Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.1359 | 0.3878 |
Entamoeba histolytica | probable proteasome subunit beta type 2, putative | 0.0042 | 0.0951 | 0.2677 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0049 | 0.1359 | 0.3878 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0049 | 0.1359 | 0.3878 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0049 | 0.1359 | 0.3878 |
Leishmania major | cathepsin L-like protease | 0.0049 | 0.1359 | 0.1639 |
Leishmania major | cathepsin L-like protease | 0.0049 | 0.1359 | 0.1639 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1359 | 0.3953 |
Brugia malayi | cathepsin L-like precursor | 0.0033 | 0.0461 | 0.1342 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0025 | 0.0042 | 0.0123 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0049 | 0.1359 | 0.1359 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.1359 | 0.3878 |
Brugia malayi | Cathepsin L-like precursor | 0.0049 | 0.1359 | 0.3953 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0049 | 0.1359 | 0.3878 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0049 | 0.1359 | 0.3878 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0049 | 0.1359 | 0.3878 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0042 | 0.0951 | 0.2768 |
Echinococcus granulosus | cathepsin l1 | 0.0033 | 0.0461 | 0.0461 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0049 | 0.1359 | 0.3878 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0025 | 0.0042 | 0.0123 |
Brugia malayi | Protein kinase domain containing protein | 0.0025 | 0.000000078631 | 0.0000002288 |
Brugia malayi | Cathepsin L-like precursor | 0.0049 | 0.1359 | 0.3953 |
Onchocerca volvulus | 0.0049 | 0.1359 | 1 | |
Giardia lamblia | Proteasome subunit beta type 1 | 0.0068 | 0.2368 | 0.5699 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0461 | 0.1342 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0049 | 0.1359 | 0.3878 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0461 | 0.1342 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0087 | 0.3437 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0049 | 0.1359 | 0.1639 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0049 | 0.1359 | 0.1359 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0033 | 0.0461 | 0.1234 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.1359 | 0.3878 |
Onchocerca volvulus | 0.0049 | 0.1359 | 1 | |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0049 | 0.1359 | 0.3953 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0049 | 0.1359 | 0.3878 |
Brugia malayi | Cathepsin L-like precursor | 0.0049 | 0.1359 | 0.3953 |
Onchocerca volvulus | 0.0049 | 0.1359 | 1 | |
Entamoeba histolytica | cysteine proteinase, putative | 0.0049 | 0.1359 | 0.3878 |
Leishmania major | cathepsin L-like protease | 0.0049 | 0.1359 | 0.1639 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0049 | 0.1359 | 0.3953 |
Onchocerca volvulus | 0.0049 | 0.1359 | 1 | |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0087 | 0.3437 | 0.3437 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0087 | 0.3437 | 1 |
Leishmania major | cathepsin L-like protease | 0.0049 | 0.1359 | 0.1639 |
Loa Loa (eye worm) | cysteine protease | 0.0049 | 0.1359 | 0.3953 |
Plasmodium vivax | vivapain-2 | 0.0049 | 0.1359 | 0.3878 |
Plasmodium vivax | proteasome subunit beta type-1, putative | 0.0068 | 0.2368 | 0.685 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0461 | 0.1342 |
Plasmodium vivax | proteasome subunit beta type-2, putative | 0.0042 | 0.0951 | 0.2677 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0087 | 0.3437 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0049 | 0.1359 | 0.3953 |
Echinococcus multilocularis | cysteine protease | 0.0049 | 0.1359 | 0.1359 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.1359 | 0.3878 |
Mycobacterium ulcerans | proteasome PrcB | 0.0087 | 0.3437 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0049 | 0.1359 | 0.3878 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0025 | 0.0007 | 0.0021 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0068 | 0.2368 | 0.685 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0068 | 0.2368 | 0.685 |
Entamoeba histolytica | cysteine protease, putative | 0.0049 | 0.1359 | 0.3878 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0033 | 0.0461 | 0.1342 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0049 | 0.1359 | 0.3878 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0049 | 0.1359 | 0.3953 |
Onchocerca volvulus | 0.0033 | 0.0461 | 0.3394 | |
Onchocerca volvulus | Cathepsin L homolog | 0.0049 | 0.1359 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0033 | 0.0461 | 0.1342 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.1359 | 0.3878 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0042 | 0.0951 | 0.2768 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0049 | 0.1359 | 0.3878 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0087 | 0.3437 | 1 |
Brugia malayi | Uncoordinated protein 44 | 0.0025 | 0.000000078631 | 0.0000002288 |
Echinococcus granulosus | proteasome prosome macropain | 0.0087 | 0.3437 | 0.3437 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.1359 | 0.3878 |
Leishmania major | cathepsin L-like protease | 0.0049 | 0.1359 | 0.1639 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0049 | 0.1359 | 0.3878 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0087 | 0.3437 | 1 |
Schistosoma mansoni | proteasome subunit beta 1 (T01 family) | 0.0068 | 0.2368 | 0.6889 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0087 | 0.3437 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0049 | 0.1359 | 0.1359 |
Echinococcus granulosus | cysteine protease | 0.0025 | 0.0042 | 0.0042 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0033 | 0.0461 | 0.1234 |
Brugia malayi | Cathepsin L-like precursor | 0.0049 | 0.1359 | 0.3953 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0049 | 0.1359 | 0.3878 |
Trypanosoma brucei | proteasome subunit beta type-2, putative | 0.0042 | 0.0951 | 0.2677 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0049 | 0.1359 | 0.3878 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.1359 | 0.3878 |
Plasmodium vivax | vivapain-2 | 0.0049 | 0.1359 | 0.3878 |
Brugia malayi | Cathepsin L-like precursor | 0.0049 | 0.1359 | 0.3953 |
Brugia malayi | proteasome subunit beta type 2 | 0.0042 | 0.0951 | 0.2768 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0049 | 0.1359 | 0.3878 |
Echinococcus granulosus | cathepsin l1 | 0.0049 | 0.1359 | 0.1359 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0206 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0049 | 0.1359 | 0.3878 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0087 | 0.3437 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.1359 | 0.3878 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0042 | 0.0951 | 0.0951 |
Trypanosoma brucei | proteasome beta 6 subunit | 0.0068 | 0.2368 | 0.685 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0025 | 0.0042 | 0.0123 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0049 | 0.1359 | 0.3878 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0049 | 0.1359 | 0.3878 |
Brugia malayi | proteasome subunit beta type 1 | 0.0068 | 0.2368 | 0.6889 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0049 | 0.1359 | 0.3878 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0033 | 0.0461 | 0.1342 |
Echinococcus multilocularis | Ankyrin | 0.0025 | 0.0007 | 0.0007 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0049 | 0.1359 | 0.3878 |
Trypanosoma cruzi | proteasome subunit beta type-2, putative | 0.0042 | 0.0951 | 0.2677 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0042 | 0.0951 | 0.2677 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0042 | 0.0951 | 0.2677 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.1359 | 0.3878 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0049 | 0.1359 | 0.1359 |
Onchocerca volvulus | 0.0049 | 0.1359 | 1 | |
Leishmania major | cathepsin L-like protease | 0.0049 | 0.1359 | 0.1639 |
Loa Loa (eye worm) | fibroinase | 0.0049 | 0.1359 | 0.3953 |
Leishmania major | proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative | 0.0068 | 0.2368 | 0.5699 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0049 | 0.1359 | 0.3878 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0049 | 0.1359 | 0.3878 |
Echinococcus granulosus | ankyrin repeat and death domain containing protein | 0.0025 | 0.000000078631 | 0.000000078631 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0068 | 0.2368 | 0.685 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.1359 | 0.3878 |
Brugia malayi | Death domain containing protein | 0.0025 | 0.000000078631 | 0.0000002288 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0087 | 0.3437 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0007 | 0.0021 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0049 | 0.1359 | 0.1359 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0049 | 0.1359 | 0.3878 |
Leishmania major | cathepsin L-like protease | 0.0049 | 0.1359 | 0.1639 |
Plasmodium falciparum | proteasome subunit beta type-2, putative | 0.0042 | 0.0951 | 0.2677 |
Echinococcus multilocularis | ankyrin repeat and death domain containing protein | 0.0025 | 0.000000078631 | 0.000000078631 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0087 | 0.3437 | 1 |
Onchocerca volvulus | 0.0049 | 0.1359 | 1 | |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0025 | 0.0042 | 0.0123 |
Schistosoma mansoni | ankyrin 23/unc44 | 0.0025 | 0.000000078631 | 0.0000002288 |
Onchocerca volvulus | Cathepsin L homolog | 0.0049 | 0.1359 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0049 | 0.1359 | 0.3878 |
Entamoeba histolytica | proteasome subunit beta type 1, putative | 0.0068 | 0.2368 | 0.685 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0049 | 0.1359 | 0.1359 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0049 | 0.1359 | 0.3953 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0087 | 0.3437 | 0.5 |
Echinococcus multilocularis | cathepsin L | 0.0025 | 0.0042 | 0.0042 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0049 | 0.1359 | 0.3878 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0087 | 0.3437 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0087 | 0.3437 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.1359 | 0.3878 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0049 | 0.1359 | 0.3953 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0049 | 0.1359 | 0.1359 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.1359 | 0.3878 |
Onchocerca volvulus | 0.0049 | 0.1359 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0049 | 0.1359 | 0.3878 |
Trypanosoma cruzi | 20S proteasome subunit | 0.0042 | 0.0951 | 0.2677 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0049 | 0.1359 | 0.3878 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0033 | 0.0461 | 0.1234 |
Loa Loa (eye worm) | proteasome subunit beta type 2 | 0.0042 | 0.0951 | 0.2768 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0068 | 0.2368 | 0.2368 |
Leishmania major | cysteine peptidase A (CPA) | 0.0049 | 0.1359 | 0.1639 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0049 | 0.1359 | 0.3878 |
Brugia malayi | Cathepsin L-like precursor | 0.0049 | 0.1359 | 0.3953 |
Echinococcus granulosus | cathepsin L | 0.0025 | 0.0042 | 0.0042 |
Brugia malayi | Cathepsin L-like precursor | 0.0033 | 0.0461 | 0.1342 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0025 | 0.0042 | 0.0123 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0068 | 0.2368 | 0.2368 |
Loa Loa (eye worm) | proteasome subunit beta type 1 | 0.0068 | 0.2368 | 0.6889 |
Toxoplasma gondii | proteasome subunit beta type 1, putative | 0.0068 | 0.2368 | 0.5699 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0025 | 0.0042 | 0.0042 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0087 | 0.3437 | 1 |
Plasmodium falciparum | proteasome subunit beta type-1, putative | 0.0068 | 0.2368 | 0.685 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0049 | 0.1359 | 0.3878 |
Leishmania major | cathepsin L-like protease | 0.0049 | 0.1359 | 0.1639 |
Echinococcus granulosus | Ankyrin | 0.0025 | 0.0007 | 0.0007 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0087 | 0.3437 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0033 | 0.0461 | 0.1234 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.1359 | 0.3878 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.1359 | 0.3878 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0042 | 0.0951 | 0.0951 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0049 | 0.1359 | 0.3878 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0087 | 0.3437 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0049 | 0.1359 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.