Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.2114 | 0.3223 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0043 | 0.0793 | 0.1044 |
Brugia malayi | Isocitrate dehydrogenase | 0.0016 | 0.0189 | 0.0236 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0039 | 0.0044 |
Schistosoma mansoni | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0012 | 0.0114 | 0.0126 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0012 | 0.0114 | 0.0126 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0016 | 0.0189 | 0.0209 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0071 | 0.143 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.005 | 0.0961 | 0.1065 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0296 | 0.6478 | 0.7178 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0189 | 0.0209 |
Onchocerca volvulus | 0.005 | 0.0961 | 0.5042 | |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.005 | 0.0961 | 0.1065 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0961 | 0.1432 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.0189 | 0.0115 |
Schistosoma mansoni | amidase | 0.0101 | 0.2114 | 0.2343 |
Toxoplasma gondii | hypothetical protein | 0.0049 | 0.0934 | 0.6 |
Onchocerca volvulus | 0.005 | 0.0961 | 0.5042 | |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0066 | 0.1322 | 0.1992 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0071 | 0.143 | 0.1585 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0071 | 0.143 | 0.1331 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0867 | 0.0961 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0061 | 0.1208 | 0.1338 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.143 | 0.216 |
Loa Loa (eye worm) | beta-lactamase | 0.0071 | 0.143 | 0.216 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0016 | 0.0189 | 0.0115 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0016 | 0.0189 | 0.0209 |
Echinococcus granulosus | carboxylesterase 5A | 0.0296 | 0.6478 | 0.7178 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0071 | 0.143 | 0.1331 |
Echinococcus granulosus | acetylcholinesterase | 0.0296 | 0.6478 | 0.7178 |
Echinococcus multilocularis | neuroligin | 0.005 | 0.0961 | 0.1065 |
Mycobacterium ulcerans | lipase LipD | 0.0071 | 0.143 | 0.3991 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0101 | 0.2114 | 0.2343 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0867 | 0.0961 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0071 | 0.143 | 0.2022 |
Brugia malayi | putative amidase | 0.0012 | 0.0114 | 0.012 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.005 | 0.0961 | 0.1065 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.143 | 0.216 |
Echinococcus granulosus | dnaJ subfamily B | 0.041 | 0.9024 | 1 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0038 | 0.0698 | 0.0773 |
Brugia malayi | Carboxylesterase family protein | 0.005 | 0.0961 | 0.1436 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0867 | 0.0961 |
Onchocerca volvulus | 0.005 | 0.0961 | 0.5042 | |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0066 | 0.1322 | 0.1856 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0066 | 0.1322 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.005 | 0.0961 | 0.0857 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0066 | 0.1322 | 0.1465 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0055 | 0.1061 | 0.703 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0189 | 0.0209 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0961 | 0.1432 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.005 | 0.0961 | 0.1065 |
Trichomonas vaginalis | esterase, putative | 0.0071 | 0.143 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0071 | 0.143 | 0.2022 |
Loa Loa (eye worm) | amidase | 0.0012 | 0.0114 | 0.0116 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0066 | 0.1322 | 0.1856 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0012 | 0.0114 | 0.0126 |
Schistosoma mansoni | hypothetical protein | 0.041 | 0.9024 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0071 | 0.143 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0071 | 0.143 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0961 | 0.1432 |
Schistosoma mansoni | gliotactin | 0.005 | 0.0961 | 0.1065 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0016 | 0.0189 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0016 | 0.0189 | 0.0232 |
Loa Loa (eye worm) | amidase | 0.0012 | 0.0114 | 0.0116 |
Echinococcus multilocularis | geminin | 0.0164 | 0.352 | 0.39 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0961 | 0.1432 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0071 | 0.143 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0071 | 0.143 | 0.2163 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0189 | 0.0209 |
Plasmodium vivax | hypothetical protein, conserved | 0.0071 | 0.143 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0961 | 0.1432 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0071 | 0.143 | 0.3991 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0052 | 0.1002 | 0.1364 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.352 | 0.39 |
Echinococcus granulosus | BC026374 protein S09 family | 0.005 | 0.0961 | 0.1065 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0066 | 0.1322 | 0.1465 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.143 | 0.216 |
Brugia malayi | amidase | 0.0101 | 0.2114 | 0.3225 |
Mycobacterium ulcerans | beta-lactamase | 0.0071 | 0.143 | 0.3991 |
Brugia malayi | Carboxylesterase family protein | 0.005 | 0.0961 | 0.1436 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.005 | 0.0961 | 0.1065 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0521 | 0.0578 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0039 | 0.0044 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0066 | 0.1322 | 0.1465 |
Brugia malayi | hypothetical protein | 0.005 | 0.0961 | 0.1436 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.005 | 0.0961 | 0.1065 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0071 | 0.143 | 0.3991 |
Echinococcus multilocularis | glutamyl tRNA(Gln) amidotransferase subunit A | 0.0012 | 0.0114 | 0.0126 |
Echinococcus multilocularis | acetylcholinesterase | 0.0296 | 0.6478 | 0.7178 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0143 | 0.3049 | 0.4511 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0867 | 0.0961 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0101 | 0.2114 | 0.2343 |
Echinococcus granulosus | glutamyl tRNAGln amidotransferase subunit A | 0.0012 | 0.0114 | 0.0126 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0867 | 0.1289 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.0189 | 0.0115 |
Mycobacterium ulcerans | hypothetical protein | 0.0071 | 0.143 | 0.3991 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0867 | 0.0961 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.352 | 0.39 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.0485 | 0.0537 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.005 | 0.0961 | 0.1065 |
Brugia malayi | Carboxylesterase family protein | 0.005 | 0.0961 | 0.1436 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0012 | 0.0114 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.005 | 0.0961 | 0.1065 |
Onchocerca volvulus | 0.005 | 0.0961 | 0.5042 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0296 | 0.6478 | 0.7178 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0066 | 0.1322 | 0.1856 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.005 | 0.0961 | 0.0857 |
Onchocerca volvulus | 0.0071 | 0.143 | 1 | |
Brugia malayi | Amidase family protein | 0.0012 | 0.0114 | 0.012 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0303 | 0.6621 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0303 | 0.6621 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0303 | 0.6621 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0296 | 0.6478 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.0485 | 0.0695 |
Onchocerca volvulus | 0.0071 | 0.143 | 1 | |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0189 | 0.0209 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0066 | 0.1322 | 0.1995 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0296 | 0.6478 | 1 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0012 | 0.0114 | 0.0126 |
Brugia malayi | beta-lactamase | 0.0071 | 0.143 | 0.2163 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0043 | 0.0793 | 0.1044 |
Onchocerca volvulus | 0.005 | 0.0961 | 0.5042 | |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0071 | 0.143 | 0.1331 |
Mycobacterium leprae | conserved hypothetical protein | 0.0071 | 0.143 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0867 | 0.1285 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0043 | 0.0793 | 0.1044 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0071 | 0.143 | 0.1585 |
Loa Loa (eye worm) | carboxylesterase | 0.005 | 0.0961 | 0.1432 |
Brugia malayi | follicle stimulating hormone receptor | 0.0224 | 0.487 | 0.7503 |
Loa Loa (eye worm) | carboxylesterase | 0.005 | 0.0961 | 0.1432 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.005 | 0.0961 | 0.1065 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0101 | 0.2114 | 0.2343 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0224 | 0.487 | 0.7502 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0143 | 0.3049 | 0.4511 |
Brugia malayi | isocitrate dehydrogenase | 0.0016 | 0.0189 | 0.0236 |
Echinococcus granulosus | geminin | 0.0164 | 0.352 | 0.39 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.005 | 0.0961 | 0.1065 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.0189 | 0.0115 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.143 | 0.216 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0961 | 0.1432 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0038 | 0.0698 | 0.0773 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0012 | 0.0114 | 0.5 |
Onchocerca volvulus | 0.0071 | 0.143 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.005 | 0.0961 | 0.1436 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0071 | 0.143 | 0.1331 |
Mycobacterium tuberculosis | Conserved protein | 0.0071 | 0.143 | 0.1331 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0303 | 0.6621 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.0485 | 0.0692 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0071 | 0.143 | 0.1585 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0101 | 0.2114 | 0.2343 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0071 | 0.143 | 0.1331 |
Brugia malayi | Carboxylesterase family protein | 0.0296 | 0.6478 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0296 | 0.6478 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.005 | 0.0961 | 0.0857 |
Schistosoma mansoni | acetylcholinesterase | 0.005 | 0.0961 | 0.1065 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0071 | 0.143 | 0.1331 |
Echinococcus granulosus | neuroligin | 0.005 | 0.0961 | 0.1065 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0867 | 0.0961 |
Echinococcus multilocularis | acetylcholinesterase | 0.0296 | 0.6478 | 0.7178 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0071 | 0.143 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0101 | 0.2114 | 0.2343 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0071 | 0.143 | 0.216 |
Loa Loa (eye worm) | carboxylesterase | 0.0296 | 0.6478 | 1 |
Echinococcus multilocularis | dnaJ subfamily B | 0.041 | 0.9024 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0043 | 0.0793 | 0.1044 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0071 | 0.143 | 0.2022 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0159 | 0.3412 | 0.3336 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0071 | 0.143 | 0.2022 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0071 | 0.143 | 0.1585 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0012 | 0.0114 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0071 | 0.143 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0071 | 0.143 | 0.1331 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0143 | 0.3049 | 0.4511 |
Loa Loa (eye worm) | hypothetical protein | 0.0296 | 0.6478 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0071 | 0.143 | 0.2163 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0961 | 0.1432 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.143 | 0.216 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0016 | 0.0189 | 0.0076 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0071 | 0.143 | 0.1331 |
Mycobacterium ulcerans | hypothetical protein | 0.0159 | 0.3412 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0071 | 0.143 | 1 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0521 | 0.0578 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0016 | 0.0189 | 0.0567 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.0521 | 0.0578 |
Echinococcus granulosus | acetylcholinesterase | 0.0296 | 0.6478 | 0.7178 |
Brugia malayi | beta-lactamase family protein | 0.0071 | 0.143 | 0.2163 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.005 | 0.0961 | 0.2569 |
Mycobacterium tuberculosis | Conserved protein | 0.0071 | 0.143 | 0.1331 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0867 | 0.0961 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.0521 | 0.0578 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0066 | 0.1322 | 0.1856 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0016 | 0.0189 | 0.0115 |
Brugia malayi | Amidase family protein | 0.0012 | 0.0114 | 0.012 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0016 | 0.0189 | 0.0209 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.143 | 0.216 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.