Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0381 | 0.0381 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0051 | 0.0838 | 0.0838 |
Trichomonas vaginalis | esterase, putative | 0.0037 | 0.0437 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0037 | 0.0437 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0136 | 0.3255 | 0.3255 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0037 | 0.0437 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.0436 | 0.0436 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.0437 | 0.5 |
Onchocerca volvulus | 0.0037 | 0.0437 | 1 | |
Trypanosoma cruzi | Wee1-like protein kinase, putative | 0.0127 | 0.3015 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0436 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0436 | 0.0436 |
Schistosoma mansoni | tar DNA-binding protein | 0.0136 | 0.3255 | 0.3255 |
Schistosoma mansoni | tar DNA-binding protein | 0.0136 | 0.3255 | 0.3255 |
Schistosoma mansoni | tar DNA-binding protein | 0.0136 | 0.3255 | 0.3255 |
Echinococcus multilocularis | tar DNA binding protein | 0.0136 | 0.3255 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0136 | 0.3255 | 0.3255 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.0843 | 0.0843 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.0843 | 0.0843 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0437 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0381 | 0.0381 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0437 | 0.0437 |
Leishmania major | protein kinase, putative,serine/threonine protein kinase, putative | 0.0127 | 0.3015 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.0437 | 0.5 |
Trypanosoma cruzi | Wee1-like protein kinase, putative | 0.0127 | 0.3015 | 1 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0127 | 0.3015 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.0436 | 0.134 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0037 | 0.0437 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0437 | 0.0437 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0437 | 0.0437 |
Trypanosoma cruzi | Wee1-like protein kinase, putative | 0.0127 | 0.3015 | 1 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.0372 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0436 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0136 | 0.3255 | 0.3255 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.0838 | 0.2576 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0436 | 0.5 |
Brugia malayi | RNA binding protein | 0.0136 | 0.3255 | 0.3255 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0136 | 0.3255 | 0.3255 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0381 | 0.0381 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0436 | 0.0436 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.0838 | 0.2576 |
Onchocerca volvulus | 0.0037 | 0.0437 | 1 | |
Toxoplasma gondii | ABC1 family protein | 0.0037 | 0.0437 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0437 | 0.0437 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0236 | 0.6121 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0843 | 0.0843 |
Echinococcus granulosus | tar DNA binding protein | 0.0136 | 0.3255 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0437 | 0.0437 |
Mycobacterium ulcerans | hypothetical protein | 0.0037 | 0.0437 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0136 | 0.3255 | 0.3255 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0037 | 0.0437 | 0.1343 |
Mycobacterium ulcerans | beta-lactamase | 0.0037 | 0.0437 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.0037 | 0.0437 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0437 | 0.0437 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0372 | 1 | 1 |
Brugia malayi | beta-lactamase | 0.0037 | 0.0437 | 0.0437 |
Loa Loa (eye worm) | beta-lactamase | 0.0037 | 0.0437 | 0.0437 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.0838 | 0.0838 |
Loa Loa (eye worm) | RNA binding protein | 0.0136 | 0.3255 | 0.3255 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.0843 | 0.0843 |
Onchocerca volvulus | 0.0037 | 0.0437 | 1 | |
Mycobacterium ulcerans | lipase LipD | 0.0037 | 0.0437 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0436 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.0838 | 0.0838 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0037 | 0.0437 | 0.1343 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0437 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0051 | 0.0838 | 0.0838 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0437 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.0436 | 0.134 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0037 | 0.0437 | 0.0437 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0437 | 0.0437 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.0838 | 0.2576 |
Trypanosoma brucei | wee1-like protein kinase | 0.0127 | 0.3015 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0437 | 0.0437 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0437 | 0.0437 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.0838 | 0.0838 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.0838 | 0.2576 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0437 | 0.0437 |
Plasmodium vivax | hypothetical protein, conserved | 0.0037 | 0.0437 | 0.5 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0037 | 0.0437 | 0.0437 |
Loa Loa (eye worm) | TAR-binding protein | 0.0136 | 0.3255 | 0.3255 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.