.2171
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0009 0.0032 0.5
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0013 0.0058 0.0034
Schistosoma mansoni thyroid hormone receptor 0.001 0.0035 0.0412
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0035 0.1113
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0319 1
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0242 0.9547
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0009 0.0032 0.5
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0251 0.1407
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0035 0.0234
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0013 0.0058 0.0034
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0058 0.0034
Schistosoma mansoni cpg binding protein 0.003 0.0186 0.216
Brugia malayi beta-lactamase 0.0038 0.0251 0.1655
Brugia malayi MH2 domain containing protein 0.0008 0.0025 0.0166
Schistosoma mansoni Smad4 0.0008 0.0025 0.0292
Loa Loa (eye worm) hypothetical protein 0.0025 0.0148 0.0977
Plasmodium vivax SET domain protein, putative 0.003 0.0187 0.6709
Schistosoma mansoni smad1 5 8 and 0.0008 0.0025 0.0292
Brugia malayi ecdysteroid receptor 0.001 0.0035 0.0234
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0058 0.0382
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0035 0.1113
Mycobacterium ulcerans beta-lactamase 0.0038 0.0251 0.0227
Brugia malayi nuclear hormone receptor 0.001 0.0035 0.0234
Mycobacterium ulcerans lipase LipD 0.0038 0.0251 0.0227
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0058 0.0093
Treponema pallidum NADH oxidase 0.0013 0.0058 0.0034
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0148 0.4673
Schistosoma mansoni smad1 5 8 and 0.0008 0.0025 0.0292
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0242 0.9547
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0251 0.0318
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0025 0.0791
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0234
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0251 0.1407
Brugia malayi Pre-SET motif family protein 0.0203 0.1514 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0251 0.1407
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0035 0.0234
Trypanosoma brucei trypanothione reductase 0.0037 0.0242 0.9547
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0035 0.0234
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0251 0.0318
Brugia malayi Smad1 0.0008 0.0025 0.0166
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0373 0.1237
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0035 0.0412
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0044 0.1393
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0009 0.0032 0.0134
Echinococcus granulosus expressed protein 0.0008 0.0024 0.0742
Loa Loa (eye worm) histone methyltransferase 0.001 0.0035 0.0228
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0025 0.0166
Trichomonas vaginalis esterase, putative 0.0038 0.0251 0.1407
Plasmodium vivax glutathione reductase, putative 0.0037 0.0242 0.9547
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.037 0.2791 0.2749
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.0943 0.717 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0035 0.1113
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0035 0.1113
Schistosoma mansoni cpg binding protein 0.003 0.0186 0.216
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0022 0.0676
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0035 0.1113
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0022 0.0676
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0058 0.0286
Toxoplasma gondii thioredoxin reductase 0.0037 0.0242 0.076
Mycobacterium leprae Probable lipase LipE 0.0038 0.0251 0.0318
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0013 0.0058 0.0034
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0035 0.0412
Trichomonas vaginalis pc-MYB2, putative 0.0009 0.0032 0.0134
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0035 0.0234
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0009 0.0032 0.0134
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0251 0.1655
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0422 0.4894
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0319 0.3697
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0035 0.0234
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0009 0.0032 0.0134
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0251 0.1407
Trichomonas vaginalis MYB, putative 0.0009 0.0032 0.0136
Brugia malayi glutathione reductase 0.0037 0.0242 0.1597
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0251 0.7862
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0148 0.4673
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.0602 0.081
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0035 0.1113
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0009 0.0032 0.0136
Echinococcus multilocularis ferritin 0.0008 0.0024 0.0742
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1313 1 1
Brugia malayi beta-lactamase family protein 0.0038 0.0251 0.1655
Onchocerca volvulus 0.0231 0.1728 1
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0148 0.042
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0035 0.0234
Brugia malayi Pre-SET motif family protein 0.003 0.0187 0.1236
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0013 0.0058 0.0048
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0035 0.1113
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0034 0.0223
Brugia malayi CXXC zinc finger family protein 0.0028 0.0174 0.1149
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0251 0.0318
Mycobacterium ulcerans hypothetical protein 0.0038 0.0251 0.0227
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0319 1
Onchocerca volvulus 0.0038 0.0251 0.1271
Loa Loa (eye worm) beta-lactamase 0.0038 0.0251 0.1655
Schistosoma mansoni coup transcription factor 0.001 0.0035 0.0412
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0035 0.1113
Brugia malayi MH2 domain containing protein 0.0008 0.0025 0.0166
Brugia malayi beta-lactamase family protein 0.0038 0.0251 0.1655
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0035 0.0412
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0148 0.4894
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0319 0.2105
Loa Loa (eye worm) hypothetical protein 0.0038 0.0251 0.1655
Plasmodium falciparum glutathione reductase 0.0037 0.0242 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0035 0.1113
Onchocerca volvulus 0.0038 0.0251 0.1271
Echinococcus multilocularis expressed protein 0.0008 0.0024 0.0742
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0035 0.1113
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.1514 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.0674 0.091
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0035 0.1113
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0035 0.0234
Mycobacterium tuberculosis Probable reductase 0.0084 0.0602 0.081
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0035 0.0234
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0148 0.4673
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0035 0.1113
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0009 0.0032 0.5
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0035 0.0234
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0025 0.0791
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0251 1
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0009 0.0032 0.0134
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0009 0.0032 0.0134
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0187 0.5872
Brugia malayi hypothetical protein 0.0016 0.0081 0.0538
Brugia malayi MH2 domain containing protein 0.0125 0.0913 0.6032
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0025 0.0791
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0022 0.0676
Toxoplasma gondii ABC1 family protein 0.0038 0.0251 0.0792
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0035 0.0234
Loa Loa (eye worm) hypothetical protein 0.0038 0.0251 0.1655
Loa Loa (eye worm) hypothetical protein 0.0038 0.0251 0.1655
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0251 0.0227
Echinococcus granulosus smad 0.0008 0.0025 0.0791
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0058 0.0286
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0009 0.0032 0.0134
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0044 0.1393
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0009 0.0032 0.0211
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0035 0.1085
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0251 0.1407
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0187 0.0562
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0234
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0035 0.0234
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0035 0.0234
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0009 0.0032 0.5
Echinococcus granulosus cpg binding protein 0.003 0.0186 0.5843
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0022 0.025
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0035 0.0234
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.037 0.2791 0.2774
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.0674 0.091

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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