Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | 0.0884 | 0.4275 | 0.2934 |
Brugia malayi | Dihydrofolate reductase | 0.0479 | 0.2274 | 0.2501 |
Brugia malayi | thymidylate synthase | 0.1858 | 0.9093 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0479 | 0.2274 | 0.2501 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.2041 | 1 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0479 | 0.2274 | 0.2501 |
Brugia malayi | dihydrofolate reductase family protein | 0.0479 | 0.2274 | 0.2501 |
Echinococcus multilocularis | calpain A | 0.0045 | 0.0127 | 0.0139 |
Echinococcus multilocularis | Lipid transport protein, N terminal | 0.0664 | 0.3189 | 0.3507 |
Echinococcus granulosus | thymidylate synthase | 0.1858 | 0.9093 | 1 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0043 | 0.0117 | 0.0129 |
Loa Loa (eye worm) | hypothetical protein | 0.0664 | 0.3189 | 0.3507 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0043 | 0.0117 | 0.0129 |
Loa Loa (eye worm) | thymidylate synthase | 0.1858 | 0.9093 | 1 |
Onchocerca volvulus | 0.1858 | 0.9093 | 1 | |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0045 | 0.0127 | 0.0139 |
Echinococcus granulosus | dihydrofolate reductase | 0.0479 | 0.2274 | 0.2501 |
Echinococcus granulosus | Lipid transport protein N terminal | 0.0664 | 0.3189 | 0.3507 |
Echinococcus multilocularis | microsomal triglyceride transfer protein large | 0.1171 | 0.5693 | 0.6261 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0032 | 0.006 | 0.0066 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2041 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0884 | 0.4275 | 0.4701 |
Brugia malayi | calpain family protein 1 | 0.0043 | 0.0117 | 0.0129 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0036 | 0.004 |
Schistosoma mansoni | dihydrofolate reductase | 0.0479 | 0.2274 | 0.2501 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0117 | 0.0129 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0093 | 0.0102 |
Onchocerca volvulus | 0.0027 | 0.0036 | 0.004 | |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.1858 | 0.9093 | 1 |
Echinococcus multilocularis | calpain family protein 1, d | 0.0032 | 0.006 | 0.0066 |
Loa Loa (eye worm) | hypothetical protein | 0.1171 | 0.5693 | 0.6261 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0884 | 0.4275 | 1 |
Echinococcus granulosus | calpain A | 0.0045 | 0.0127 | 0.0139 |
Echinococcus granulosus | family C2 unassigned peptidase C02 family | 0.0045 | 0.0127 | 0.0139 |
Brugia malayi | calpain family protein 1 | 0.0043 | 0.0117 | 0.0129 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1858 | 0.9093 | 1 |
Echinococcus granulosus | microsomal triglyceride transfer protein large | 0.1171 | 0.5693 | 0.6261 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0045 | 0.0127 | 0.0139 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1858 | 0.9093 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.006 | 0.0066 |
Echinococcus multilocularis | family C2 unassigned peptidase (C02 family) | 0.0045 | 0.0127 | 0.0139 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.2041 | 1 | 1 |
Onchocerca volvulus | Apolipophorins homolog | 0.0664 | 0.3189 | 0.3507 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0479 | 0.2274 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.1858 | 0.9093 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1171 | 0.5693 | 0.6261 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.2041 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2041 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.1858 | 0.9093 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.