Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | microtubule-associated protein tau | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K04380 microtubule-associated protein tau, putative | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Echinococcus granulosus | microtubule associated protein 2 | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Schistosoma mansoni | microtubule-associated protein tau | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Echinococcus multilocularis | microtubule associated protein 2 | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Matrixin family protein | 0.06 | 0.0285 | 0.0285 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0901 | 0.0633 | 0.0353 |
Loa Loa (eye worm) | hypothetical protein | 0.2763 | 0.2775 | 0.2833 |
Onchocerca volvulus | Matrilysin homolog | 0.055 | 0.0228 | 0.0823 |
Echinococcus multilocularis | Cyclin dependent kinase 2 associated protein | 0.2763 | 0.2775 | 1 |
Echinococcus granulosus | Cyclin dependent kinase 2 associated protein | 0.2763 | 0.2775 | 1 |
Schistosoma mansoni | deleted in oral cancer 1/cdk2-associated protein-like | 0.2763 | 0.2775 | 0.3011 |
Brugia malayi | Protein kinase domain containing protein | 0.8361 | 0.9218 | 0.9218 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.8361 | 0.9218 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0833 | 0.0554 | 0.0601 |
Loa Loa (eye worm) | matrixin family protein | 0.06 | 0.0285 | 0.0063 |
Onchocerca volvulus | Diphthamide biosynthesis protein 7 homolog | 0.2763 | 0.2775 | 1 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0901 | 0.0633 | 0.0353 |
Schistosoma mansoni | serine/threonine protein kinase | 0.8361 | 0.9218 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.055 | 0.0228 | 0.0823 |
Wolbachia endosymbiont of Brugia malayi | extracellular metallopeptidase | 0.0985 | 0.0729 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.5119 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (binding) | = 3.5481 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.