Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.012 | 0.2234 | 0.1738 |
Echinococcus multilocularis | cathepsin b | 0.0295 | 0.9471 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.012 | 0.2234 | 1 |
Onchocerca volvulus | 0.012 | 0.2234 | 1 | |
Entamoeba histolytica | cysteine proteinase, putative | 0.012 | 0.2234 | 1 |
Onchocerca volvulus | 0.012 | 0.2234 | 1 | |
Leishmania major | cysteine peptidase A (CPA) | 0.012 | 0.2234 | 0.0438 |
Onchocerca volvulus | 0.012 | 0.2234 | 1 | |
Echinococcus multilocularis | cathepsin b | 0.0295 | 0.9471 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.012 | 0.2234 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0111 | 0.1877 | 0.8406 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 0.2234 | 1 |
Plasmodium vivax | vivapain-2 | 0.012 | 0.2234 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0295 | 0.9471 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0083 | 0.0711 | 0.3182 |
Leishmania major | cathepsin L-like protease | 0.012 | 0.2234 | 0.0438 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0295 | 0.9471 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0111 | 0.1877 | 0.5 |
Loa Loa (eye worm) | fibroinase | 0.012 | 0.2234 | 0.1738 |
Onchocerca volvulus | 0.012 | 0.2234 | 1 | |
Schistosoma mansoni | cathepsin F (C01 family) | 0.012 | 0.2234 | 0.2358 |
Leishmania major | cathepsin L-like protease | 0.0308 | 1 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.012 | 0.2234 | 0.2358 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.012 | 0.2234 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 0.2234 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.012 | 0.2234 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0308 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.012 | 0.2234 | 0.2358 |
Brugia malayi | Cathepsin L-like precursor | 0.012 | 0.2234 | 0.2358 |
Echinococcus multilocularis | cysteine protease | 0.012 | 0.2234 | 0.2358 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.2234 | 0.1738 |
Leishmania major | cathepsin L-like protease | 0.012 | 0.2234 | 0.0438 |
Plasmodium vivax | vivapain-2 | 0.012 | 0.2234 | 1 |
Leishmania major | cathepsin L-like protease | 0.012 | 0.2234 | 0.0438 |
Brugia malayi | Papain family cysteine protease containing protein | 0.012 | 0.2234 | 0.2358 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 0.2234 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.012 | 0.2234 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.012 | 0.2234 | 0.2358 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0083 | 0.0711 | 0.075 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.2234 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.2234 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.012 | 0.2234 | 0.2234 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 0.2234 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.2234 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0111 | 0.1877 | 0.1877 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 0.2234 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0308 | 1 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0308 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 0.2234 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.012 | 0.2234 | 0.1738 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0295 | 0.9471 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0308 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0308 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0083 | 0.0711 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.2234 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.012 | 0.2234 | 0.2358 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0308 | 1 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.012 | 0.2234 | 0.1738 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0295 | 0.9471 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0111 | 0.1877 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0295 | 0.9471 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0308 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.012 | 0.2234 | 0.2358 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0111 | 0.1877 | 0.1877 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.012 | 0.2234 | 0.2358 |
Onchocerca volvulus | 0.012 | 0.2234 | 1 | |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0217 | 0.6244 | 0.6244 |
Brugia malayi | Cathepsin L-like precursor | 0.0083 | 0.0711 | 0.075 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 0.2234 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.012 | 0.2234 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.012 | 0.2234 | 0.2358 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0308 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0083 | 0.0711 | 0.075 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.2234 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.012 | 0.2234 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0308 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.0295 | 0.9471 | 1 |
Onchocerca volvulus | 0.012 | 0.2234 | 1 | |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0111 | 0.1877 | 0.1982 |
Onchocerca volvulus | 0.012 | 0.2234 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.2234 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.012 | 0.2234 | 0.2358 |
Leishmania major | cathepsin L-like protease | 0.012 | 0.2234 | 0.0438 |
Brugia malayi | Cathepsin L-like precursor | 0.012 | 0.2234 | 0.2358 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0308 | 1 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.012 | 0.2234 | 0.1738 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.2234 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0111 | 0.1877 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.012 | 0.2234 | 0.0438 |
Toxoplasma gondii | cathepsin CPL | 0.012 | 0.2234 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.012 | 0.2234 | 0.2358 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0308 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.2234 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.2234 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0083 | 0.0711 | 0.3182 |
Brugia malayi | cathepsin L-like precursor | 0.0083 | 0.0711 | 0.075 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.2234 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.2234 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.2234 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 0.2234 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0083 | 0.0711 | 0.075 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.012 | 0.2234 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.012 | 0.2234 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.012 | 0.2234 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.2234 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0111 | 0.1877 | 0.1332 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0308 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0308 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0308 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0271 | 0.8477 | 0.8477 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0308 | 1 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0083 | 0.0711 | 0.075 |
Brugia malayi | Cathepsin L-like precursor | 0.012 | 0.2234 | 0.2358 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.012 | 0.2234 | 0.2358 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.012 | 0.2234 | 0.2358 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0295 | 0.9471 | 0.9471 |
Loa Loa (eye worm) | hypothetical protein | 0.0295 | 0.9471 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.012 | 0.2234 | 1 |
Leishmania major | cathepsin L-like protease | 0.0308 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.0295 | 0.9471 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.012 | 0.2234 | 0.2358 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.012 | 0.2234 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.