TDR Targets

Basic information

Technical information

TDR Targets ID: 872669
Name: N-[(4-chlorophenyl)methyl]-1-[6-(4-methylphen yl)imidazo[1,2-d][1,3,4]thiadiazol-2-yl]piper idine-4-carboxamide
MW: 465.998 | Formula: C24H24ClN5OS
H donors: 1 H acceptors: 3 LogP: 5.22 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1)c1nc2n(c1)nc(s2)N1CCC(CC1)C(=O)NCc1ccc(cc1)Cl
InChi: 1S/C24H24ClN5OS/c1-16-2-6-18(7-3-16)21-15-30-23(27-21)32-24(28-30)29-12-10-19(11-13-29)22(31)26-14-17-4-8-20(25)9-5-17/h2-9,15,19H,10-14H2,1H3,(H,26,31)
InChiKey: NWWQTULPEDDLJD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[(4-chlorophenyl)methyl]-1-[6-(4-methylphenyl)-2-imidazo[1,2-d][1,3,4]thiadiazolyl]-4-piperidinecarboxamide
N-(4-chlorobenzyl)-1-[6-(4-methylphenyl)imidazo[1,2-d][1,3,4]thiadiazol-2-yl]isonipecotamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.1359	0.3878
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0033	0.0461	0.1342
Trypanosoma cruzi	cysteine peptidase, putative	0.0049	0.1359	0.3878
Schistosoma mansoni	cathepsin F (C01 family)	0.0049	0.1359	0.3953
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.1359	0.3878
Schistosoma mansoni	proteasome subunit beta 1 (T01 family)	0.0068	0.2368	0.6889
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.1359	0.3878
Onchocerca volvulus	Cathepsin L homolog	0.0049	0.1359	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.1359	0.3878
Leishmania major	proteasome beta 5 subunit, putative	0.0087	0.3437	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0049	0.1359	0.3878
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0042	0.0951	0.2768
Leishmania major	cathepsin L-like protease	0.0049	0.1359	0.1639
Brugia malayi	Cathepsin L-like precursor	0.0049	0.1359	0.3953
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0087	0.3437	1
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0042	0.0951	0.2677
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0087	0.3437	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.1359	0.3878
Brugia malayi	Cathepsin L-like precursor	0.0033	0.0461	0.1342
Echinococcus granulosus	Ankyrin	0.0025	0.0007	0.0007
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0068	0.2368	0.685
Onchocerca volvulus		0.0049	0.1359	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0049	0.1359	0.3878
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.1359	0.3878
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0087	0.3437	1
Loa Loa (eye worm)	proteasome subunit beta type 2	0.0042	0.0951	0.2768
Onchocerca volvulus		0.0049	0.1359	1
Onchocerca volvulus		0.0049	0.1359	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0049	0.1359	0.3878
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0049	0.1359	0.1359
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0461	0.1342
Brugia malayi	Uncoordinated protein 44	0.0025	0.000000078631	0.0000002288
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0049	0.1359	0.1359
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0068	0.2368	0.685
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0049	0.1359	0.3953
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.1359	0.3878
Echinococcus multilocularis	cathepsin L	0.0025	0.0042	0.0042
Onchocerca volvulus		0.0049	0.1359	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0025	0.0042	0.0123
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0042	0.0951	0.0951
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.1359	0.3878
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0049	0.1359	0.1359
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.0087	0.3437	0.5
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0068	0.2368	0.685
Onchocerca volvulus		0.0049	0.1359	1
Plasmodium falciparum	proteasome subunit beta type-2, putative	0.0042	0.0951	0.2677
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0042	0.0951	0.0951
Brugia malayi	Proteasome A-type and B-type family protein	0.0087	0.3437	1
Trypanosoma cruzi	proteasome subunit beta type-2, putative	0.0042	0.0951	0.2677
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.1359	0.3878
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.1359	0.3878
Entamoeba histolytica	cysteine proteinase, putative	0.0033	0.0461	0.1234
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0068	0.2368	0.2368
Brugia malayi	Cathepsin L-like precursor	0.0049	0.1359	0.3953
Brugia malayi	Cathepsin L-like precursor	0.0049	0.1359	0.3953
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.1359	0.3878
Toxoplasma gondii	proteasome subunit beta type 1, putative	0.0068	0.2368	0.5699
Leishmania major	cathepsin L-like protease	0.0049	0.1359	0.1639
Leishmania major	cysteine peptidase A (CPA)	0.0049	0.1359	0.1639
Loa Loa (eye worm)	fibroinase	0.0049	0.1359	0.3953
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.1359	0.3878
Loa Loa (eye worm)	cysteine protease	0.0049	0.1359	0.3953
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0025	0.000000078631	0.000000078631
Echinococcus granulosus	proteasome prosome macropain	0.0087	0.3437	0.3437
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.1359	0.3878
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0461	0.1234
Plasmodium vivax	vivapain-2	0.0049	0.1359	0.3878
Toxoplasma gondii	cathepsin CPL	0.0049	0.1359	0.1639
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.1359	0.3878
Leishmania major	cathepsin L-like protease	0.0049	0.1359	0.1639
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0049	0.1359	0.3878
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.0087	0.3437	0.5
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0042	0.0951	0.2768
Echinococcus multilocularis	Ankyrin	0.0025	0.0007	0.0007
Echinococcus granulosus	cathepsin l1	0.0033	0.0461	0.0461
Entamoeba histolytica	proteasome subunit beta type 1, putative	0.0068	0.2368	0.685
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0461	0.1342
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0049	0.1359	0.3953
Echinococcus multilocularis	cysteine protease	0.0049	0.1359	0.1359
Trypanosoma cruzi	cysteine peptidase, putative	0.0049	0.1359	0.3878
Trypanosoma cruzi	cysteine peptidase, putative	0.0049	0.1359	0.3878
Brugia malayi	proteasome subunit beta type 2	0.0042	0.0951	0.2768
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0049	0.1359	0.1359
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.1359	0.3878
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.1359	0.3878
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.1359	0.3878
Trypanosoma cruzi	cysteine peptidase, putative	0.0049	0.1359	0.3878
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.1359	0.3878
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.1359	0.3878
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0025	0.0007	0.0021
Echinococcus granulosus	cysteine protease	0.0025	0.0042	0.0042
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0025	0.000000078631	0.000000078631
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1359	0.3953
Echinococcus multilocularis	cathepsin L cysteine protease	0.0049	0.1359	0.1359
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.0087	0.3437	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.1359	0.3878
Trypanosoma brucei	proteasome beta 6 subunit	0.0068	0.2368	0.685
Plasmodium vivax	proteasome subunit beta type-1, putative	0.0068	0.2368	0.685
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.0087	0.3437	1
Entamoeba histolytica	probable proteasome subunit beta type 2, putative	0.0042	0.0951	0.2677
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0025	0.0042	0.0123
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0068	0.2368	0.2368
Brugia malayi	Cathepsin L-like precursor	0.0033	0.0461	0.1342
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0033	0.0461	0.1234
Echinococcus granulosus	cathepsin L	0.0025	0.0042	0.0042
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.1359	0.3878
Brugia malayi	Death domain containing protein	0.0025	0.000000078631	0.0000002288
Leishmania major	cathepsin L-like protease	0.0049	0.1359	0.1639
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0461	0.1234
Plasmodium falciparum	proteasome subunit beta type-5	0.0087	0.3437	1
Onchocerca volvulus		0.0049	0.1359	1
Brugia malayi	Cathepsin L-like precursor	0.0049	0.1359	0.3953
Leishmania major	cathepsin L-like protease	0.0049	0.1359	0.1639
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.1359	0.3878
Plasmodium vivax	proteasome subunit beta type-2, putative	0.0042	0.0951	0.2677
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.1359	0.3878
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.1359	0.3878
Entamoeba histolytica	cysteine proteinase, putative	0.0049	0.1359	0.3878
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.0087	0.3437	1
Onchocerca volvulus		0.0049	0.1359	1
Echinococcus multilocularis	proteasome (prosome, macropain)	0.0087	0.3437	0.3437
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0087	0.3437	1
Brugia malayi	Papain family cysteine protease containing protein	0.0025	0.0042	0.0123
Onchocerca volvulus		0.0033	0.0461	0.3394
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.1359	0.3878
Leishmania major	cathepsin L-like protease	0.0049	0.1359	0.1639
Onchocerca volvulus	Cathepsin L homolog	0.0049	0.1359	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0033	0.0461	0.1342
Brugia malayi	Papain family cysteine protease containing protein	0.0049	0.1359	0.3953
Brugia malayi	Cathepsin L-like precursor	0.0049	0.1359	0.3953
Trypanosoma cruzi	20S proteasome subunit	0.0042	0.0951	0.2677
Toxoplasma gondii	proteasome subunit beta type, putative	0.0087	0.3437	1
Leishmania major	cathepsin L-like protease	0.0049	0.1359	0.1639
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0007	0.0021
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.0087	0.3437	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.1359	0.3878
Trypanosoma cruzi	cruzipain precursor, putative	0.0049	0.1359	0.3878
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0461	0.1342
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0042	0.0951	0.2677
Schistosoma mansoni	cathepsin F (C01 family)	0.0049	0.1359	0.3953
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.1359	0.3878
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.1359	0.3878
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0206	1	1
Loa Loa (eye worm)	ctsf protein	0.0049	0.1359	0.3953
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.1359	0.3878
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.1359	0.3878
Echinococcus multilocularis	cathepsin L cysteine protease	0.0049	0.1359	0.1359
Schistosoma mansoni	ankyrin 23/unc44	0.0025	0.000000078631	0.0000002288
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.1359	0.3878
Leishmania major	proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative	0.0068	0.2368	0.5699
Echinococcus granulosus	cathepsin l1	0.0049	0.1359	0.1359
Giardia lamblia	Proteasome subunit beta type 1	0.0068	0.2368	0.5699
Entamoeba histolytica	cysteine proteinase, putative	0.0049	0.1359	0.3878
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.1359	0.3878
Onchocerca volvulus	Cathepsin F homolog	0.0049	0.1359	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0025	0.0042	0.0123
Echinococcus granulosus	cathepsin L cysteine protease	0.0025	0.0042	0.0042
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.1359	0.3878
Plasmodium vivax	vivapain-2	0.0049	0.1359	0.3878
Brugia malayi	Cathepsin L-like precursor	0.0049	0.1359	0.3953
Loa Loa (eye worm)	proteasome subunit beta type 1	0.0068	0.2368	0.6889
Trypanosoma brucei	proteasome subunit beta type-2, putative	0.0042	0.0951	0.2677
Brugia malayi	cathepsin L-like precursor	0.0033	0.0461	0.1342
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0049	0.1359	0.3878
Echinococcus multilocularis	cysteine protease	0.0049	0.1359	0.1359
Entamoeba histolytica	cysteine protease, putative	0.0049	0.1359	0.3878
Plasmodium vivax	proteasome subunit beta type-5, putative	0.0087	0.3437	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0049	0.1359	0.3878
Brugia malayi	proteasome subunit beta type 1	0.0068	0.2368	0.6889
Leishmania major	cathepsin L-like protease	0.0049	0.1359	0.1639
Brugia malayi	Protein kinase domain containing protein	0.0025	0.000000078631	0.0000002288
Brugia malayi	Papain family cysteine protease containing protein	0.0025	0.0042	0.0123
Plasmodium falciparum	proteasome subunit beta type-1, putative	0.0068	0.2368	0.685
Mycobacterium ulcerans	proteasome PrcB	0.0087	0.3437	0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 872669