Detailed information for compound 871264

Basic information

Technical information
  • TDR Targets ID: 871264
  • Name: ethyl 2-[[4-(4-nitrophenyl)-3H-imidazol-2-yl] sulfanyl]acetate
  • MW: 307.325 | Formula: C13H13N3O4S
  • H donors: 1 H acceptors: 4 LogP: 2.68 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)CSc1[nH]cc(n1)c1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C13H13N3O4S/c1-2-20-12(17)8-21-13-14-7-11(15-13)9-3-5-10(6-4-9)16(18)19/h3-7H,2,8H2,1H3,(H,14,15)
  • InChiKey: QLMQRYKDGADRLZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[4-(4-nitrophenyl)-3H-imidazol-2-yl]thio]acetic acid ethyl ester
  • ethyl 2-[[4-(4-nitrophenyl)-3H-imidazol-2-yl]sulfanyl]ethanoate
  • ZINC04555691
  • Oprea1_016784
  • A2374/0100365
  • ZINC00032586
  • Oprea1_157362
  • MLS000679132
  • SMR000270065
  • ethyl {[4-(4-nitrophenyl)-1H-imidazol-2-yl]thio}acetate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) K+ channel tetramerisation domain-containing protein 0.0011 0.0019 0.0062
Echinococcus multilocularis shaker cognate 0.0021 0.0137 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0152 0.0168
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0152 0.0168
Echinococcus multilocularis geminin 0.0165 0.1882 0.1882
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0022 0.0152 1
Loa Loa (eye worm) Kv4.2 voltage-gated potassium channel 0.0011 0.0019 0.0062
Echinococcus granulosus geminin 0.0165 0.1882 0.1882
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0152 0.0606
Echinococcus granulosus smad 0.001 0.0001 0.0001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0001 0.0001
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0068 0.0225
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0022 0.0152 0.0152
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0001 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0234 0.0234
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0001 0.0004
Echinococcus granulosus BTB:POZ domain containing protein 0.0011 0.0019 0.0019
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0221 0.0221
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.1542 0.1542
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0152 0.0606
Brugia malayi K+ channel tetramerisation domain containing protein 0.0011 0.0019 0.0062
Schistosoma mansoni smad1 5 8 and 0.001 0.0001 0.0001
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0068 0.0068
Schistosoma mansoni ap endonuclease 0.0019 0.0109 0.0109
Brugia malayi hypothetical protein 0.0035 0.0306 0.1016
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0022 0.0152 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0493 0.1633
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0068 0.0068
Echinococcus granulosus Protein patched homolog 1 0.0041 0.038 0.038
Echinococcus granulosus BTB:POZ domain containing protein KCTD16 0.0011 0.0019 0.0019
Echinococcus granulosus expressed conserved protein 0.009 0.0973 0.0973
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0022 0.0152 0.0152
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0022 0.0152 0.0152
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0022 0.0152 0.0152
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0001 0.0001
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0022 0.0152 0.0152
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0234 0.0234
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0022 0.0152 0.0168
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0152 0.0606
Echinococcus multilocularis smad 0.001 0.0001 0.0001
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0001 0.0001
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0152 0.0606
Onchocerca volvulus 0.0011 0.0019 0.0066
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0022 0.0152 0.0152
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0022 0.0152 0.0168
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0137 0.0137
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.1044 0.346
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0001 0.0001
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0022 0.0152 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0001 0.0001
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0068 0.1156
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0001 0.0001
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0022 0.0152 0.0152
Onchocerca volvulus 0.023 0.2677 1
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0793 0.9515 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0152 0.0168
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0152 0.0606
Echinococcus multilocularis potassium voltage gated channel protein 0.0258 0.3017 0.3017
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0161 0.1832 0.1832
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0553 0.0553
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0022 0.0152 0.0168
Plasmodium falciparum phosphodiesterase delta, putative 0.0022 0.0152 1
Brugia malayi isocitrate dehydrogenase 0.0015 0.0068 0.0226
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0306 0.0306
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0096 0.1044 0.346
Brugia malayi MH1 domain containing protein 0.001 0.0001 0.0004
Schistosoma mansoni voltage-gated potassium channel 0.0258 0.3017 0.3017
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0152 0.0168
Echinococcus granulosus voltage gated potassium channel 0.0021 0.0137 0.0137
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0109 0.6762
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0161 0.1832 0.6072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0001 0.0004
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0022 0.0152 0.0504
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.1062 0.1062
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.038 0.038
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0004
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0001 0.0001
Leishmania major hypothetical protein, conserved 0.0022 0.0152 0.3114
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0068 0.3713
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0022 0.0152 0.0168
Echinococcus granulosus Smad4 0.001 0.0001 0.0001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0001 0.0001
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0022 0.0152 0.0504
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0032 0.027 0.1142
Onchocerca volvulus 0.0011 0.0019 0.0066
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0152 0.0606
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0183 0.2102 0.2102
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0001 0.0004
Echinococcus multilocularis muscleblind protein 0.018 0.2072 0.2072
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0152 0.6191
Plasmodium vivax phosphodiesterase gamma, putative 0.0022 0.0152 0.6191
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0001 0.0001
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0021 0.0137 0.0137
Echinococcus multilocularis voltage gated potassium channel 0.0021 0.0137 0.0137
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0152 0.0168
Echinococcus multilocularis potassium voltage gated channel protein 0.0021 0.0137 0.0137
Loa Loa (eye worm) K+ channel tetramerisation domain-containing protein 0.0011 0.0019 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.038 0.1057
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0021 0.0137 0.0454
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0004
Trypanosoma brucei hypothetical protein, conserved 0.0022 0.0152 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0001 0.0004
Brugia malayi Pre-SET motif family protein 0.0029 0.0234 0.0776
Echinococcus multilocularis BTB:POZ domain containing protein 0.0011 0.0019 0.0019
Entamoeba histolytica hypothetical protein 0.0035 0.0306 0.2113
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0022 0.0152 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0152 0.0168
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0152 0.0606
Schistosoma mansoni hypothetical protein 0.0035 0.0306 0.0306
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0001 0.0001
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0152 1
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.1044 0.1044
Giardia lamblia Hypothetical protein 0.0022 0.0152 0.0217
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0119 0.1328 0.4401
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0109 0.0361
Mycobacterium ulcerans aldehyde dehydrogenase 0.0047 0.0447 0.0359
Brugia malayi steroid hormone receptor 0.001 0.0001 0.0004
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0022 0.0152 0.0504
Echinococcus granulosus potassium voltage gated channel protein 0.0258 0.3017 0.3017
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1632 0.5411
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0137 0.0137
Brugia malayi MH1 domain containing protein 0.001 0.0001 0.0004
Echinococcus granulosus potassium voltage gated channel protein 0.0021 0.0137 0.0137
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0152 0.0606
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0001 0.0001
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0022 0.0152 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1632 0.5411
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0022 0.0152 0.0504
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0553 0.0553
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0001 0.0001
Schistosoma mansoni smad1 5 8 and 0.001 0.0001 0.0001
Entamoeba histolytica hypothetical protein 0.0035 0.0306 0.2113
Schistosoma mansoni aldehyde dehydrogenase 0.0047 0.0447 0.0447
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0152 0.0168
Leishmania major cAMP-specific phosphodiesterase, putative 0.0022 0.0152 0.3114
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0109 0.5
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0109 0.2106
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0068 0.0068
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0152 0.0168
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0001 0.0004
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0068 0.0225
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0022 0.0152 0.3114
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0022 0.0152 0.0168
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0022 0.0152 0.0168
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0062
Schistosoma mansoni hypothetical protein 0.004 0.0362 0.0362
Schistosoma mansoni hypothetical protein 0.028 0.3282 0.3282
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0062
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0068 0.0068
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0022 0.0152 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0001 0.0004
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0001 0.0004
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0152 0.0168
Schistosoma mansoni vesicular amine transporter 0.0021 0.0137 0.0137
Loa Loa (eye worm) voltage-gated potassium channel 0.0021 0.0137 0.0454
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0019 0.0019
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0022 0.0152 1
Loa Loa (eye worm) hypothetical protein 0.0183 0.2102 0.6968
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0001 0.0004
Schistosoma mansoni Smad4 0.001 0.0001 0.0001
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0152 0.0606
Loa Loa (eye worm) potassium channel tetramerisation domain containing 5 0.0011 0.0019 0.0062
Schistosoma mansoni thyroid hormone receptor 0.001 0.0001 0.0001
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0068 0.3713
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0068 0.3713
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0004
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0553 0.0553
Onchocerca volvulus 0.0011 0.0019 0.0066
Schistosoma mansoni hypothetical protein 0.0165 0.1882 0.1882
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0152 0.0606
Loa Loa (eye worm) hypothetical protein 0.0258 0.3017 1
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0022 0.0152 0.0152
Echinococcus multilocularis Smad4 0.001 0.0001 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0234 0.0234
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0193 0.222 1
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0022 0.0152 0.0152
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0109 0.0109
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0022 0.0152 0.0152
Schistosoma mansoni patched 1 0.0041 0.038 0.038
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.1044 1
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0022 0.0152 1
Brugia malayi MH2 domain containing protein 0.001 0.0001 0.0004
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0004
Brugia malayi ecdysteroid receptor 0.001 0.0001 0.0004
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0001 0.0001
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0001 0.0001
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0001 0.0001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0047 0.0447 0.0359
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0068 0.3713
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0001 0.0001
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0247 0.288 0.288
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0022 0.0152 0.0504
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0022 0.0152 0.0168
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0022 0.0152 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0152 0.0168
Brugia malayi nuclear hormone receptor 0.001 0.0001 0.0004
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.1542 0.1542
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0553 0.0553
Schistosoma mansoni smad1 5 8 and 0.001 0.0001 0.0001
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0109 0.4186
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0019 0.0019
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0022 0.0152 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0152 0.0606
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.2338 0.775
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0152 0.0606
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0001 0.0004
Brugia malayi Smad1 0.001 0.0001 0.0004
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0109 0.6762
Loa Loa (eye worm) hypothetical protein 0.018 0.2072 0.6868
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0022 0.0152 0.0152
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0001 0.0004
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0022 0.0152 0.0152
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0234 0.0234
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0152 1
Onchocerca volvulus 0.0011 0.0019 0.0066
Trichomonas vaginalis set domain proteins, putative 0.023 0.2677 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0001 0.0001
Loa Loa (eye worm) Smad1 0.001 0.0001 0.0004
Plasmodium falciparum phosphodiesterase gamma, putative 0.0022 0.0152 1
Loa Loa (eye worm) potassium channel tetramerisation domain containing 3 0.0011 0.0019 0.0062
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0022 0.0152 0.6191
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0234 0.0234
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0022 0.0152 0.0152
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0109 0.5
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0152 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0022 0.0152 0.0168
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0109 0.0361
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0152 0.0168
Loa Loa (eye worm) hypothetical protein 0.0029 0.0234 0.0776
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0068 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0152 0.0168
Echinococcus granulosus muscleblind protein 0.018 0.2072 0.2072
Giardia lamblia hypothetical protein 0.0022 0.0152 0.0217
Onchocerca volvulus 0.0029 0.0234 0.0871
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0183 0.2102 0.2102
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0021 0.0137 0.0137
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0001 0.0001
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0152 0.0168
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0152 0.0168
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0022 0.0152 0.0504
Echinococcus granulosus potassium voltage gated channel protein 0.0021 0.0137 0.0137
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0068 0.0068
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0001 0.0004
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0047 0.0447 0.0447
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0109 0.0109
Schistosoma mansoni coup transcription factor 0.001 0.0001 0.0001
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0553 0.1831
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0022 0.0152 0.0152
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0152 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0068 0.3713
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0021 0.0137 0.0454
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0234 0.0978
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0022 0.0152 0.0152
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0022 0.0152 0.0152
Schistosoma mansoni edp1-related 0.0011 0.0019 0.0019
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0068 0.2299
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0183 0.2102 0.2102
Echinococcus multilocularis transfer RNA-Gly 0.0021 0.0137 0.0137
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0047 0.0447 0.0401
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0553 0.1831
Mycobacterium ulcerans aldehyde dehydrogenase 0.0047 0.0447 0.0359
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0021 0.0137 0.0137
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0022 0.0152 0.0152
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0021 0.0137 0.0137
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0001 0.0001
Brugia malayi K+ channel tetramerisation domain containing protein 0.0011 0.0019 0.0062
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0047 0.0447 1
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0152 1
Plasmodium vivax SET domain protein, putative 0.0029 0.0234 1
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0152 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0001 0.0004
Schistosoma mansoni hypothetical protein 0.0165 0.1882 0.1882
Loa Loa (eye worm) PDE1B protein 0.0022 0.0152 0.0504
Brugia malayi Muscleblind-like protein 0.018 0.2072 0.6868
Echinococcus multilocularis BTB:POZ domain containing protein KCTD16 0.0011 0.0019 0.0019
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0793 0.9515 0.5
Loa Loa (eye worm) hypothetical protein 0.0022 0.0152 0.0504
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0022 0.0152 0.0152
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0022 0.0152 0.0168
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0553 0.0553
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0152 0.0168
Schistosoma mansoni smad 0.001 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.004 0.0362 0.0362
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0004
Brugia malayi nuclear receptor NHR-88 0.001 0.0001 0.0004
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0022 0.0152 0.0168
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0022 0.0152 0.0168
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0022 0.0152 0.0168
Toxoplasma gondii exonuclease III APE 0.0019 0.0109 0.0409
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0152 0.0168
Brugia malayi hypothetical protein 0.0119 0.1328 0.4401
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0152 0.6191
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0788 0.9452 0.9452
Toxoplasma gondii aldehyde dehydrogenase 0.0047 0.0447 0.1945
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0022 0.0152 0.0504
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0152 0.0606
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0152 0.0168
Loa Loa (eye worm) hypothetical protein 0.0022 0.0152 0.0504
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0001 0.0004
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0068 0.0068
Schistosoma mansoni voltage-gated potassium channel 0.0258 0.3017 0.3017
Loa Loa (eye worm) K+ channel tetramerisation domain-containing protein 0.0011 0.0019 0.0062
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0183 0.2102 0.2102
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0258 0.3017 0.3017
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0152 0.0168
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0047 0.0447 0.0447
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0152 0.0606
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0001 0.0004
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0022 0.0152 0.0168
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0183 0.2102 1
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0022 0.0152 1
Schistosoma mansoni nuclear hormone receptor 0.001 0.0001 0.0001
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0022 0.0152 0.0168
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0152 0.0168
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0021 0.0137 0.0137
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0001 0.0004
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0109 0.6762
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0062
Entamoeba histolytica hypothetical protein 0.0035 0.0306 0.2113
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0234 0.0234
Schistosoma mansoni hypothetical protein 0.004 0.0362 0.0362
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0022 0.0152 1
Brugia malayi K+ channel tetramerisation domain containing protein 0.0011 0.0019 0.0062
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0553 0.0553
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0021 0.0137 0.0137
Schistosoma mansoni ap endonuclease 0.0019 0.0109 0.0109
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0001 0.0001
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0152 0.0168
Echinococcus multilocularis protein dispatched 1 0.0047 0.0451 0.0451
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0152 0.0168
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0001 0.0001
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0022 0.0152 0.0168
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0152 0.0606
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0001 0.0004
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0021 0.0137 0.0137
Brugia malayi mKIAA0176 protein 0.0011 0.0019 0.0062
Loa Loa (eye worm) hypothetical protein 0.0041 0.038 0.1261
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0306 0.0306
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0152 0.0168
Brugia malayi MH2 domain containing protein 0.001 0.0001 0.0004
Echinococcus multilocularis muscleblind protein 1 0.018 0.2072 0.2072
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0152 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0004
Schistosoma mansoni hypothetical protein 0.004 0.0362 0.0362
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0068 0.0226
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0001 0.0001
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0022 0.0152 0.0168
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0161 0.1832 0.6072
Leishmania major hypothetical protein, conserved 0.0022 0.0152 0.3114
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0152 1
Brugia malayi CHE-14 protein 0.0041 0.038 0.1261
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0068 0.0226
Echinococcus granulosus FTZ F1 alpha 0.001 0.0001 0.0001
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0152 0.0606
Mycobacterium ulcerans proteasome PrcA 0.0793 0.9515 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0001 0.0004
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0001 0.0001
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0161 0.1832 0.1832
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0001 0.0001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0553 0.0553
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0306 0.0306
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0021 0.0137 0.0454
Echinococcus multilocularis potassium voltage gated channel protein 0.0021 0.0137 0.0137
Echinococcus multilocularis protein patched 0.0041 0.038 0.038
Echinococcus granulosus shaker cognate 0.0021 0.0137 0.0137
Brugia malayi Voltage-gated potassium channel, Shal-family (KCND, Kv4-like) alpha-subunit. C. elegans shl-1 ortholog 0.0011 0.0019 0.0062
Onchocerca volvulus Huntingtin homolog 0.0119 0.1328 0.4957
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0109 0.6762
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0001 0.0004
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0022 0.0152 0.0152
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0001 0.0004
Loa Loa (eye worm) hypothetical protein 0.018 0.2072 0.6868
Onchocerca volvulus 0.0011 0.0019 0.0066
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0001 0.0001
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0152 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0019 0.0019
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0137 0.0137
Brugia malayi MH2 domain containing protein 0.0144 0.1632 0.5411
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0234 0.0234
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0001 0.0001
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0152 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.1328 0.4401
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0183 0.2102 0.2102
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0137 0.0137
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0001 0.0001
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0152 0.0168
Brugia malayi K+ channel tetramerisation domain containing protein 0.0011 0.0019 0.0062
Schistosoma mansoni aldehyde dehydrogenase 0.0047 0.0447 0.0447
Echinococcus multilocularis X box binding protein 1 0.028 0.3282 0.3282
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0152 0.0168
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0022 0.0152 0.0152
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0001 0.0004
Echinococcus multilocularis expressed conserved protein 0.009 0.0973 0.0973
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0001 0.0004
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0152 0.0168
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0001 0.0004
Schistosoma mansoni potassium channel tetramerization domain-containing 0.0011 0.0019 0.0019
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0022 0.0152 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.038 0.038
Loa Loa (eye worm) hypothetical protein 0.0022 0.0152 0.0504
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0109 0.0043
Onchocerca volvulus Huntingtin homolog 0.0119 0.1328 0.4957
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0152 0.0168
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0022 0.0152 0.0152
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0019 0.0019
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0001 0.0004
Brugia malayi Pre-SET motif family protein 0.0202 0.2338 0.775
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0001 0.0004
Echinococcus granulosus X box binding protein 1 0.028 0.3282 0.3282
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.1044 0.1044
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0137 0.0137
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0001 0.0004
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.038 0.1261
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0004
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0022 0.0152 0.0152
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0152 0.0168
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0152 0.0168
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0152 0.0168
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0258 0.3017 1
Entamoeba histolytica hypothetical protein 0.0035 0.0306 0.2113
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0001 0.0001
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0022 0.0152 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0022 0.0152 0.0168
Schistosoma mansoni thyroid hormone receptor 0.001 0.0001 0.0001

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.3115 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (binding) = 17.7828 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) 17.7828 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 125.8925 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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