Detailed information for compound 872516

Basic information

Technical information
  • TDR Targets ID: 872516
  • Name: N-ethyl-1-[6-(4-methylphenyl)imidazo[1,2-d][1 ,3,4]thiadiazol-2-yl]piperidine-3-carboxamide
  • MW: 369.484 | Formula: C19H23N5OS
  • H donors: 1 H acceptors: 3 LogP: 3.47 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCNC(=O)C1CCCN(C1)c1nn2c(s1)nc(c2)c1ccc(cc1)C
  • InChi: 1S/C19H23N5OS/c1-3-20-17(25)15-5-4-10-23(11-15)19-22-24-12-16(21-18(24)26-19)14-8-6-13(2)7-9-14/h6-9,12,15H,3-5,10-11H2,1-2H3,(H,20,25)
  • InChiKey: HVXZQWBZIYFHDN-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-ethyl-1-[6-(4-methylphenyl)-2-imidazo[1,2-d][1,3,4]thiadiazolyl]-3-piperidinecarboxamide
  • N-ethyl-1-[6-(4-methylphenyl)imidazo[1,2-d][1,3,4]thiadiazol-2-yl]nipecotamide
  • E626-0957
  • NCGC00123710-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.009 0.0143 0.0114
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.031 0.0655 0.1435
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.023 0.0469 0.0469
Brugia malayi hypothetical protein 0.199 0.4562 1
Loa Loa (eye worm) hypothetical protein 0.023 0.0469 0.0468
Onchocerca volvulus 0.023 0.0469 1
Echinococcus granulosus hyperpolarization activated cyclic 0.0061 0.0076 0.0076
Onchocerca volvulus 0.023 0.0469 1
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.009 0.0143 0.0313
Echinococcus granulosus puromycin sensitive aminopeptidase 0.023 0.0469 0.0469
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.023 0.0469 1
Brugia malayi Cyclic-nucleotide gated cation channel 0.0061 0.0076 0.0168
Echinococcus granulosus cGMP dependent protein kinase 1 0.0041 0.0029 0.0029
Mycobacterium ulcerans hypothetical protein 0.0041 0.0029 0.0611
Treponema pallidum cyclic nucleotide binding protein 0.0041 0.0029 0.5
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0035 0.0006
Leishmania major protein kinase A regulatory subunit, putative 0.0041 0.0029 0.0611
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0029 0.0065
Echinococcus granulosus puromycin sensitive aminopeptidase 0.023 0.0469 0.0469
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0061 0.0076 0.0076
Schistosoma mansoni voltage-gated potassium channel 0.0338 0.0721 0.0721
Brugia malayi hypothetical protein 0.023 0.0469 0.1027
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.0041 0.0029 0.0477
Leishmania major regulatory subunit of protein kinase a-like protein 0.0041 0.0029 0.0611
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0074 0.0162
Schistosoma mansoni voltage-gated potassium channel 0.009 0.0143 0.0143
Trypanosoma brucei cAMP response protein 1, putative 0.0041 0.0029 0.0618
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.023 0.0469 0.0441
Brugia malayi AMP-binding enzyme family protein 0.0029 0 0.0001
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0061 0.0076 0.0076
Trypanosoma brucei Flagellar Member 6 0.0041 0.0029 0.0618
Entamoeba histolytica hypothetical protein 0.0043 0.0035 0.0736
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.023 0.0469 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0061 0.0076 0.0076
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0041 0.0029 0.0029
Mycobacterium ulcerans transmembrane transport protein 0.0041 0.0029 0.0611
Loa Loa (eye worm) hypothetical protein 0.009 0.0143 0.0142
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0061 0.0076 0.0076
Leishmania major protein kinase, putative 0.0041 0.0029 0.0611
Trypanosoma cruzi Aminopeptidase M1, putative 0.023 0.0469 1
Trypanosoma brucei protein kinase A regulatory subunit 0.0041 0.0029 0.0618
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0041 0.0029 0.0029
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.023 0.0469 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.023 0.0469 0.0441
Loa Loa (eye worm) peptidase family M1 containing protein 0.023 0.0469 0.0468
Mycobacterium ulcerans regulatory protein 0.0041 0.0029 0.0611
Entamoeba histolytica hypothetical protein 0.0043 0.0035 0.0736
Echinococcus granulosus aminopeptidase N 0.023 0.0469 0.0469
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0061 0.0076 0.0076
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0029 0.0029
Echinococcus multilocularis leukotriene A 4 hydrolase 0.4328 1 1
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.023 0.0469 1
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0041 0.0029 0.0029
Echinococcus multilocularis hyperpolarization activated cyclic 0.0061 0.0076 0.0048
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0041 0.0029 0.0029
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.023 0.0469 0.0441
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0029 1
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.023 0.0469 1
Mycobacterium ulcerans aminopeptidase N PepN 0.023 0.0469 1
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.1872 0.1848
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.0041 0.0029 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0 0.0126
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.023 0.0469 0.0469
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0269 0.0269
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0061 0.0076 0.1258
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0041 0.0029 0.0029
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0041 0.0029 0.0029
Mycobacterium ulcerans transcriptional regulatory protein 0.0041 0.0029 0.0611
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.023 0.0469 0.7716
Mycobacterium leprae Conserved hypothetical protein 0.0041 0.0029 1
Brugia malayi Peptidase family M1 containing protein 0.023 0.0469 0.1027
Mycobacterium ulcerans hypothetical protein 0.0041 0.0029 0.0611
Echinococcus multilocularis hyperpolarization activated cyclic 0.0061 0.0076 0.0048
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.029 0.0607 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0041 0.0029 0.0029
Leishmania major hypothetical protein, unknown function 0.0041 0.0029 0.0611
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.023 0.0469 1
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0041 0.0029 0.0029
Brugia malayi AMP-binding enzyme family protein 0.0029 0 0.0001
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0047 0.0047
Schistosoma mansoni aminopeptidase A (M01 family) 0.023 0.0469 0.0469
Leishmania major protein kinase, putative 0.0041 0.0029 0.0611
Toxoplasma gondii aminopeptidase n, putative 0.023 0.0469 1
Toxoplasma gondii aminopeptidase N protein 0.023 0.0469 1
Plasmodium falciparum M1-family alanyl aminopeptidase 0.023 0.0469 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0 0.0001
Echinococcus granulosus puromycin sensitive aminopeptidase 0.023 0.0469 0.0469
Trypanosoma cruzi aminopeptidase, putative 0.023 0.0469 1
Trypanosoma brucei Aminopeptidase M1, putative 0.023 0.0469 1
Schistosoma mansoni voltage-gated potassium channel 0.0338 0.0721 0.0721
Echinococcus granulosus patatin phospholipase domain containing protein 0.0041 0.0029 0.0029
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0061 0.0076 0.0076
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.023 0.0469 1
Entamoeba histolytica hypothetical protein 0.0043 0.0035 0.0736
Echinococcus granulosus potassium voltage gated channel subfamily H 0.009 0.0143 0.0143
Brugia malayi N-terminal motif family protein 0.0041 0.0029 0.0064
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.031 0.0655 0.0628
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0041 0.0029 0.0029
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0041 0.0029 0.0611
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0074 0.0073
Echinococcus granulosus puromycin sensitive aminopeptidase 0.023 0.0469 0.0469
Trypanosoma brucei cAMP binding protein, putative 0.0041 0.0029 0.0618
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.023 0.0469 1
Echinococcus granulosus voltage gated potassium channel 0.009 0.0143 0.0143
Brugia malayi Peptidase family M1 containing protein 0.023 0.0469 0.1027
Echinococcus granulosus cGMP dependent protein kinase 1 0.0041 0.0029 0.0029
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0061 0.0076 0.0076
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0041 0.0029 0.0029
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.0041 0.0029 0.5
Mycobacterium ulcerans hypothetical protein 0.0041 0.0029 0.0611
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0029 0.0477
Trypanosoma cruzi aminopeptidase, putative 0.023 0.0469 1
Trypanosoma brucei aminopeptidase, putative 0.023 0.0469 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0 0.0126
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.023 0.0469 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.006 0.0074 0.0073
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0041 0.0029 0.0618
Loa Loa (eye worm) hypothetical protein 0.0041 0.0029 0.0029
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0041 0.0029 0.0029
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.023 0.0469 0.7716
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0041 0.0029 0.0477
Brugia malayi Egg laying defective protein 4 0.0041 0.0029 0.0064
Echinococcus granulosus puromycin sensitive aminopeptidase 0.023 0.0469 0.0469
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0041 0.0029 0.0029
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0035 0.0035
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0061 0.0076 0.0076
Giardia lamblia CAMP-dependent protein kinase regulatory chain 0.0041 0.0029 0.5
Loa Loa (eye worm) TATA binding protein associated factor 0.023 0.0469 0.0468
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0074 0.0162
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0029 0.0029
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.4328 1 1
Brugia malayi hypothetical protein 0.0043 0.0035 0.0076
Loa Loa (eye worm) hypothetical protein 0.023 0.0469 0.0468
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.023 0.0469 0.0441
Schistosoma mansoni 60S ribosomal protein L21 0.0049 0.0047 0.0047
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0029 1
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0061 0.0076 0.0048
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.023 0.0469 1
Echinococcus granulosus cGMP dependent protein kinase 0.0041 0.0029 0.0029
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0061 0.0076 0.0048
Loa Loa (eye worm) hypothetical protein 0.0041 0.0029 0.0029
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0041 0.0029 0.0029
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.0041 0.0029 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.029 0.0607 1
Brugia malayi Peptidase family M1 containing protein 0.023 0.0469 0.1027
Schistosoma mansoni hypothetical protein 0.0041 0.0029 0.0029
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.023 0.0469 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.023 0.0469 0.0441
Schistosoma mansoni voltage-gated potassium channel 0.009 0.0143 0.0143
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.1872 0.1872
Mycobacterium ulcerans hypothetical protein 0.0041 0.0029 0.0611
Treponema pallidum catabolite gene activator (Crp) 0.0041 0.0029 0.5
Toxoplasma gondii aminopeptidase N, putative 0.023 0.0469 1
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0041 0.0029 0.0029
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.023 0.0469 1
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0041 0.0029 0.0064
Brugia malayi hypothetical protein 0.023 0.0469 0.1027
Echinococcus granulosus potassium voltage gated channel subfamily H 0.031 0.0655 0.0655
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0041 0.0029 0.0064
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0061 0.0076 0.0076
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.0041 0.0029 0.0477
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.023 0.0469 0.0441
Treponema pallidum catabolite gene activator 0.0041 0.0029 0.5
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0041 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0041 0.0029 0.0029
Treponema pallidum cyclic nucleotide binding protein 0.0041 0.0029 0.5
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.023 0.0469 0.7716
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0061 0.0076 0.0076
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0061 0.0076 0.0048
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0061 0.0076 0.0076
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0041 0.0029 1
Brugia malayi TATA binding protein associated factor 0.023 0.0469 0.1027
Brugia malayi MH2 domain containing protein 0.0144 0.0269 0.059
Echinococcus multilocularis voltage gated potassium channel 0.009 0.0143 0.0114
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0035 0.0035
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.023 0.0469 1
Onchocerca volvulus 0.0041 0.0029 0.0611
Onchocerca volvulus 0.0041 0.0029 0.0611
Loa Loa (eye worm) AGC/PKG protein kinase 0.0041 0.0029 0.0029
Entamoeba histolytica hypothetical protein 0.0043 0.0035 0.0736
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.023 0.0469 0.0469
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0061 0.0076 0.1258
Schistosoma mansoni hypothetical protein 0.0041 0.0029 0.0029
Echinococcus granulosus microtubule associated protein 2 0.0833 0.1872 0.1872
Mycobacterium ulcerans aminopeptidase N PepN 0.023 0.0469 1
Loa Loa (eye worm) aminopeptidase N 0.023 0.0469 0.0468
Echinococcus granulosus puromycin sensitive aminopeptidase 0.023 0.0469 0.0469
Schistosoma mansoni hypothetical protein 0.0043 0.0035 0.0035
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.031 0.0655 0.0654
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0041 0.0029 0.0029
Leishmania major hypothetical protein, conserved 0.0041 0.0029 0.0611
Entamoeba histolytica aminopeptidase, putative 0.023 0.0469 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0269 0.0269
Echinococcus granulosus hyperpolarization activated cyclic 0.0061 0.0076 0.0076
Schistosoma mansoni voltage-gated potassium channel 0.0061 0.0076 0.0076
Echinococcus multilocularis aminopeptidase N 0.023 0.0469 0.0441
Trypanosoma brucei Aminopeptidase M1, putative 0.023 0.0469 1
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0041 0.0029 0.0618
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0041 0.0029 0.0477
Loa Loa (eye worm) leukotriene A4 hydrolase 0.4328 1 1
Leishmania major cyclic nucleotide-binding protein-like protein 0.0041 0.0029 0.0611
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0041 0.0029 0.0064
Onchocerca volvulus 0.023 0.0469 1
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.0041 0.0029 1
Loa Loa (eye worm) hypothetical protein 0.023 0.0469 0.0468
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0041 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0269 0.056 0.0559
Mycobacterium tuberculosis Conserved protein 0.0041 0.0029 1
Leishmania major hypothetical protein, conserved 0.0041 0.0029 0.0611
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0029 0.0029
Leishmania major hypothetical protein, conserved 0.0041 0.0029 0.0611

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.1582 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 1.1995 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (binding) = 14.1254 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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