TDR Targets

Basic information

Technical information

TDR Targets ID: 872288
Name: N-(2-bromophenyl)-1-(4-methylpiperidin-1-yl)s ulfonylpiperidine-3-carboxamide
MW: 444.386 | Formula: C18H26BrN3O3S
H donors: 1 H acceptors: 3 LogP: 2.72 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CC1CCN(CC1)S(=O)(=O)N1CCCC(C1)C(=O)Nc1ccccc1Br
InChi: 1S/C18H26BrN3O3S/c1-14-8-11-21(12-9-14)26(24,25)22-10-4-5-15(13-22)18(23)20-17-7-3-2-6-16(17)19/h2-3,6-7,14-15H,4-5,8-13H2,1H3,(H,20,23)
InChiKey: OVQNZTICOKNIFT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(2-bromophenyl)-1-[(4-methyl-1-piperidyl)sulfonyl]piperidine-3-carboxamide
N-(2-bromophenyl)-1-[(4-methyl-1-piperidinyl)sulfonyl]-3-piperidinecarboxamide
N-(2-bromophenyl)-1-[(4-methyl-1-piperidyl)sulfonyl]nipecotamide
N-(2-bromophenyl)-1-(4-methylpiperidin-1-yl)sulfonyl-piperidine-3-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	ecdysone induced protein 78C	0.0021	0.0611	0.0611
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0021	0.0611	0.0776
Brugia malayi	nuclear hormone receptor	0.0021	0.0611	0.0776
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0021	0.0611	0.0611
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0021	0.0611	0.0719
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0021	0.0611	0.0776
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0021	0.0611	0.0611
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0021	0.0611	0.0776
Loa Loa (eye worm)	hypothetical protein	0.0027	0.1041	0.1321
Brugia malayi	ecdysteroid receptor	0.0021	0.0611	0.0776
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0611	0.0776
Schistosoma mansoni	retinoic acid receptor RXR	0.0021	0.0611	0.0611
Schistosoma mansoni	tar DNA-binding protein	0.0109	0.6914	0.6914
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0611	0.0776
Schistosoma mansoni	hypothetical protein	0.0131	0.8492	0.8492
Loa Loa (eye worm)	steroid hormone receptor	0.0021	0.0611	0.0776
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0021	0.0611	0.0611
Loa Loa (eye worm)	MH2 domain-containing protein	0.0123	0.7875	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.0611	0.0611
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0021	0.0611	0.0776
Brugia malayi	photoreceptor-specific nuclear receptor	0.0021	0.0611	0.0776
Brugia malayi	steroid hormone receptor	0.0021	0.0611	0.0776
Onchocerca volvulus	Protein ultraspiracle homolog	0.0021	0.0611	0.5
Onchocerca volvulus	Bile acid receptor homolog	0.0021	0.0611	0.5
Brugia malayi	Steroid receptor seven-up type 2	0.0021	0.0611	0.0776
Echinococcus multilocularis	tar DNA binding protein	0.0109	0.6914	0.6914
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0021	0.0611	0.0611
Brugia malayi	Nuclear hormone receptor-like 1	0.0021	0.0611	0.0776
Schistosoma mansoni	nuclear hormone receptor	0.0021	0.0611	0.0611
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0021	0.0611	0.0776
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0021	0.0611	0.0611
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0611	0.0776
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0021	0.0611	0.0611
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0021	0.0611	0.0719
Schistosoma mansoni	thyroid hormone receptor	0.0152	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0021	0.0611	0.0776
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0021	0.0611	0.0776
Brugia malayi	RNA binding protein	0.0109	0.6914	0.8779
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0611	0.0776
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0021	0.0611	0.0611
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.004	0.1937	0.246
Brugia malayi	Calcitonin receptor-like protein seb-1	0.004	0.1937	0.246
Schistosoma mansoni	hypothetical protein	0.0027	0.1041	0.1041
Schistosoma mansoni	tar DNA-binding protein	0.0109	0.6914	0.6914
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0109	0.6914	0.8779
Loa Loa (eye worm)	transcription factor SMAD2	0.0123	0.7875	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0611	0.0776
Schistosoma mansoni	tar DNA-binding protein	0.0109	0.6914	0.6914
Schistosoma mansoni	thyroid hormone receptor	0.0152	1	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.0611	0.0719
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0021	0.0611	0.0611
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0021	0.0611	0.0776
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0611	0.0776
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0021	0.0611	0.0611
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0021	0.0611	0.0776
Schistosoma mansoni	coup transcription factor	0.0021	0.0611	0.0611
Brugia malayi	MH2 domain containing protein	0.0123	0.7875	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.0611	0.0611
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0611	0.0776
Schistosoma mansoni	RAR-like nuclear receptor	0.0021	0.0611	0.0611
Schistosoma mansoni	tar DNA-binding protein	0.0109	0.6914	0.6914
Brugia malayi	RNA recognition motif domain containing protein	0.0109	0.6914	0.8779
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0021	0.0611	0.0719
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0021	0.0611	0.5
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0021	0.0611	0.0611
Loa Loa (eye worm)	TAR-binding protein	0.0109	0.6914	0.8779
Echinococcus multilocularis	FTZ F1 alpha	0.0021	0.0611	0.0611
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0131	0.8492	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0611	0.0776
Echinococcus granulosus	tar DNA binding protein	0.0109	0.6914	0.8141
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0021	0.0611	0.0776
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.004	0.1937	0.246
Brugia malayi	latrophilin 2 splice variant baaae	0.0027	0.1041	0.1321
Echinococcus granulosus	ecdysone induced protein 78C	0.0021	0.0611	0.0719
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0611	0.0776
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0021	0.0611	0.0719
Echinococcus granulosus	FTZ F1 alpha	0.0021	0.0611	0.0719
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0611	0.0776
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0021	0.0611	0.0719
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0021	0.0611	0.0776
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0611	0.0776
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0021	0.0611	0.0776
Loa Loa (eye worm)	hypothetical protein	0.004	0.1937	0.246
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.0611	0.0719
Schistosoma mansoni	tar DNA-binding protein	0.0109	0.6914	0.6914
Loa Loa (eye worm)	RNA binding protein	0.0109	0.6914	0.8779
Brugia malayi	nuclear receptor NHR-88	0.0021	0.0611	0.0776
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0021	0.0611	0.0611
Onchocerca volvulus		0.0021	0.0611	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0611	0.0776
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0021	0.0611	0.0776
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0611	0.0776
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0021	0.0611	0.0776
Brugia malayi	TAR-binding protein	0.0109	0.6914	0.8779
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0131	0.8492	0.8492
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0611	0.0776

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 872288