TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 271.275 | Formula: C13H13N5O2
H donors: 1 H acceptors: 4 LogP: 1.09 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: COC(=C1C(=Nc2n(C1c1ccccc1)nnn2)C)O
InChi: 1S/C13H13N5O2/c1-8-10(12(19)20-2)11(9-6-4-3-5-7-9)18-13(14-8)15-16-17-18/h3-7,11,19H,1-2H3
InChiKey: IZHQJQVLYDJLQJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0995	0.0707
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.3444	0.3444
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0468	0.0468
Schistosoma mansoni	sodium/chloride dependent transporter	0.0015	0.0464	0.0464
Brugia malayi	MH2 domain containing protein	0.0008	0.0033	0.0048
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0015	0.0464	0.0464
Echinococcus granulosus	sodium and chloride dependent glycine	0.0015	0.0464	0.0464
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.3444	0.3444
Loa Loa (eye worm)	glutathione reductase	0.0048	0.2452	0.355
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0565	0.0035
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0015	0.0464	0.0464
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0995	1
Mycobacterium tuberculosis	Probable reductase	0.011	0.6195	0.8837
Brugia malayi	Thioredoxin reductase	0.0048	0.2452	0.355
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0995	1
Plasmodium vivax	acyl-CoA synthetase, putative	0.0018	0.0625	0.0808
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.2494	0.3611
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0677	0.0677
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0122	0.6938	1
Schistosoma mansoni	hypothetical protein	0.0015	0.0468	0.0468
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0677	0.1073
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0015	0.0464	0.0464
Brugia malayi	MH2 domain containing protein	0.0008	0.0033	0.0048
Loa Loa (eye worm)	transcription factor SMAD2	0.0121	0.6907	1
Schistosoma mansoni	smad	0.0008	0.0033	0.0033
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0008	0.0033	0.0033
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.2356	0.3412
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0464	0.0672
Loa Loa (eye worm)	MH1 domain-containing protein	0.0008	0.0033	0.0048
Mycobacterium tuberculosis	Probable dehydrogenase	0.011	0.6195	0.8837
Echinococcus granulosus	tar DNA binding protein	0.0064	0.3444	0.3444
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0995	0.237
Schistosoma mansoni	ap endonuclease	0.0019	0.0677	0.0677
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.2356	0.2356
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.2356	0.2356
Loa Loa (eye worm)	hypothetical protein	0.0049	0.2494	0.3611
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0015	0.0464	0.0672
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0625	0.0905
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0468	0.0678
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0995	0.1441
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0677	0.0981
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0995	1
Toxoplasma gondii	exonuclease III APE	0.0019	0.0677	0.1073
Plasmodium falciparum	thioredoxin reductase	0.0048	0.2452	1
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.0995	1
Loa Loa (eye worm)	solute carrier family 6 member 4	0.009	0.5032	0.7285
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0468	0.0468
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0015	0.0464	0.0464
Onchocerca volvulus		0.0015	0.0464	0.0922
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0017	0.0543	0.0395
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0468	0.0678
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0017	0.0543	0.0786
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0677	1
Echinococcus granulosus	Smad4	0.0008	0.0033	0.0033
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0017	0.0543	0.4888
Echinococcus granulosus	smad	0.0008	0.0033	0.0033
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.009	0.5032	0.5032
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0015	0.0464	0.0464
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.0677	0.2978
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0015	0.0464	0.0672
Schistosoma mansoni	hypothetical protein	0.0172	1	1
Plasmodium falciparum	glutathione reductase	0.0048	0.2452	1
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0995	0.0707
Echinococcus granulosus	sodium and chloride dependent glycine	0.0015	0.0464	0.0464
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0677	0.0706
Schistosoma mansoni	sodium/chloride dependent transporter	0.009	0.5032	0.5032
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0015	0.0464	0.0672
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0995	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0565	0.0035
Brugia malayi	MH1 domain containing protein	0.0008	0.0033	0.0048
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0677	0.0706
Brugia malayi	MH1 domain containing protein	0.0008	0.0033	0.0048
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.011	0.6195	0.8837
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0015	0.0464	0.0464
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.3444	0.3444
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0015	0.0464	0.0672
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.009	0.5032	0.7285
Echinococcus granulosus	serotonin transporter	0.009	0.5032	0.5032
Echinococcus multilocularis	Smad4	0.0008	0.0033	0.0033
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0015	0.0464	0.0464
Brugia malayi	glutathione reductase	0.0048	0.2452	0.355
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0015	0.0464	0.0464
Loa Loa (eye worm)	MH2 domain-containing protein	0.0008	0.0033	0.0048
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0008	0.0033	0.0033
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0008	0.0033	0.0033
Trypanosoma cruzi	trypanothione reductase, putative	0.0048	0.2452	1
Plasmodium falciparum	thioredoxin reductase	0.0017	0.0543	0.0395
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0017	0.0543	0.0543
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0468	0.0678
Brugia malayi	Smad1	0.0008	0.0033	0.0048
Loa Loa (eye worm)	serotonin transporter b	0.009	0.5032	0.7285
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0677	0.0211
Brugia malayi	MH2 domain containing protein	0.0121	0.6907	1
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.011	0.6195	0.8837
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0995	1
Loa Loa (eye worm)	TAR-binding protein	0.0064	0.3444	0.4987
Trypanosoma brucei	trypanothione reductase	0.0048	0.2452	1
Brugia malayi	hypothetical protein	0.0015	0.0464	0.0672
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0995	1
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0017	0.0543	0.0395
Echinococcus granulosus	GPCR family 2	0.0015	0.0468	0.0468
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0565	0.0035
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0018	0.0625	0.1815
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0995	0.1441
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0012	0.0274	0.0397
Plasmodium falciparum	acyl-CoA synthetase	0.0018	0.0625	0.0808
Schistosoma mansoni	hypothetical protein	0.0172	1	1
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0048	0.2452	0.2985
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0625	0.0905
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0995	0.1441
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0015	0.0464	0.0464
Echinococcus multilocularis	geminin	0.0172	1	1
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.011	0.6195	0.8837
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0677	0.0677
Plasmodium vivax	thioredoxin reductase, putative	0.0048	0.2452	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0464	0.0672
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0017	0.0543	0.0395
Echinococcus multilocularis	smad	0.0008	0.0033	0.0033
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0015	0.0464	0.0464
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0677	1
Loa Loa (eye worm)	hypothetical protein	0.009	0.5032	0.7285
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0015	0.0464	0.0464
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0015	0.0464	0.0672
Leishmania major	trypanothione reductase	0.0048	0.2452	1
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0677	0.0706
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.2356	0.2356
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.3444	0.3444
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0625	0.0905
Plasmodium vivax	glutathione reductase, putative	0.0048	0.2452	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0995	0.1441
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0017	0.0543	0.0543
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0995	0.1441
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0677	1
Loa Loa (eye worm)	hypothetical protein	0.009	0.5032	0.7285
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0625	0.0128
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.2356	0.2356
Onchocerca volvulus		0.0015	0.0464	0.0922
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0995	0.1441
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0048	0.2452	0.2452
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0012	0.0274	0.0397
Schistosoma mansoni	hypothetical protein	0.0015	0.0468	0.0468
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.2356	0.3412
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.2494	0.3611
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0565	0.0035
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0677	0.03
Schistosoma mansoni	sodium/chloride dependent transporter	0.0015	0.0464	0.0464
Echinococcus multilocularis	tar DNA binding protein	0.0064	0.3444	0.3444
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.011	0.6195	0.8749
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0468	0.0468
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0468	0.0468
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0468	0.0678
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.2356	0.2356
Loa Loa (eye worm)	thioredoxin reductase	0.0048	0.2452	0.355
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.3444	0.3444
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.1556	0.2253
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0464	0.0672
Schistosoma mansoni	hypothetical protein	0.0033	0.1556	0.1556
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0015	0.0464	0.0464
Brugia malayi	RNA recognition motif domain containing protein	0.0064	0.3444	0.4987
Loa Loa (eye worm)	hypothetical protein	0.009	0.5032	0.7285
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0625	0.0905
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0122	0.6938	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.1556	0.2253
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0995	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0468	0.0468
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0464	0.0672
Loa Loa (eye worm)	MH2 domain-containing protein	0.0121	0.6907	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0464	0.0672
Onchocerca volvulus		0.0015	0.0464	0.0922
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0015	0.0464	0.0672
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0015	0.0464	0.0464
Echinococcus multilocularis	serotonin transporter	0.009	0.5032	0.5032
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.2356	0.2356
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0677	0.0706
Treponema pallidum	sodium- and chloride- dependent transporter	0.009	0.5032	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0625	0.0905
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.2356	0.2356
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0015	0.0464	0.0464
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0008	0.0033	0.0033
Loa Loa (eye worm)	norepinephrine transporter	0.009	0.5032	0.7285
Toxoplasma gondii	thioredoxin reductase	0.0048	0.2452	1
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0017	0.0543	0.0395
Onchocerca volvulus		0.0024	0.0995	0.1978
Brugia malayi	RNA binding protein	0.0064	0.3444	0.4987
Mycobacterium tuberculosis	Probable oxidoreductase	0.0122	0.6938	1
Schistosoma mansoni	hypothetical protein	0.0015	0.0468	0.0468
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.011	0.6195	0.8837
Schistosoma mansoni	ap endonuclease	0.0019	0.0677	0.0677
Loa Loa (eye worm)	RNA binding protein	0.0064	0.3444	0.4987
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0015	0.0464	0.0464
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0464	0.0672
Onchocerca volvulus		0.009	0.5032	1
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.0677	1
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0015	0.0464	0.0464
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0995	1
Toxoplasma gondii	NADPH-glutathione reductase	0.0017	0.0543	0.0395
Echinococcus granulosus	thioredoxin glutathione reductase	0.0048	0.2452	0.2452
Schistosoma mansoni	hypothetical protein	0.0015	0.0468	0.0468
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0995	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0464	0.0672
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0064	0.3444	0.4987
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0015	0.0464	0.0464
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.0625	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.2494	0.3611
Schistosoma mansoni	Smad4	0.0008	0.0033	0.0033
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0995	0.237
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0033	0.0033
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0033	0.0033
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0995	0.237
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0017	0.0543	0.0395
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0677	0.0981
Brugia malayi	TAR-binding protein	0.0064	0.3444	0.4987
Plasmodium falciparum	glutathione reductase	0.0017	0.0543	0.0395
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0677	0.1073
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0015	0.0464	0.0464
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0995	1
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0033	0.0033
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0122	0.6938	1
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0017	0.0543	0.0543
Echinococcus granulosus	mothers against decapentaplegic 5	0.0008	0.0033	0.0033
Loa Loa (eye worm)	Smad1	0.0008	0.0033	0.0048

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 871442