Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | aminopeptidase N | 0.0178 | 0.0032 | 0.0032 |
Trypanosoma cruzi | metallo-peptidase, Clan MA(E) Family M1 | 0.0178 | 0.0032 | 0.5 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0178 | 0.0032 | 0.5 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.0178 | 0.0032 | 0.5 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0178 | 0.0032 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.0032 | 0.0032 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.0047 | 0.0047 |
Entamoeba histolytica | aminopeptidase, putative | 0.0178 | 0.0032 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0178 | 0.0032 | 0.5 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 1.0881 | 1 | 1 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0194 | 0.0047 | 0.0052 |
Plasmodium falciparum | M1-family alanyl aminopeptidase, putative | 0.0178 | 0.0032 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0178 | 0.0032 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.0032 | 0.0032 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0178 | 0.0032 | 0.5 |
Onchocerca volvulus | 0.0178 | 0.0032 | 0.5 | |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0178 | 0.0032 | 0.5 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0194 | 0.0047 | 0.5 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0178 | 0.0032 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0178 | 0.0032 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | TATA binding protein associated factor | 0.0178 | 0.0032 | 0.0032 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0178 | 0.0032 | 0.5 |
Onchocerca volvulus | 0.0178 | 0.0032 | 0.5 | |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0178 | 0.0032 | 0.0032 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0194 | 0.0047 | 0.0052 |
Trypanosoma cruzi | puromycin-sensitive aminopeptidase-like protein, putative | 0.0178 | 0.0032 | 0.5 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.335 | 0.2986 | 0.2986 |
Onchocerca volvulus | 0.0178 | 0.0032 | 0.5 | |
Brugia malayi | Peptidase family M13 containing protein | 0.0194 | 0.0047 | 0.0015 |
Leishmania major | puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0178 | 0.0032 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0003 | 0.0003 |
Trypanosoma cruzi | puromycin-sensitive aminopeptidase-like protein, putative | 0.0178 | 0.0032 | 0.5 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0194 | 0.0047 | 0.0015 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0178 | 0.0032 | 0.5 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.0178 | 0.0032 | 0.5 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0194 | 0.0047 | 1 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0178 | 0.0032 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.0032 | 0.0032 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.0047 | 0.0047 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0194 | 0.0047 | 0.0052 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0194 | 0.0047 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0003 | 0.0003 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0178 | 0.0032 | 0.5 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.335 | 0.2986 | 1 |
Brugia malayi | hypothetical protein | 0.154 | 0.1301 | 0.1273 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.0047 | 0.0047 |
Toxoplasma gondii | peptidase family M13 protein | 0.0194 | 0.0047 | 1 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0178 | 0.0032 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0003 | 0.0003 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.335 | 0.2986 | 1 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.335 | 0.2986 | 1 |
Plasmodium falciparum | M1-family alanyl aminopeptidase | 0.0178 | 0.0032 | 0.5 |
Trypanosoma brucei | aminopeptidase, putative | 0.0178 | 0.0032 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0003 | 0.0003 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0178 | 0.0032 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 2 % | Inhibition of human NPP1 using p-Nph-5'-TMP as substrate at 10 uM | ChEMBL. | 25372276 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.