Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0118 | 0.068 | 0.1148 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.035 | 1 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0101 | 0 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.035 | 1 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0248 | 0.5922 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0118 | 0.068 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0248 | 0.5922 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0248 | 0.5922 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.035 | 1 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.035 | 1 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0248 | 0.5922 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0248 | 0.5922 | 1 |
Brugia malayi | thymidylate synthase | 0.0248 | 0.5922 | 1 |
Onchocerca volvulus | 0.0248 | 0.5922 | 0.5 | |
Mycobacterium tuberculosis | Hypothetical protein | 0.0118 | 0.068 | 0.1148 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0248 | 0.5922 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0248 | 0.5922 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.035 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.