Detailed information for compound 872404

Basic information

Technical information
  • TDR Targets ID: 872404
  • Name: 2-ethyl-N-(2-methoxy-5-methylphenyl)-2,3-dihy dro-1,4-benzothiazine-4-carboxamide
  • MW: 342.455 | Formula: C19H22N2O2S
  • H donors: 1 H acceptors: 1 LogP: 4.25 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC1Sc2ccccc2N(C1)C(=O)Nc1cc(C)ccc1OC
  • InChi: 1S/C19H22N2O2S/c1-4-14-12-21(16-7-5-6-8-18(16)24-14)19(22)20-15-11-13(2)9-10-17(15)23-3/h5-11,14H,4,12H2,1-3H3,(H,20,22)
  • InChiKey: AHMZXDKAUXPOQL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-ethyl-N-(2-methoxy-5-methyl-phenyl)-2,3-dihydro-1,4-benzothiazine-4-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Immunoglobulin I-set domain containing protein 0.0009 0.0025 0.0002
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0098 0.0098
Echinococcus multilocularis roundabout 2 0.0019 0.0306 0.0306
Schistosoma mansoni tyrosine kinase 0.0111 0.3083 0.3067
Schistosoma mansoni adapter molecule crk 0.0013 0.0146 0.0124
Loa Loa (eye worm) hypothetical protein 0.0012 0.0115 0.0115
Schistosoma mansoni tyrosine kinase 0.0111 0.3083 0.3067
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0432 1
Brugia malayi Prion-like- 0.0009 0.0025 0.0002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0513 0.0513
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.1328 0.5
Echinococcus multilocularis tyrosine kinase 0.0012 0.0098 0.0098
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0528 0.0506
Brugia malayi Immunoglobulin I-set domain containing protein 0.0009 0.0025 0.0002
Schistosoma mansoni cpg binding protein 0.0029 0.0626 0.0605
Echinococcus granulosus tyrosine protein kinase Srms 0.0012 0.0098 0.0098
Brugia malayi Immunoglobulin I-set domain containing protein 0.0009 0.0025 0.0002
Schistosoma mansoni hypothetical protein 0.0047 0.1148 0.1128
Echinococcus granulosus tyrosine kinase 0.0041 0.0981 0.0981
Brugia malayi SH2 domain containing protein 0.0012 0.0098 0.0075
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.1181 0.1181
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0432 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0432 0.0411
Echinococcus multilocularis lachesin 0.0009 0.0025 0.0025
Brugia malayi hypothetical protein 0.0012 0.0098 0.0075
Echinococcus multilocularis lamin 0.0026 0.0528 0.0528
Echinococcus granulosus c src tyrosine kinase 0.0019 0.0298 0.0298
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0098 0.0098
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0432 0.4939
Onchocerca volvulus 0.0023 0.0432 0.3631
Schistosoma mansoni roundabout 0.0009 0.0025 0.0002
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0048 0.1181 0.1181
Echinococcus multilocularis Immunoglobulin 0.0009 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0012 0.0098 0.0098
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.664 0.664
Schistosoma mansoni tyrosine kinase 0.018 0.5145 0.5134
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0258 0.139
Onchocerca volvulus 0.0012 0.0098 0.0649
Loa Loa (eye worm) TK/INSR protein kinase 0.0111 0.3083 0.3083
Schistosoma mansoni tyrosine kinase 0.0213 0.6141 0.6132
Brugia malayi SH2 domain containing protein 0.0012 0.0098 0.0075
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0019 0.0298 0.0298
Echinococcus granulosus roundabout 2 0.0009 0.0025 0.0025
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0009 0.0025 0.0025
Brugia malayi SRC-1 0.0048 0.1181 0.1161
Onchocerca volvulus 0.0028 0.0579 0.4932
Echinococcus granulosus tyrosine protein kinase Lyn 0.0048 0.1181 0.1181
Schistosoma mansoni cell adhesion molecule 0.0009 0.0025 0.0002
Schistosoma mansoni tyrosine kinase 0.0185 0.5296 0.5286
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0009 0.0025 0.0002
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0258 0.5
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0111 0.3083 0.3083
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0041 0.0981 0.0981
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0009 0.0025 0.0002
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0098 0.0098
Schistosoma mansoni tyrosine kinase 0.0048 0.1181 0.1161
Echinococcus granulosus roundabout 2 0.0019 0.0306 0.0306
Loa Loa (eye worm) hypothetical protein 0.0009 0.0023 0.0023
Onchocerca volvulus 0.0026 0.0528 0.4477
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0011 0.0084 0.0084
Loa Loa (eye worm) RNA binding protein 0.0123 0.3428 0.3428
Onchocerca volvulus 0.0012 0.0098 0.0649
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0123 0.3428 0.3428
Schistosoma mansoni growth factor receptor-bound protein 0.0013 0.0146 0.0124
Echinococcus granulosus NCK adaptor protein 0.0013 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0017 0.0258 0.0258
Schistosoma mansoni cell adhesion molecule 0.0009 0.0025 0.0002
Echinococcus multilocularis hemicentin 1 0.0009 0.0025 0.0025
Schistosoma mansoni neuroglian 0.0009 0.0025 0.0002
Loa Loa (eye worm) hypothetical protein 0.0009 0.0023 0.0023
Echinococcus multilocularis tyrosine protein kinase Blk 0.0041 0.0981 0.0981
Echinococcus multilocularis lamin dm0 0.0026 0.0528 0.0528
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0009 0.0025 0.0025
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0432 1
Schistosoma mansoni cell adhesion molecule 0.0012 0.0115 0.0092
Schistosoma mansoni cpg binding protein 0.0028 0.0579 0.0557
Loa Loa (eye worm) hypothetical protein 0.0023 0.0432 0.0432
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0098 0.0098
Brugia malayi CXXC zinc finger family protein 0.0028 0.0579 0.0557
Echinococcus granulosus tyrosine protein kinase Fyn 0.0048 0.1181 0.1181
Echinococcus granulosus tyrosine protein kinase Src64B 0.0048 0.1181 0.1181
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0162 0.014
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0432 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.1068 0.1068
Loa Loa (eye worm) hypothetical protein 0.0009 0.0025 0.0025
Echinococcus granulosus tyrosine protein kinase ABL1 0.022 0.6346 0.6346
Echinococcus multilocularis tyrosine protein kinase Abl 0.0098 0.2687 0.2687
Echinococcus multilocularis peroxidasin 0.0009 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0009 0.0025 0.0025
Echinococcus multilocularis tyrosine protein kinase otk 0.0009 0.0025 0.0025
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0098 0.0098
Echinococcus multilocularis cpg binding protein 0.0029 0.0626 0.0626
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.1068 0.1068
Echinococcus granulosus tyrosine protein kinase shark 0.0012 0.0098 0.0098
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0048 0.1181 0.1181
Brugia malayi Tyrosine-protein kinase abl-1 0.0098 0.2687 0.267
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0432 1
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0013 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0009 0.0023 0.0023
Echinococcus granulosus growth factor receptor bound protein 2 0.0013 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0009 0.0025 0.0025
Echinococcus granulosus peroxidasin 0.0009 0.0025 0.0025
Onchocerca volvulus 0.0012 0.0098 0.0649
Echinococcus multilocularis tyrosine protein kinase HCK 0.0034 0.0776 0.0776
Brugia malayi hypothetical protein 0.023 0.664 0.6632
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0019 0.0298 0.0276
Loa Loa (eye worm) hypothetical protein 0.0019 0.0306 0.0306
Onchocerca volvulus 0.0012 0.0098 0.0649
Brugia malayi Immunoglobulin I-set domain containing protein 0.0009 0.0025 0.0002
Echinococcus multilocularis roundabout 2 0.0009 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0019 0.0306 0.0306
Schistosoma mansoni nephrin 0.0009 0.0025 0.0002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0106 0.0106
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0012 0.0115 0.0115
Echinococcus multilocularis tar DNA binding protein 0.0123 0.3428 0.3428
Echinococcus multilocularis neuroglian 0.0009 0.0025 0.0025
Brugia malayi Immunoglobulin I-set domain containing protein 0.0009 0.0025 0.0002
Brugia malayi Protein kinase domain containing protein 0.0111 0.3083 0.3067
Schistosoma mansoni survival motor neuron protein 0.0047 0.1148 0.1128
Brugia malayi Protein kinase domain containing protein 0.0012 0.0098 0.0075
Echinococcus granulosus epidermal growth factor receptor 0.0185 0.5296 0.5296
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0432 1
Brugia malayi RNA recognition motif domain containing protein 0.0123 0.3428 0.3413
Loa Loa (eye worm) hypothetical protein 0.0026 0.0528 0.0528
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0009 0.0025 0.0025
Echinococcus multilocularis musashi 0.0026 0.0528 0.0528
Echinococcus multilocularis tyrosine protein kinase Srms 0.0041 0.0981 0.0981
Brugia malayi Protein kinase domain containing protein 0.0012 0.0098 0.0075
Schistosoma mansoni tyrosine kinase 0.0341 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0092 0.007
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0048 0.1181 0.1181
Echinococcus multilocularis Immunoglobulin 0.0009 0.0023 0.0023
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.1068 0.1068
Loa Loa (eye worm) TK/ROR protein kinase 0.0011 0.0084 0.0084
Echinococcus multilocularis epidermal growth factor receptor 0.0185 0.5296 0.5296
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.1518 0.1499
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0048 0.1181 0.1181
Brugia malayi Variant SH3 domain containing protein 0.0013 0.0146 0.0124
Echinococcus multilocularis tyrosine protein kinase shark 0.0012 0.0098 0.0098
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0432 0.4939
Brugia malayi Immunoglobulin I-set domain containing protein 0.0009 0.0025 0.0002
Onchocerca volvulus Tyrosine kinase homolog 0.0011 0.0084 0.0531
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0098 0.0098
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0009 0.0025 0.0025
Brugia malayi Sex muscle abnormal protein 5 0.0013 0.0146 0.0124
Schistosoma mansoni tyrosine kinase 0.018 0.5145 0.5134
Schistosoma mansoni lamin 0.0026 0.0528 0.0506
Onchocerca volvulus 0.0026 0.0528 0.4477
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0432 0.5
Brugia malayi RNA binding protein 0.0123 0.3428 0.3413
Schistosoma mansoni tyrosine kinase 0.018 0.5145 0.5134
Schistosoma mansoni cell adhesion molecule 0.0009 0.0025 0.0002
Echinococcus granulosus hemicentin 1 0.0009 0.0025 0.0025
Echinococcus multilocularis epidermal growth factor receptor 0.0341 1 1
Echinococcus granulosus roundabout 2 0.0009 0.0025 0.0025
Schistosoma mansoni lamin 0.0026 0.0528 0.0506
Onchocerca volvulus 0.0012 0.0098 0.0649
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0432 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0023 0.0023
Echinococcus multilocularis roundabout 2 0.0009 0.0025 0.0025
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0528 0.0528
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0023 0.0432 0.0432
Brugia malayi Immunoglobulin I-set domain containing protein 0.0009 0.0025 0.0002
Echinococcus granulosus tar DNA binding protein 0.0123 0.3428 0.3428
Schistosoma mansoni tyrosine kinase 0.0014 0.0176 0.0154
Echinococcus granulosus intermediate filament protein 0.0026 0.0528 0.0528
Loa Loa (eye worm) hypothetical protein 0.0013 0.0146 0.0146
Schistosoma mansoni septate junction protein 0.0009 0.0025 0.0002
Schistosoma mansoni tar DNA-binding protein 0.0123 0.3428 0.3413
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.012 0.012
Echinococcus granulosus tyrosine kinase 0.0012 0.0098 0.0098
Echinococcus granulosus Immunoglobulin 0.0009 0.0023 0.0023
Schistosoma mansoni titin 0.0009 0.0025 0.0002
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0048 0.1181 0.1181
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.1148 0.1128
Loa Loa (eye worm) hypothetical protein 0.0023 0.0432 0.0432
Echinococcus granulosus neuroglian 0.0016 0.0215 0.0215
Brugia malayi Peroxidasin 0.0009 0.0025 0.0002
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0528 0.0528
Echinococcus granulosus lachesin 0.0009 0.0025 0.0025
Schistosoma mansoni tar DNA-binding protein 0.0123 0.3428 0.3413
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0009 0.0023 0.0023
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0432 1
Brugia malayi intermediate filament protein 0.0026 0.0528 0.0506
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0432 0.4939
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0009 0.0025 0.0025
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0009 0.0025 0.0025
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.1068 0.1048
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.1181 0.1181
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.1068 0.1048
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.1068 0.1048
Loa Loa (eye worm) hypothetical protein 0.0009 0.0025 0.0025
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0111 0.3083 0.3083
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0432 0.0411
Schistosoma mansoni tar DNA-binding protein 0.0123 0.3428 0.3413
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0098 0.0098
Echinococcus granulosus lamin dm0 0.0026 0.0528 0.0528
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0011 0.0084 0.0084
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0013 0.0146 0.0146
Loa Loa (eye worm) SRC-1 0.0048 0.1181 0.1181
Echinococcus granulosus twitchin 0.0016 0.0215 0.0215
Mycobacterium ulcerans hypothetical protein 0.0023 0.0432 1
Echinococcus granulosus epidermal growth factor receptor 0.0341 1 1
Schistosoma mansoni nephrin 0.0016 0.0215 0.0192
Entamoeba histolytica protein kinase, putative 0.0034 0.0776 1
Echinococcus multilocularis NCK adaptor protein 0.0013 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0017 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0009 0.0023 0.0023
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0013 0.0146 0.0124
Schistosoma mansoni nck2/grb4 0.0013 0.0146 0.0124
Schistosoma mansoni tyrosine kinase 0.0012 0.0098 0.0075
Onchocerca volvulus 0.0047 0.1148 1
Echinococcus granulosus survival motor neuron protein 1 0.023 0.664 0.664
Echinococcus multilocularis growth factor receptor bound protein 2 0.0013 0.0146 0.0146
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0432 0.5
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0048 0.1181 0.1181
Brugia malayi Protein kinase domain containing protein 0.0012 0.0098 0.0075
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0185 0.5296 0.5296
Brugia malayi Variant SH3 domain containing protein 0.0013 0.0146 0.0124
Loa Loa (eye worm) hypothetical protein 0.0017 0.0258 0.0258
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.1068 0.1048
Onchocerca volvulus 0.0012 0.0098 0.0649
Brugia malayi TAR-binding protein 0.0123 0.3428 0.3413
Loa Loa (eye worm) TK/ABL protein kinase 0.022 0.6346 0.6346
Schistosoma mansoni tar DNA-binding protein 0.0123 0.3428 0.3413
Brugia malayi Immunoglobulin I-set domain containing protein 0.0017 0.0266 0.0244
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0012 0.0098 0.0098
Schistosoma mansoni tyrosine kinase 0.0019 0.0298 0.0276
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0017 0.0266 0.0266
Echinococcus granulosus contactin 0.0009 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0009 0.0025 0.0025
Schistosoma mansoni cpg binding protein 0.0029 0.0626 0.0605
Echinococcus granulosus lamin 0.0026 0.0528 0.0528
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0036 0.0829 0.0829
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0048 0.1181 0.1181
Echinococcus multilocularis neuroglian 0.0016 0.0215 0.0215
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0009 0.0025 0.0025
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0258 0.5
Echinococcus granulosus tyrosine protein kinase otk 0.0009 0.0025 0.0025
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0432 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.1068 0.1068
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0162 0.0162
Brugia malayi Protein kinase domain containing protein 0.0012 0.0098 0.0075
Loa Loa (eye worm) hypothetical protein 0.0009 0.0023 0.0023
Echinococcus multilocularis c src tyrosine kinase 0.0019 0.0298 0.0298
Echinococcus granulosus tyrosine protein kinase Blk 0.0041 0.0981 0.0981
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0579 0.0579
Loa Loa (eye worm) TK protein kinase 0.0034 0.0776 0.0776
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0009 0.0025 0.0025
Echinococcus multilocularis insulin receptor 0.0111 0.3083 0.3083
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0098 0.0098
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0432 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0009 0.0025 0.0002
Echinococcus granulosus insulin receptor 0.0111 0.3083 0.3083
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0098 0.0098
Loa Loa (eye worm) TK/EGFR protein kinase 0.0341 1 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0011 0.0084 0.0062
Loa Loa (eye worm) TK protein kinase 0.0041 0.0981 0.0981
Echinococcus granulosus tyrosine protein kinase HCK 0.0034 0.0776 0.0776
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0009 0.0025 0.0025
Echinococcus multilocularis 0.0105 0.2887 0.2887
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.1181 0.1181
Schistosoma mansoni septate junction protein 0.0009 0.0025 0.0002
Brugia malayi protein-tyrosine kinase 0.0041 0.0981 0.096
Echinococcus granulosus defective proboscis extension response 0.0009 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0009 0.0025 0.0025
Echinococcus granulosus tyrosine protein kinase Fyn 0.0048 0.1181 0.1181
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0432 0.0411
Schistosoma mansoni tar DNA-binding protein 0.0123 0.3428 0.3413
Echinococcus multilocularis hemicentin 1 0.0009 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0085 0.2281 0.2281
Schistosoma mansoni intermediate filament proteins 0.0026 0.0528 0.0506
Loa Loa (eye worm) TK/FER protein kinase 0.0012 0.0098 0.0098
Echinococcus granulosus tyrosine protein kinase Src42A 0.0048 0.1181 0.1181
Schistosoma mansoni tyrosine kinase 0.0012 0.0098 0.0075
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0009 0.0025 0.0025
Loa Loa (eye worm) TAR-binding protein 0.0123 0.3428 0.3428
Loa Loa (eye worm) hypothetical protein 0.0017 0.0258 0.0258
Schistosoma mansoni growth factor receptor-bound protein 0.0013 0.0146 0.0124
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.1068 0.1068
Echinococcus multilocularis tyrosine protein kinase ABL1 0.022 0.6346 0.6346
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0048 0.1181 0.1181
Brugia malayi Protein kinase domain containing protein 0.0012 0.0098 0.0075
Schistosoma mansoni tyrosine kinase 0.0019 0.0298 0.0276
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0041 0.0981 0.0981
Brugia malayi Immunoglobulin I-set domain containing protein 0.0009 0.0025 0.0002
Echinococcus granulosus tyrosine protein kinase Fyn 0.0048 0.1181 0.1181
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0019 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0017 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0009 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0012 0.0106 0.0106
Brugia malayi Tyrosine-protein kinase abl-1 0.0128 0.36 0.3586
Loa Loa (eye worm) hypothetical protein 0.023 0.664 0.664
Echinococcus granulosus neuroglian 0.0009 0.0025 0.0025
Schistosoma mansoni tyrosine kinase 0.0048 0.1181 0.1161
Echinococcus granulosus tyrosine protein kinase Src42A 0.0036 0.0829 0.0829
Loa Loa (eye worm) hypothetical protein 0.0009 0.0025 0.0025
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0012 0.0098 0.0098
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0258 0.5
Schistosoma mansoni tyrosine kinase 0.0185 0.5296 0.5286
Loa Loa (eye worm) hypothetical protein 0.0013 0.012 0.012
Echinococcus granulosus cpg binding protein 0.0029 0.0626 0.0626
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0432 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0432 0.5
Loa Loa (eye worm) TK protein kinase 0.0011 0.0084 0.0084

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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