Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0083 | 0.017 | 0.0176 |
Brugia malayi | steroid hormone receptor | 0.0083 | 0.017 | 0.0176 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0083 | 0.017 | 0.0176 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0083 | 0.017 | 0.0176 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.017 | 0.0176 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.017 | 0.0176 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0083 | 0.017 | 0.0176 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.017 | 0.0176 |
Brugia malayi | ecdysteroid receptor | 0.0083 | 0.017 | 0.0176 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0083 | 0.017 | 0.0176 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0083 | 0.017 | 0.0176 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0083 | 0.017 | 0.0176 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0083 | 0.017 | 0.0176 |
Loa Loa (eye worm) | hypothetical protein | 0.1335 | 0.9387 | 0.9701 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0083 | 0.017 | 0.0176 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.017 | 0.0176 |
Chlamydia trachomatis | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase | 0.07 | 0.4709 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0181 | 0.0892 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.017 | 0.0176 |
Brugia malayi | nuclear hormone receptor | 0.1374 | 0.9676 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0083 | 0.017 | 0.0176 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0083 | 0.017 | 0.0176 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0083 | 0.017 | 0.0176 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0083 | 0.017 | 0.0176 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0083 | 0.017 | 0.0176 |
Brugia malayi | nuclear hormone receptor | 0.0083 | 0.017 | 0.0176 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.1374 | 0.9676 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0083 | 0.017 | 0.0176 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0137 | 0.0568 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0083 | 0.017 | 0.0176 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0083 | 0.017 | 0.0176 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.017 | 0.0176 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0083 | 0.017 | 0.0176 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0083 | 0.017 | 0.0176 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0083 | 0.017 | 0.0176 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.017 | 0.0176 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0083 | 0.017 | 0.0176 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0083 | 0.017 | 0.0176 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0083 | 0.017 | 0.0176 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.017 | 0.0176 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0083 | 0.017 | 0.0176 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0181 | 0.0892 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0083 | 0.017 | 0.0176 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 3.5481 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 5.0119 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.6234 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | 39.8107 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.