Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | monoglyceride lipase | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | esterase, putative | monoglyceride lipase | 303 aa | 254 aa | 19.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | monoglyceride lipase, putative | 0.0084 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.1286 | 0.0889 |
Leishmania major | DNA polymerase eta, putative | 0.0044 | 0.4103 | 0.3834 |
Brugia malayi | hypothetical protein | 0.0025 | 0.1286 | 0.3135 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0436 | 0.1062 |
Mycobacterium tuberculosis | Possible lysophospholipase | 0.0084 | 1 | 1 |
Mycobacterium ulcerans | lysophospholipase | 0.0084 | 1 | 1 |
Plasmodium falciparum | lysophospholipase, putative | 0.0084 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4103 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0044 | 0.4103 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.1286 | 0.0889 |
Plasmodium falciparum | lysophospholipase, putative | 0.0084 | 1 | 1 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0084 | 1 | 1 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0084 | 1 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0044 | 0.4103 | 0.3834 |
Echinococcus granulosus | dna polymerase eta | 0.0044 | 0.4103 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0031 | 0.2187 | 0.1831 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0044 | 0.4103 | 0.3834 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.1286 | 0.2319 |
Mycobacterium ulcerans | hypothetical protein | 0.0084 | 1 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 1 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.1286 | 0.0889 |
Plasmodium vivax | PST-A protein | 0.0084 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0084 | 1 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 1 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 1 | 1 |
Trichomonas vaginalis | valacyclovir hydrolase, putative | 0.0084 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.1286 | 0.0889 |
Plasmodium falciparum | lysophospholipase, putative | 0.0084 | 1 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0.0436 | 0.5 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0084 | 1 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 1 | 1 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0031 | 0.2187 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 1 | 1 |
Mycobacterium leprae | POSSIBLE LYSOPHOSPHOLIPASE | 0.0084 | 1 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0044 | 0.4103 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0084 | 1 | 1 |
Trypanosoma cruzi | monoglyceride lipase, putative | 0.0084 | 1 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0044 | 0.4103 | 1 |
Plasmodium falciparum | esterase, putative | 0.0084 | 1 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0031 | 0.2187 | 0.1831 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.61 | Inhibition of Homo sapiens (human) recombinant fatty acid amide hydrolase assessed as inhibition of [3H]-AEA hydrolysis after 10 min by liquid scintillation counting | ChEMBL. | No reference |
IC50 (binding) | = 5.02 | Inhibition of Homo sapiens (human) recombinant monoacylglycerol lipase assessed as inhibition of [3H]-2-oleolylglycerol hydrolysis after 10 min by liquid scintillation counting | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.