Detailed information for compound 871646

Basic information

Technical information
  • TDR Targets ID: 871646
  • Name: N-(4-Fluorophenyl)-2-nitrobenzenesulfonamide
  • MW: 296.274 | Formula: C12H9FN2O4S
  • H donors: 1 H acceptors: 4 LogP: 2.37 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)NS(=O)(=O)c1ccccc1[N+](=O)[O-]
  • InChi: 1S/C12H9FN2O4S/c13-9-5-7-10(8-6-9)14-20(18,19)12-4-2-1-3-11(12)15(16)17/h1-8,14H
  • InChiKey: VOWSWSRNOUJIIW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-fluorophenyl)-2-nitro-benzenesulfonamide
  • Benzenesulfonamide, 2-nitro-N-(4-fluorophenyl)-
  • STK058502
  • ZINC00168586

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae putative S-adenosyl-L-homocysteine hydrolase SahH 0.0513 0.3143 1
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0245 0.0868 0.1355
Schistosoma mansoni adenosylhomocysteinase 0.0317 0.1484 0.2315
Mycobacterium leprae PROBABLE DNA-3-METHYLADENINE GLYCOSYLASE I TAGA (TAG I) (3-methyladenine-DNA glycosylase I, constitutive) (DNA-3-methyladenine g 0.0167 0.0209 0.0666
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0264 0.1032 0.161
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0297 0.1309 0.2042
Mycobacterium tuberculosis Probable DNA-3-methyladenine glycosylase I TagA (tag I) (3-methyladenine-DNA glycosylase I, constitutive) (DNA-3-methyladenine g 0.0167 0.0209 0.0666
Echinococcus granulosus adam 17 protease 0.0691 0.4656 0.7265
Loa Loa (eye worm) phosphatidylinositol 3 0.0898 0.641 0.641
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0264 0.1032 0.161
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0394 0.2137 0.3334
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0264 0.1032 0.3283
Trichomonas vaginalis DNA-3-methyladenine glycosylase, putative 0.0337 0.1652 0.5255
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0242 0.084 0.2672
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0898 0.641 1
Loa Loa (eye worm) matrixin family protein 0.0216 0.0624 0.0624
Onchocerca volvulus 0.0898 0.641 1
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0242 0.084 0.1311
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0264 0.1032 0.3283
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0264 0.1032 0.3283
Entamoeba histolytica hypothetical protein 0.0264 0.1032 0.3283
Toxoplasma gondii adenosylhomocysteinase, putative 0.0513 0.3143 1
Plasmodium vivax adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative 0.0513 0.3143 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0264 0.1032 0.161
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0264 0.1032 0.161
Loa Loa (eye worm) hypothetical protein 0.0245 0.0868 0.0868
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0898 0.641 1
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0297 0.1309 0.2042
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0513 0.3143 1
Echinococcus multilocularis adenosylhomocysteinase 0.0513 0.3143 0.4904
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0898 0.641 1
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0245 0.0868 0.1355
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0364 0.1876 0.5967
Trichomonas vaginalis DNA-3-methyladenine glycosylase, putative 0.0337 0.1652 0.5255
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0264 0.1032 0.3283
Schistosoma mansoni ADAM17 peptidase (M12 family) 0.0629 0.4125 0.6435
Loa Loa (eye worm) phosphatidylinositol 3 0.0898 0.641 0.641
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0364 0.1876 0.1876
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0264 0.1032 0.3283
Loa Loa (eye worm) matrixin family protein 0.0236 0.0789 0.0789
Mycobacterium tuberculosis Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) 0.0513 0.3143 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0264 0.1032 0.3283
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0242 0.084 0.2672
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0264 0.1032 0.3283
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0242 0.084 0.2672
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0264 0.1032 0.3283
Loa Loa (eye worm) phosphatidylinositol 3 0.0264 0.1032 0.1032
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0245 0.0868 0.1355
Entamoeba histolytica adenosylhomocysteinase, putative 0.0513 0.3143 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0264 0.1032 0.3283
Schistosoma mansoni adenosylhomocysteinase 0.0317 0.1484 0.2315
Trypanosoma brucei S-adenosylhomocysteine hydrolase, putative 0.0513 0.3143 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0264 0.1032 0.3283
Schistosoma mansoni adenosylhomocysteinase 0.0317 0.1484 0.2315
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.0513 0.3143 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0264 0.1032 0.3283
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0242 0.0844 0.2684
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0364 0.1876 0.5967
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0242 0.084 0.2672
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0264 0.1032 0.161
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0363 0.1872 0.5955
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0898 0.641 1
Echinococcus multilocularis 0.0242 0.084 0.1311
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0898 0.641 1
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0264 0.1032 0.3283
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0364 0.1876 0.2926
Giardia lamblia Phosphatidylinositol 4-kinase 0.0242 0.084 0.814
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0394 0.2137 0.3334
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0245 0.0868 0.1355
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0264 0.1032 0.161
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0364 0.1876 0.5967
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0245 0.0868 0.1355
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0264 0.1032 0.3283
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0898 0.641 1
Loa Loa (eye worm) hypothetical protein 0.0245 0.0868 0.0868
Brugia malayi metalloprotease disintegrin 16 with thrombospondin type I motif 0.0297 0.1309 0.2042
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0513 0.3143 1
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0161 0.0156 0.0497
Onchocerca volvulus 0.0898 0.641 1
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0264 0.1032 0.161
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0364 0.1876 0.5967
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0364 0.1876 0.2926
Plasmodium falciparum adenosylhomocysteinase 0.0513 0.3143 1
Echinococcus granulosus adenosylhomocysteinase 0.0513 0.3143 0.4904
Leishmania major phosphatidylinositol 4-kinase, putative 0.0242 0.084 0.2672
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0264 0.1032 0.3283
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0242 0.084 0.2672
Echinococcus multilocularis adam 17 protease 0.0629 0.4125 0.6435
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.0513 0.3143 1
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0264 0.1032 0.3283
Loa Loa (eye worm) hypothetical protein 0.0264 0.1032 0.1032
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0354 0.1796 0.2802
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0264 0.1032 0.161
Loa Loa (eye worm) adenosylhomocysteinase 0.0513 0.3143 0.3143
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0264 0.1032 0.3283
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0364 0.1876 0.5967
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0364 0.1876 0.2926
Schistosoma mansoni adenosylhomocysteinase 0.0317 0.1484 0.2315
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0264 0.1032 0.3283
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0264 0.1032 0.161
Loa Loa (eye worm) phosphatidylinositol kinase 0.0898 0.641 0.641
Brugia malayi Adenosylhomocysteinase 0.0513 0.3143 0.4904
Leishmania major S-adenosylhomocysteine hydrolase 0.0513 0.3143 1
Echinococcus multilocularis Zinc finger, PHD finger 0.0264 0.1032 0.161
Brugia malayi Matrixin family protein 0.0236 0.0789 0.1231
Mycobacterium ulcerans S-adenosyl-L-homocysteine hydrolase 0.0513 0.3143 1
Schistosoma mansoni dopamine-beta-monooxygenase 0.0464 0.2725 0.4251
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0264 0.1032 0.3283
Loa Loa (eye worm) hypothetical protein 0.0898 0.641 0.641
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0898 0.641 1
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0264 0.1032 0.161
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0264 0.1032 0.161
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0833 0.5861 0.9143
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0364 0.1876 0.5967
Loa Loa (eye worm) phosphatidylinositol 3 0.0242 0.084 0.084
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0264 0.1032 0.3283
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0354 0.1796 0.2802
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0297 0.1309 0.2042
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0264 0.1032 1
Schistosoma mansoni adenosylhomocysteinase 0.0513 0.3143 0.4904
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0264 0.1032 0.3283
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0264 0.1032 0.3283
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0264 0.1032 0.3283
Schistosoma mansoni peptidylglycine monooxygenase 0.0245 0.0868 0.1355
Toxoplasma gondii S-Adenosyl homocysteine hydrolase 0.0513 0.3143 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0242 0.084 0.1311
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0242 0.084 0.1311
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0264 0.1032 0.3283
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0364 0.1876 0.2926
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0364 0.1876 0.5967

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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