Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bacillus subtilis (strain 168) | ATP-dependent Clp protease proteolytic subunit | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.0634 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0426 | 1 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.0634 | 0.5 |
Onchocerca volvulus | 0.0072 | 0 | 0.5 | |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0094 | 0.0634 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0072 | 0 | 0.5 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.0634 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.0634 | 0.5 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0094 | 0.0634 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0426 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0426 | 1 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0094 | 0.0634 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0072 | 0 | 0.5 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0094 | 0.0634 | 0.0634 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0426 | 1 | 1 |
Onchocerca volvulus | 0.0072 | 0 | 0.5 | |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.0634 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0634 | 0.0634 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0094 | 0.0634 | 0.0634 |
Onchocerca volvulus | 0.0072 | 0 | 0.5 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0426 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0426 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0426 | 1 | 1 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0094 | 0.0634 | 0.0634 |
Echinococcus granulosus | carboxylesterase 5A | 0.0426 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0426 | 1 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0094 | 0.0634 | 0.5 |
Onchocerca volvulus | 0.0072 | 0 | 0.5 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0072 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0426 | 1 | 1 |
Onchocerca volvulus | 0.0072 | 0 | 0.5 | |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0072 | 0 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0072 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0426 | 1 | 1 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.0634 | 0.5 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.0634 | 1 |
Brugia malayi | Probable ClpP-like protease | 0.0094 | 0.0634 | 0.0634 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0426 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.1623 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.