Detailed information for compound 872634

Basic information

Technical information
  • TDR Targets ID: 872634
  • Name: 1-[6-(4-methylphenyl)imidazo[1,2-d][1,3,4]thi adiazol-2-yl]-N-propan-2-ylpiperidine-3-carbo xamide
  • MW: 383.51 | Formula: C20H25N5OS
  • H donors: 1 H acceptors: 3 LogP: 3.9 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(NC(=O)C1CCCN(C1)c1nn2c(s1)nc(c2)c1ccc(cc1)C)C
  • InChi: 1S/C20H25N5OS/c1-13(2)21-18(26)16-5-4-10-24(11-16)20-23-25-12-17(22-19(25)27-20)15-8-6-14(3)7-9-15/h6-9,12-13,16H,4-5,10-11H2,1-3H3,(H,21,26)
  • InChiKey: LDNOJULYZIMGCZ-UHFFFAOYSA-N  

Network

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Synonyms

  • N-isopropyl-1-[6-(4-methylphenyl)imidazo[1,2-d][1,3,4]thiadiazol-2-yl]piperidine-3-carboxamide
  • N-isopropyl-1-[6-(4-methylphenyl)-2-imidazo[1,2-d][1,3,4]thiadiazolyl]-3-piperidinecarboxamide
  • N-isopropyl-1-[6-(4-methylphenyl)imidazo[1,2-d][1,3,4]thiadiazol-2-yl]nipecotamide
  • 1-[6-(4-methylphenyl)imidazo[1,2-d][1,3,4]thiadiazol-2-yl]-N-propan-2-yl-piperidine-3-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trypanosoma brucei Aminopeptidase M1, putative 0.023 0.0469 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0061 0.0076 0.1258
Leishmania major protein kinase A regulatory subunit, putative 0.0041 0.0029 0.0611
Leishmania major hypothetical protein, conserved 0.0041 0.0029 0.0611
Echinococcus multilocularis hyperpolarization activated cyclic 0.0061 0.0076 0.0048
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.009 0.0143 0.0114
Echinococcus multilocularis voltage gated potassium channel 0.009 0.0143 0.0114
Treponema pallidum catabolite gene activator 0.0041 0.0029 0.5
Loa Loa (eye worm) hypothetical protein 0.0061 0.0076 0.0076
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0074 0.0162
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.0041 0.0029 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.029 0.0607 1
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.023 0.0469 0.7716
Leishmania major hypothetical protein, conserved 0.0041 0.0029 0.0611
Mycobacterium ulcerans hypothetical protein 0.0041 0.0029 0.0611
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.031 0.0655 0.1435
Brugia malayi Peptidase family M1 containing protein 0.023 0.0469 0.1027
Leishmania major hypothetical protein, unknown function 0.0041 0.0029 0.0611
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.023 0.0469 1
Brugia malayi Egg laying defective protein 4 0.0041 0.0029 0.0064
Loa Loa (eye worm) hypothetical protein 0.023 0.0469 0.0468
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.0041 0.0029 0.5
Onchocerca volvulus 0.023 0.0469 1
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.0041 0.0029 0.0477
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0041 0.0029 0.0029
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0061 0.0076 0.0048
Echinococcus granulosus microtubule associated protein 2 0.0833 0.1872 0.1872
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0269 0.0269
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0061 0.0076 0.0048
Onchocerca volvulus 0.0041 0.0029 0.0611
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.023 0.0469 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.023 0.0469 0.0441
Loa Loa (eye worm) hypothetical protein 0.0041 0.0029 0.0029
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.0041 0.0029 1
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0041 0.0029 0.0029
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0061 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.009 0.0143 0.0142
Entamoeba histolytica hypothetical protein 0.0043 0.0035 0.0736
Echinococcus granulosus cGMP dependent protein kinase 1 0.0041 0.0029 0.0029
Schistosoma mansoni hypothetical protein 0.0043 0.0035 0.0035
Echinococcus granulosus puromycin sensitive aminopeptidase 0.023 0.0469 0.0469
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.023 0.0469 0.0441
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0061 0.0076 0.0076
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0061 0.0076 0.0076
Brugia malayi AMP-binding enzyme family protein 0.0029 0 0.0001
Entamoeba histolytica hypothetical protein 0.0043 0.0035 0.0736
Leishmania major cyclic nucleotide-binding protein-like protein 0.0041 0.0029 0.0611
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.023 0.0469 0.7716
Leishmania major protein kinase, putative 0.0041 0.0029 0.0611
Treponema pallidum catabolite gene activator (Crp) 0.0041 0.0029 0.5
Echinococcus granulosus puromycin sensitive aminopeptidase 0.023 0.0469 0.0469
Echinococcus granulosus puromycin sensitive aminopeptidase 0.023 0.0469 0.0469
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0269 0.0269
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0041 0.0029 0.0477
Mycobacterium ulcerans aminopeptidase N PepN 0.023 0.0469 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0 0.0001
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0061 0.0076 0.0076
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0041 0.0029 0.0029
Trypanosoma cruzi aminopeptidase, putative 0.023 0.0469 1
Leishmania major hypothetical protein, conserved 0.0041 0.0029 0.0611
Echinococcus granulosus puromycin sensitive aminopeptidase 0.023 0.0469 0.0469
Trypanosoma cruzi aminopeptidase, putative 0.023 0.0469 1
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.0041 0.0029 0.0477
Loa Loa (eye worm) peptidase family M1 containing protein 0.023 0.0469 0.0468
Loa Loa (eye worm) hypothetical protein 0.0041 0.0029 0.0029
Mycobacterium leprae Conserved hypothetical protein 0.0041 0.0029 1
Trypanosoma brucei cAMP response protein 1, putative 0.0041 0.0029 0.0618
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.023 0.0469 0.0441
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.023 0.0469 1
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0041 0.0029 0.0029
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0041 0.0029 0.0029
Schistosoma mansoni voltage-gated potassium channel 0.009 0.0143 0.0143
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0074 0.0162
Brugia malayi hypothetical protein 0.023 0.0469 0.1027
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.031 0.0655 0.0628
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.023 0.0469 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.031 0.0655 0.0655
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0041 0.0029 0.0064
Echinococcus granulosus aminopeptidase N 0.023 0.0469 0.0469
Trypanosoma brucei protein kinase A regulatory subunit 0.0041 0.0029 0.0618
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0041 0.0029 0.0029
Brugia malayi TATA binding protein associated factor 0.023 0.0469 0.1027
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0041 0.0029 0.0064
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0041 0.0029 0.0611
Toxoplasma gondii aminopeptidase N protein 0.023 0.0469 1
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0041 0.0029 0.0029
Loa Loa (eye worm) TATA binding protein associated factor 0.023 0.0469 0.0468
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0061 0.0076 0.0076
Entamoeba histolytica hypothetical protein 0.0043 0.0035 0.0736
Leishmania major protein kinase, putative 0.0041 0.0029 0.0611
Schistosoma mansoni voltage-gated potassium channel 0.0338 0.0721 0.0721
Loa Loa (eye worm) aminopeptidase N 0.023 0.0469 0.0468
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.023 0.0469 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0061 0.0076 0.1258
Entamoeba histolytica hypothetical protein 0.0043 0.0035 0.0736
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.023 0.0469 0.0441
Loa Loa (eye worm) hypothetical protein 0.023 0.0469 0.0468
Leishmania major regulatory subunit of protein kinase a-like protein 0.0041 0.0029 0.0611
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0 0.0126
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.023 0.0469 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.023 0.0469 0.0469
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0035 0.0035
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0 0.0126
Treponema pallidum cyclic nucleotide binding protein 0.0041 0.0029 0.5
Loa Loa (eye worm) hypothetical protein 0.006 0.0074 0.0073
Echinococcus granulosus potassium voltage gated channel subfamily H 0.009 0.0143 0.0143
Brugia malayi N-terminal motif family protein 0.0041 0.0029 0.0064
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0041 0.0029 0.0029
Mycobacterium ulcerans aminopeptidase N PepN 0.023 0.0469 1
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0029 0.0029
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0029 0.0029
Treponema pallidum cyclic nucleotide binding protein 0.0041 0.0029 0.5
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.023 0.0469 0.0469
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.023 0.0469 1
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.023 0.0469 0.0469
Brugia malayi MH2 domain containing protein 0.0144 0.0269 0.059
Brugia malayi hypothetical protein 0.0043 0.0035 0.0076
Brugia malayi AMP-binding enzyme family protein 0.0029 0 0.0001
Echinococcus multilocularis hyperpolarization activated cyclic 0.0061 0.0076 0.0048
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.023 0.0469 0.0441
Mycobacterium ulcerans hypothetical protein 0.0041 0.0029 0.0611
Mycobacterium ulcerans transcriptional regulatory protein 0.0041 0.0029 0.0611
Loa Loa (eye worm) leukotriene A4 hydrolase 0.4328 1 1
Giardia lamblia CAMP-dependent protein kinase regulatory chain 0.0041 0.0029 0.5
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.0041 0.0029 1
Mycobacterium ulcerans transmembrane transport protein 0.0041 0.0029 0.0611
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.023 0.0469 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0061 0.0076 0.0076
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0041 0.0029 0.0618
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0029 1
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.1872 0.1872
Echinococcus granulosus hyperpolarization activated cyclic 0.0061 0.0076 0.0076
Trypanosoma brucei Flagellar Member 6 0.0041 0.0029 0.0618
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0074 0.0073
Trypanosoma brucei Aminopeptidase M1, putative 0.023 0.0469 1
Loa Loa (eye worm) hypothetical protein 0.023 0.0469 0.0468
Onchocerca volvulus 0.023 0.0469 1
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0041 0.0029 0.0618
Onchocerca volvulus 0.023 0.0469 1
Trypanosoma brucei cAMP binding protein, putative 0.0041 0.0029 0.0618
Echinococcus granulosus puromycin sensitive aminopeptidase 0.023 0.0469 0.0469
Schistosoma mansoni voltage-gated potassium channel 0.009 0.0143 0.0143
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0041 0.0029 0.0029
Echinococcus granulosus cGMP dependent protein kinase 0.0041 0.0029 0.0029
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0029 1
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.009 0.0143 0.0313
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0041 0.0029 0.0029
Trypanosoma cruzi Aminopeptidase M1, putative 0.023 0.0469 1
Toxoplasma gondii aminopeptidase n, putative 0.023 0.0469 1
Brugia malayi hypothetical protein 0.023 0.0469 0.1027
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0047 0.0047
Onchocerca volvulus 0.0041 0.0029 0.0611
Loa Loa (eye worm) hypothetical protein 0.0041 0.0029 0.0029
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.023 0.0469 0.0441
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.023 0.0469 0.0469
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0041 0.0029 0.0029
Brugia malayi Cyclic-nucleotide gated cation channel 0.0061 0.0076 0.0168
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.023 0.0469 0.7716
Schistosoma mansoni hypothetical protein 0.0041 0.0029 0.0029
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0061 0.0076 0.0076
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0041 0.0029 0.0029
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0041 0.0029 0.0029
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.023 0.0469 1
Mycobacterium ulcerans hypothetical protein 0.0041 0.0029 0.0611
Echinococcus granulosus voltage gated potassium channel 0.009 0.0143 0.0143
Schistosoma mansoni voltage-gated potassium channel 0.0338 0.0721 0.0721
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0029 0.0029
Schistosoma mansoni voltage-gated potassium channel 0.0061 0.0076 0.0076
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0041 0.0029 0.0477
Loa Loa (eye worm) hypothetical protein 0.0269 0.056 0.0559
Schistosoma mansoni hypothetical protein 0.0041 0.0029 0.0029
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0035 0.0006
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.1872 0.1848
Entamoeba histolytica aminopeptidase, putative 0.023 0.0469 1
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0029 0.0477
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0061 0.0076 0.0076
Mycobacterium tuberculosis Conserved protein 0.0041 0.0029 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0035 0.0035
Echinococcus multilocularis leukotriene A 4 hydrolase 0.4328 1 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.023 0.0469 1
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0041 0.0029 0.0029
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.029 0.0607 1
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0061 0.0076 0.0048
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0029 0.0065
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.4328 1 1
Echinococcus granulosus hyperpolarization activated cyclic 0.0061 0.0076 0.0076
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0061 0.0076 0.0076
Brugia malayi Peptidase family M1 containing protein 0.023 0.0469 0.1027
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0041 0.0029 0.0029
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.031 0.0655 0.0654
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.023 0.0469 1
Schistosoma mansoni aminopeptidase A (M01 family) 0.023 0.0469 0.0469
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0061 0.0076 0.0076
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0041 0.0029 1
Echinococcus granulosus patatin phospholipase domain containing protein 0.0041 0.0029 0.0029
Loa Loa (eye worm) AGC/PKG protein kinase 0.0041 0.0029 0.0029
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0041 0.0029 0.0029
Brugia malayi Peptidase family M1 containing protein 0.023 0.0469 0.1027
Mycobacterium ulcerans regulatory protein 0.0041 0.0029 0.0611
Brugia malayi hypothetical protein 0.199 0.4562 1
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.023 0.0469 1
Echinococcus granulosus cGMP dependent protein kinase 1 0.0041 0.0029 0.0029
Schistosoma mansoni 60S ribosomal protein L21 0.0049 0.0047 0.0047
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.023 0.0469 1
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0041 0.0029 0.0064
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0041 0.0029 0.0029
Mycobacterium ulcerans hypothetical protein 0.0041 0.0029 0.0611
Plasmodium falciparum M1-family alanyl aminopeptidase 0.023 0.0469 1
Toxoplasma gondii aminopeptidase N, putative 0.023 0.0469 1
Echinococcus multilocularis aminopeptidase N 0.023 0.0469 0.0441
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0061 0.0076 0.0076
Trypanosoma brucei aminopeptidase, putative 0.023 0.0469 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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