TDR Targets

Basic information

Technical information

TDR Targets ID: 872442
Name: 1-[6-(4-fluorophenyl)imidazo[1,2-d][1,3,4]thi adiazol-2-yl]-N-[(2-fluorophenyl)methyl]piper idine-3-carboxamide
MW: 453.508 | Formula: C23H21F2N5OS
H donors: 1 H acceptors: 3 LogP: 4.43 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(C1CCCN(C1)c1nn2c(s1)nc(c2)c1ccc(cc1)F)NCc1ccccc1F
InChi: 1S/C23H21F2N5OS/c24-18-9-7-15(8-10-18)20-14-30-22(27-20)32-23(28-30)29-11-3-5-17(13-29)21(31)26-12-16-4-1-2-6-19(16)25/h1-2,4,6-10,14,17H,3,5,11-13H2,(H,26,31)
InChiKey: RVYQXXIMVHFMRD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-[6-(4-fluorophenyl)-2-imidazo[1,2-d][1,3,4]thiadiazolyl]-N-[(2-fluorophenyl)methyl]-3-piperidinecarboxamide
N-(2-fluorobenzyl)-1-[6-(4-fluorophenyl)imidazo[1,2-d][1,3,4]thiadiazol-2-yl]nipecotamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	voltage-gated potassium channel	0.0017	0.008	0.0011
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0042	0.046	0.138
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0588	1
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0017	0.008	0.0237
Schistosoma mansoni	hypothetical protein	0.0169	0.2333	0.2279
Brugia malayi	Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog	0.0017	0.008	0.0237
Brugia malayi	ion channel NompC	0.0017	0.008	0.0237
Echinococcus multilocularis	transient receptor potential cation channel	0.0017	0.008	0.008
Loa Loa (eye worm)	hypothetical protein	0.0123	0.1642	0.4942
Echinococcus granulosus	calcium activated potassium channel variant	0.0219	0.3069	0.3069
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0186	0.3277
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0017	0.008	0.008
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0186	0.0557
Loa Loa (eye worm)	hypothetical protein	0.0017	0.008	0.0237
Echinococcus granulosus	TRP transient receptor potential channel	0.0017	0.008	0.008
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0037	0.0381	0.0314
Echinococcus granulosus	mitogen activated protein kinase	0.0051	0.0588	0.0588
Loa Loa (eye worm)	hypothetical protein	0.0017	0.008	0.0237
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0017	0.008	0.008
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0017	0.008	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0186	0.0557
Echinococcus granulosus	transient receptor potential cation channel	0.0017	0.008	0.008
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0017	0.008	0.008
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0368	0.5659
Schistosoma mansoni	calcium-activated potassium channel	0.0219	0.3069	0.302
Echinococcus multilocularis	transient receptor potential cation channel	0.0017	0.008	0.008
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0098	0.0291
Echinococcus multilocularis	short transient receptor potential channel 6	0.0017	0.008	0.008
Leishmania major	DNA polymerase kappa, putative	0.0019	0.0122	0.0603
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0122	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0368	0.1102
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.046	0.7473
Echinococcus multilocularis	voltage gated potassium channel	0.0017	0.008	0.008
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0186	0.0326
Echinococcus granulosus	short transient receptor potential channel 6	0.0017	0.008	0.008
Plasmodium falciparum	phd finger protein, putative	0.0029	0.0267	0.3475
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0017	0.008	0.008
Echinococcus multilocularis	sodium leak channel non selective protein	0.0017	0.008	0.008
Schistosoma mansoni	voltage-gated potassium channel	0.0017	0.008	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0017	0.008	0.0237
Brugia malayi	jmjC domain containing protein	0.0037	0.0381	0.1143
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0122	0.1212
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.007	0.0204
Onchocerca volvulus		0.0036	0.0368	0.1839
Echinococcus granulosus	Protein patched homolog 1	0.0042	0.046	0.046
Brugia malayi	Voltage-gated calcium channel, alpha subunit	0.0017	0.008	0.0237
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0037	0.0381	0.0314
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0017	0.008	0.008
Loa Loa (eye worm)	jmjC domain-containing protein	0.0037	0.0381	0.1143
Loa Loa (eye worm)	hypothetical protein	0.0017	0.008	0.0237
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0368	1
Echinococcus granulosus	voltage gated hydrogen channel 1	0.0017	0.008	0.008
Echinococcus granulosus	potassium voltage gated channel protein	0.0017	0.008	0.008
Brugia malayi	CXXC zinc finger family protein	0.0029	0.026	0.0779
Trypanosoma cruzi	DNA polymerase eta, putative	0.0019	0.0122	0.0603
Onchocerca volvulus		0.0029	0.026	0.1151
Schistosoma mansoni	ryanodine receptor related	0.0017	0.008	0.0011
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0368	0.0903
Schistosoma mansoni	voltage-gated cation channel	0.0017	0.008	0.0011
Echinococcus multilocularis	calcium activated potassium channel	0.0236	0.3319	0.3319
Onchocerca volvulus		0.0024	0.0186	0.0679
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0122	0.1212
Brugia malayi	MAP kinase sur-1	0.0051	0.0588	0.1766
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0368	0.5659
Loa Loa (eye worm)	ryanodine receptor	0.0017	0.008	0.0237
Schistosoma mansoni	hypothetical protein	0.0048	0.0548	0.0481
Schistosoma mansoni	calcium-activated potassium channel	0.0236	0.3312	0.3265
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.023	0.3225	1
Trypanosoma cruzi	calcium/potassium channel (CAKC), putative	0.0063	0.0761	1
Schistosoma mansoni	transient receptor potential channel 4	0.0017	0.008	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0017	0.008	0.0237
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0122	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0237	0.332	1
Echinococcus granulosus	hyperpolarization activated cyclic	0.0017	0.008	0.008
Onchocerca volvulus		0.0036	0.0368	0.1839
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0368	0.0903
Schistosoma mansoni	voltage-gated potassium channel	0.0017	0.008	0.0011
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0017	0.008	0.0011
Brugia malayi	jmjC domain containing protein	0.0096	0.1244	0.3742
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0051	0.0588	0.1766
Schistosoma mansoni	hypothetical protein	0.0169	0.2333	0.2279
Loa Loa (eye worm)	hypothetical protein	0.0017	0.008	0.0237
Echinococcus granulosus	PHD finger protein rhinoceros	0.0029	0.0267	0.0267
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0368	0.0903
Echinococcus multilocularis	ryanodine receptor 44f	0.0017	0.008	0.008
Brugia malayi	Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog	0.0157	0.2145	0.646
Loa Loa (eye worm)	hypothetical protein	0.005	0.0573	0.1723
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0017	0.008	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0186	0.0557
Echinococcus granulosus	dna polymerase eta	0.0019	0.0122	0.0122
Schistosoma mansoni	voltage-gated potassium channel	0.0017	0.008	0.0011
Echinococcus multilocularis	voltage dependent calcium channel	0.0017	0.008	0.008
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0017	0.008	0.0237
Echinococcus granulosus	sodium leak channel non selective protein	0.0017	0.008	0.008
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0122	0.0361
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0122	0.0603
Echinococcus multilocularis	potassium voltage gated channel protein	0.0017	0.008	0.008
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.007	0.007
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0122	0.0122
Echinococcus granulosus	Niemann Pick C1 protein	0.0098	0.1287	0.1287
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0186	0.1557
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0054	0.0639	0.8201
Echinococcus multilocularis	peregrin	0.0029	0.0267	0.0267
Echinococcus multilocularis	lysine specific demethylase 5A	0.0035	0.0357	0.0357
Schistosoma mansoni	cpg binding protein	0.003	0.0284	0.0216
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0122	0.0866
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0029	0.0267	0.0198
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0017	0.008	0.008
Echinococcus granulosus	potassium voltage gated channel protein	0.0017	0.008	0.008
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0051	0.0588	0.7618
Trichomonas vaginalis	DNA polymerase eta, putative	0.0019	0.0122	0.0809
Echinococcus multilocularis	conserved hypothetical protein	0.0017	0.008	0.008
Schistosoma mansoni	voltage-gated potassium channel	0.0017	0.008	0.0011
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0368	0.0903
Brugia malayi	Transient-receptor-potential like protein	0.0017	0.008	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0016	0.007	0.0204
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.007	0.007
Schistosoma mansoni	voltage-gated potassium channel	0.0017	0.008	0.0011
Echinococcus multilocularis	Niemann Pick C1 protein	0.0141	0.1909	0.1909
Schistosoma mansoni	voltage-gated potassium channel	0.0017	0.008	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0098	0.0291
Loa Loa (eye worm)	hypothetical protein	0.0017	0.008	0.0237
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0122	0.1212
Schistosoma mansoni	voltage-dependent calcium channel	0.0017	0.008	0.0011
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0571	0.1717
Schistosoma mansoni	transient receptor potential channel	0.0017	0.008	0.0011
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0186	0.3277
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0017	0.008	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0761	0.2288
Brugia malayi	hypothetical protein	0.0123	0.1642	0.4942
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0368	0.1102
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0186	0.3277
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0098	0.0291
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0122	0.0052
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0186	0.3277
Echinococcus multilocularis	survival motor neuron protein 1	0.0237	0.332	0.332
Schistosoma mansoni	voltage-gated potassium channel	0.0017	0.008	0.0011
Echinococcus multilocularis	mitogen activated protein kinase	0.0051	0.0588	0.0588
Toxoplasma gondii	ion channel protein	0.0063	0.0761	1
Toxoplasma gondii	ABC1 family protein	0.0036	0.0368	0.4218
Loa Loa (eye worm)	ion channel NompC	0.0017	0.008	0.0237
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0186	0.3277
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0051	0.0588	0.7453
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0017	0.008	0.008
Leishmania major	calcium/potassium channel (CAKC), putative	0.0063	0.0761	1
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0368	0.4593
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0186	0.3277
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0267	0.2735
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0186	0.0557
Schistosoma mansoni	hypothetical protein	0.0041	0.0437	0.037
Echinococcus granulosus	sodium channel protein	0.0017	0.008	0.008
Schistosoma mansoni	voltage-gated potassium channel	0.0017	0.008	0.0011
Echinococcus granulosus	geminin	0.0169	0.2333	0.2333
Echinococcus granulosus	transient receptor potential cation channel	0.0017	0.008	0.008
Echinococcus granulosus	Niemann Pick C1 protein	0.0141	0.1909	0.1909
Echinococcus granulosus	survival motor neuron protein 1	0.0237	0.332	0.332
Echinococcus multilocularis	voltage gated hydrogen channel 1	0.0017	0.008	0.008
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0019	0.0122	0.012
Loa Loa (eye worm)	hypothetical protein	0.0017	0.008	0.0237
Schistosoma mansoni	patched 1	0.0042	0.046	0.0393
Loa Loa (eye worm)	MaxiK calcium-activated potassium channel	0.0157	0.2145	0.646
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0122	0.0866
Schistosoma mansoni	hypothetical protein	0.0029	0.0267	0.0198
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0051	0.0588	0.7453
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0017	0.008	0.008
Mycobacterium ulcerans	lipase LipD	0.0036	0.0368	1
Schistosoma mansoni	voltage-gated potassium channel	0.0017	0.008	0.0011
Schistosoma mansoni	transient receptor potential channel	0.0017	0.008	0.0011
Echinococcus granulosus	voltage dependent calcium channel	0.0017	0.008	0.008
Trypanosoma cruzi	calcium/potassium channel (CAKC), putative	0.0063	0.0761	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.06	0.1802
Echinococcus granulosus	potassium voltage gated channel protein	0.0017	0.008	0.008
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0051	0.0588	0.7453
Echinococcus multilocularis	potassium voltage gated channel protein	0.0017	0.008	0.008
Leishmania major	hypothetical protein, conserved	0.0063	0.0761	1
Loa Loa (eye worm)	hypothetical protein	0.0123	0.1642	0.4942
Echinococcus granulosus	calcium activated potassium channel	0.0236	0.3319	0.3319
Echinococcus multilocularis	geminin	0.0169	0.2333	0.2333
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0122	0.1212
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0571	0.1717
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0339	0.1017
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0017	0.008	0.008
Onchocerca volvulus	Huntingtin homolog	0.0123	0.1642	1
Echinococcus granulosus	shaker cognate	0.0017	0.008	0.008
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0186	0.0326
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0368	0.5659
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.007	0.0204
Echinococcus granulosus	dnaJ subfamily B	0.0409	0.5861	0.5861
Schistosoma mansoni	DNA polymerase eta	0.0019	0.0122	0.0052
Echinococcus multilocularis	dna polymerase eta	0.0019	0.0122	0.0122
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0017	0.008	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0017	0.008	0.0237
Echinococcus granulosus	transient receptor potential cation channel	0.0017	0.008	0.008
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0017	0.008	0.008
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0017	0.008	0.0011
Brugia malayi	Niemann-Pick C1 protein precursor	0.0098	0.1287	0.3874
Loa Loa (eye worm)	hypothetical protein	0.0017	0.008	0.0237
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.0017	0.008	0.008
Echinococcus multilocularis	transient receptor potential cation channel	0.0017	0.008	0.008
Echinococcus multilocularis	potassium voltage gated channel protein	0.0017	0.008	0.008
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.0122	0.0052
Echinococcus granulosus	hyperpolarization activated cyclic	0.0017	0.008	0.008
Loa Loa (eye worm)	hypothetical protein	0.0017	0.008	0.0237
Echinococcus granulosus	ryanodine receptor 44f	0.0017	0.008	0.008
Echinococcus granulosus	hypothetical protein	0.0017	0.008	0.008
Echinococcus multilocularis	short transient receptor potential channel 6	0.0017	0.008	0.008
Loa Loa (eye worm)	hypothetical protein	0.0017	0.008	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0368	0.1102
Echinococcus multilocularis	transient receptor potential cation channel	0.0017	0.008	0.008
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0017	0.008	0.0011
Echinococcus granulosus	mitogen activated protein kinase 3	0.0051	0.0588	0.0588
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0017	0.008	0.0237
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0017	0.008	0.008
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0098	0.0291
Brugia malayi	hypothetical protein	0.0237	0.332	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.007	0.007
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0019	0.0122	0.012
Schistosoma mansoni	hypothetical protein	0.0041	0.0437	0.037
Echinococcus granulosus	cpg binding protein	0.003	0.0284	0.0284
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0368	0.0368
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0017	0.008	0.008
Loa Loa (eye worm)	calcium channel	0.0017	0.008	0.0237
Echinococcus multilocularis	potassium large conductance calcium activated	0.0236	0.3312	0.3312
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0368	0.0903
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0186	0.0557
Echinococcus multilocularis	GPCR, family 2	0.0016	0.007	0.007
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0548	0.1645
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.0017	0.008	0.0649
Leishmania major	hypothetical protein, conserved	0.0036	0.0368	0.4218
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0029	0.0267	0.0267
Echinococcus granulosus	lysine specific demethylase 5A	0.0037	0.0381	0.0381
Brugia malayi	Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog	0.0017	0.008	0.0237
Echinococcus multilocularis	transient receptor potential cation channel	0.0017	0.008	0.008
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0017	0.008	0.0011
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0588	1
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0051	0.0588	0.7453
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0548	0.0481
Schistosoma mansoni	voltage-gated potassium channel	0.0017	0.008	0.0011
Echinococcus multilocularis	protein dispatched 1	0.0048	0.0547	0.0547
Schistosoma mansoni	voltage-gated potassium channel	0.0017	0.008	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0017	0.008	0.0237
Schistosoma mansoni	microtubule-associated protein tau	0.069	1	1
Echinococcus granulosus	two pore calcium channel protein 1	0.0017	0.008	0.008
Echinococcus multilocularis	protein patched	0.0042	0.046	0.046
Loa Loa (eye worm)	hypothetical protein	0.0017	0.008	0.0237
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0017	0.008	0.008
Schistosoma mansoni	two-pore calcium channel	0.0017	0.008	0.0011
Onchocerca volvulus		0.0048	0.0548	0.2992
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0368	0.0368
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0368	0.1102
Brugia malayi	CHE-14 protein	0.0042	0.046	0.138
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0186	0.1557
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0267	0.2735
Echinococcus multilocularis	transfer RNA-Gly	0.0017	0.008	0.008
Loa Loa (eye worm)	hypothetical protein	0.005	0.0571	0.1717
Echinococcus multilocularis	transient receptor potential cation channel	0.0017	0.008	0.008
Echinococcus multilocularis	two pore calcium channel protein 1	0.0017	0.008	0.008
Echinococcus multilocularis	calcium activated potassium channel variant	0.0219	0.3069	0.3069
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0122	0.1212
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.01	0.131	0.1249
Brugia malayi	F/Y-rich N-terminus family protein	0.0018	0.0107	0.0317
Brugia malayi	cation channel family protein	0.0017	0.008	0.0237
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0096	0.1244	0.1244
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0588	1
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0122	0.0361
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0122	0.1212
Plasmodium falciparum	potassium channel	0.0063	0.0761	1
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.0017	0.008	0.008
Plasmodium vivax	potassium channel, putative	0.0063	0.0761	1
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0017	0.008	0.0011
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0017	0.008	0.008
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0017	0.008	0.008
Trypanosoma brucei	inositol 1,4,5-trisphosphate receptor	0.0017	0.008	0.0649
Loa Loa (eye worm)	voltage-gated potassium channel	0.0017	0.008	0.0237
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0368	0.03
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0017	0.008	0.008
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0122	0.1212
Loa Loa (eye worm)	jmjC domain-containing protein	0.006	0.0724	0.2176
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0017	0.008	0.008
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0368	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0571	0.1717
Onchocerca volvulus	Huntingtin homolog	0.0123	0.1642	1
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0368	0.0903
Loa Loa (eye worm)	hypothetical protein	0.0017	0.008	0.0237
Trypanosoma brucei	calcium/potassium channel (CAKC), putative	0.0063	0.0761	1
Echinococcus granulosus	transient receptor potential gamma protein	0.0017	0.008	0.008
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0186	0.3277
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0186	0.0557
Trichomonas vaginalis	esterase, putative	0.0036	0.0368	0.5659
Echinococcus multilocularis	sterol regulatory element binding protein	0.0042	0.046	0.046
Loa Loa (eye worm)	hypothetical protein	0.0017	0.008	0.0237
Echinococcus multilocularis	two pore calcium channel protein 2	0.0017	0.008	0.008
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0017	0.008	0.008
Leishmania major	DNA polymerase eta, putative	0.0019	0.0122	0.0603
Loa Loa (eye worm)	voltage-gated calcium channel	0.0017	0.008	0.0237
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.007	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0368	0.1102
Loa Loa (eye worm)	voltage-dependent calcium channel	0.0017	0.008	0.0237
Schistosoma mansoni	voltage-gated potassium channel KCNQ	0.0017	0.008	0.0011
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0368	0.1102
Echinococcus granulosus	sterol regulatory element binding protein	0.0042	0.046	0.046
Echinococcus multilocularis	sodium channel protein	0.0017	0.008	0.008
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0122	0.1212
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0122	0.1212
Loa Loa (eye worm)	PHD-finger family protein	0.0029	0.0267	0.0798
Echinococcus multilocularis	jumonji domain containing protein	0.0041	0.0435	0.0435
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0017	0.008	0.008
Brugia malayi	Bromodomain containing protein	0.0029	0.0267	0.0798
Trypanosoma brucei	unspecified product	0.0019	0.0122	0.1212
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0017	0.008	0.0011
Brugia malayi	beta-lactamase family protein	0.0036	0.0368	0.1102
Schistosoma mansoni	voltage-gated potassium channel	0.0017	0.008	0.0011
Brugia malayi	hypothetical protein	0.0017	0.008	0.0237
Brugia malayi	beta-lactamase family protein	0.0036	0.0368	0.1102
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0017	0.008	0.0237
Plasmodium vivax	acyl-CoA synthetase, putative	0.0018	0.0098	0.1251
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog	0.0017	0.008	0.0237
Giardia lamblia	PHD finger protein 15	0.0029	0.0267	0.3113
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0368	1
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	0.0017	0.008	0.0237
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0051	0.0588	0.7453
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0017	0.008	0.008
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0122	0.1212
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0017	0.008	0.0237
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0186	0.0557
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0096	0.1244	0.1244
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0017	0.008	0.008
Schistosoma mansoni	vesicular amine transporter	0.0017	0.008	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0017	0.008	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0186	0.0557
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0368	0.1102
Echinococcus granulosus	transient receptor potential cation channel	0.0017	0.008	0.008
Schistosoma mansoni	voltage-gated potassium channel	0.0017	0.008	0.0011
Echinococcus multilocularis	transient receptor potential gamma protein	0.0017	0.008	0.008
Loa Loa (eye worm)	voltage-gated potassium channel	0.0017	0.008	0.0237
Plasmodium vivax	hypothetical protein, conserved	0.0029	0.0267	0.3475
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0368	0.1102
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0017	0.008	0.008
Schistosoma mansoni	jumonji domain containing protein	0.0076	0.0954	0.0891
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0368	0.5659
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0017	0.008	0.0011
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0368	0.0903
Loa Loa (eye worm)	large conductance calcium-activated potassium channel alpha subunit ai	0.0219	0.3069	0.9244
Schistosoma mansoni	serine/threonine protein kinase	0.0051	0.0588	0.0522
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0368	0.0903
Schistosoma mansoni	voltage-gated ion channel	0.0017	0.008	0.0011
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0186	0.3277
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0017	0.008	0.0237
Brugia malayi	olfactory channel protein osm-9	0.0017	0.008	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0157	0.2145	0.646
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0019	0.0122	0.0809
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0051	0.0588	0.0588
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0017	0.008	0.0011
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0017	0.008	0.0011
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0368	0.4218
Schistosoma mansoni	voltage-gated potassium channel	0.0017	0.008	0.0011
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0019	0.0122	0.0603
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0368	0.03
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0061	0.0734	0.0669
Schistosoma mansoni	voltage-gated potassium channel	0.0017	0.008	0.0011
Schistosoma mansoni	60S ribosomal protein L21	0.0017	0.008	0.0011
Echinococcus multilocularis	voltage gated potassium channel	0.0017	0.008	0.008
Echinococcus granulosus	potassium voltage gated channel protein	0.0017	0.008	0.008
Loa Loa (eye worm)	hypothetical protein	0.0017	0.008	0.0237
Echinococcus granulosus	voltage gated potassium channel	0.0017	0.008	0.008
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0017	0.008	0.0237
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0017	0.008	0.0011
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0051	0.0588	0.7453
Echinococcus granulosus	transient receptor potential cation channel	0.0017	0.008	0.008
Loa Loa (eye worm)	hypothetical protein	0.0042	0.046	0.138
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0368	0.4806
Echinococcus multilocularis	shaker cognate	0.0017	0.008	0.008
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0122	0.1212
Toxoplasma gondii	ion channel protein	0.0063	0.0761	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0122	0.0603
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0017	0.008	0.0237
Brugia malayi	Ryanodine Receptor TM 4-6 family protein	0.0017	0.008	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0267	0.0798
Echinococcus multilocularis	potassium voltage gated channel subfamily KQT	0.0017	0.008	0.008
Schistosoma mansoni	hypothetical protein	0.0017	0.008	0.0011
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit	0.0017	0.008	0.0237
Echinococcus granulosus	two pore calcium channel protein 2	0.0017	0.008	0.008
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0122	0.1212
Echinococcus multilocularis	Niemann Pick C1 protein	0.0098	0.1287	0.1287
Echinococcus multilocularis	microtubule associated protein 2	0.069	1	1
Echinococcus multilocularis	voltage dependent calcium channel	0.0017	0.008	0.008
Giardia lamblia	Kinase, CMGC MAPK	0.0051	0.0588	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.008	0.0237
Echinococcus granulosus	potassium channel KvQLT family member kqt 1	0.0017	0.008	0.008
Brugia malayi	cation channel family protein	0.0017	0.008	0.0237
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0588	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.008	0.0237
Schistosoma mansoni	transient receptor potential channel	0.0017	0.008	0.0011
Trypanosoma brucei	DNA polymerase eta, putative	0.0019	0.0122	0.1212
Echinococcus multilocularis	potassium voltage gated channel protein	0.0017	0.008	0.008
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0017	0.008	0.008
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0122	0.1212
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0122	0.0122
Schistosoma mansoni	hypothetical protein	0.0034	0.0339	0.0271
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0368	1
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0368	1
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0368	0.0903
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0368	1
Echinococcus granulosus	potassium voltage gated channel protein	0.0017	0.008	0.008
Onchocerca volvulus		0.0036	0.0368	0.1839
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0017	0.008	0.008
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0368	0.0903
Echinococcus granulosus	potassium large conductance calcium activated	0.0236	0.3312	0.3312
Loa Loa (eye worm)	hypothetical protein	0.0017	0.008	0.0237
Brugia malayi	Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog	0.0017	0.008	0.0237
Schistosoma mansoni	cpg binding protein	0.0029	0.026	0.0192
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0186	0.1557
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0017	0.008	0.008
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.007	0.007
Echinococcus granulosus	potassium voltage gated channel subfamily C	0.0017	0.008	0.008
Echinococcus granulosus	peregrin	0.0029	0.0267	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0122	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0368	0.1102
Brugia malayi	PHD-finger family protein	0.0029	0.0267	0.0798
Echinococcus multilocularis	potassium voltage gated channel subfamily C	0.0017	0.008	0.008
Echinococcus granulosus	short transient receptor potential channel 6	0.0017	0.008	0.008
Brugia malayi	voltage-dependent calcium channel	0.0017	0.008	0.0237
Echinococcus granulosus	GPCR family 2	0.0016	0.007	0.007
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1287	0.3874
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0098	0.0291
Plasmodium falciparum	acyl-CoA synthetase	0.0018	0.0098	0.1251
Schistosoma mansoni	hypothetical protein	0.0041	0.0437	0.037
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.0098	0.5
Echinococcus granulosus	expressed conserved protein	0.0093	0.1199	0.1199
Echinococcus granulosus	Potassium voltage gated channel protein Shaw	0.0017	0.008	0.008
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0017	0.0083	0.0013
Schistosoma mansoni	cpg binding protein	0.003	0.0284	0.0216
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0122	0.0603
Schistosoma mansoni	calcium-activated potassium channel	0.0063	0.0761	0.0696
Schistosoma mansoni	hypothetical protein	0.0041	0.0437	0.037
Echinococcus multilocularis	dnaJ subfamily B	0.0409	0.5861	0.5861
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0339	0.1017
Schistosoma mansoni	voltage-gated potassium channel	0.0017	0.008	0.0011
Echinococcus granulosus	transient receptor potential cation channel	0.0017	0.008	0.008
Schistosoma mansoni	hypothetical protein	0.0409	0.5861	0.5832
Echinococcus granulosus	voltage dependent calcium channel	0.0017	0.008	0.008
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0017	0.008	0.008
Schistosoma mansoni	voltage-gated potassium channel	0.0017	0.008	0.0011
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0098	0.0045
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0017	0.008	0.008
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0122	0.0361
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0051	0.0588	0.7453
Brugia malayi	beta-lactamase	0.0036	0.0368	0.1102
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog	0.0017	0.008	0.0237
Echinococcus granulosus	voltage gated potassium channel	0.0017	0.008	0.008
Echinococcus granulosus	jumonji domain containing protein	0.0041	0.0435	0.0435
Schistosoma mansoni	calcium channel voltage-dependent p/q type alpha 1a-related	0.0017	0.008	0.0011
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0017	0.008	0.0011
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.026	0.0779
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0017	0.008	0.0011
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.0186	0.0557
Echinococcus multilocularis	cpg binding protein	0.003	0.0284	0.0284
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0368	0.4218
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0017	0.008	0.008
Onchocerca volvulus	Alhambra homolog	0.0029	0.0267	0.1192
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0368	0.5659
Loa Loa (eye worm)	hypothetical protein	0.0017	0.008	0.0237
Echinococcus multilocularis	expressed conserved protein	0.0093	0.1199	0.1199
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0098	0.1287	1
Schistosoma mansoni	inositol 145-trisphosphate receptor	0.0017	0.008	0.0011
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0122	0.0603
Trypanosoma brucei	protein kinase, putative	0.0051	0.0588	0.7618

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 872442