TDR Targets

Basic information

Technical information

TDR Targets ID: 871382
Name: propan-2-yl 2-methyl-6-oxo-4-[2-(trifluoromet hyl)phenyl]-4,5-dihydro-1H-pyridine-3-carboxy late
MW: 341.325 | Formula: C17H18F3NO3
H donors: 1 H acceptors: 2 LogP: 3.02 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C1NC(=C(C(C1)c1ccccc1C(F)(F)F)C(=O)OC(C)C)C
InChi: 1S/C17H18F3NO3/c1-9(2)24-16(23)15-10(3)21-14(22)8-12(15)11-6-4-5-7-13(11)17(18,19)20/h4-7,9,12H,8H2,1-3H3,(H,21,22)
InChiKey: CRFALNWADJDUSS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

isopropyl 2-methyl-6-oxo-4-[2-(trifluoromethyl)phenyl]-4,5-dihydro-1H-pyridine-3-carboxylate
2-methyl-6-oxo-4-[2-(trifluoromethyl)phenyl]-4,5-dihydro-1H-pyridine-3-carboxylic acid isopropyl ester
6-keto-2-methyl-4-[2-(trifluoromethyl)phenyl]-4,5-dihydro-1H-pyridine-3-carboxylic acid isopropyl ester
MixCom6_002377
CBMicro_047433
EU-0040693
BIM-0047568.P001
UNM000000580501
A2387/0101005

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0169	0.0235
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0035	0.0298	0.0298
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0112	0.1274	1
Mycobacterium tuberculosis	Probable polyketide synthase Pks7	0.0035	0.0306	0.038
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0035	0.0306	0.4951
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 3	0.0112	0.1274	0.1274
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0169	0.0235
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.003	0.0234	0.0234
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	0.0035	0.0306	0.0424
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.017	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0169	0.0235
Plasmodium vivax	importin-beta 2, putative	0.003	0.0243	0.7954
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0324	0.3972	0.5516
Toxoplasma gondii	type I fatty acid synthase, putative	0.0035	0.0306	0.4951
Echinococcus granulosus	NAD dependent deacetylase sirtuin 6	0.0016	0.0067	0.0075
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0016	0.0067	0.0105
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0112	0.1274	0.2004
Echinococcus multilocularis	NADH dehydrogenase (ubiquinone) flavoprotein 1	0.0512	0.6357	0.6357
Trichomonas vaginalis	chromobox protein, putative	0.0069	0.0727	0.1144
Brugia malayi	Hr1 repeat family protein	0.0035	0.0298	0.0414
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0035	0.0306	0.0424
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0025	0.0169	0.0169
Toxoplasma gondii	aldehyde dehydrogenase	0.006	0.0617	1
Entamoeba histolytica	protein kinase, putative	0.0035	0.0298	0.2341
Loa Loa (eye worm)	transcriptional regulator	0.0016	0.0067	0.0092
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0035	0.0306	0.038
Brugia malayi	Variant SH3 domain containing protein	0.0025	0.0169	0.0235
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0193	0.0269
Echinococcus multilocularis	AMP dependent ligase	0.0035	0.0306	0.0306
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0035	0.0298	0.0414
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0112	0.1274	0.1769
Schistosoma mansoni	chromatin regulatory protein sir2	0.0112	0.1274	0.1442
Schistosoma mansoni	unc-13 (munc13)	0.003	0.0234	0.0265
Plasmodium falciparum	transcriptional regulatory protein sir2a	0.0016	0.0067	0.2178
Leishmania major	NADH-ubiquinone oxidoreductase, mitochondrial, putative	0.0512	0.6357	1
Echinococcus granulosus	netrin receptor unc 5	0.0014	0.004	0.0046
Echinococcus granulosus	geminin	0.0345	0.4232	0.479
Mycobacterium tuberculosis	Probable polyketide synthase Pks5	0.0035	0.0306	0.038
Mycobacterium tuberculosis	Probable polyketide synthase Pks17	0.0035	0.0306	0.038
Brugia malayi	NAD-dependent deacetylase SIRT1	0.0016	0.0067	0.0092
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.003	0.0234	0.0265
Schistosoma mansoni	netrin receptor unc5	0.0014	0.004	0.0046
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.0617	0.0698
Loa Loa (eye worm)	transcriptional regulator	0.0016	0.0067	0.0092
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0022	0.0141	0.0196
Mycobacterium leprae	Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas	0.0035	0.0306	0.5
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0035	0.0298	0.0338
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0022	0.0141	0.2289
Mycobacterium ulcerans	polyketide synthase MbtD	0.0035	0.0306	0.038
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0469	0.0531
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0035	0.0306	0.038
Brugia malayi	NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial precursor	0.0512	0.6357	0.8827
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD	0.0035	0.0306	0.5
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0022	0.0141	0.4624
Schistosoma mansoni	lamin	0.0026	0.0193	0.0219
Mycobacterium tuberculosis	Probable polyketide synthase Pks9	0.0035	0.0306	0.038
Trypanosoma cruzi	Acyl carrier protein, mitochondrial, putative	0.0035	0.0306	0.038
Echinococcus granulosus	chromatin regulatory protein sir2	0.0112	0.1274	0.1442
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0025	0.0179	0.0248
Echinococcus multilocularis	Acyl carrier protein, mitochondrial	0.0035	0.0306	0.0306
Echinococcus granulosus	protein kinase c epsilon type	0.0064	0.0674	0.0763
Echinococcus granulosus	AMP dependent ligase	0.0035	0.0306	0.0346
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0022	0.0141	0.0196
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.006	0.0617	0.0875
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0469	0.0531
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0025	0.0179	0.0179
Entamoeba histolytica	protein kinase, putative	0.0035	0.0298	0.2341
Toxoplasma gondii	histone deacetylase SIR2	0.0016	0.0067	0.1079
Toxoplasma gondii	acyl carrier protein ACP	0.0035	0.0306	0.4951
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.0037	0.0052
Mycobacterium tuberculosis	Polyketide synthase Pks12	0.0035	0.0306	0.038
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0022	0.0141	0.0141
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0035	0.0298	0.0414
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	0.0035	0.0306	0.0424
Echinococcus granulosus	RNA directed DNA polymerase	0.016	0.189	0.2139
Entamoeba histolytica	NAD-dependent deacetylase 1, putative	0.0016	0.0067	0.0523
Toxoplasma gondii	beta-ketoacyl synthase, N-terminal domain-containing protein	0.0035	0.0306	0.4951
Echinococcus granulosus	protein kinase C gamma type	0.02	0.2395	0.2711
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0469	0.0531
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0193	0.0269
Schistosoma mansoni	chromatin regulatory protein sir2	0.0016	0.0067	0.0075
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0015	0.0042	0.0048
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0022	0.0141	0.0119
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0617	0.0875
Echinococcus granulosus	myotubularin protein 13	0.0025	0.0169	0.0191
Toxoplasma gondii	AGC kinase	0.0035	0.0298	0.4832
Brugia malayi	small heat shock protein	0.0579	0.7201	1
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0035	0.0306	0.038
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.006	0.0617	0.0617
Echinococcus multilocularis	unc 13 (munc13)	0.003	0.0234	0.0234
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0074	0.0794	0.0899
Leishmania major	GTP-binding protein, putative	0.0022	0.0141	0.0119
Mycobacterium ulcerans	membrane protein ComEA	0.0114	0.1306	0.1971
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0243	0.0281
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0469	0.0531
Loa Loa (eye worm)	hypothetical protein	0.003	0.0243	0.0337
Echinococcus multilocularis	netrin receptor unc 5	0.0014	0.004	0.004
Echinococcus granulosus	Protein kinase C brain isozyme	0.0225	0.2707	0.3063
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0067	0.0092
Mycobacterium ulcerans	polyketide synthase	0.0035	0.0306	0.038
Trichomonas vaginalis	importin beta-1, putative	0.0025	0.017	0.0268
Echinococcus multilocularis	myotubularin protein 13	0.0025	0.0169	0.0169
Echinococcus granulosus	NAD dependent deacetylase sirtuin 3	0.0112	0.1274	0.1442
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0025	0.017	0.0165
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0193	0.0219
Plasmodium vivax	NAD-dependent deacetylase, putative	0.0016	0.0067	0.2178
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.006	0.0617	0.0698
Schistosoma mansoni	chromatin regulatory protein sir2	0.0112	0.1274	0.1442
Schistosoma mansoni	protein kinase C	0.003	0.0234	0.0265
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0064	0.0674	0.0937
Trichomonas vaginalis	AGC family protein kinase	0.0035	0.0298	0.0469
Schistosoma mansoni	unc-13 (munc13)	0.003	0.0234	0.0265
Entamoeba histolytica	protein kinase, putative	0.0035	0.0298	0.2341
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0035	0.0306	0.038
Schistosoma mansoni	vav2	0.0025	0.0169	0.0191
Onchocerca volvulus	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial homolog	0.0275	0.3341	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0169	0.0235
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 7	0.0016	0.0067	0.0067
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0035	0.0298	0.0298
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0035	0.0298	0.0298
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0345	0.0543
Schistosoma mansoni	serine/threonine protein kinase	0.0225	0.2707	0.3063
Schistosoma mansoni	serine/threonine protein kinase	0.0035	0.0298	0.0338
Brugia malayi	Protein kinase c protein 2	0.0191	0.2275	0.316
Echinococcus granulosus	Diacylglycerol kinase theta	0.0025	0.0169	0.0191
Plasmodium falciparum	importin beta, putative	0.003	0.0243	0.7954
Brugia malayi	Pleckstrin Homology Domain	0.0025	0.0169	0.0235
Brugia malayi	protein kinase C II.	0.0064	0.0674	0.0937
Echinococcus granulosus	protein kinase c iota type	0.0059	0.061	0.069
Loa Loa (eye worm)	hypothetical protein	0.0013	0.002	0.0027
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0016	0.0067	0.0092
Trichomonas vaginalis	AGC family protein kinase	0.0035	0.0298	0.0469
Schistosoma mansoni	microtubule-associated protein tau	0.0708	0.8835	1
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0035	0.0306	0.038
Brugia malayi	RhoGEF domain containing protein	0.0025	0.0169	0.0235
Mycobacterium tuberculosis	Meromycolate extension acyl carrier protein AcpM	0.0035	0.0306	0.038
Entamoeba histolytica	Ran family GTPase	0.0022	0.0141	0.1109
Brugia malayi	Protein kinase domain containing protein	0.0035	0.0298	0.0414
Echinococcus multilocularis	chromobox protein 1	0.0069	0.0727	0.0727
Onchocerca volvulus	Fatty acid synthase homolog	0.0035	0.0306	0.0915
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 6	0.0016	0.0067	0.0067
Brugia malayi	Phosphopantetheine attachment site family protein	0.0035	0.0306	0.0424
Brugia malayi	AMP-binding enzyme family protein	0.0035	0.0306	0.0424
Brugia malayi	p70 ribosomal S6 kinase beta	0.0035	0.0298	0.0414
Echinococcus granulosus	intermediate filament protein	0.0026	0.0193	0.0219
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0016	0.0067	0.0105
Brugia malayi	protein kinase C3,putative	0.0025	0.0179	0.0248
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0035	0.0306	0.038
Schistosoma mansoni	NADH-ubiquinone oxidoreductase	0.0512	0.6357	0.7195
Echinococcus multilocularis	Diacylglycerol kinase theta	0.0025	0.0169	0.0169
Trypanosoma brucei	Acyl carrier protein, mitochondrial	0.0035	0.0306	0.038
Schistosoma mansoni	chromatin regulatory protein sir2	0.0112	0.1274	0.1442
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0035	0.0306	0.038
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0035	0.0298	0.0338
Trypanosoma brucei	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial, putative	0.0512	0.6357	1
Schistosoma mansoni	chromobox protein	0.0069	0.0727	0.0823
Mycobacterium ulcerans	acyl carrier protein	0.0035	0.0306	0.038
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0016	0.0067	0.0105
Echinococcus granulosus	Ankyrin	0.0015	0.0042	0.0048
Schistosoma mansoni	hypothetical protein	0.0345	0.4232	0.479
Mycobacterium ulcerans	acyl-CoA synthetase	0.0035	0.0306	0.038
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0306	0.038
Trypanosoma cruzi	NADH-ubiquinone oxidoreductase, mitochondrial, putative	0.0512	0.6357	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0002	0.0002
Echinococcus multilocularis	snurportin 1	0.0324	0.3972	0.3972
Mycobacterium tuberculosis	Probable acyl carrier protein AcpA (ACP)	0.0035	0.0306	0.038
Brugia malayi	Heterochromatin protein 1	0.0069	0.0727	0.101
Echinococcus granulosus	NDR protein kinase	0.0035	0.0298	0.0338
Loa Loa (eye worm)	hypothetical protein	0.003	0.0234	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0298	0.0414
Loa Loa (eye worm)	acyl carrier protein	0.0035	0.0306	0.0424
Brugia malayi	hypothetical protein	0.0011	0.0002	0.0002
Onchocerca volvulus		0.0025	0.0169	0.0506
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0345	0.0543
Echinococcus multilocularis	protein kinase c iota type	0.0059	0.061	0.061
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0469	0.0531
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0187	0.026
Schistosoma mansoni	ankyrin 23/unc44	0.0014	0.004	0.0046
Onchocerca volvulus	Netrin receptor homolog	0.0014	0.004	0.0121
Mycobacterium ulcerans	multifunctional mycocerosic acid synthase membrane-associated Mas	0.0035	0.0306	0.038
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB	0.0035	0.0306	0.5
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0025	0.0169	0.0235
Echinococcus multilocularis	lamin dm0	0.0026	0.0193	0.0193
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0014	0.004	0.0046
Trichomonas vaginalis	AGC family protein kinase	0.0035	0.0298	0.0469
Schistosoma mansoni	serine/threonine protein kinase	0.0225	0.2707	0.3063
Brugia malayi	chromobox protein homolog 3	0.0038	0.0345	0.0479
Chlamydia trachomatis	acyl carrier protein	0.0035	0.0306	0.5
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0035	0.0306	0.038
Mycobacterium tuberculosis	Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F)	0.0512	0.6357	1
Brugia malayi	intermediate filament protein	0.0026	0.0193	0.0269
Echinococcus multilocularis	Chromobox protein 3	0.0011	0.000000010598	0.000000010598
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0016	0.0067	0.0105
Schistosoma mansoni	chromatin regulatory protein sir2	0.0016	0.0067	0.0075
Schistosoma mansoni	chromatin regulatory protein sir2	0.0016	0.0067	0.0075
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0022	0.0141	0.0619
Echinococcus granulosus	microtubule associated protein 2	0.0708	0.8835	1
Trichomonas vaginalis	AGC family protein kinase	0.0035	0.0298	0.0469
Schistosoma mansoni	serine/threonine kinase	0.0035	0.0298	0.0338
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0035	0.0298	0.0368
Mycobacterium leprae	Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase)	0.0035	0.0306	0.5
Schistosoma mansoni	hypothetical protein	0.0025	0.0169	0.0191
Brugia malayi	diacylglycerol kinase	0.0025	0.0169	0.0235
Brugia malayi	AMP-binding enzyme family protein	0.0035	0.0306	0.0424
Mycobacterium ulcerans	NADH dehydrogenase I subunit F	0.0512	0.6357	1
Schistosoma mansoni	serine/threonine protein kinase	0.0035	0.0298	0.0338
Echinococcus multilocularis	musashi	0.0026	0.0193	0.0193
Onchocerca volvulus		0.0035	0.0306	0.0915
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0345	0.0479
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0025	0.0169	0.0169
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0035	0.0298	0.0298
Echinococcus granulosus	lamin	0.0026	0.0193	0.0219
Mycobacterium ulcerans	acyl carrier protein	0.0035	0.0306	0.038
Trichomonas vaginalis	AGC family protein kinase	0.0035	0.0298	0.0469
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0035	0.0306	0.2399
Echinococcus multilocularis	serine threonine protein kinase	0.02	0.2395	0.2395
Loa Loa (eye worm)	hypothetical protein	0.003	0.024	0.0333
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0035	0.0306	0.038
Schistosoma mansoni	diacylglycerol kinase theta	0.0025	0.0169	0.0191
Brugia malayi	Protein kinase domain containing protein	0.0035	0.0298	0.0414
Echinococcus granulosus	snurportin 1	0.0324	0.3972	0.4496
Onchocerca volvulus		0.003	0.024	0.0718
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0016	0.0067	0.0105
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0035	0.0298	0.0298
Trichomonas vaginalis	AGC family protein kinase	0.0035	0.0298	0.0469
Schistosoma mansoni	chromobox protein	0.0069	0.0727	0.0823
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0016	0.0067	0.0105
Brugia malayi	RNA, U transporter 1	0.0086	0.0954	0.1324
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0022	0.0141	0.4624
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0193	0.0269
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.002	0.002
Mycobacterium leprae	Probable polyketide synthase Pks1	0.0035	0.0306	0.5
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0038	0.0345	0.1033
Schistosoma mansoni	rac gtpase activating protein	0.0025	0.0169	0.0191
Brugia malayi	acyl carrier protein, mitochondrial precursor, putative	0.0035	0.0306	0.0424
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.002	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0014	0.0019
Toxoplasma gondii	histone deacetylase SIR2-like	0.0016	0.0067	0.1079
Brugia malayi	RhoGAP domain containing protein	0.0025	0.0169	0.0235
Mycobacterium ulcerans	non-ribosomal peptide synthetase	0.0035	0.0306	0.038
Plasmodium vivax	hypothetical protein, conserved	0.0016	0.0067	0.2178
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0035	0.0306	0.038
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0034	0.0289	0.0454
Echinococcus granulosus	importin subunit beta 1	0.003	0.0243	0.0275
Schistosoma mansoni	protein kinase C mu	0.0025	0.0169	0.0191
Mycobacterium ulcerans	fatty-acid-CoA ligase FadD9	0.0035	0.0306	0.038
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0022	0.0141	0.016
Loa Loa (eye worm)	raf kinase	0.0025	0.0169	0.0235
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0016	0.0067	0.0105
Schistosoma mansoni	hypothetical protein	0.0345	0.4232	0.479
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0035	0.0306	0.038
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0025	0.0179	0.0248
Brugia malayi	diacylglycerol kinase	0.0025	0.0169	0.0235
Echinococcus multilocularis	chromobox protein 1	0.0069	0.0727	0.0727
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0166	0.1964	0.2727
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0025	0.0179	0.0202
Echinococcus granulosus	NAD dependent deacetylase sirtuin 1	0.0016	0.0067	0.0075
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0025	0.0169	0.0191
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0382	0.1144
Onchocerca volvulus		0.0026	0.0193	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0306	0.0424
Echinococcus multilocularis	geminin	0.0345	0.4232	0.4232
Echinococcus granulosus	Chromobox protein 3	0.0011	0.000000010598	0.000000011996
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0016	0.0067	0.0523
Echinococcus granulosus	NADH dehydrogenase	0.0035	0.0306	0.0346
Trichomonas vaginalis	NADH-ubiquinone oxidoreductase flavoprotein, putative	0.0512	0.6357	1
Mycobacterium tuberculosis	Polyketide synthase Pks13	0.0035	0.0306	0.038
Echinococcus multilocularis	microtubule associated protein 2	0.0708	0.8835	0.8835
Plasmodium vivax	acyl carrier protein, putative	0.0035	0.0306	1
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0112	0.1274	0.2004
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0035	0.0306	0.038
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0617	0.0875
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0016	0.0067	0.0105
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0025	0.0169	0.0235
Entamoeba histolytica	hypothetical protein	0.0025	0.0169	0.1328
Schistosoma mansoni	hypothetical protein	0.0014	0.004	0.0046
Echinococcus multilocularis	Ankyrin	0.0015	0.0042	0.0042
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0025	0.0169	0.0191
Trypanosoma cruzi	NADH-ubiquinone oxidoreductase, mitochondrial, putative	0.0512	0.6357	1
Mycobacterium leprae	Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0035	0.0306	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0064	0.0674	0.0763
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0169	0.0235
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0025	0.0169	0.0191
Mycobacterium tuberculosis	Acyl carrier protein (ACP) MbtL	0.0035	0.0306	0.038
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0035	0.0298	0.0414
Leishmania major	acyl carrier protein, putative	0.0035	0.0306	0.038
Schistosoma mansoni	ran	0.0022	0.0141	0.016
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0074	0.0794	0.0794
Loa Loa (eye worm)	transcriptional regulator	0.0112	0.1274	0.1769
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0016	0.0067	0.0105
Brugia malayi	Death domain containing protein	0.0014	0.004	0.0056
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA	0.0035	0.0306	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0035	0.0298	0.0469
Loa Loa (eye worm)	Ras association domain family 1 isoform A	0.0025	0.0169	0.0235
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.0617	0.0698
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0037	0.0052
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0203	0.0319
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0469	0.0469
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.0141	0.0119
Mycobacterium ulcerans	polyketide synthase Pks13	0.0035	0.0306	0.038
Trichomonas vaginalis	AGC family protein kinase	0.0035	0.0298	0.0469
Schistosoma mansoni	serine/threonine protein kinase	0.0035	0.0298	0.0338
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0048	0.0469	0.0651
Leishmania major	importin beta-1 subunit, putative	0.0025	0.017	0.0165
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0035	0.0306	0.0424
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0014	0.004	0.004
Mycobacterium tuberculosis	Polyketide synthase Pks2	0.0035	0.0306	0.038
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.0112	0.1274	0.1919
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0112	0.1274	1
Brugia malayi	Uncoordinated protein 44	0.0014	0.004	0.0056
Echinococcus multilocularis	protein kinase c epsilon type	0.0064	0.0674	0.0674
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0193	0.0269
Brugia malayi	Protein kinase domain containing protein	0.0015	0.005	0.0069
Mycobacterium ulcerans	peptide synthetase Nrp (peptide synthase)	0.0035	0.0306	0.038
Echinococcus granulosus	unc 13 munc13	0.003	0.0234	0.0265
Schistosoma mansoni	importin beta-1	0.003	0.0243	0.0275
Schistosoma mansoni	chromatin regulatory protein sir2	0.0016	0.0067	0.0075
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0114	0.1306	0.1971
Loa Loa (eye worm)	NADH-ubiquinone oxidoreductase 51 kDa subunit	0.0512	0.6357	0.8827
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.017	0.0268
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0025	0.0169	0.0235
Echinococcus granulosus	chromobox protein 1	0.0069	0.0727	0.0823
Treponema pallidum	nitrogen fixation protein (rnfC)	0.0114	0.1306	1
Mycobacterium ulcerans	polyketide synthase Pks9	0.0035	0.0306	0.038
Loa Loa (eye worm)	heterochromatin protein 1	0.0069	0.0727	0.101
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0469	0.0469
Trichomonas vaginalis	ran, putative	0.0022	0.0141	0.0222
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtE	0.0035	0.0306	0.038
Echinococcus multilocularis	NADH dehydrogenase	0.0035	0.0306	0.0306
Onchocerca volvulus		0.0026	0.0193	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0014	0.004	0.0056
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 1	0.0016	0.0067	0.0067
Mycobacterium tuberculosis	Probable polyketide synthase Pks1	0.0035	0.0306	0.038
Schistosoma mansoni	serine/threonine protein kinase	0.0025	0.0179	0.0202
Schistosoma mansoni	lamin	0.0026	0.0193	0.0219
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0035	0.0306	0.038
Echinococcus granulosus	serine:threonine protein kinase N2	0.0035	0.0298	0.0338
Echinococcus multilocularis	protein kinase c eta type	0.0025	0.0169	0.0169
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0035	0.0298	0.0414
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0035	0.0298	0.0414
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0025	0.0179	0.0248
Trypanosoma brucei	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	0.0512	0.6357	1
Schistosoma mansoni	atypical protein kinase C	0.0059	0.061	0.069
Onchocerca volvulus		0.0011	0.000000010598	0.000000031719
Echinococcus multilocularis	N chimaerin	0.0025	0.0169	0.0169
Onchocerca volvulus		0.0035	0.0306	0.0915
Echinococcus multilocularis	importin subunit beta 1	0.003	0.0243	0.0243
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.0112	0.1274	0.1919
Mycobacterium ulcerans	phenyloxazoline synthase MbtB	0.0035	0.0306	0.038
Loa Loa (eye worm)	phosphopantetheine attachment site family protein	0.0035	0.0306	0.0424
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0014	0.0019
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0035	0.0306	0.038
Loa Loa (eye worm)	hypothetical protein	0.016	0.189	0.2624
Onchocerca volvulus	Acyl carrier protein, mitochondrial homolog	0.0035	0.0306	0.0915
Loa Loa (eye worm)	acyl carrier protein	0.0035	0.0306	0.0424
Trichomonas vaginalis	NADH-ubiquinone oxidoreductase flavoprotein, putative	0.0512	0.6357	1
Loa Loa (eye worm)	hypothetical protein	0.0579	0.7201	1
Wolbachia endosymbiont of Brugia malayi	NADH dehydrogenase I subunit F	0.0512	0.6357	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0014	0.004	0.0056
Schistosoma mansoni	serine/threonine protein kinase	0.0035	0.0298	0.0338
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0016	0.0067	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0169	0.0235
Schistosoma mansoni	diacylglycerol kinase theta	0.0025	0.0169	0.0191
Giardia lamblia	Hypothetical protein	0.0112	0.1274	1
Brugia malayi	C1-like domain containing protein	0.0025	0.0179	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0042	0.0058
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0382	0.0601
Trichomonas vaginalis	chromobox protein, putative	0.0069	0.0727	0.1144
Echinococcus multilocularis	lamin	0.0026	0.0193	0.0193
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0035	0.0298	0.0298
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0035	0.0298	0.0414
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.016	0.189	0.189
Loa Loa (eye worm)	sirtuin 4	0.0016	0.0067	0.0092
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0243	0.0281
Brugia malayi	Protein kinase domain containing protein	0.0035	0.0298	0.0414
Echinococcus granulosus	NADH dehydrogenase ubiquinone flavoprotein 1	0.0512	0.6357	0.7195
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0203	0.0319
Schistosoma mansoni	protein kinase C mu	0.0025	0.0179	0.0202
Trichomonas vaginalis	AGC family protein kinase	0.0035	0.0298	0.0469
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0169	0.0235
Leishmania major	silent information regulator 2, putative	0.0112	0.1274	0.1919
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0035	0.0306	0.038
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE	0.0035	0.0306	0.5
Echinococcus granulosus	Rac GTPase activating protein 1	0.0025	0.0169	0.0191
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0617	0.0875
Entamoeba histolytica	hypothetical protein, conserved	0.0016	0.0067	0.0523
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0014	0.004	0.0056
Onchocerca volvulus		0.0035	0.0306	0.0915
Schistosoma mansoni	hypothetical protein	0.0324	0.3972	0.4496
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0169	0.0235
Echinococcus multilocularis	Rac GTPase activating protein 1	0.0025	0.0169	0.0169
Toxoplasma gondii	type I fatty acid synthase, putative	0.0035	0.0306	0.4951
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0382	0.0601
Mycobacterium tuberculosis	Polyketide synthetase MbtD (polyketide synthase)	0.0035	0.0306	0.038
Mycobacterium tuberculosis	Probable multifunctional mycocerosic acid synthase membrane-associated Mas	0.0035	0.0306	0.038
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0169	0.0235
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0225	0.2707	0.2707
Entamoeba histolytica	diacylglycerol kinase, putative	0.0025	0.0169	0.1328
Mycobacterium leprae	Polyketide synthase Pks13	0.0035	0.0306	0.5
Onchocerca volvulus		0.003	0.0234	0.07
Brugia malayi	Importin beta-1 subunit	0.003	0.0243	0.0337
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0035	0.0306	0.038
Toxoplasma gondii	HEAT repeat-containing protein	0.003	0.0243	0.3938
Brugia malayi	Protein kinase domain containing protein	0.0025	0.0179	0.0248
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0306	0.5
Echinococcus multilocularis	RNA directed DNA polymerase	0.016	0.189	0.189
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0035	0.0298	0.0414
Brugia malayi	Ras association domain family 1 isoform A	0.0025	0.0169	0.0235
Schistosoma mansoni	acyl carrier protein	0.0035	0.0306	0.0346
Echinococcus granulosus	N chimaerin	0.0025	0.0169	0.0191
Trichomonas vaginalis	AGC family protein kinase	0.0035	0.0298	0.0469
Loa Loa (eye worm)	hypothetical protein	0.0185	0.2201	0.3057
Entamoeba histolytica	hypothetical protein	0.0025	0.017	0.1336
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0169	0.0235
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsB	0.0035	0.0306	0.038
Echinococcus granulosus	acyl carrier protein mitochondrial	0.0035	0.0306	0.0346
Mycobacterium ulcerans	polyketide synthase	0.0035	0.0306	0.038
Echinococcus multilocularis	chromatin regulatory protein sir2	0.0112	0.1274	0.1274
Entamoeba histolytica	protein kinase, putative	0.0035	0.0298	0.2341
Plasmodium falciparum	transcriptional regulatory protein sir2b	0.0016	0.0067	0.2178
Toxoplasma gondii	diacylglycerol kinase, putative	0.0025	0.0169	0.2741
Echinococcus granulosus	NAD dependent deacetylase sirtuin 7	0.0016	0.0067	0.0075
Entamoeba histolytica	diacylglycerol kinase, putative	0.0025	0.0169	0.1328
Onchocerca volvulus		0.0025	0.0169	0.0506
Schistosoma mansoni	serine/threonine protein kinase	0.0025	0.0179	0.0202
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.006	0.0617	0.0875
Echinococcus granulosus	chromobox protein 1	0.0069	0.0727	0.0823
Schistosoma mansoni	serine/threonine protein kinase	0.0025	0.0169	0.0191
Echinococcus granulosus	protein kinase c eta type	0.0025	0.0169	0.0191
Echinococcus granulosus	lamin dm0	0.0026	0.0193	0.0219
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtF	0.0035	0.0306	0.038
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0048	0.0469	0.0651
Echinococcus granulosus	death domain containing protein	0.0014	0.004	0.0046
Trichomonas vaginalis	AGC family protein kinase	0.0035	0.0298	0.0469
Schistosoma mansoni	ran	0.0022	0.0141	0.016
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC	0.0035	0.0306	0.5
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0035	0.0306	0.2399
Trypanosoma brucei	Silent information regulator 2 related protein 1	0.0112	0.1274	0.1919
Mycobacterium tuberculosis	Probable membrane bound polyketide synthase Pks6	0.0035	0.0306	0.038
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsE	0.0035	0.0306	0.038
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.0141	0.0119
Echinococcus granulosus	raf serine:threonine protein kinase	0.0025	0.0169	0.0191
Brugia malayi	RhoGAP domain containing protein	0.0025	0.0169	0.0235
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0035	0.0298	0.0338
Schistosoma mansoni	hypothetical protein	0.0035	0.0306	0.0346
Plasmodium falciparum	acyl carrier protein	0.0035	0.0306	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 871382