TDR Targets

Basic information

Technical information

TDR Targets ID: 872540
Name: N-(2-methylphenyl)-4-(piperidin-1-ylmethyl)pi peridine-1-carboxamide
MW: 315.453 | Formula: C19H29N3O
H donors: 1 H acceptors: 1 LogP: 3.1 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(N1CCC(CC1)CN1CCCCC1)Nc1ccccc1C
InChi: 1S/C19H29N3O/c1-16-7-3-4-8-18(16)20-19(23)22-13-9-17(10-14-22)15-21-11-5-2-6-12-21/h3-4,7-8,17H,2,5-6,9-15H2,1H3,(H,20,23)
InChiKey: WCHJPKNHLDTFSY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(2-methylphenyl)-4-(1-piperidylmethyl)piperidine-1-carboxamide
N-(2-methylphenyl)-4-(1-piperidylmethyl)-1-piperidinecarboxamide
N-(2-methylphenyl)-4-(piperidinomethyl)piperidine-1-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0095	0.066	0.066
Brugia malayi	hypothetical protein	0.0095	0.066	0.2478
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0201	0.2662	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0201	0.2662	1
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0106	0.0874	0.0874
Loa Loa (eye worm)	hypothetical protein	0.0201	0.2662	1
Brugia malayi	hypothetical protein	0.0095	0.066	0.2478
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0201	0.2662	0.2144
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0106	0.0874	0.023
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0201	0.2662	0.2144
Brugia malayi	photoreceptor-specific nuclear receptor	0.0201	0.2662	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0201	0.2662	0.2144
Loa Loa (eye worm)	gamma-secretase subunit aph-1	0.0197	0.2598	0.9761
Loa Loa (eye worm)	hypothetical protein	0.0095	0.066	0.2478
Brugia malayi	MH2 domain containing protein	0.0107	0.0899	0.3377
Schistosoma mansoni	zinc finger protein	0.0095	0.066	0.066
Brugia malayi	gamma-secretase subunit aph-1	0.0197	0.2598	0.9761
Brugia malayi	nuclear receptor RXR	0.0095	0.066	0.2478
Schistosoma mansoni	RAR-like nuclear receptor	0.0201	0.2662	0.2662
Echinococcus granulosus	gamma secretase subunit aph 1	0.0197	0.2598	0.2076
Brugia malayi	nuclear receptor NHR-88	0.0201	0.2662	1
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0095	0.066	0.2478
Brugia malayi	ecdysteroid receptor	0.0201	0.2662	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0201	0.2662	0.2662
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0201	0.2662	0.2144
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0201	0.2662	1
Schistosoma mansoni	nuclear hormone receptor	0.0201	0.2662	0.2662
Loa Loa (eye worm)	hypothetical protein	0.0095	0.066	0.2478
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0201	0.2662	0.2144
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0201	0.2662	1
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0095	0.066	0.2478
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0874	0.3284
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0201	0.2662	0.2662
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0201	0.2662	0.2144
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0201	0.2662	1
Loa Loa (eye worm)	DR-78	0.0095	0.066	0.2478
Loa Loa (eye worm)	hypothetical protein	0.0201	0.2662	1
Brugia malayi	steroid hormone receptor	0.0201	0.2662	1
Loa Loa (eye worm)	hypothetical protein	0.0095	0.066	0.2478
Loa Loa (eye worm)	hypothetical protein	0.0095	0.066	0.2478
Trypanosoma cruzi	Aph-1 protein, putative	0.0077	0.0324	0.5
Loa Loa (eye worm)	hypothetical protein	0.0095	0.066	0.2478
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0201	0.2662	0.2662
Schistosoma mansoni	retinoic acid receptor RXR	0.0201	0.2662	0.2662
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0874	0.3284
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0095	0.066	0.2478
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0106	0.0874	0.023
Echinococcus multilocularis	microtubule associated protein 2	0.0589	1	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0201	0.2662	1
Brugia malayi	hypothetical protein	0.0106	0.0874	0.3284
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0201	0.2662	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0201	0.2662	0.2662
Schistosoma mansoni	nuclear receptor	0.0095	0.066	0.066
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0522	0.1962
Brugia malayi	nuclear receptor NHR-67	0.0095	0.066	0.2478
Schistosoma mansoni	microtubule-associated protein tau	0.0589	1	1
Schistosoma mansoni	nuclear hormone receptor	0.0095	0.066	0.066
Brugia malayi	nuclear hormone receptor family member odr-7	0.0095	0.066	0.2478
Schistosoma mansoni	thyroid hormone receptor	0.0201	0.2662	0.2662
Loa Loa (eye worm)	hypothetical protein	0.0095	0.066	0.2478
Trypanosoma cruzi	Aph-1 protein, putative	0.0077	0.0324	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0201	0.2662	1
Brugia malayi	ecdysone receptor	0.0095	0.066	0.2478
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0874	0.3284
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0201	0.2662	1
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0095	0.066	0.066
Schistosoma mansoni	coup transcription factor	0.0201	0.2662	0.2662
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0201	0.2662	0.2144
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0874	0.3284
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0201	0.2662	0.2144
Loa Loa (eye worm)	hypothetical protein	0.0095	0.066	0.2478
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0201	0.2662	1
Brugia malayi	nuclear hormone receptor	0.0201	0.2662	1
Brugia malayi	Nuclear hormone receptor E75	0.0095	0.066	0.2478
Schistosoma mansoni	thyroid hormone receptor	0.0201	0.2662	0.2662
Brugia malayi	Nuclear hormone receptor-like 1	0.0106	0.0874	0.3284
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0201	0.2662	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0107	0.0899	0.3377
Echinococcus multilocularis	ecdysone induced protein 78C	0.0201	0.2662	0.2144
Schistosoma mansoni	nuclear receptor nhr-48	0.0095	0.066	0.066
Loa Loa (eye worm)	hypothetical protein	0.0095	0.066	0.2478
Loa Loa (eye worm)	hypothetical protein	0.0201	0.2662	1
Brugia malayi	nuclear hormone receptor	0.0095	0.066	0.2478
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0874	0.3284
Loa Loa (eye worm)	hypothetical protein	0.0201	0.2662	1
Brugia malayi	conserved hypotetical protein	0.0095	0.066	0.2478
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0201	0.2662	0.2144
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0087	0.0522	0.1962
Loa Loa (eye worm)	hypothetical protein	0.0201	0.2662	1
Brugia malayi	orphan nuclear receptor NR2E1	0.0095	0.066	0.2478
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0201	0.2662	0.2144
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0201	0.2662	1
Loa Loa (eye worm)	hypothetical protein	0.0095	0.066	0.2478
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0201	0.2662	0.2662
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0201	0.2662	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0201	0.2662	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0201	0.2662	0.2144
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0201	0.2662	0.2144
Echinococcus multilocularis	gamma secretase subunit aph 1	0.0197	0.2598	0.2076
Schistosoma mansoni	gamma-secretase subunit aph-1	0.0197	0.2598	0.2598
Brugia malayi	Steroid receptor seven-up type 2	0.0201	0.2662	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0201	0.2662	1
Onchocerca volvulus	Bile acid receptor homolog	0.0201	0.2662	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0201	0.2662	1
Loa Loa (eye worm)	hypothetical protein	0.0201	0.2662	1
Loa Loa (eye worm)	hypothetical protein	0.0095	0.066	0.2478
Loa Loa (eye worm)	hypothetical protein	0.0095	0.066	0.2478
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0201	0.2662	0.2144
Onchocerca volvulus		0.0201	0.2662	1
Brugia malayi	tailless protein	0.0095	0.066	0.2478
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0201	0.2662	0.2662
Echinococcus multilocularis	FTZ F1 alpha	0.0201	0.2662	0.2144
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0087	0.0522	0.1962
Brugia malayi	nuclear receptor RXR	0.0106	0.0874	0.3284
Loa Loa (eye worm)	transcription factor SMAD2	0.0107	0.0899	0.3377
Brugia malayi	Nuclear hormone receptor-like 1	0.0201	0.2662	1
Brugia malayi	nuclear receptor NHR-88	0.0095	0.066	0.2478
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0201	0.2662	0.2662
Loa Loa (eye worm)	hypothetical protein	0.0095	0.066	0.2478
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0201	0.2662	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0201	0.2662	1
Loa Loa (eye worm)	hypothetical protein	0.0095	0.066	0.2478
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0106	0.0874	0.3284
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0201	0.2662	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0201	0.2662	0.2144
Onchocerca volvulus	Protein ultraspiracle homolog	0.0201	0.2662	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0201	0.2662	0.2144
Loa Loa (eye worm)	hypothetical protein	0.0201	0.2662	1
Schistosoma mansoni	nuclear hormone receptor	0.0095	0.066	0.066
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0201	0.2662	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0106	0.0874	0.0874
Trypanosoma brucei	Aph-1 protein, putative	0.0077	0.0324	0.5
Echinococcus granulosus	FTZ F1 alpha	0.0201	0.2662	0.2144
Brugia malayi	hypothetical protein	0.0106	0.0874	0.3284
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0201	0.2662	1
Loa Loa (eye worm)	hypothetical protein	0.0201	0.2662	1
Schistosoma mansoni	nuclear receptor	0.0095	0.066	0.066
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0095	0.066	0.2478
Loa Loa (eye worm)	nuclear hormone receptor	0.0095	0.066	0.2478
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0087	0.0522	0.1962
Brugia malayi	Nuclear hormone receptor-like 1	0.0106	0.0874	0.3284
Loa Loa (eye worm)	steroid hormone receptor	0.0201	0.2662	1
Brugia malayi	Nuclear hormone receptor E75	0.0095	0.066	0.2478

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 872540